In aplastic anemia (AA), the bone marrow stops making enough red blood cells, white blood cells, and platelets.Aplastic anemia may appear at any age but is diagnosed more often in children and young adults. Estimates vary, but between 1.5 and about seven cases are diagnosed per million people each year.
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Symptoms
The symptoms of aplastic anemia come on slowly. The symptoms are related to the low levels of blood cells:
Diagnosis
The symptoms of aplastic anemia often point the way to a diagnosis. The physician will obtain acomplete blood cell count(CBC), and the blood will be examined under a microscope (blood smear).
The CBC will show the low levels of red cells, white cells, and platelets in the blood. Looking at the cells under the microscope will distinguish aplastic anemia from other blood disorders.
In addition to the blood tests, a bone marrow biopsy (sample) will be taken and examined under the microscope.In aplastic anemia, it will show few new blood cells being formed. Examining the bone marrow also helps distinguish aplastic anemia from other bone marrow disorders, such as myelodysplastic disorder or leukemia.
Staging
Classifying or staging the disease is based on the criteria of the International Aplastic Anemia Study Group, which defines levels according to the numbers of blood cells present in the blood tests and bone marrow biopsy.Aplastic anemia is classified as moderate (MAA), severe (SAA), or very severe (VSAA).
Treatment
For young individuals with aplastic anemia, abone marrow or stem cell transplantreplaces the defective bone marrow with healthy blood-forming cells.
Transplantation carries many risks, so it is not always used as a treatment for middle-aged or elderly individuals. About 86% of individuals who receive a bone marrow transplant have a complete recovery.
For older individuals, treatment of aplastic anemia focuses on suppressing the immune system with Atgam (anti-thymocyte globulin) and Sandimmune (cyclosporine), along with Promacta (eltrombopag), a drug that stimulates the bone marrow. These drugs may be used alone or in combination.
Since individuals with aplastic anemia have low numbers of white blood cells, they are at high risk for infection.Therefore, preventing infections, and treating them quickly once they occur, is important.
13 Sources
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