Table of ContentsView AllTable of ContentsFeverHeadache and FatigueSwollen Lymph NodesSore Muscles and Joint PainUnexplained RashNausea and DiarrheaOral ThrushSore Throat and Dry CoughNight SweatsWeight LossSTISex Differences
Table of ContentsView All
View All
Table of Contents
Fever
Headache and Fatigue
Swollen Lymph Nodes
Sore Muscles and Joint Pain
Unexplained Rash
Nausea and Diarrhea
Oral Thrush
Sore Throat and Dry Cough
Night Sweats
Weight Loss
STI
Sex Differences
Unexplained rash, swollen lymph nodes, oral thrush, night sweats, and sudden and unexplained weight loss are all possible signs ofhuman immunodeficiency virus(HIV). Some symptoms appear in the early stage of HIV, while others show up in later stages. However, not everyone will experience the same symptoms at the same stage.
Thesigns or symptomsof HIV are not always obvious, and most people who have HIV do not exhibit any of them. If you do have early (acute) symptoms, they’re likely to appear in the first month or two after you’ve been infected. They may be similar to flu symptoms, including fever, headache, and fatigue.
These first signs ofHIVdiffer from late-stage symptoms when the virus weakens your immune system. These persistent (chronic) symptoms indicate the progression of illness. They may include diarrhea for over one week, persistent cough, and rapid weight loss.
Early acute HIV infection (AHI) can cause symptoms similar to the flu, including fever and chills. These symptoms may appear two to six weeks after you’ve been infected, and then go away.If your HIV remains untreated, they may return a few years later.
If you do get a fever, you will likely also have other flu-like symptoms.This is because your immune system is reacting to the virus as it replicates and moves through your system.
What Is ARS?ARS stands for acute retroviral syndrome. This is the collection of HIV signs and symptoms that occur during acute HIV infection (AHI) when theimmune systemmounts a defense against the virus as it first enters the body.As many as two out of three people with acute-stage HIV do not know they have it.
What Is ARS?
ARS stands for acute retroviral syndrome. This is the collection of HIV signs and symptoms that occur during acute HIV infection (AHI) when theimmune systemmounts a defense against the virus as it first enters the body.As many as two out of three people with acute-stage HIV do not know they have it.
AHI can also cause headaches and fatigue.This is because your body’s initial immune response to the virus generates inflammation.
You may get tired much faster than usual and you may feel out of breath even after light activity. You may experience a persistent headache that can range from mild to severe.
Headache and fatigue can also be symptoms of later-stage HIV.
Swollen lymph nodes(lymphadenopathy) can occur in the early stages of HIV as the body tries to kill the virus.
Thelymph nodesof the armpits, neck, groin, or behind the ear may get bigger. Sometimes, the swelling is very noticeable. Swollen lymph nodes may hurt or be tender to the touch.
Even as the other signs of the acute HIV infection go away, swollen lymph nodes can persist in some people for many weeks or months.
Lymphadenopathyis also common withopportunistic infectionsliketuberculosisand HIV-associated cancers.
Sore muscles and joint pain are common symptoms of many different viral illnesses. This symptom tends to occur alongside the other flu-like symptoms that are common in early HIV, such as fever, fatigue, and headache.
A rash is often the first sign of HIV, but it only appears in two of every five newly infected people.
AnHIV rashlooks a certain way: large areas of flat, reddened skin peppered with tiny bumps. The rash can be itchy or painful. It often occurs alongsideflu-like symptoms.
The HIV rash usually starts two to six weeks after exposure to the virus and will go away within one to two weeks. The rash is widespread and mainly affects the trunk and face, but can also be on the hands and feet.
This photo contains content that some people may find graphic or disturbing.See PhotoU.S. National Library of Medicine / National Institutes of Health
This photo contains content that some people may find graphic or disturbing.See Photo
This photo contains content that some people may find graphic or disturbing.
U.S. National Library of Medicine / National Institutes of Health
If you have a sudden rash with flu-like symptoms two to six weeks after having sex with a partner of unknown HIV status, you should get tested for HIV.
Some people also experience gastrointestinal (GI) symptoms during the early stage of HIV.GI symptoms may include nausea and vomiting and/or diarrhea.
GI symptoms can be present in many other illnesses, but they typically resolve quickly. If you have persistent nausea and vomiting or diarrhea, make sure you stay hydrated and see your healthcare provider.
One of the early opportunistic infections in people living with HIV isoral thrush.It is considered “opportunistic” because it takes the opportunity to infect a person when their immune system is weak.
People who are relatively healthy can also get oral thrush, but it is a sign that their immune system is breaking down. When a person’s immune system function is poor, thefungus can spreadinto the lungs and cause pneumonia.It can even spread to the bloodstream.
Having oral thrush does not automatically mean that you have HIV, but it could be a sign that you should get tested if you’re at risk.
This photo contains content that some people may find graphic or disturbing.See PhotoSol Silverman, Jr., D.D.S. / Centers for Disease Control and Prevention
Sol Silverman, Jr., D.D.S. / Centers for Disease Control and Prevention
Chronic symptoms of HIV develop as the virus breaks down the body’s immune defenses, leaving it open to infection. During the chronic stage of HIV, many symptoms are non-specific, meaning a person may assume they are due to another cause.
Sore throat and dry cough can be symptoms of early HIV infection, but they also appear in later stages of HIV. In later stages, these are persistent symptoms that do not resolve with medications such as inhalers or antibiotics.They are often related to secondary lung infections, which are common in the later stages of HIV.
A persistent cough is always a reason to see your healthcare provider, especially if it’s getting worse over time.
Night sweatscan occur during the acute stage as the body fights the virus and during the chronic phase if there is an opportunistic infection.
