Table of ContentsView AllTable of ContentsConstipation and FatigueCausesIBS and Chronic FatigueTreatmentPreventionWhen to See a Healthcare ProviderFrequently Asked Questions
Table of ContentsView All
View All
Table of Contents
Constipation and Fatigue
Causes
IBS and Chronic Fatigue
Treatment
Prevention
When to See a Healthcare Provider
Frequently Asked Questions
Constipationandfatigueoften go together. They don’t cause each other, but they can both be symptoms of many things.
With constipation, bowel movements are more difficult or less frequent than usual. Fatigue makes you tired, lethargic.
When you have both, it could be fromdehydrationormalnutrition. Or a medication or medical condition may be to blame.
In this article, you’ll learn the possible causes of constipation and fatigue, the link between fatigue and irritable bowel syndrome, and what treatment and prevention methods may help.
Both constipation and fatigue have to be judged against what’s “normal” for you.
Medically speaking, constipation is defined as fewer than three bowel movements a week.If you regularly go less than that, it’s consideredchronic constipation.
But if you typically have three or four bowel movements a day, your personal benchmark is different. Pay attention to your normal patterns, and watch for changes that may signal a problem.
Symptoms of constipation include:
Fatigue can also be tricky to gauge. If you regularly don’t get enoughsleepor have chronic stress, you may be fatigued a lot of the time. If you tend to sleep well and feel energized most days, you’re likely to notice a new cause of fatigue much faster than someone who’s always yawning.
Base your assessment on your normal. A new symptom or significant change is something worth paying attention to.
Constipation and Fatigue Causes
Fatigue isn’t a constipation symptom. But the two symptoms can come from many of the same medical problems.
Malnutrition and Dehydration
Certain Medications
Medications that can cause fatigue and/or constipation include:
Autoimmune/Autoinflammatory Diseases
Autoimmune andautoinflammatorydiseasesinvolve an immune system disorder that attacks healthy parts of your body. Fatigue is a major symptom of many autoimmune and autoinflammatory diseases.
Some diseases directly affect thedigestive system, includingceliac diseaseand autoimmune GI dysmotility.
Many other diseases have systemic effects that may include digestive problems and constipation. They include:
Fibromyalgia and ME/CFS
Fibromyalgiaandmyalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) are classified as central sensitivity syndromes. Some causes may involve autoimmunity.
Fatigue is a defining symptom of both conditions. They also can involve bowel problems, including constipation.
Alterations in gut microbiota may play a role in constipation and other bowel problems in people with ME/CFS, but more research is needed to see if there is a casual relationship.
Risk Factors for ConstipationSome risk factors for constipation include female biology, a sedentary lifestyle, being over 75,obesity, low water intake, and lowdietary fiber.
Risk Factors for Constipation
Some risk factors for constipation include female biology, a sedentary lifestyle, being over 75,obesity, low water intake, and lowdietary fiber.
The Link Between IBS and Chronic Fatigue
Irritable bowel syndrome(IBS) often involves constipation. It comes in foursubtypes:
Only IBS-D doesn’t involve constipation.
Research suggests that about 55% of people with IBS have fatigue.The link isn’t fully understood. It may be due to genetic abnormalities that affectserotonin, aneurotransmitterand hormone that deals with digestion and sleep.
Serotonin dysregulation is also linked to fibromyalgia, ME/CFS, and othercentral sensitivity syndromes. Those conditions frequently overlap with IBS.
Meanwhile, you may get symptom relief from other treatments. Work with your healthcare provider to get a diagnosis and find treatments that help.
Some places to start include changing your diet, taking or changing medications, and improving your sleep schedule.
Diet Changes/Supplements
Dietary changes may help both constipation and fatigue. For constipation:
For fatigue, ask your healthcare provider to check fornutritional deficiencies. Correcting those is an easy place to start.
Certain herbs and nutrients may increase your energy levels or help you sleep. It can be hard to get enough through diet alone, though. Supplements can be a more consistent and reliable method. However, there is little in the way of hard research that proves supplements will give you more energy or improve your sleep. If you’re thinking of taking a supplement, talk to your healthcare provider first, only take the recommended dosage, and watch for side effects and drug interactions.
For energy, you may want to try:
Supplements that may help with sleep include:
Note that magnesium is in all of the above lists, which could make it an ideal supplement fortreating constipationand fatigue.
