Table of ContentsView AllTable of ContentsOpioids for Pain ManagementWhat Is ConZip?What Is Percocet?Dosing GuidelinesSide Effects and PrecautionsSafely Taking ConZip vs. PercocetReview of EfficacyAlternative Treatment OptionsFrequently Asked Questions
Table of ContentsView All
View All
Table of Contents
Opioids for Pain Management
What Is ConZip?
What Is Percocet?
Dosing Guidelines
Side Effects and Precautions
Safely Taking ConZip vs. Percocet
Review of Efficacy
Alternative Treatment Options
Frequently Asked Questions
ConZip (tramadol) and Percocet (oxycodone/acetaminophen) are Food and Drug Administration (FDA)-approved prescriptionopioidsused for the management of moderate to severe,persistent painin adults.
While these drugs are similar, they carry notable differences that potential users should be aware of.
The significant difference between ConZip and Percocet is their drug classes and active ingredients: ConZip is an opioid agonist and contains a single active ingredient.
Meanwhile, Percocet contains oxycodone, a narcotic pain reliever, and acetaminophen, an analgesic pain reliever.
This article will provide an overview of ConZip and Percocet, highlighting their similarities and differences, guidance on using them safely, potential side effects, storage requirements, and more.
Getty Images / Maca and Naca
The following will outline and provide context regarding the use of opioids in the treatment of pain management.
Understanding Opioids
Opioids are a group of medications used to treat andmanage pain.
This group of medications earned their name as “opioids” because they attach to opioid receptors in the body, which are found in thenervous systemandgastrointestinal (GI) tract.
Healthcare providers use opioids to manage pain because they are effective at providing pain relief for people experiencing pain-related conditions.
Many providers must assess the risks versus benefits of using opioids for pain management due to the risks associated with their use.
How Healthcare Providers Assess Pain
Healthcare providers usually use apain scaletorecognize and assessmoderate to severe pain. There are several different scales used to rate and classify pain.
Using a pain scale helps providers quantify an individual’s pain levels.
Other factors to consider when assessing pain include the source of the pain, whether or not it interrupts daily activities and functioning, and whether or not other health conditions also exist.
Defining pain can be difficult as pain levels vary from person to person. Pain that is mild for one person may be severe for another.
How Opioids Work
Prevalence of Use
Data from a 2021 report indicated that nearly 22% of adults with chronic pain used an opioid in the past three months.
Commonly Prescribed Opioids: Examples
Some other notable examples of opioids used for pain management include:
Prescription Requirements
Opioids are classified as controlled substances due to the potential for abuse, misuse, and diversion.
Controlled substances are medications that have a high risk of being used differently than their intended use, resulting in a high risk of substance use disorder.
Federal regulations require the following components to be included on any prescription for a controlled substance:
Individual state laws may have stricter requirements.
Conditions Requiring ConZip vs. Percocet
Some common conditions that may require the use of ConZip or Percocet include:
Controlled Substance Status: ConZip vs. Percocet
ConZip is classified as a Schedule IV drug, which means it has a low potential forabuseand a low risk of dependence.
Percocet is classified as a Schedule II drug and has a high potential for abuse, with the potential to lead to dependence.
Opioids like ConZip and Percocet are considered controlled substances because of their potential to be misused and their risk of potential abuse and addiction.
A Word From VerywellConZip can be more effective for neuropathy (pain involving nerves) due to its effect on norepinephrine. Given its extended-release (ER) formulation, it can also be a better option for baseline pain management.When prescribing Percocet, it is critical to look at any other sources of acetaminophen (both Rx and OTC) to be sure the individual isn’t reaching or exceeding the maximum allowed dose per day.—LINDSAY COOK, PHARMD, MEDICAL EXPERT BOARD
A Word From Verywell
ConZip can be more effective for neuropathy (pain involving nerves) due to its effect on norepinephrine. Given its extended-release (ER) formulation, it can also be a better option for baseline pain management.When prescribing Percocet, it is critical to look at any other sources of acetaminophen (both Rx and OTC) to be sure the individual isn’t reaching or exceeding the maximum allowed dose per day.—LINDSAY COOK, PHARMD, MEDICAL EXPERT BOARD
ConZip can be more effective for neuropathy (pain involving nerves) due to its effect on norepinephrine. Given its extended-release (ER) formulation, it can also be a better option for baseline pain management.When prescribing Percocet, it is critical to look at any other sources of acetaminophen (both Rx and OTC) to be sure the individual isn’t reaching or exceeding the maximum allowed dose per day.
