Table of ContentsView AllTable of ContentsDifferencesKind of Pain TreatedDosageSide EffectsCan You Take Both?Special ConsiderationsFrequently Asked Questions
Table of ContentsView All
View All
Table of Contents
Differences
Kind of Pain Treated
Dosage
Side Effects
Can You Take Both?
Special Considerations
Frequently Asked Questions
Hydrocodoneandtramadolare both strong opioid prescription pain medicines. ConZip (tramadol) is commonly prescribed to relieve moderate to moderately severe pain that’s always present.Hydrocodone is a stronger opioid used to relieve severe pain.
Opioids and narcotic pain medicines can lead to opioid use disorder. Therefore, healthcare providers typically aim to prescribe just enough pain relief for your condition. Stronger pain medicines like hydrocodone are usually reserved for when other pain medicines, such as tramadol or codeine, don’t work.
This article will compare tramadol and hydrocodone based on their side effects, uses, and dosages, as well as which is considered stronger.
Rockaa / Getty Images
Basic Drug Differences: Tramadol vs. Hydrocodone
Both tramadol and hydrocodone areopioids—strong pain-relieving drugs. These drugs change how the brain and nervous system respond to pain. They can also have “feel-good” effects due to releasing brain chemicals like dopamine and norepinephrine.
Hydrocodone is a more potent opioid. It has a higher potency but a higher potential of being misused. The Drug Enforcement Administration (DEA) classifies hydrocodone as a Schedule II drug. Tramadol has a lower potential for misuse and is classified as a Schedule IV drug. It is also a less potent painkiller.
These drugs are both controlled substances. They are closely regulated, and healthcare providers closely monitor patients using them. If opioids are needed to control pain, the healthcare provider will start with low doses and keep the amounts as small as possible. That’s because these drugs can be addictive. They treat severe pain after an operation or due to cancer.
Common brand names for tramadol include ConZip, FusePaq Synapryn, and Qdolo. When combined with acetaminophen, the active ingredient in Tylenol, tramadol is marketed as Ultracet.
Cost
Compare drug prices online to find the most cost-effective options for your situation.
Hydrocodone is used in many brands of prescription pain relievers and is commonly sold in combination with over-the-counter (OTC) pain relievers and decongestants, as follows:
Hydrocodone is also marketed in extended-release formulations that only need to be taken once daily, including Zohydro ER and Hysingla ER.
What Kind of Pain They Treat: Tramadol vs. Hydrocodone
Both drugs are potent pain relievers for moderate to severe pain. Tramadol typically relieves short-lived pain of the muscles and joints, or pain due to a wound. Extended-release tramadol medications may be used forchronic painlike osteoarthritis.
Hydrocodone is a powerful pain reliever often used when other pain medicines are no longer working. Hydrocodone is only given to people with chronic, severe, around-the-clock pain who cannot be treated with other medicines or treatments.
Types of pain these two drugs treat include:
Tramadol vs. Oxycodone: What Are the Differences?
Tramadol vs. Hydrocodone: How Strong Is the Dosage?
Opiates are compared using a morphine-equivalent dose. This is the amount of the drug needed to equal a dose of morphine. One 30-milligram (mg) dose of hydrocodone is equivalent to one 30 mg dose of morphine. But 300 mg of tramadol would be equivalent to one 30 mg dose of morphine or hydrocodone.
Tramadol is available in immediate-release doses of 50 mg and 100 mg tablets and extended-release capsules of 100 mg and 150 mg. Quantities are up to 300 mg given once daily for extended release. Immediate-release tramadol can be dosed up to 400 mg per day up to 75 years old and 300 mg per day above 75.
Hydrocodone usually is available at doses from 2.5 mg to 10 mg, often along with 300 or 325 mg of acetaminophen. The maximum daily amount of hydrocodone with acetaminophen should not exceed 60 mg of hydrocodone and 4,000 mg of acetaminophen.
Bioavailability
The oral bioavailability of hydrocodone is reported to be 25%.The relative bioavailability when comparing extended-release hydrocodone products and combination hydrocodone bitartrate and acetaminophen tablets is unknown, so a healthcare provider should monitor the person closely when switching products.
Tramadol and hydrocodone are strong prescription pain relievers. They both have extensive lists of side effects. They are both addictive and can lead to opioid use disorder.
What Is Opioid Use Disorder?Opioid use disorder is when someone misuses or overuses opioid medications or drugs, causing significant impairment or distress.They may take these drugs unprescribed, take more than prescribed, and experience withdrawal if they stop taking the drug.
What Is Opioid Use Disorder?
Opioid use disorder is when someone misuses or overuses opioid medications or drugs, causing significant impairment or distress.They may take these drugs unprescribed, take more than prescribed, and experience withdrawal if they stop taking the drug.
