Table of ContentsView AllTable of ContentsWhat Is Percocet?What Is Hydrocodone?DosageSide EffectsSafety PrecautionsDrug InteractionsWhich One Works Better?Frequently Asked Questions
Table of ContentsView All
View All
Table of Contents
What Is Percocet?
What Is Hydrocodone?
Dosage
Side Effects
Safety Precautions
Drug Interactions
Which One Works Better?
Frequently Asked Questions
Percocet (acetaminophen and oxycodone)and hydrocodone are two narcotic pain relievers that relieve moderate to severe pain.Both medications are similarly effective at reducing pain.However, oxycodone is considered to be a more potent opioid than hydrocodone.
Percocet is a combination drug that contains both an opioid (oxycodone) and a nonopioid analgesic (acetaminophen).Hydrocodone is an opioid that is a single agent, although it is commonly dispensed in combination products.Hydrocodone may be combined with other medications like acetaminophen.
This article will discuss the similarities and differences between Percocet and hydrocodone for pain relief.
Getty Images /Tom Kelley
Percocet is an opioid pain medication. It contains a combination ofacetaminophen(the active ingredient in brand-name Tylenol) andoxycodone, which helps to treat moderate to severe pain. It is only available with a healthcare provider’s prescription and should be taken as prescribed for the best results.
Due to its risk of addiction and misuse, Percocet is typically reserved for those who are not able to achieve adequate symptom relief withnonopioid pain relieversalone.
How Does Percocet Work?
Oxycodone binds to specific opioid receptors, such as mu, kappa, and delta receptors, to help reduce pain levels.
Acetaminophen helps with minor aches and pains while boosting the effects of oxycodone.
Hydrocodone is an opioid medication often prescribed to treat pain. It is marketed under the brand name Hysingla in an extended-release (ER) tablet for pain severe enough to require daily, long-term opioid treatment. It acts on the central nervous system (made up of the brain and spinal cord) and changes how the body recognizes pain.
How Does Hydrocodone Work?
What’s the Difference Between Oxycodone and Hydrocodone?
Dosage: Percocet vs. Hydrocodone
Percocet, a combination of oxycodone and acetaminophen, is prescribed for moderate to severe pain relief. The dosage combines two active ingredients, oxycodone and acetaminophen, with different strengths.
Hydrocodone is available in ER formulations. The dosage will vary depending on the condition being treated and the individual’s response to it.The ER hydrocodone products have different dosing schedules, but are often taken once daily.
The following table summarizes the dosing information for Percocet and hydrocodone.
Side Effects: Percocet vs. Hydrocodone
Both Percocet and hydrocodone have similar side effects, which can include:
Severe side effects that are associated with both Percocet and hydrocodone include:
Because both medications are opioids, there is a potential risk of dependence and misuse, which can lead to an overdose. Talk to your healthcare provider if you are concerned about substance dependence.
Both medications should be taken with caution and under the supervision of a healthcare provider.
Safety Precautions with Opioid Use
When using Percocet or hydrocodone, keep in mind the following safety considerations:
If you or a loved one is struggling with substance use or addiction, contact theSubstance Abuse and Mental Health Services Administration (SAMHSA) National Helplineat 800-662-4357 for information on support and treatment facilities in your area.
Drug interactions occur when two drugs influence each other, affecting how they work in the body.
Interactions can produce unwanted effects, reduce the efficacy of one or both medications and even increase the risk of side effects.It is essential to ask your healthcare providers which medications to avoid when taking hydrocodone.
Acetaminophen is a component of Percocet. Therefore, it’s important to consider acetaminophen interactions.
Acetaminophen can be found in over-the-counter (OTC) medications such as cough and cold medicines such asDayQuilandTylenol Cold and Flu.
The maximum dosage for acetaminophen is 4,000 mg/day, and exceeding this amount can cause liver damage and failure.Be cautious when using OTC medications that also contain acetaminophen, and ensure you stay within the daily limit.
Percocet and hydrocodone can also interact with the following:
Overdose Risk
Possiblesymptoms of overdoseinclude:
If you are prescribed an opioid treatment, your healthcare provider may recommend naloxone. Naloxone can reverse the overdose effects of Percocet, hydrocodone, or similar medications. Reversal of an overdose will also likely result in reversal of the therapeutic effect, so pain symptoms may return. Always call 911 in the event of an overdose, even if naloxone is administered.