ConZip can be more effective for neuropathy (pain involving nerves) due to its effect on norepinephrine. Given its extended-release (ER) formulation, it can also be a better option for baseline pain management.
When prescribing Percocet, it is critical to look at any other sources of acetaminophen (both Rx and OTC) to be sure the individual isn’t reaching or exceeding the maximum allowed dose per day.
—LINDSAY COOK, PHARMD, MEDICAL EXPERT BOARD
ConZip is a brand-name opioid agonist. It is an ER formulation of the active ingredient tramadol.
This medication is used for the management of moderate to severe, persistent pain that requires long-term treatment with a daily opioid when other treatment options have failed.
ConZip should not be used on children 12 years old or younger. It should not be used in children under 18 years of age following medical procedures to remove thetonsilsor theadenoids.
ConZip prescriptions may be written, called into the pharmacy, or faxed, and they may be refilled up to five times in six months.
Available Strengths
ConZip is orally administered and available as a capsule and generic medication.
ConZip is available at the following strengths:
Boxed Warning
ConZip carries a boxed warning regarding the potential risk of opioid addiction, abuse, and misuse, which can result in overdose or death.
Other boxed warnings for ConZip include:
Off-Label Uses
A medication is used off-label when it is prescribed for a purpose or at a dose other than its FDA-approved use.
The active ingredient in ConZip (tramadol) has been used off-label as anantidepressantand for the treatment of malesexual dysfunction.
Tramadol is also available in combination with acetaminophen (brand name: Ultracet) andcelecoxib (seglentis)for the treatment of pain in adults.
How It Works
It does not bind to specific receptors in the same way more potent opioids can.
ConZip works differently than other opioids because it inhibits the reabsorption ofnorepinephrineandserotonin, which contributes to its ability to relieve pain.
ConZip is designed to provide sustained pain relief over an extended time as an ER formulation.
Percocet, a full opioid agonist, is an IR medication containing a combination of two medications: oxycodone (a narcotic pain reliever) and acetaminophen (an analgesic pain reliever).
Like ConZip, it is also FDA-approved for the management of severe and persistent pain that requires treatment with an opioid medication when other treatment options have failed.
Percocet prescriptions have stricter requirements than ConZip prescriptions. Percocet prescriptions can be written or faxed. They can only be called into the pharmacy under particular circumstances.
Percocet prescriptions cannot be refilled.
However, multiple prescriptions may be issued for a total supply of at most 90 days under certain conditions.
Brand-name Percocet is orally administered and is available in tablet or liquid form.
As a combination of oxycodone and acetaminophen, g as a generic medication.
Percocet is available at the following strengths of oxycodone and acetaminophen, respectively:
Percocet use in the pediatric population has not been established.
However, oxycodone use in people 11 years and older who are opioid-tolerant may be appropriate.
This medication should not be used in people with notable respiratory depression, acute or severeasthma, orGI obstruction.
Percocet carries the following boxed warnings:
Percocet may be used off-label for fibromyalgia syndrome and other pain-related diagnoses.
Oxycodone and acetaminophen work together to create the desired effect of pain relief.
Oxycodone is an opioid agonist and works to disrupt the transmission of pain signals and the perception of pain.
The following provides general dosing guidelines for using ConZip and Percocet for pain management (note that your healthcare provider may decide to titrate your dose to achieve optimal pain relief):
How Quickly Does Each Drug Work?
Generally, how long the effects of ConZip or Percocet last in the body depends on factors such as how much of the medication was taken and the time it was taken.
