Table of ContentsView AllTable of ContentsWhat Is a Migraine?Are Migraines a Symptom of Hypothyroidism?Effect of TreatmentWhen to See a Healthcare Provider
Table of ContentsView All
View All
Table of Contents
What Is a Migraine?
Are Migraines a Symptom of Hypothyroidism?
Effect of Treatment
When to See a Healthcare Provider
Migraine headaches are common in people withhypothyroidism(an underactive thyroid). In fact around 30% of people with hypothyroidism have a history of headaches.It is not clear exactly what is responsible for the association, but some research suggests that a history of headaches can predispose someone to hypothyroidism.This article explains the correlation between migraine headaches and thyroid disease, symptoms, and treatment options.Verywell / JR BeeWhat Is a Migraine?Amigraineis a type of severe headache that typically comes with many other symptoms, such as nausea, extreme sensitivity to light and noise, and visual changes (called anaura). A migraine headache usually involves throbbing or pulsating pain, often on one side of the head. It is different from other types ofheadaches.Are Migraines a Symptom of Hypothyroidism?Migraines are often a symptom of hypothyroidism, and people with migraines may be more likely to develop hypothyroidism.In a 2016 study published in the journalHeadache,researchers monitored 8,412 people over 20 years. They excluded anyone with a prior history of thyroid disease or an abnormal thyroid reading at the start of the study.The study found that those with pre-existing headache disorders had a 21% increased risk of new-onset hypothyroidism compared to people with no history of headaches.In addition, compared to the general population, people with a history of migraines (as opposed totension-type headaches) had a 41% increased risk of new-onset hypothyroidism.Thus far, there is no research that explains a definitive reason for the association. Another study done in 2017 suggested that headache disorders may activate the immune system, predisposing someone to develop hypothyroidism in the future. Stress, environmental, and genetic factors might play a role as well.Treatment and Management of MigrainesFor people with hypothyroidism as well as migraines, thyroid hormone replacement therapy, most typically in the form oflevothyroxine, can help minimize hypothyroid symptoms, including migraines.A study published in 2016 found that people with both subclinical and overt hypothyroidism reported a similar relief from headaches with levothyroxine treatment.It is also important to note that headache is a common side effect of levothyroxine use.In people with moderate to severe hypothyroidism, which would require higher doses, the drug could potentially trigger headaches or worsen existing symptoms.Treatments for migraines in general (whether or not they exist in conjunction with hypothyroidism) include medications such as:Triptans, such as Zembrace SymTouch (sumatriptan)Gepants, such asQulipta(atogepant)Ditans, such asReyvow(lasmiditan)Nasal sprays, such asTrudhesa(dihydroergotamine mesylate)Non-steroidal anti-inflammatory drugs (NSAIDs), such as ibuprofenPreventive treatments include neuromodulation devices (Cefaly) and monoclonal antibody infusions such as Vyepti (eptinezumab) that can be self-administered as an injection or delivered via an intravenous infusion.When to See a Healthcare ProviderIf your migraines seem to be getting worse or more frequent, talk to your healthcare provider, who may want to adjust your treatment plan.Seek emergency care if you experience:Unusually severe migraine symptomsConfusionFeverVision changesA stiff neckNumbness or weaknessTrouble speakingSummaryHeadaches are common in people with hypothyroidism. It is unclear whether headaches are a side effect of an underactive thyroid or a risk factor for developing the condition. If you have hypothyroidism and migraines, the thyroid hormone replacement medication levothyroxine may reduce the frequency of migraines.A Word From VerywellMigraines can be debilitating in some cases. If levothyroxine does not improve your headaches or if it makes them worse, you may need to treat your headache separately as a distinct disorder. Talk to your healthcare provider, who may want to refer you to aheadache specialist.
Migraine headaches are common in people withhypothyroidism(an underactive thyroid). In fact around 30% of people with hypothyroidism have a history of headaches.
It is not clear exactly what is responsible for the association, but some research suggests that a history of headaches can predispose someone to hypothyroidism.
This article explains the correlation between migraine headaches and thyroid disease, symptoms, and treatment options.
Verywell / JR Bee
Amigraineis a type of severe headache that typically comes with many other symptoms, such as nausea, extreme sensitivity to light and noise, and visual changes (called anaura). A migraine headache usually involves throbbing or pulsating pain, often on one side of the head. It is different from other types ofheadaches.
Migraines are often a symptom of hypothyroidism, and people with migraines may be more likely to develop hypothyroidism.
In a 2016 study published in the journalHeadache,researchers monitored 8,412 people over 20 years. They excluded anyone with a prior history of thyroid disease or an abnormal thyroid reading at the start of the study.
The study found that those with pre-existing headache disorders had a 21% increased risk of new-onset hypothyroidism compared to people with no history of headaches.In addition, compared to the general population, people with a history of migraines (as opposed totension-type headaches) had a 41% increased risk of new-onset hypothyroidism.
Thus far, there is no research that explains a definitive reason for the association. Another study done in 2017 suggested that headache disorders may activate the immune system, predisposing someone to develop hypothyroidism in the future. Stress, environmental, and genetic factors might play a role as well.
Treatment and Management of Migraines
For people with hypothyroidism as well as migraines, thyroid hormone replacement therapy, most typically in the form oflevothyroxine, can help minimize hypothyroid symptoms, including migraines.A study published in 2016 found that people with both subclinical and overt hypothyroidism reported a similar relief from headaches with levothyroxine treatment.
It is also important to note that headache is a common side effect of levothyroxine use.In people with moderate to severe hypothyroidism, which would require higher doses, the drug could potentially trigger headaches or worsen existing symptoms.
Treatments for migraines in general (whether or not they exist in conjunction with hypothyroidism) include medications such as:
Preventive treatments include neuromodulation devices (Cefaly) and monoclonal antibody infusions such as Vyepti (eptinezumab) that can be self-administered as an injection or delivered via an intravenous infusion.
If your migraines seem to be getting worse or more frequent, talk to your healthcare provider, who may want to adjust your treatment plan.
Seek emergency care if you experience:
Summary
Headaches are common in people with hypothyroidism. It is unclear whether headaches are a side effect of an underactive thyroid or a risk factor for developing the condition. If you have hypothyroidism and migraines, the thyroid hormone replacement medication levothyroxine may reduce the frequency of migraines.
A Word From Verywell
Migraines can be debilitating in some cases. If levothyroxine does not improve your headaches or if it makes them worse, you may need to treat your headache separately as a distinct disorder. Talk to your healthcare provider, who may want to refer you to aheadache specialist.
7 Sources
Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read oureditorial processto learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.
International Headache Society.10.4 Headache attributed to hypothyroidism.The International Classification of Headache Disorders.3rd ed.Phoenix, Arizona: IHS.
Martin A, Pinney S, Xie C. et al.Headache disorders may be a risk factor for the development of new onset hypothyroidism.Headache.2017;57(1):21-30. doi:10.1111/head.12943
Lima Carvalho MF, de Medeiros JS, Valença MM.Headache in recent onset hypothyroidism: Prevalence, characteristics and outcome after treatment with levothyroxine.Cephalalgia. 2017;37(10):938-946. doi:10.1177/0333102416658714
MedlinePlus.Levothyroxine.
American Migraine Foundation.New treatments for migraine.
American Migraine Foundation.Understanding migraine treatment in the emergency room.
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