Natural Constipation Remedies
Medication
You and your healthcare provider should look over your current medications and supplements. Something may be causing or contributing to your symptoms. If so, you may want to adjust your dosage or switch to a different medication.
You have a few medication options for treating constipation:
Talk to your healthcare provider about the proper way to use laxatives. If you over-use them, they can make constipation worse.
Fatigue can be treated with medications that keep you awake, those that help you sleep, or both. Stimulant medications include:
Antidepressants are sometimes used to improve sleep, as well. These include:
However, although these medications may help you get to sleep, they may make your constipation worse.
Sleep Schedule
Improving yoursleep schedulecan relieve fatigue, and maybe constipation, too. A study suggests sleeping for longer or shorter periods than average can increase constipation rates.
To get better sleep, you can establish a few healthy habits:
If these steps don’t help, talk to your healthcare provider about the possibility ofsleep disorders.
What Time Should You Go to Bed?
You may be able to prevent bouts of constipation. Things to try include:
You should get medical attention for constipation plus:
Also, make an appointment if your constipation doesn’t clear up with self-care. If you have a family history ofcolon or rectal cancer, always get constipation checked out.
Summary
Don’t just live with constipation and fatigue. See a healthcare provider to figure out what’s causing them and if you have prolonged or severe symptoms.
Frequently Asked QuestionsConstipation usually doesn’t cause depression or other mood disorders, but constipation and depression may go together. Research suggests it’s because they both involve low serotonin levels or activity.No, constipation doesn’t cause weight gain—at least, it doesn’t make you gain fat. Temporarily, your weight may go up simply because you have a lot of stool in your intestine. Once it’s out, you’ll be back at your pre-constipation weight.Constipation has many possible causes, not just dehydration. You may not be eating enough fiber, getting enough activity, or sleeping well. All those things can contribute to constipation.
Constipation usually doesn’t cause depression or other mood disorders, but constipation and depression may go together. Research suggests it’s because they both involve low serotonin levels or activity.
No, constipation doesn’t cause weight gain—at least, it doesn’t make you gain fat. Temporarily, your weight may go up simply because you have a lot of stool in your intestine. Once it’s out, you’ll be back at your pre-constipation weight.
Constipation has many possible causes, not just dehydration. You may not be eating enough fiber, getting enough activity, or sleeping well. All those things can contribute to constipation.
33 SourcesVerywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read oureditorial processto learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.MedlinePlus.Constipation.Johns Hopkins Medicine.Constipation.Allard JP, Keller H, Gramlich L, Jeejeebhoy KN, Laporte M, Duerksen DR.GLIM criteria has fair sensitivity and specificity for diagnosing malnutrition when using SGA as comparator.Clin Nutr.2019. doi:10.1016/j.clnu.2019.12.004MedlinePlus.Dehydration.National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases.Symptoms & causes of constipation.Zielinski MR, Systrom DM, Rose NR.Fatigue, sleep, and autoimmune and related disorders.Front Immunol. 