Be careful when taking these medications. Always take them the same way (with food or without) at the same time of the day. Take them exactly as prescribed. Do not give them to other people, even if they ask you to try your medication.
Opioids like tramadol and hydrocodonecan cause constipation. Talk to your healthcare provider about changing your diet and using other medications to treat or prevent constipation.
Tramadol
Annoying, but not necessarily serious, side effects of tramadol can include:
Tell a healthcare provider if the side effects are severe or do not go away.
Some side effects of tramadol are more serious. It can cause life-threatening breathing problems, especially during the first few days of use or when the dose is increased.
The side effects listed below should be immediately reported to a healthcare provider. Seek emergency medical treatment if you’re experiencing any of these symptoms:
Hydrocodone
Side effects of hydrocodone include:
Tell a healthcare provider if the side effects listed above are severe or do not go away.
Some side effects can be severe. If you experience any of these side effects, call a healthcare provider immediately or get emergency medical treatment:
Can You Take Tramadol With Hydrocodone?
Your healthcare provider will prescribe either tramadol or hydrocodone. These two medications should not be used at the same time. Taking them together could cause an overdose or severe side effects that could threaten your life.
AlternativesWhen findingthe right combination of treatmentsto help reduce your chronic pain, look beyond opioids and narcotics. Combining these medications with othermedications to relieve pain, like nonsteroidal anti-inflammatory drugs (NSAIDs) and Tylenol, can help.In addition, you can try antidepressants, anticonvulsants, and topical pain medications. Someherbs are helpful for pain relief, as well.
Alternatives
When findingthe right combination of treatmentsto help reduce your chronic pain, look beyond opioids and narcotics. Combining these medications with othermedications to relieve pain, like nonsteroidal anti-inflammatory drugs (NSAIDs) and Tylenol, can help.In addition, you can try antidepressants, anticonvulsants, and topical pain medications. Someherbs are helpful for pain relief, as well.
When findingthe right combination of treatmentsto help reduce your chronic pain, look beyond opioids and narcotics. Combining these medications with othermedications to relieve pain, like nonsteroidal anti-inflammatory drugs (NSAIDs) and Tylenol, can help.
In addition, you can try antidepressants, anticonvulsants, and topical pain medications. Someherbs are helpful for pain relief, as well.
Overdosing on opioids causes shallow breathing that deprives the brain of oxygen. This leads to passing out and possible brain damage or death. Overdose can be reversed with a medicine called Narcan (naloxone).
Other Possible Drug Interactions
People on opioids should not drink alcohol. This can cause serious life-threatening side effects.
Many other medications may interact with opioids, so careful monitoring is required if you also take other prescriptions regularly. Be sure to inform your healthcare provider of any other medicines you take, including those purchased over the counter, to avoid potential complications.
Herbal supplements like Saint-John’s-wort andtryptophancan also cause adverse interactions.
Some examples of types of medications that may negatively interact with opioids include:
Prescription Pain Medication Special Considerations
Long-term use of opioids can also lead totolerance, in which higher doses and more potent medicines are needed to have the same pain-relieving effect. This can lead to opioid use disorder oroverdose. Opioid overdoses killed more than 100,000 Americans in 2021.
Formulations with acetaminophen can alsocause dangerous toxicitythat can permanently damage the liver if you take more than directed.
Not only can prescription opioid pain relievers cause overdose and lead to opioid use disorder, but they can have a rebound effect.
Opioid-induced hyperalgesia and allodyniaare when the pain of everyday sensations strengthens after taking opioids.Hyperalgesiais pain felt more intensely than it should.Allodyniais pain from something that isn’t usually painful, such as a light touch or fabric moving across your skin.
Summary
Tramadol is often given after surgery if you’ve suffered significant trauma. The extended-release capsule may be helpful for some chronic conditions like osteoarthritis. Hydrocodone is used if weaker drugs like tramadol do not work.
They have similar side effects and can cause reduced breathing and deadly overdose. You shouldn’t take these two medicines together or with alcohol, many other prescription or OTC drugs, or herbs or supplements.
Frequently Asked QuestionsUltram is a brand name for tramadol but is no longer being sold in the United States.The Drug Enforcement Administration (DEA) classifiestramadol as a Schedule IV controlled substance. It’s considered to have a lower risk of misuse than hydrocodone. However, a study in 2019 found that people prescribed tramadol or hydrocodone after surgery had similar rates of prolonged opioid use.Learn MoreWhat Is Opioid Use Disorder?
Ultram is a brand name for tramadol but is no longer being sold in the United States.
The Drug Enforcement Administration (DEA) classifiestramadol as a Schedule IV controlled substance. It’s considered to have a lower risk of misuse than hydrocodone. However, a study in 2019 found that people prescribed tramadol or hydrocodone after surgery had similar rates of prolonged opioid use.Learn MoreWhat Is Opioid Use Disorder?