Also calledsleephyperhidrosis, night sweats are more than justbeing sweaty in your sleep—they will drench your clothes and bedding. Night sweats can also soak through these materials and cause shivers.
Drenching night sweats are never considered normal. You should let your provider know if you’re having them.
Night sweats can have causes other than HIV, and some of them are not as serious as others—for example,menopausecommonly causes night sweats but many types ofcancercan as well.
Sudden, Unexplained Weight Loss
Weight loss is common in people living with HIV during the advanced stages of the disease.
This type of weight loss is more than just a few pounds—it’s a sudden,unexplained weight lossof 10% or more of a person’s body weight, in which both fat mass and lean muscle are lost.
The condition is also calledHIV wasting syndrome. It’s not as common today as it once was becauseantiretroviral drugskeep the virus suppressed and allow the immune system to rebuild itself. Wasting is mainly seen in people who have not been treated for HIV.
Other causes of wasting includemalnutrition,chronic diarrhea,tuberculosis, andcancer—all of which require urgent diagnosis and treatment.
A Sexually Transmitted Infection (STI)
If you have asexually transmitted infection (STI), there is a chance you may have HIV as well. Some STIs likesyphilisandherpescause open sores that make it easier for HIV to get inside the body.
STIs likegonorrheaandchlamydiacause inflammation in the genitals that attract the immune cells (CD4 T cells) that HIV likes to target and infect.
Only anHIV testcan tell you for sure if you have the virus.
Sex Differences With HIV Signs
Biological females and males generally have the same symptoms of HIV, butfemalesmay also have frequentyeast infectionsand irregular periods. Females living with HIV are also at an increased risk ofpelvic inflammatory diseaseand cervical cancer.
Summary
Many people who are HIV-positive do not know they have the virus. The only way to find out for sure is to get tested.
There are some clues that could mean you have HIV, especially if you’re at risk. The first signs of HIV can seem like the flu with symptoms like fever, headache, and fatigue. Sometimes the first sign of HIV is a rash with flat, reddened skin and tiny bumps.
Late-stage symptoms may include recurring night sweats, diarrhea for more than a week, and rapid weight loss. Having another STI may also indicate that you’re at risk for HIV.
22 Sources
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HIV.gov.How can you tell if you have HIV?
HIV.org.Symptoms of HIV.
Burns DN, Degruttola V, Pilcher CD, et al.Toward an endgame: finding and engaging people unaware of their HIV-1 infection in treatment and prevention.AIDS Res Hum Retroviruses.2014;30(3):217-224. doi:10.1089/aid.2013.0274
Zhu Z, Zhao R, Hu Y.Symptom clusters in people living with HIV: A systematic review.J Pain Symptom Manage. 2019;58(1):115-133. doi:10.1016/j.jpainsymman.2019.03.018
National Library of Medicine.Swollen lymph nodes.
Nag D, Dey S, Nandi A, Bandyopadyay R, Roychowdry D, Roy R.Etiological study of lymphadenopathy in HIV-infected patients in a tertiary care hospital.J Cytol.2016;33(2):66–70. doi:10.4103/0970-9371.182518
Lopez-Rios J, Frasca T, Kindlon MJ, et al.Limited knowledge and lack of screening for acute HIV infection at primary care clinics in high-prevalence communities of New York City.AIDS Behav. 2019;23(10):2870-2878. doi:10.1007/s10461-019-02527-3
National Library of Medicine.HIV.
Klatt EC.Pathology of HIV/AIDS.
Patil S, Majumdar B, Sarode SC, Sarode GS, Awan KH.Oropharyngeal candidosis in HIV-infected patients-An update.Front Microbiol. 2018;9:980. doi:10.3389/fmicb.2018.00980
Kaur R, Mehra B, Dhakad MS, Goyal R, Bhalla P, Dewan R.Fungal opportunistic pneumonias in HIV/AIDS patients: An Indian tertiary care experience.J Clin Diagn Res. 2017;11(2):DC14-DC19. doi:10.7860/JCDR/2017/24219.9277
Aldamova A, Ovsepian Z.Features of the clinical course of invasive Candidiasis in HIV-infected patients.Ann Rom Soc Cell Biol. 2021;25(3):5476-81.
Pastor L, Casellas A, Carrillo J, et al. IP-10Levels as an accurate screening tool to detect acute HIV infection in resource-limited settings.Sci Rep. 2017;7(1):8104. doi:10.1038/s41598-017-08218-0
Sax PE, Bartlett J, Bloom A.Acute and early HIV infection: Clinical manifestations and diagnosis.Up To Date. 2019.
Qiuwan Z.Atlas of AIDS Co-infection. Walter de Gruyter GmbH & Co KG; 2015.
Shaw J, Matin N.Opportunistic infections in HIV.Medicine. 2022;50(5):294-7. doi:10.1016/j.mpmed.2022.02.010
Bryce C.Persistent night sweats: diagnostic evaluation.Am Fam Physician. 2020;102(7):427-433.
Erlandson KM, Li X, Abraham AG, et al.Long-term impact of HIV wasting on physical function in the Multicenter AIDS Cohort Study.AIDS. 2016;30(3):445–454. doi:10.1097/QAD.0000000000000932
Cohen MS, Council OD, Chen JS.Sexually transmitted infections and HIV in the era of antiretroviral treatment and prevention: the biologic basis for epidemiologic synergy.J Int AIDS Soc.2019;22(Suppl 6):e25355. doi:10.1002/jia2.25355
HIV.gov.Syphilis and HIV: a dangerous duo affecting gay and bisexual men.
Scully EP.Sex differences in HIV infection.Curr HIV/AIDS Rep. 2018;15(2):136-46. doi:10.1007/s11904-018-0383-2
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