2019;10:1827. doi:10.3389/fimmu.2019.01827National Institutes of Health, Genetic and Rare Diseases Information Center.Autoimmune gastrointestinal dysmotility.Lupus Foundation of America.Lupus and the digestive system.National Multiple Sclerosis Society.Constipation & loss of bowel control due to multiple sclerosis.Johns Hopkins Medicine.Constipation: Cause and prevention tips.International Foundation for Gastrointestinal Disorders.Scleroderma.University of Washington: UW Medicine.Fibromyalgia.Varesi A, Deumer US, Ananth S, Ricevuti G.The emerging role of gut microbiota in myalgic encephalomyelitis/chronic fatigue syndrome (me/cfs): current evidence and potential therapeutic applications.J Clin Med. 2021;10(21):5077. doi:10.3390/jcm10215077Yurtdaş G, Acar-Tek N, Akbulut G, et al.Risk factors for constipation in adults: a cross-sectional study.J Am Coll Nutr. 2020;39(8):713-719. doi:10.1080/07315724.2020.1727380Palsson OS, Whitehead W, Törnblom H, Sperber AD, Simren M.Prevalence of Rome IV functional bowel disorders among adults in the United States, Canada, and the United Kingdom.Gastroenterology. 2020;158(5):1262-1273.e3. doi: 10.1053/j.gastro.2019.12.021Han CJ, Yang GS.Fatigue in irritable bowel syndrome: a systematic review and meta-analysis of pooled frequency and severity of fatigue.Asian Nurs Res (Korean Soc Nurs Sci). 2016;10(1):1-10. doi:10.1016/j.anr.2016.01.003Han CJ, Jarrett ME, Cain KC, Jun S, Heitkemper MM.Association of fatigue with tph2 genetic polymorphisms in women with irritable bowel syndrome.Biol Res Nurs. 2019;21(1):72-79. doi:10.1177/1099800418806055Fleming KC, Volcheck MM.Central sensitization syndrome and the initial evaluation of a patient with fibromyalgia: a review.Rambam Maimonides Med J. 2015;6(2):e0020. doi:10.5041/RMMJ.10204Tardy AL, Pouteau E, Marquez D, Yilmaz C, Scholey A.Vitamins and minerals for energy, fatigue and cognition: a narrative review of the biochemical and clinical evidence.Nutrients. 2020;12(1):228. doi:10.3390/nu12010228Bai XL, Deng XL, Wu GJ, Li WJ, Jin S.Rhodiola and salidroside in the treatment of metabolic disorders.Mini Rev Med Chem. 2019;19(19):1611-1626. doi:10.2174/1389557519666190903115424Ferreira GC, McKenna MC.L-carnitine and acetyl-l-carnitine roles and neuroprotection in developing brain.Neurochem Res. 2017;42(6):1661-1675. doi:10.1007/s11064-017-2288-7Filler K, Lyon D, Bennett J, et al.Association of mitochondrial dysfunction and fatigue: a review of the literature.BBA Clin. 2014;1:12-23. doi:10.1016/j.bbacli.2014.04.001Ramírez-Campillo R, González-Jurado JA, Martínez C, et al.Effects of plyometric training and creatine supplementation on maximal-intensity exercise and endurance in female soccer players.J Sci Med Sport. 2016;19(8):682-687. doi:10.1016/j.jsams.2015.10.005Djokic G, Vojvodić P, Korcok D, et al.The effects of magnesium - melatonin - vit b complex supplementation in treatment of insomnia.Open Access Maced J Med Sci. 2019;7(18):3101-3105. doi:10.3889/oamjms.2019.771Bent S, Padula A, Moore D, Patterson M, Mehling W.Valerian for sleep: a systematic review and meta-analysis.Am J Med. 2006;119(12):1005-1012. doi:10.1016/j.amjmed.2006.02.026Kim S, Jo K, Hong KB, Han SH, Suh HJ.GABA and l-theanine mixture decreases sleep latency and improves NREM sleep.Pharm Biol. 2019;57(1):65-73. doi:10.1080/13880209.2018.1557698Lillehei AS, Halcón LL, Savik K, Reis R.Effect of inhaled lavender and sleep hygiene on self-reported sleep issues: a randomized controlled trial.J Altern Complement Med. 2015;21(7):430-438. doi:10.1089/acm.2014.0327Bayliak MM, Dmytriv TR, Melnychuk AV, Strilets NV, Storey KB, Lushchak VI.Chamomile as a potential remedy for obesity and metabolic syndrome.EXCLI J. 2021;20:1261-1286. doi:10.17179/excli2021-4013Harvard University, Harvard Medical School, Division of Sleep Medicine.Treating narcolepsy: Medications.MedlinePlus.Medicine for sleep.Adeyinka C, Adejumo, Kuo B, Staller K.Abnormal sleep duration is associated with constipation in a national study.Gastroenterology. 2020;158(6):S-393-S-394. doi:10.1016/S0016-5085(20)31675-9Centers for Disease Control and Prevention.About sleep.National Health Service: NHSinform.Constipation.Additional ReadingMedlinePlus.Fatigue.National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases.Constipation.