The Drug Enforcement Administration (DEA) classifiestramadol as a Schedule IV controlled substance. It’s considered to have a lower risk of misuse than hydrocodone. However, a study in 2019 found that people prescribed tramadol or hydrocodone after surgery had similar rates of prolonged opioid use.
Learn MoreWhat Is Opioid Use Disorder?
18 SourcesVerywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read oureditorial processto learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.MedlinePlus.Tramadol.MedlinePlus.Hydrocodone combination products.Federal Register.Schedules of controlled substances: placement of tramadol into schedule IV.Duehmke RM, Derry S, Wiffen PJ, Bell RF, Aldington D, Moore RA.Tramadol for neuropathic pain in adults.Cochrane Database Syst Rev. 2017;6(6):CD003726. doi:10.1002/14651858.CD003726.pub4Schembri, E.Are opioids effective in relieving neuropathic pain?SN Compr Clin Med.2019;1:30–46. doi:10.1007/s42399-018-0009-4Oregon Pain Guidance.Opioid conversion calculator for morphine equivalents.Medscape.Ultram, ConZip (tramadol) dosing, indications, interactions, adverse effects, and moreTexas Vendor Drug Program.Drug use criteria: hydrocodone bitartrate / hydrocodone polistirex.Food and Drug Administration.Ultram (tramadol hydrochloride) tablets: full prescribing information.Angeletti C, Guetti C, Paladini A, Varrassi G.Tramadol extended-release for the management of pain due to osteoarthritis.ISRN Pain. 2013;2013:245346. doi:10.1155/2013/245346Firestein GS, Budd RC, Gabriel SE, McInnes IB, O’Dell JR.Kelley and Firestein’s Textbook of Rheumatology. Elsevier Health Sciences; 2016.Food and Drug Administration.Hydrocodone bitartrate and acetaminophen tablets.Centers for Disease Control and Prevention.Preventing opioid use disorder.Centers for Disease Control and Prevention.Polysubstance use facts.Feng XQ, Zhu LL, Zhou Q.Opioid analgesics-related pharmacokinetic drug interactions: from the perspectives of evidence based on randomized controlled trials and clinical risk management.J Pain Res. 2017;10:1225-1239. doi:10.2147/JPR.S138698National Institute on Drug Abuse.Overdose death rates.Drug Enforcement Administration.Hydrocodone.Thiels CA, Habermann EB, Hooten WM, Jeffery MM.Chronic use of tramadol after acute pain episode: cohort study.BMJ.2019;365:l1849 doi:10.1136/bmj.l1849
18 Sources
Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read oureditorial processto learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.MedlinePlus.Tramadol.MedlinePlus.Hydrocodone combination products.Federal Register.Schedules of controlled substances: placement of tramadol into schedule IV.Duehmke RM, Derry S, Wiffen PJ, Bell RF, Aldington D, Moore RA.Tramadol for neuropathic pain in adults.Cochrane Database Syst Rev. 2017;6(6):CD003726. doi:10.1002/14651858.CD003726.pub4Schembri, E.Are opioids effective in relieving neuropathic pain?SN Compr Clin Med.2019;1:30–46. doi:10.1007/s42399-018-0009-4Oregon Pain Guidance.Opioid conversion calculator for morphine equivalents.Medscape.Ultram, ConZip (tramadol) dosing, indications, interactions, adverse effects, and moreTexas Vendor Drug Program.Drug use criteria: hydrocodone bitartrate / hydrocodone polistirex.Food and Drug Administration.Ultram (tramadol hydrochloride) tablets: full prescribing information.Angeletti C, Guetti C, Paladini A, Varrassi G.Tramadol extended-release for the management of pain due to osteoarthritis.ISRN Pain. 2013;2013:245346. doi:10.1155/2013/245346Firestein GS, Budd RC, Gabriel SE, McInnes IB, O’Dell JR.Kelley and Firestein’s Textbook of Rheumatology. Elsevier Health Sciences; 2016.Food and Drug Administration.Hydrocodone bitartrate and acetaminophen tablets.Centers for Disease Control and Prevention.Preventing opioid use disorder.Centers for Disease Control and Prevention.Polysubstance use facts.Feng XQ, Zhu LL, Zhou Q.Opioid analgesics-related pharmacokinetic drug interactions: from the perspectives of evidence based on randomized controlled trials and clinical risk management.J Pain Res. 2017;10:1225-1239. doi:10.2147/JPR.S138698National Institute on Drug Abuse.Overdose death rates.Drug Enforcement Administration.Hydrocodone.Thiels CA, Habermann EB, Hooten WM, Jeffery MM.Chronic use of tramadol after acute pain episode: cohort study.BMJ.2019;365:l1849 doi:10.1136/bmj.l1849
Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read oureditorial processto learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.
