Key Takeaways
If vaccines had been rolled out at half the actual rate, an additional 121,000 Americans could have died and more than 450,000 more could have been hospitalized.
“This isn’t just an abstract thing,”Eric Schneider, MD, MSc, an author of the study and senior vice president for policy and research at the Commonwealth Fund, tells Verywell. ”This is actually affecting the population. Here are the people whose lives were saved as a result of this intervention.”
COVID-19 vaccines prevented around 279,000 deaths in the U.S.Source: The Commonwealth Fund

Source: The Commonwealth Fund
As of July 11, the U.S. has administered over 387 million COVID-19 vaccine doses, with 55.5% of Americans having received at least one dose.Between January and mid-June, the number of cases has fallen from more than 300,000 to less than 20,000 per day.
However, researchers of the study warn that the spread of new viral variants, likeDelta, threaten to reverse these gains.
Delta Variant Is Creating a Web of Regional COVID-19 Epidemics
COVID-19 Vaccines Averted a Spring Surge
The U.S. recorded roughly 300,000 deaths during the first half of 2021.Rapid vaccination rollout has prevented that number from doubling, according to the researchers.
“That’s a big impact for any public health intervention,” Schneider says. “The most we usually hope for is sort of a 10% or 20% reduction, but this is huge in a short time frame.”
Schneider estimates that the surge in deaths in the U.S. would have peaked in April or May when the Alpha variant took hold of the country. It would likely have been larger than any previous waves of outbreaks. Instead, COVID-19 cases declined during much of the spring thanks to the vaccine development and rollout efforts.
COVID-19 vaccines prevented about 26 million cases.Source: The Commonwealth Fund

According to the study, the COVID-19 vaccines prevented about 26 million cases. With a vaccination program at half the pace, some 22 million cases would have been averted. The difference between both these scenarios is relatively little, compared to the estimations for hospitalizations and deaths. The study shows that while the vaccines are highly effective at preventing serious disease, they do not likely totally prevent transmission and mild illness.
“The vaccines may not be completely effective when it comes to preventing infection with these new variants, but they’re very effective when it comes to preventing severe outcomes,”Joshua Cohen, PhD,deputy director of the Center for the Evaluation of Value and Risk in Health at the Institute for Clinical Research and Health Policy Studies at Tufts Medical Center, tells Verywell.
What This Means For YouThe report underscores how effective the vaccines are at preventing serious illness and death. If you are unvaccinated, you can find more information about how they work and where to schedule an appointment at Vaccines.gov.
What This Means For You
The report underscores how effective the vaccines are at preventing serious illness and death. If you are unvaccinated, you can find more information about how they work and where to schedule an appointment at Vaccines.gov.
Building a Reliable Model
The researchers accumulated data from various sources including the Centers for Disease Control and Prevention (CDC) and published scientific papers.
To run a simulated model, they factored in the U.S. demographics, how different age groups experienced cases and hospitalizations, the relative transmissibility of each variant, how long it took infected people to become contagious, and more.
Researchers had to train and run the model to see how well it reflected reality over a period of time. Once it was proven reliable, they tested different scenarios, like how changes in the vaccination rate affected the number of cases and hospitalizations.
While the model considers a wide array of factors that drive COVID-19 health outcomes, Schneider says it can be challenging to account for how people actually act.
“You could probably walk around any American city right now and see different parts of the city, behaving in different ways, and that can be hard to capture accurately in a model," he says.
Implications for the Future
“By looking at how our actions have affected outcomes so far, it can help us understand the benefits of vaccination going forward,” Cohen says.
The model could also be useful in showing how the differences in states’ vaccination rates impact health outcomes. More than70% of people have been vaccinatedin some states, while vaccination rates remained below 30% in about 1,000 U.S. counties as of July 1, CDC director Rochelle Walenskysaid last week.
Publishing data on the success of vaccines while the world is still in the midst of the pandemic could help guide prevention efforts in upcoming months and years. The authors say they hope the findings will encourage people to get vaccinated.
“It’s very hard to roll out prevention programs and for people to take them seriously because people aren’t aware of the deaths that didn’t occur, or the cancers that didn’t happen or the car crashes in which people’s lives were saved,” Schneider says. “We tend to see the deaths and illnesses and cancers and forget that we actually have some agency and some control.”
The information in this article is current as of the date listed, which means newer information may be available when you read this. For the most recent updates on COVID-19, visit ourcoronavirus news page.
3 Sources
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Centers for Disease Control and Prevention.COVID data tracker.
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