Percocet vs. Hydrocodone: Which One Works Better?
Percocet and hydrocodone are similar narcotic medications used to manage pain. Both medications have similar effectiveness in relieving pain, although oxycodone is considered to be stronger than hydrocodone.
Ultimately, the best medication will depend on your specific needs and should be discussed with a healthcare provider.
Vicodin vs. Percocet: How Do They Compare?
Summary
Both medications come in different strengths and have similar side effects and interactions. Your dosage will depend on your tolerance and condition. Whether you are prescribed hydrocodone or Percocet, it’s important to follow your healthcare provider’s instructions for taking your medication safely.
Frequently Asked QuestionsNo, it is not recommended to take Percocet and hydrocodone together, as both medications contain opioids. Taking them together can increase the risk of severe side effects, including but not limited to respiratory depression and a potential overdose.Alternative treatments for pain relief include physical therapy, chiropractic care, acupuncture, massage, and yoga. Heat or ice applications can also be used to help reduce muscle tension that contributes to pain.Pain relief medications known asnonsteroidal anti-inflammatory drugs (NSAIDs), such asAleve(naproxen sodium) and Motrin or Advil (ibuprofen), can help relieve acute pain and reduce inflammation.If you’re considering herbal or dietary supplements, remember that some supplements can have side effects or interactions with certain medications. Always consult a healthcare provider before trying new herbal or dietary supplements.No, it is not recommended to take a sleep aid with Percocet or hydrocodone. Doing so may increase your risk of severe side effects like breathing problems. Talk to your healthcare provider before taking any sleep-promoting medications to reduce the potential risks and find a safe treatment alternative if needed.
No, it is not recommended to take Percocet and hydrocodone together, as both medications contain opioids. Taking them together can increase the risk of severe side effects, including but not limited to respiratory depression and a potential overdose.
Alternative treatments for pain relief include physical therapy, chiropractic care, acupuncture, massage, and yoga. Heat or ice applications can also be used to help reduce muscle tension that contributes to pain.Pain relief medications known asnonsteroidal anti-inflammatory drugs (NSAIDs), such asAleve(naproxen sodium) and Motrin or Advil (ibuprofen), can help relieve acute pain and reduce inflammation.If you’re considering herbal or dietary supplements, remember that some supplements can have side effects or interactions with certain medications. Always consult a healthcare provider before trying new herbal or dietary supplements.
Alternative treatments for pain relief include physical therapy, chiropractic care, acupuncture, massage, and yoga. Heat or ice applications can also be used to help reduce muscle tension that contributes to pain.Pain relief medications known asnonsteroidal anti-inflammatory drugs (NSAIDs), such asAleve(naproxen sodium) and Motrin or Advil (ibuprofen), can help relieve acute pain and reduce inflammation.
If you’re considering herbal or dietary supplements, remember that some supplements can have side effects or interactions with certain medications. Always consult a healthcare provider before trying new herbal or dietary supplements.
No, it is not recommended to take a sleep aid with Percocet or hydrocodone. Doing so may increase your risk of severe side effects like breathing problems. Talk to your healthcare provider before taking any sleep-promoting medications to reduce the potential risks and find a safe treatment alternative if needed.
The author would like to recognize and thank Leen Alyaseen for contributing to this article.