33 Sources
Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read oureditorial processto learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.MedlinePlus.Constipation.Johns Hopkins Medicine.Constipation.Allard JP, Keller H, Gramlich L, Jeejeebhoy KN, Laporte M, Duerksen DR.GLIM criteria has fair sensitivity and specificity for diagnosing malnutrition when using SGA as comparator.Clin Nutr.2019. doi:10.1016/j.clnu.2019.12.004MedlinePlus.Dehydration.National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases.Symptoms & causes of constipation.Zielinski MR, Systrom DM, Rose NR.Fatigue, sleep, and autoimmune and related disorders.Front Immunol. 2019;10:1827. doi:10.3389/fimmu.2019.01827National Institutes of Health, Genetic and Rare Diseases Information Center.Autoimmune gastrointestinal dysmotility.Lupus Foundation of America.Lupus and the digestive system.National Multiple Sclerosis Society.Constipation & loss of bowel control due to multiple sclerosis.Johns Hopkins Medicine.Constipation: Cause and prevention tips.International Foundation for Gastrointestinal Disorders.Scleroderma.University of Washington: UW Medicine.Fibromyalgia.Varesi A, Deumer US, Ananth S, Ricevuti G.The emerging role of gut microbiota in myalgic encephalomyelitis/chronic fatigue syndrome (me/cfs): current evidence and potential therapeutic applications.J Clin Med. 2021;10(21):5077. doi:10.3390/jcm10215077Yurtdaş G, Acar-Tek N, Akbulut G, et al.Risk factors for constipation in adults: a cross-sectional study.J Am Coll Nutr. 2020;39(8):713-719. doi:10.1080/07315724.2020.1727380Palsson OS, Whitehead W, Törnblom H, Sperber AD, Simren M.Prevalence of Rome IV functional bowel disorders among adults in the United States, Canada, and the United Kingdom.Gastroenterology. 2020;158(5):1262-1273.e3. doi: 10.1053/j.gastro.2019.12.021Han CJ, Yang GS.Fatigue in irritable bowel syndrome: a systematic review and meta-analysis of pooled frequency and severity of fatigue.Asian Nurs Res (Korean Soc Nurs Sci). 2016;10(1):1-10. doi:10.1016/j.anr.2016.01.003Han CJ, Jarrett ME, Cain KC, Jun S, Heitkemper MM.Association of fatigue with tph2 genetic polymorphisms in women with irritable bowel syndrome.Biol Res Nurs. 2019;21(1):72-79. doi:10.1177/1099800418806055Fleming KC, Volcheck MM.Central sensitization syndrome and the initial evaluation of a patient with fibromyalgia: a review.Rambam Maimonides Med J. 2015;6(2):e0020. doi:10.5041/RMMJ.10204Tardy AL, Pouteau E, Marquez D, Yilmaz C, Scholey A.Vitamins and minerals for energy, fatigue and cognition: a narrative review of the biochemical and clinical evidence.Nutrients. 2020;12(1):228. doi:10.3390/nu12010228Bai XL, Deng XL, Wu GJ, Li WJ, Jin S.Rhodiola and salidroside in the treatment of metabolic disorders.Mini Rev Med Chem. 2019;19(19):1611-1626. doi:10.2174/1389557519666190903115424Ferreira GC, McKenna MC.L-carnitine and acetyl-l-carnitine roles and neuroprotection in developing brain.Neurochem Res. 2017;42(6):1661-1675. doi:10.1007/s11064-017-2288-7Filler K, Lyon D, Bennett J, et al.Association of mitochondrial dysfunction and fatigue: a review of the literature.BBA Clin. 2014;1:12-23. doi:10.1016/j.bbacli.2014.04.001Ramírez-Campillo R, González-Jurado JA, Martínez C, et al.Effects of plyometric training and creatine supplementation on maximal-intensity exercise and endurance in female soccer players.J Sci Med Sport. 2016;19(8):682-687. doi:10.1016/j.jsams.2015.10.005Djokic G, Vojvodić P, Korcok D, et al.The effects of magnesium - melatonin - vit b complex supplementation in treatment of insomnia.Open Access Maced J Med Sci. 2019;7(18):3101-3105. doi:10.3889/oamjms.2019.771Bent S, Padula A, Moore D, Patterson M, Mehling W.Valerian for sleep: a systematic review and meta-analysis.Am J Med. 2006;119(12):1005-1012. doi:10.1016/j.amjmed.2006.02.026Kim S, Jo K, Hong KB, Han SH, Suh HJ.GABA and l-theanine mixture decreases sleep latency and improves NREM sleep.Pharm Biol. 2019;57(1):65-73. doi:10.1080/13880209.2018.1557698Lillehei AS, Halcón LL, Savik K, Reis R.Effect of inhaled lavender and sleep hygiene on self-reported sleep issues: a randomized controlled trial.J Altern Complement Med. 2015;21(7):430-438. doi:10.1089/acm.2014.0327Bayliak MM, Dmytriv TR, Melnychuk AV, Strilets NV, Storey KB, Lushchak VI.Chamomile as a potential remedy for obesity and metabolic syndrome.EXCLI J. 2021;20:1261-1286. doi:10.17179/excli2021-4013Harvard University, Harvard Medical School, Division of Sleep Medicine.Treating narcolepsy: Medications.MedlinePlus.Medicine for sleep.Adeyinka C, Adejumo, Kuo B, Staller K.Abnormal sleep duration is associated with constipation in a national study.Gastroenterology. 2020;158(6):S-393-S-394. doi:10.1016/S0016-5085(20)31675-9Centers for Disease Control and Prevention.About sleep.National Health Service: NHSinform.Constipation.Additional ReadingMedlinePlus.Fatigue.National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases.Constipation.
Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read oureditorial processto learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.
MedlinePlus.Constipation.Johns Hopkins Medicine.Constipation.Allard JP, Keller H, Gramlich L, Jeejeebhoy KN, Laporte M, Duerksen DR.GLIM criteria has fair sensitivity and specificity for diagnosing malnutrition when using SGA as comparator.Clin Nutr.2019. doi:10.1016/j.clnu.2019.12.004MedlinePlus.Dehydration.National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases.Symptoms & causes of constipation.Zielinski MR, Systrom DM, Rose NR.Fatigue, sleep, and autoimmune and related disorders.Front Immunol. 2019;10:1827. doi:10.3389/fimmu.2019.01827National Institutes of Health, Genetic and Rare Diseases Information Center.Autoimmune gastrointestinal dysmotility.Lupus Foundation of America.Lupus and the digestive system.National Multiple Sclerosis Society.Constipation & loss of bowel control due to multiple sclerosis.Johns Hopkins Medicine.Constipation: Cause and prevention tips.International Foundation for Gastrointestinal Disorders.Scleroderma.University of Washington: UW Medicine.Fibromyalgia.Varesi A, Deumer US, Ananth S, Ricevuti G.The emerging role of gut microbiota in myalgic encephalomyelitis/chronic fatigue syndrome (me/cfs): current evidence and potential therapeutic applications.J Clin Med. 2021;10(21):5077. doi:10.3390/jcm10215077Yurtdaş G, Acar-Tek N, Akbulut G, et al.Risk factors for constipation in adults: a cross-sectional study.J Am Coll Nutr. 2020;39(8):713-719. doi:10.1080/07315724.2020.1727380Palsson OS, Whitehead W, Törnblom H, Sperber AD, Simren M.Prevalence of Rome IV functional bowel disorders among adults in the United States, Canada, and the United Kingdom.Gastroenterology. 2020;158(5):1262-1273.e3. doi: 10.1053/j.gastro.2019.12.021Han CJ, Yang GS.Fatigue in irritable bowel syndrome: a systematic review and meta-analysis of pooled frequency and severity of fatigue.Asian Nurs Res (Korean Soc Nurs Sci). 2016;10(1):1-10. doi:10.1016/j.anr.2016.01.003Han CJ, Jarrett ME, Cain KC, Jun S, Heitkemper MM.Association of fatigue with tph2 genetic polymorphisms in women with irritable bowel syndrome.Biol Res Nurs. 2019;21(1):72-79. doi:10.1177/1099800418806055Fleming KC, Volcheck MM.Central sensitization syndrome and the initial evaluation of a patient with fibromyalgia: a review.Rambam Maimonides Med J. 2015;6(2):e0020. doi:10.5041/RMMJ.10204Tardy AL, Pouteau E, Marquez D, Yilmaz C, Scholey A.Vitamins and minerals for energy, fatigue and cognition: a narrative review of the biochemical and clinical evidence.Nutrients. 