Table of ContentsView AllTable of ContentsIndicationsHow It WorksProcedureSide Effects
Table of ContentsView All
View All
Table of Contents
Indications
How It Works
Procedure
Side Effects
Chimeric antigen receptor T-cell treatment, also called CAR-T therapy, is a type of adoptive cell transfer therapy used for treating certain kinds of cancer.
Normally, T-cells fight cancer cells to prevent them from multiplying and causing disease. Most of the research on CAR-T treatment has been focused on blood cancers likeleukemiaandlymphoma.
2:35CAR T-Cell Therapy
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CAR T-Cell Therapy
Immunotherapy is a process that uses a person’s own immune cells to treat diseases. CAR-T involves multiple steps in which immune cells are removed from a person’s own body, genetically modified in a laboratory using the drug, and then placed back into the body to fight cancer.
If you are having CAR-T therapy, you may also need to take immunosuppressive chemotherapeutic medication to help optimize the effects of your treatment.
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The medications used in CAR-T therapy are approved for the treatment of specific tumors in certain age groups.
In the research setting, a number of clinical trials investigating the effects of these approved CAR-T medications, as well as other CAR-T drugs, are still in the development phase.
Experimental trial protocols may permit the use of CAR-T drugs for other indications and ages besides those for which FDA-approved therapies are already approved.
How CAR-T Immunotherapy Works
After the modified immune cells are re-infused, the changes they have undergone cause them to bind to the cancer cells. The immune cells then multiply within the body and work to help eradicate the cancer.
White blood cellsinclude two major types of immune cells: T-cells and B-cells. Normally, T-cells fight cancer cells to prevent them from multiplying and causing disease.
How T-Cells Help Fight Cancer
Gene Editing
The genetic modification of the T-cells is described as gene editing. Kymriah and Yescarta use a lentiviral vector to insert the anti-CD19 gene into the T-cells. Even though a virus is used to insert genetic material into the DNA of a target cell, the process is controlled and won’t cause a viral infection.
Another gene editing tool, clustered regularly interspaced short palindromic repeats (CRISPR), uses a type of technology that allows precise insertion of DNA into the genes of the target cell. SomeCAR-T researchuses CRISPR rather than retroviral vector gene editing.
LimitationsIn general, CAR-T is more effective for the treatment of blood cancers than other types of cancer. With blood cancers, like lymphoma and leukemia, the cancer cells tend to circulate throughout the body.The modified T-cells can more easily locate and bind to circulating cancer cells than to tumor growths, which may have many cancer cells enclosed deep within a tumor where the T-cells can’t reach.
Limitations
In general, CAR-T is more effective for the treatment of blood cancers than other types of cancer. With blood cancers, like lymphoma and leukemia, the cancer cells tend to circulate throughout the body.The modified T-cells can more easily locate and bind to circulating cancer cells than to tumor growths, which may have many cancer cells enclosed deep within a tumor where the T-cells can’t reach.
In general, CAR-T is more effective for the treatment of blood cancers than other types of cancer. With blood cancers, like lymphoma and leukemia, the cancer cells tend to circulate throughout the body.
The modified T-cells can more easily locate and bind to circulating cancer cells than to tumor growths, which may have many cancer cells enclosed deep within a tumor where the T-cells can’t reach.
CAR-T treatment involves several steps. First, T-cells are collected through leukapheresis, which is the removal of white blood cells from the blood. This can take two to four hours.
A needle is placed in the vein, and after the white blood cells are removed and saved through a filtering technique, the blood is placed back into the body through another vein.
If you experience any side effects, be sure to tell your medical team so your procedure can be slowed down or adjusted as needed.
You should recover from this part of the procedure fairly quickly, and you will likely be discharged home on the same day.
Cell Preparation
The T-cells are then sent to the laboratory, treated with the medication, and genetically altered to become CAR-T cells. The modified T-cells multiply in the laboratory for several weeks. You can expect to wait approximately four weeks after your cells are collected before your CAR-T cells are ready to be infused into your body.
While you are waiting, you may undergo treatment with lymphodepletion chemotherapy to reduce your circulating immune cells.This can optimize the effects of the CAR-T cells. Your oncologist will explain any risks and side effects of the chemotherapy so you will know what to look out for.
Infusion
Your CAR-T cell infusion will be given intravenously (IV, in a vein) over several hours in a medical setting, such as an infusion center.
If you experience any complications or side effects, be sure to tell the team of providers who are taking care of you.
You will be monitored to make sure that your vital signs—such as your blood pressure, temperature, and heart rate—are normal before you will be discharged to go home on the day of your infusion.
Recovery
Studies have shown a high rate (over 70%) of remission (cancer-free) in response to CAR-T. Because it is a relatively new type of therapy, long-term outcomes are not known.
If you have a good outcome, it is still important that you follow up with your oncologist so that you can continue to have routine monitoring to see if there are any signs of cancer recurrence.
A number of side effects can develop as a result of CAR-T treatment. The most common are cytokine release syndrome (CRS) and neurological toxicities, and these side effects have been described in over 80% of people who have CAR-T therapy.Nevertheless, experts who treat patients with CAR-T therapy are prepared to recognize the signs of these side effects and to treat them.
What to Watch Out ForCRS: This can manifest with fevers, chills, nausea, vomiting, diarrhea, dizziness, and low blood pressure. It may begin a few days after infusion, and it can be treated with Actemra (tocilizumab), an immunosuppressive drug that is approved for the treatment of CRS.Neurological toxicities: This can begin within a week after the infusion and may include confusion, changes in consciousness, agitation, and seizures.Urgent treatment is necessary if any of these side effects develop.
What to Watch Out For
CRS: This can manifest with fevers, chills, nausea, vomiting, diarrhea, dizziness, and low blood pressure. It may begin a few days after infusion, and it can be treated with Actemra (tocilizumab), an immunosuppressive drug that is approved for the treatment of CRS.Neurological toxicities: This can begin within a week after the infusion and may include confusion, changes in consciousness, agitation, and seizures.Urgent treatment is necessary if any of these side effects develop.
There is some variation in the incidence of side effects of the two approved CAR-T drugs, but they are generally similar.
A Word From Verywell
Cancer is treated with several different methods, and sometimes with a combination of therapies.
CAR-T therapy uses genetic modification to help fight cancer. It is one of the newer approaches in cancer treatment, and while there are still only a few approved indications currently, there is a great deal of ongoing research into wider application of this technology for cancer treatment.
How Immunotherapy Works for Cancer Treatment
8 Sources
Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read oureditorial processto learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.
Food and Drug Administration.Breyanzi label.
Food and Drug Administration.Carvykti label.
Food and Drug Administration.KYMRIAH (tisagenlecleucel).
Food and Drug Administration.Tecartus label.
Food and Drug Administration.YESCARTA (axicabtagene ciloleucel).
Cai Y, Mikkelsen JG.Lentiviral delivery of proteins for genome engineering.Curr Gene Ther. 2016;16(3):194-206. doi:10.2174/1566523216666160527143702
Mollanoori H, Shahraki H, Rahmati Y, Teimourian S.CRISPR/Cas9 and CAR-T cell, collaboration of two revolutionary technologies in cancer immunotherapy, an instruction for successful cancer treatment.Hum Immunol.2018;79(12):876-882. doi:10.1016/j.humimm.2018.09.007
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