Table of ContentsView AllTable of ContentsUses of Calcium D-GlucarateSupplement SafetyInteractionsNutrition
Table of ContentsView All
View All
Table of Contents
Uses of Calcium D-Glucarate
Supplement Safety
Interactions
Nutrition
Calcium D-glucarate has an active ingredient,glucaric acid, that has been touted to lower estrogen and slow the growth of hormone-dependent cancers. However, these results are mainly from lab studies using animals, and there isn’t enough research in people to support either claim.
In the United States, the Food and Drug Administration (FDA) does not regulate supplements the way it regulates prescription drugs. That means some supplement products may not contain what the label says. Whenchoosing a supplement, look for independently tested products and consult a healthcare provider, registered dietitian nutritionist (RD or RDN), or pharmacist.
Getty Images / ljubaphoto
A healthcare professional, such as a registered dietitian, pharmacist, or healthcare provider, should individualize and vet supplement use. No supplement’s intended purpose is to treat, cure, or prevent disease.
Calcium D-glucarate is sometimes marketed as helping to prevent or reduce cancer. Animal studies have shown that calcium D-glucarate may slow tumor development. However, only mice and rats have been the subjects of these studies.
No human studies support the use of calcium D-glucarate supplements for preventing or treating any health condition, including cancer.
Though calcium D-glucarate does contain some calcium, it is not intended for use as a calcium supplement.
Human vs. Animal StudiesAnimal studies are often conducted in non-human species such as mice, rabbits, or rats. Although these studies often help further medical research, animal studies may not accurately predict human reactions or outcomes. Therefore, they are not a sufficient substitute for high-quality clinical trials.When reading about animal research, it is important not to draw conclusions based on the results. More research is necessary to confirm any results found in animals.
Human vs. Animal Studies
Animal studies are often conducted in non-human species such as mice, rabbits, or rats. Although these studies often help further medical research, animal studies may not accurately predict human reactions or outcomes. Therefore, they are not a sufficient substitute for high-quality clinical trials.When reading about animal research, it is important not to draw conclusions based on the results. More research is necessary to confirm any results found in animals.
Animal studies are often conducted in non-human species such as mice, rabbits, or rats. Although these studies often help further medical research, animal studies may not accurately predict human reactions or outcomes. Therefore, they are not a sufficient substitute for high-quality clinical trials.
When reading about animal research, it is important not to draw conclusions based on the results. More research is necessary to confirm any results found in animals.
There is not enough data to report the potential side effects of taking calcium d-glucarate or any other safety considerations. People who are pregnant or nursing should not take calcium d-glucarate supplements for this reason (nor should children).
Additionally, there is not enough research to provide a recommended dosage for calcium d-glucarate supplements.
Does Calcium D-Glucarate Interact With Any Drugs?
If you decide to take a calcium D-glucarate supplement, it’s important to be aware of any potential drug interactions.
Carefully read a supplement’s ingredient list and nutrition facts panel to know which ingredients and how much of each ingredient is included is essential. Please review this supplement label with your healthcare provider to discuss any potential interactions with foods, other supplements, and medications.
Can You Get Calcium D-Glucarate in Your Diet?
The body naturally produces calcium D-glucarate in small amounts. However, you can also get it in certain foods, such as fruits, vegetables, and the seeds of certain plants.
Calcium D-glucarate is found in the following foods:
A food-first approach is always best when trying to get the nutrients your body needs. A well-balanced, nutritious diet is key to improving and maintaining your overall health.
Summary
Calcium D-glucarate is the calcium salt of d-glucaric acid, which the body produces naturally. It is also found in certain foods, including fruits and vegetables, and marketed as a dietary supplement. Animal research suggests that its supplement form can play a role in cancer prevention, but there is no human data to support this.
If you want to make sure you’re getting enough calcium D-glucarate, increase your fruit and vegetable intake. Consuming the right nutrients in your diet can benefit your overall health.
6 Sources
Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read oureditorial processto learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.
Memorial Sloan Kettering Cancer Center.Calcium glucarate.
Abou-Issa H, Moeschberger M, el-Masry W, et al.Relative efficacy of glucarate on the initiation and promotion phases of rat mammary carcinogenesis.Anticancer Res. 1995;15(3):805-810.
Singh J, Gupta KP.Calcium glucarate prevents tumor formation in mouse skin.Biomed Environ Sci. 2003;16(1):9-16.
National Library of Medicine.Calcium-d-glucarate.Altern Med Rev. 2002;7(4):336-339.
Dwivedi C, Heck WJ, Downie AA, et al.Effect of calcium glucarate on beta-glucuronidase activity and glucarate content of certain vegetables and fruits.Biochem Med Metab Biol. 1990;43(2):83-92. doi:10.1016/0885-4505(90)90012-p
Meet Our Medical Expert Board
Share Feedback
Was this page helpful?Thanks for your feedback!What is your feedback?OtherHelpfulReport an ErrorSubmit
Was this page helpful?
Thanks for your feedback!
What is your feedback?OtherHelpfulReport an ErrorSubmit
What is your feedback?