2020;12(1):228. doi:10.3390/nu12010228Bai XL, Deng XL, Wu GJ, Li WJ, Jin S.Rhodiola and salidroside in the treatment of metabolic disorders.Mini Rev Med Chem. 2019;19(19):1611-1626. doi:10.2174/1389557519666190903115424Ferreira GC, McKenna MC.L-carnitine and acetyl-l-carnitine roles and neuroprotection in developing brain.Neurochem Res. 2017;42(6):1661-1675. doi:10.1007/s11064-017-2288-7Filler K, Lyon D, Bennett J, et al.Association of mitochondrial dysfunction and fatigue: a review of the literature.BBA Clin. 2014;1:12-23. doi:10.1016/j.bbacli.2014.04.001Ramírez-Campillo R, González-Jurado JA, Martínez C, et al.Effects of plyometric training and creatine supplementation on maximal-intensity exercise and endurance in female soccer players.J Sci Med Sport. 2016;19(8):682-687. doi:10.1016/j.jsams.2015.10.005Djokic G, Vojvodić P, Korcok D, et al.The effects of magnesium - melatonin - vit b complex supplementation in treatment of insomnia.Open Access Maced J Med Sci. 2019;7(18):3101-3105. doi:10.3889/oamjms.2019.771Bent S, Padula A, Moore D, Patterson M, Mehling W.Valerian for sleep: a systematic review and meta-analysis.Am J Med. 2006;119(12):1005-1012. doi:10.1016/j.amjmed.2006.02.026Kim S, Jo K, Hong KB, Han SH, Suh HJ.GABA and l-theanine mixture decreases sleep latency and improves NREM sleep.Pharm Biol. 2019;57(1):65-73. doi:10.1080/13880209.2018.1557698Lillehei AS, Halcón LL, Savik K, Reis R.Effect of inhaled lavender and sleep hygiene on self-reported sleep issues: a randomized controlled trial.J Altern Complement Med. 2015;21(7):430-438. doi:10.1089/acm.2014.0327Bayliak MM, Dmytriv TR, Melnychuk AV, Strilets NV, Storey KB, Lushchak VI.Chamomile as a potential remedy for obesity and metabolic syndrome.EXCLI J. 2021;20:1261-1286. doi:10.17179/excli2021-4013Harvard University, Harvard Medical School, Division of Sleep Medicine.Treating narcolepsy: Medications.MedlinePlus.Medicine for sleep.Adeyinka C, Adejumo, Kuo B, Staller K.Abnormal sleep duration is associated with constipation in a national study.Gastroenterology. 2020;158(6):S-393-S-394. doi:10.1016/S0016-5085(20)31675-9Centers for Disease Control and Prevention.About sleep.National Health Service: NHSinform.Constipation.
MedlinePlus.Constipation.
Johns Hopkins Medicine.Constipation.
Allard JP, Keller H, Gramlich L, Jeejeebhoy KN, Laporte M, Duerksen DR.GLIM criteria has fair sensitivity and specificity for diagnosing malnutrition when using SGA as comparator.Clin Nutr.2019. doi:10.1016/j.clnu.2019.12.004
MedlinePlus.Dehydration.
National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases.Symptoms & causes of constipation.
Zielinski MR, Systrom DM, Rose NR.Fatigue, sleep, and autoimmune and related disorders.Front Immunol. 2019;10:1827. doi:10.3389/fimmu.2019.01827
National Institutes of Health, Genetic and Rare Diseases Information Center.Autoimmune gastrointestinal dysmotility.
Lupus Foundation of America.Lupus and the digestive system.
National Multiple Sclerosis Society.Constipation & loss of bowel control due to multiple sclerosis.
Johns Hopkins Medicine.Constipation: Cause and prevention tips.
International Foundation for Gastrointestinal Disorders.Scleroderma.
University of Washington: UW Medicine.Fibromyalgia.