However, users will typically begin to feel the effects of Percocet for pain relief within 10 to 30 minutes of consumption.
In comparison, because ConZip is an ER medication, users may need several hours to feel its pain-relieving effects.
ConZip and Percocet carry the potential for side effects of varying severities.
Therefore, if using either drug, be sure to monitor yourself or a loved one closely for the emergence of side effects that fail to dissipate or worsen over time.
If you believe you are experiencing a medical emergency, dial 911 immediately.
Common Side Effects
The most common side effects associated with the use of ConZip and Percocet include the following:
Severe Side Effects
Severe side effects associated with the use of ConZip include:
Severe side effects associated with the use of Percocet include:
ConZip should be taken at most once daily, while Percocet may be taken throughout the day as directed or prescribed.
If prescribed ConZip or Percocet, you should never double your dose, but you may take a missed dose as soon as you remember. If it’s almost time for your next dose, skip the missed dose and continue your usual schedule.
Use of either medication is not recommended in pregnant or breastfeeding people and has the potential to result in fetal harm.
ConZip capsules should be swallowed whole. Avoid breaking, chewing, or splitting the capsules.
These medications should be titrated or discontinued under the supervision of your provider. Do not abruptly discontinue the use of either medication.
Potential for Interaction
Avoid taking ConZip with the following medications due to their potential to affect absorption and effectiveness:
Benzodiazepinesand other nervous system depressants, such asanxiety medications, muscle relaxants, antipsychotics, and other opioids, should be avoided due to the potentially harmful effects that may occur when taken together.
Finally, avoid alcohol intake when taking either drug.
Opioids are seen as effective treatment options for pain management when used short-term (less than three months).
However, overall, more research is needed to assess the long-term efficacy of opioids.
Head-to-Head Review
Tramadol was found to be just as effective as oxycodone when used for pain relief following various types of surgery.
Some non-drugtherapiesfor pain management include:
Summary
Opioids are a group of medications used to treat and manage pain.
Conzip (tramadol) and Percocet (oxycodone/acetaminophen) are both prescription-only medications that are FDA-approved for the management of severe and persistent pain.
The significant difference between ConZip and Percocet is their drug classes and active ingredients.
ConZip is an opioid agonist and contains a single active ingredient. Percocet contains oxycodone, which is a narcotic pain reliever, and acetaminophen, which is an analgesic pain reliever.
Understanding the differences between these drugs is essential to appropriately assess the pain management strategies you may be presented with.
These medications should be prescribed, titrated, and discontinued under the supervision of your provider to prevent medication tolerance or abuse. Do not abruptly discontinue the use of either medication.
ConZip and Percocet should be stored in a secure, dry area at room temperature (68–77 degrees F).Do not store either medication in bathrooms or other areas susceptible to high heat, light, or moisture.They should be kept out of the sight and reach of children and pets.
ConZip and Percocet should be stored in a secure, dry area at room temperature (68–77 degrees F).
Do not store either medication in bathrooms or other areas susceptible to high heat, light, or moisture.
They should be kept out of the sight and reach of children and pets.
Tylenol can be taken alongside ConZip. Use caution when taking additional Tylenol with Percocet as it already contains the active ingredient in Tylenol (acetaminophen).Liver injury is associated with doses of acetaminophen exceeding 4 grams (g) per day, especially if taking more than one medication containing acetaminophen.
Tylenol can be taken alongside ConZip. Use caution when taking additional Tylenol with Percocet as it already contains the active ingredient in Tylenol (acetaminophen).
Liver injury is associated with doses of acetaminophen exceeding 4 grams (g) per day, especially if taking more than one medication containing acetaminophen.
Tolerance occurs when more medication is required over time to experience the same pain-relief effect. The risk of developing opioid tolerance increases with repeat opioid use.
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Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read oureditorial processto learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.
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DailyMed.Label: Conzip - tramadol hydrochloride capsule, extended release.
DailyMed.Label: Percocet - oxycodone hydrochloride and acetaminophen tablet.