12 SourcesVerywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read oureditorial processto learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.Raffa RB, Pergolizzi JV, Segarnick DJ, Tallarida RJ.Oxycodone combinations for pain relief.Drugs Today (Barc). 2010;46(6):379-398. doi:10.1358/dot.2010.46.6.1470106Marco CA, Plewa MC, Buderer N, Black C, Roberts A.Comparison of oxycodone and hydrocodone for the treatment of acute pain associated with fractures: a double-blind, randomized, controlled trial.Acad Emerg Med. 2005;12(4):282-288. doi: 10.1197/j.aem.2004.12.005Food and Drug Administration.Hysingla (hydrocodone bitartrate) label.DailyMed.Label: Percocet- oxycodone hydrochloride and acetaminophen tablet.Ordóñez Gallego A, González Barón M, Espinosa Arranz E.Oxycodone: a pharmacological and clinical review.Clin Transl Oncol. 2007;9(5):298-307. doi:10.1007/s12094-007-0057-9Gatti A, Sabato E, Di Paolo AR, Mammucari M, Sabato AF.Oxycodone/paracetamol: a low-dose synergic combination useful in different types of pain.Clin Drug Investig. 2010;30 Suppl 2:3-14. doi:10.2165/1158414-S0-000000000-00000Cardia L, Calapai G, Quattrone D, et al.Preclinical and clinical pharmacology of hydrocodone for chronic pain: a mini review.Front Pharmacol. 2018;9:1122. doi:10.3389/fphar.2018.01122Koziolek M, Alcaro S, Augustijns P, et al.The mechanisms of pharmacokinetic food-drug interactions - A perspective from the UNGAP group.Eur J Pharm Sci. 2019;134:31-59. doi:10.1016/j.ejps.2019.04.003Substance Abuse and Mental Health Services Administration.Opioid overdose.National Institute on Drug Abuse.Naloxone DrugFacts.U.S. Department of Veterans Affairs.VHA pain management.Preuss CV, Kalava A, King KC.Prescription of Controlled Substances: Benefits and Risks.[Updated 2023 Apr 29]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK537318/
12 Sources
Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read oureditorial processto learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.Raffa RB, Pergolizzi JV, Segarnick DJ, Tallarida RJ.Oxycodone combinations for pain relief.Drugs Today (Barc). 2010;46(6):379-398. doi:10.1358/dot.2010.46.6.1470106Marco CA, Plewa MC, Buderer N, Black C, Roberts A.Comparison of oxycodone and hydrocodone for the treatment of acute pain associated with fractures: a double-blind, randomized, controlled trial.Acad Emerg Med. 2005;12(4):282-288. doi: 10.1197/j.aem.2004.12.005Food and Drug Administration.Hysingla (hydrocodone bitartrate) label.DailyMed.Label: Percocet- oxycodone hydrochloride and acetaminophen tablet.Ordóñez Gallego A, González Barón M, Espinosa Arranz E.Oxycodone: a pharmacological and clinical review.Clin Transl Oncol. 2007;9(5):298-307. doi:10.1007/s12094-007-0057-9Gatti A, Sabato E, Di Paolo AR, Mammucari M, Sabato AF.Oxycodone/paracetamol: a low-dose synergic combination useful in different types of pain.Clin Drug Investig. 2010;30 Suppl 2:3-14. doi:10.2165/1158414-S0-000000000-00000Cardia L, Calapai G, Quattrone D, et al.Preclinical and clinical pharmacology of hydrocodone for chronic pain: a mini review.Front Pharmacol. 2018;9:1122. doi:10.3389/fphar.2018.01122Koziolek M, Alcaro S, Augustijns P, et al.The mechanisms of pharmacokinetic food-drug interactions - A perspective from the UNGAP group.Eur J Pharm Sci. 2019;134:31-59. doi:10.1016/j.ejps.2019.04.003Substance Abuse and Mental Health Services Administration.Opioid overdose.National Institute on Drug Abuse.Naloxone DrugFacts.U.S. Department of Veterans Affairs.VHA pain management.Preuss CV, Kalava A, King KC.Prescription of Controlled Substances: Benefits and Risks.[Updated 2023 Apr 29]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK537318/
Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read oureditorial processto learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.