Varesi A, Deumer US, Ananth S, Ricevuti G.The emerging role of gut microbiota in myalgic encephalomyelitis/chronic fatigue syndrome (me/cfs): current evidence and potential therapeutic applications.J Clin Med. 2021;10(21):5077. doi:10.3390/jcm10215077
Yurtdaş G, Acar-Tek N, Akbulut G, et al.Risk factors for constipation in adults: a cross-sectional study.J Am Coll Nutr. 2020;39(8):713-719. doi:10.1080/07315724.2020.1727380
Palsson OS, Whitehead W, Törnblom H, Sperber AD, Simren M.Prevalence of Rome IV functional bowel disorders among adults in the United States, Canada, and the United Kingdom.Gastroenterology. 2020;158(5):1262-1273.e3. doi: 10.1053/j.gastro.2019.12.021
Han CJ, Yang GS.Fatigue in irritable bowel syndrome: a systematic review and meta-analysis of pooled frequency and severity of fatigue.Asian Nurs Res (Korean Soc Nurs Sci). 2016;10(1):1-10. doi:10.1016/j.anr.2016.01.003
Han CJ, Jarrett ME, Cain KC, Jun S, Heitkemper MM.Association of fatigue with tph2 genetic polymorphisms in women with irritable bowel syndrome.Biol Res Nurs. 2019;21(1):72-79. doi:10.1177/1099800418806055
Fleming KC, Volcheck MM.Central sensitization syndrome and the initial evaluation of a patient with fibromyalgia: a review.Rambam Maimonides Med J. 2015;6(2):e0020. doi:10.5041/RMMJ.10204
Tardy AL, Pouteau E, Marquez D, Yilmaz C, Scholey A.Vitamins and minerals for energy, fatigue and cognition: a narrative review of the biochemical and clinical evidence.Nutrients. 2020;12(1):228. doi:10.3390/nu12010228
Bai XL, Deng XL, Wu GJ, Li WJ, Jin S.Rhodiola and salidroside in the treatment of metabolic disorders.Mini Rev Med Chem. 2019;19(19):1611-1626. doi:10.2174/1389557519666190903115424
Ferreira GC, McKenna MC.L-carnitine and acetyl-l-carnitine roles and neuroprotection in developing brain.Neurochem Res. 2017;42(6):1661-1675. doi:10.1007/s11064-017-2288-7
Filler K, Lyon D, Bennett J, et al.Association of mitochondrial dysfunction and fatigue: a review of the literature.BBA Clin. 2014;1:12-23. doi:10.1016/j.bbacli.2014.04.001
Ramírez-Campillo R, González-Jurado JA, Martínez C, et al.Effects of plyometric training and creatine supplementation on maximal-intensity exercise and endurance in female soccer players.J Sci Med Sport. 2016;19(8):682-687. doi:10.1016/j.jsams.2015.10.005
Djokic G, Vojvodić P, Korcok D, et al.The effects of magnesium - melatonin - vit b complex supplementation in treatment of insomnia.Open Access Maced J Med Sci. 2019;7(18):3101-3105. doi:10.3889/oamjms.2019.771
Bent S, Padula A, Moore D, Patterson M, Mehling W.Valerian for sleep: a systematic review and meta-analysis.Am J Med. 2006;119(12):1005-1012. doi:10.1016/j.amjmed.2006.02.026
Kim S, Jo K, Hong KB, Han SH, Suh HJ.GABA and l-theanine mixture decreases sleep latency and improves NREM sleep.Pharm Biol. 2019;57(1):65-73. doi:10.1080/13880209.2018.1557698
Lillehei AS, Halcón LL, Savik K, Reis R.Effect of inhaled lavender and sleep hygiene on self-reported sleep issues: a randomized controlled trial.J Altern Complement Med. 2015;21(7):430-438. doi:10.1089/acm.2014.0327
Bayliak MM, Dmytriv TR, Melnychuk AV, Strilets NV, Storey KB, Lushchak VI.Chamomile as a potential remedy for obesity and metabolic syndrome.EXCLI J. 2021;20:1261-1286. doi:10.17179/excli2021-4013
Harvard University, Harvard Medical School, Division of Sleep Medicine.Treating narcolepsy: Medications.
MedlinePlus.Medicine for sleep.
Adeyinka C, Adejumo, Kuo B, Staller K.Abnormal sleep duration is associated with constipation in a national study.Gastroenterology. 2020;158(6):S-393-S-394. doi:10.1016/S0016-5085(20)31675-9
Centers for Disease Control and Prevention.About sleep.
National Health Service: NHSinform.Constipation.
MedlinePlus.Fatigue.National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases.Constipation.
MedlinePlus.Fatigue.
National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases.Constipation.
Meet Our Medical Expert Board
Share Feedback
Was this page helpful?Thanks for your feedback!What is your feedback?OtherHelpfulReport an ErrorSubmit
Was this page helpful?
Thanks for your feedback!
What is your feedback?OtherHelpfulReport an ErrorSubmit
What is your feedback?