MedlinePlus.Tramadol.MedlinePlus.Hydrocodone combination products.Federal Register.Schedules of controlled substances: placement of tramadol into schedule IV.Duehmke RM, Derry S, Wiffen PJ, Bell RF, Aldington D, Moore RA.Tramadol for neuropathic pain in adults.Cochrane Database Syst Rev. 2017;6(6):CD003726. doi:10.1002/14651858.CD003726.pub4Schembri, E.Are opioids effective in relieving neuropathic pain?SN Compr Clin Med.2019;1:30–46. doi:10.1007/s42399-018-0009-4Oregon Pain Guidance.Opioid conversion calculator for morphine equivalents.Medscape.Ultram, ConZip (tramadol) dosing, indications, interactions, adverse effects, and moreTexas Vendor Drug Program.Drug use criteria: hydrocodone bitartrate / hydrocodone polistirex.Food and Drug Administration.Ultram (tramadol hydrochloride) tablets: full prescribing information.Angeletti C, Guetti C, Paladini A, Varrassi G.Tramadol extended-release for the management of pain due to osteoarthritis.ISRN Pain. 2013;2013:245346. doi:10.1155/2013/245346Firestein GS, Budd RC, Gabriel SE, McInnes IB, O’Dell JR.Kelley and Firestein’s Textbook of Rheumatology. Elsevier Health Sciences; 2016.Food and Drug Administration.Hydrocodone bitartrate and acetaminophen tablets.Centers for Disease Control and Prevention.Preventing opioid use disorder.Centers for Disease Control and Prevention.Polysubstance use facts.Feng XQ, Zhu LL, Zhou Q.Opioid analgesics-related pharmacokinetic drug interactions: from the perspectives of evidence based on randomized controlled trials and clinical risk management.J Pain Res. 2017;10:1225-1239. doi:10.2147/JPR.S138698National Institute on Drug Abuse.Overdose death rates.Drug Enforcement Administration.Hydrocodone.Thiels CA, Habermann EB, Hooten WM, Jeffery MM.Chronic use of tramadol after acute pain episode: cohort study.BMJ.2019;365:l1849 doi:10.1136/bmj.l1849
MedlinePlus.Tramadol.
MedlinePlus.Hydrocodone combination products.
Federal Register.Schedules of controlled substances: placement of tramadol into schedule IV.
Duehmke RM, Derry S, Wiffen PJ, Bell RF, Aldington D, Moore RA.Tramadol for neuropathic pain in adults.Cochrane Database Syst Rev. 2017;6(6):CD003726. doi:10.1002/14651858.CD003726.pub4
Schembri, E.Are opioids effective in relieving neuropathic pain?SN Compr Clin Med.2019;1:30–46. doi:10.1007/s42399-018-0009-4
Oregon Pain Guidance.Opioid conversion calculator for morphine equivalents.
Medscape.Ultram, ConZip (tramadol) dosing, indications, interactions, adverse effects, and more
Texas Vendor Drug Program.Drug use criteria: hydrocodone bitartrate / hydrocodone polistirex.
Food and Drug Administration.Ultram (tramadol hydrochloride) tablets: full prescribing information.
Angeletti C, Guetti C, Paladini A, Varrassi G.Tramadol extended-release for the management of pain due to osteoarthritis.ISRN Pain. 2013;2013:245346. doi:10.1155/2013/245346
Firestein GS, Budd RC, Gabriel SE, McInnes IB, O’Dell JR.Kelley and Firestein’s Textbook of Rheumatology. Elsevier Health Sciences; 2016.
Food and Drug Administration.Hydrocodone bitartrate and acetaminophen tablets.
Centers for Disease Control and Prevention.Preventing opioid use disorder.
Centers for Disease Control and Prevention.Polysubstance use facts.
Feng XQ, Zhu LL, Zhou Q.Opioid analgesics-related pharmacokinetic drug interactions: from the perspectives of evidence based on randomized controlled trials and clinical risk management.J Pain Res. 2017;10:1225-1239. doi:10.2147/JPR.S138698
National Institute on Drug Abuse.Overdose death rates.
Drug Enforcement Administration.Hydrocodone.
Thiels CA, Habermann EB, Hooten WM, Jeffery MM.Chronic use of tramadol after acute pain episode: cohort study.BMJ.2019;365:l1849 doi:10.1136/bmj.l1849
Meet Our Medical Expert Board
Share Feedback
Was this page helpful?Thanks for your feedback!What is your feedback?OtherHelpfulReport an ErrorSubmit
Was this page helpful?
Thanks for your feedback!
What is your feedback?OtherHelpfulReport an ErrorSubmit
What is your feedback?