Raffa RB, Pergolizzi JV, Segarnick DJ, Tallarida RJ.Oxycodone combinations for pain relief.Drugs Today (Barc). 2010;46(6):379-398. doi:10.1358/dot.2010.46.6.1470106Marco CA, Plewa MC, Buderer N, Black C, Roberts A.Comparison of oxycodone and hydrocodone for the treatment of acute pain associated with fractures: a double-blind, randomized, controlled trial.Acad Emerg Med. 2005;12(4):282-288. doi: 10.1197/j.aem.2004.12.005Food and Drug Administration.Hysingla (hydrocodone bitartrate) label.DailyMed.Label: Percocet- oxycodone hydrochloride and acetaminophen tablet.Ordóñez Gallego A, González Barón M, Espinosa Arranz E.Oxycodone: a pharmacological and clinical review.Clin Transl Oncol. 2007;9(5):298-307. doi:10.1007/s12094-007-0057-9Gatti A, Sabato E, Di Paolo AR, Mammucari M, Sabato AF.Oxycodone/paracetamol: a low-dose synergic combination useful in different types of pain.Clin Drug Investig. 2010;30 Suppl 2:3-14. doi:10.2165/1158414-S0-000000000-00000Cardia L, Calapai G, Quattrone D, et al.Preclinical and clinical pharmacology of hydrocodone for chronic pain: a mini review.Front Pharmacol. 2018;9:1122. doi:10.3389/fphar.2018.01122Koziolek M, Alcaro S, Augustijns P, et al.The mechanisms of pharmacokinetic food-drug interactions - A perspective from the UNGAP group.Eur J Pharm Sci. 2019;134:31-59. doi:10.1016/j.ejps.2019.04.003Substance Abuse and Mental Health Services Administration.Opioid overdose.National Institute on Drug Abuse.Naloxone DrugFacts.U.S. Department of Veterans Affairs.VHA pain management.Preuss CV, Kalava A, King KC.Prescription of Controlled Substances: Benefits and Risks.[Updated 2023 Apr 29]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK537318/
Raffa RB, Pergolizzi JV, Segarnick DJ, Tallarida RJ.Oxycodone combinations for pain relief.Drugs Today (Barc). 2010;46(6):379-398. doi:10.1358/dot.2010.46.6.1470106
Marco CA, Plewa MC, Buderer N, Black C, Roberts A.Comparison of oxycodone and hydrocodone for the treatment of acute pain associated with fractures: a double-blind, randomized, controlled trial.Acad Emerg Med. 2005;12(4):282-288. doi: 10.1197/j.aem.2004.12.005
Food and Drug Administration.Hysingla (hydrocodone bitartrate) label.
DailyMed.Label: Percocet- oxycodone hydrochloride and acetaminophen tablet.
Ordóñez Gallego A, González Barón M, Espinosa Arranz E.Oxycodone: a pharmacological and clinical review.Clin Transl Oncol. 2007;9(5):298-307. doi:10.1007/s12094-007-0057-9
Gatti A, Sabato E, Di Paolo AR, Mammucari M, Sabato AF.Oxycodone/paracetamol: a low-dose synergic combination useful in different types of pain.Clin Drug Investig. 2010;30 Suppl 2:3-14. doi:10.2165/1158414-S0-000000000-00000
Cardia L, Calapai G, Quattrone D, et al.Preclinical and clinical pharmacology of hydrocodone for chronic pain: a mini review.Front Pharmacol. 2018;9:1122. doi:10.3389/fphar.2018.01122
Koziolek M, Alcaro S, Augustijns P, et al.The mechanisms of pharmacokinetic food-drug interactions - A perspective from the UNGAP group.Eur J Pharm Sci. 2019;134:31-59. doi:10.1016/j.ejps.2019.04.003
Substance Abuse and Mental Health Services Administration.Opioid overdose.
National Institute on Drug Abuse.Naloxone DrugFacts.
U.S. Department of Veterans Affairs.VHA pain management.
Preuss CV, Kalava A, King KC.Prescription of Controlled Substances: Benefits and Risks.[Updated 2023 Apr 29]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK537318/
Meet Our Medical Expert Board
Share Feedback
Was this page helpful?Thanks for your feedback!What is your feedback?OtherHelpfulReport an ErrorSubmit
Was this page helpful?
Thanks for your feedback!
What is your feedback?OtherHelpfulReport an ErrorSubmit
What is your feedback?
By clicking “Accept All Cookies”, you agree to the storing of cookies on your device to enhance site navigation, analyze site usage, and assist in our marketing efforts.Cookies SettingsAccept All Cookies
By clicking “Accept All Cookies”, you agree to the storing of cookies on your device to enhance site navigation, analyze site usage, and assist in our marketing efforts.
Cookies SettingsAccept All Cookies