MedlinePlus.Tramadol.
MedlinePlus.Oxycodone.
American Psychiatric Association.Opioid use disorder.
National Institute on Drug Abuse.Prescription opioids drug facts.
Webster LR.Risk factors for opioid-use disorder and overdose.Anesth Analg. 2017;125(5):1741-1748. doi:10.1213/ANE.0000000000002496
Haefeli M, Elfering A.Pain assessment.Eur Spine J. 2006;15(suppl 1):S17-S24. doi:10.1007/s00586-005-1044-x
Dahlhamer JM, Connor EM, Bose J, Lucas JL, Zelaya CE.Prescription opioid use among adults with chronic pain: United States, 2019.Natl Health Stat Report. 2021;(162):1-9.
DailyMed.Label: Hydrocodone acetaminophen - hydrocodone, acetaminophen tablet.
DailyMed.Label: Opana - oxymorphone hydrochloride tablet.
DailyMed.Label: Oxycodone hydrochloride tablet.
DailyMed.Label: Codeine sulfate tablet.
DailyMed.Label: Fentanyl citrate injection, solution.
Gabay M.Federal controlled substances act: controlled substances prescriptions.Hospital pharmacy.2013;48(8):644–645. doi:10.1310/hpj4808-644
Centers for Disease Control and Prevention.Opioid therapy and different types of pain.
United States Drug Enforcement Agency.Drug scheduling.
Food and Drug Administration.Tramadol hydrochloride prescribing information.
Food and Drug Administration.Understanding unapproved use of approved drugs “off label”.
Bumpus JA.Low-dose tramadol as an off-label antidepressant: a data mining analysis from the patients' perspective.ACS Pharmacol Transl Sci.2020;3(6):1293–1303. doi:10.1021/acsptsci.0c00132
Eassa BI, El-Shazly MA.Safety and efficacy of tramadol hydrochloride on treatment of premature ejaculation.Asian J Androl. 2013;15(1):138-142. doi:10.1038/aja.2012.96
Arthritis Foundation.Tramadol with acetaminophen.
Pathan H, Williams J.Basic opioid pharmacology: an update.Br J Pain. 2012;6(1):11-16. doi:10.1177/2049463712438493
Gaskell H, Moore RA, Derry S, Stannard C.Oxycodone for pain in fibromyalgia in adults.Cochrane Database Syst Rev. 2016;9(9):CD012329. doi:10.1002/14651858.CD012329
Ohashi N, Kohno T.Analgesic effect of acetaminophen: a review of known and novel mechanisms of action.Front Pharmacol. 2020;11:580289 doi:10.3389/fphar.2020.580289
Dowell D, Ragan KR, Jones CM, Baldwin GT, Chou R.CDC clinical practice guideline for prescribing opioids for pain - United States, 2022.MMWR Recomm Rep. 2022;71(3):1-95. doi:10.15585/mmwr.rr7103a1
Chou R, Turner JA, Devine EB, et al.The effectiveness and risks of long-term opioid therapy for chronic pain: a systematic review for a National Institutes of Health Pathways to Prevention Workshop.Annals of internal medicine.2015;162(4):276-286. doi:10.7326/M14-2559
Meske DS, Lawal OD, Elder H, Langberg V, Paillard F, Katz N.Efficacy of opioids versus placebo in chronic pain: a systematic review and meta-analysis of enriched enrollment randomized withdrawal trials.Journal of pain research.2018;11:923–934. doi:10.2147/JPR.S160255
Hazzard S, McLaughlin A, Cacace H, Nukala V, Asnis P.Tramadol provides similar pain relief and a better side effect profile than oxycodone (or hydrocodone) alone or in combination with tramadol after anterior cruciate ligament reconstruction or arthroscopic knee debridement.Arthrosc Sports Med Rehabil.2023;5(3):e765–e771. doi:10.1016/j.asmr.2023.04.003
Centers for Disease Control and Prevention.Nonopioid therapies for pain management.
StatPearls.Opioid prescribing.
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