Table of ContentsView AllTable of ContentsWhat Is Sucralose?Safety ProfileHealth BenefitsHow to UseAlternative SweetenersIs Sucralose Good for Me?

Table of ContentsView All

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Table of Contents

What Is Sucralose?

Safety Profile

Health Benefits

How to Use

Alternative Sweeteners

Is Sucralose Good for Me?

Researchers have mainly studied sucralose’s potential roles in diabetes and weight management.

The following article covers the benefits of sucralose, its nutritional value, and safety considerations.

Hand pouring sweetener from paper packet into coffee cup.zoranm / Getty Images

Hand pouring sweetener from paper packet into coffee cup

zoranm / Getty Images

Sucralose is a zero-calorie sweetener derived from sucrose (table sugar). It is classified as nonnutritive because it does not provide nutritional value.

Sucralose is sold under the brand name Splenda. The Food and Drug Administration (FDA) approved its use as a general-purpose food sweetener in 1999. Like other sweeteners, sucralose is often used to sweeten baked goods, drinks, gum, candy, canned foods, jellies, and some dairy products.

In general, sucralose is considered safe for most people to use. However, there are concerns regarding some of its potential adverse effects.

The FDA has approved an ADI of 5 milligrams per kilogram of body weight (mg/kg) per day, which is about 2.3 mg/pound per day. However, the EFSA has approved 15 mg/kg (about 7 mg/pound) per day.According to the FDA, a person who weighs 60 kg (132 pounds) would need to consume 23 packets of Stevia in one day to reach the ADI of 5 mg/kg.

Despite these approvals, concerns remain regarding the overall safety of sucralose.

Various studies have found several potential safety issues with artificial sweeteners, including sucralose.

According to one review, sucralose negatively impacted glucose levels and post-meal hormone responses. In preclinical studies, nonnutritive/no-calorie sweeteners have also been linked tobladder cancer, coronaryheart disease, andchronic kidney disease, mainly when used in excess.However, more research is needed to prove these effects.

Sucralose may also alter thegut microbiome.

Some studies show that consuming sucralose in amounts greater than the ADI may lead to negative changes to the diversity and composition of your gut microbiome. This may be because sucralose is not fully digested and enters the gut unchanged. However, other studies have been inconclusive, and researchers can’t prove a direct correlation between sucralose consumption and microbiome changes.

Overall, more research may be warranted regarding the safety of sucralose. For now, consuming no more than 5 mg/kg of sucralose per day is recommended to lower your risk of adverse effects.

Health Benefits of Sucralose

Sucralose has been linked to certain potential health benefits.

Sucralose lacks nutritional value. It also doesn’t contain calories. For this reason, it may be a good fit for people with certain health conditions. Sucralose may also have benefits for dental health.

Impact on Blood Sugar and Weight Management

Sucralose is thought to not raiseblood sugar, at least not to the same degree as table sugar. If true, sucralose may also help with weight management. Several studies have been conducted to prove these effects, but results have mostly been inconclusive.

According to a review of artificial sweeteners, research results regarding how sucralose affects blood sugar have been unclear. In some studies, sucralose actually raised blood sugar andinsulinlevels in participants.

In one small study, people with newly diagnosedtype 2 diabetesand without diabetes used sucralose. Sucralose did not raise blood sugar in those without diabetes. However, blood sugar still increased in those with diabetes.

When it comes to weight management, study results have also been largely inconsistent.

Various animal studies have found positive results of sucralose on weight management. In one, eight weeks of sucralose use reduced weight and improved blood sugar levels in mice.

However, another animal study found that sucralose increased weight and fat mass in rats who consumed it for seven weeks.

Unfortunately, there are very few studies on the impact of sucralose on body weight in humans. And the studies that are available show inconclusive results.

Interestingly, the World Health Organization (WHO) released new guidelines for artificial sweetener use for weight control in 2023. Per the guidelines, people should not use sucralose and other artificial sweeteners to control body weight due to a lack of evidence in favor of their use.

Dental Health

Compared to sugar, sucralose may be better for your dental health.

Some research shows that sucralose does not cause tooth decay the same way that sugar can. In fact, sucralose is a common ingredient in many oral health products.

Sucralose and other similar artificial sweeteners are not metabolized in the mouth to acids like other sugars are. For this reason, sucralose isn’t believed to lead tocavities.

However, this does not mean that sucralose-containing products have no effect on your teeth.

Many foods and drinks containing sucralose contain other ingredients known to cause oral decay, especially if used in excess or if proper oral hygiene is not followed.

Digestive Health

Using sucralose may lead to issues with your digestive health. This may be especially true if you use sucralose long-term or in large quantities.

In another study, however, short-term use of sucralose (just seven days) was not related to gut microbiome changes in adult males.

Changes to the microbiome may also cause changes to digestion. This is because the bacteria in your gut are needed for the normal digestion and absorption of nutrients.

Although sucralose is believed to be unabsorbed in the gut, research shows that about 15% of the sweetener is, in fact, absorbed.

Additionally, sucralose has been shown to increase certain hormones that may slow digestion and cause upset stomach in some people.Side effects likediarrhea, gas, andbloatinghave also been linked to sucralose use.

To reduce the risk of gastrointestinal side effects, it’s recommended that you limit sucralose intake to the ADI of 5 mg/kg per day.

How to Use Sucralose

Sucralose can be used in many different ways and is typically used as a replacement for sugar.

Some products you buy at a grocery store may already contain sucralose.

Common products containing sucralose are baked goods, beverages, gum, gelatin, and frozen dairy desserts.Sucralose may be added to other products and listed on the ingredient list (sometimes as Splenda).

Some people use sucralose to sweeten their coffee or tea. You can purchase sucralose in individual packets or in bulk.

Sucralose is said to be more heat stable than otherartificial sweeteners. This means that it may be used in some baking recipes and will remain sweet even when cooked at high temperatures.

The temperature at which sucralose remains heat stable is not well-documented. Some reports suggest that it is stable up to 350 degrees F, while others say that sucralose remains intact up to 450 degrees F.

According to the Splenda website, baked goods may bake more quickly when using their product (or other brands of sucralose) instead of sugar.

It’s worth noting, however, that a 2020 study found that sucralose may decompose when cooked at high temperatures, such as those used in baking. If true, sucralose may release potentially toxic chlorine substances if it becomes too hot.More research is needed to prove these effects.

When using sucralose, remember it is about 600 times sweeter than sugar.This fact may change how much sucralose you use in recipes or when sweetening your coffee or tea.

Artificial sweeteners may be natural or synthetic.

The FDA has approved six synthetic sugar substitutes. These include sucralose,aspartame,acesulfame potassium(acesulfame-K, or ace-K),neotame,advantame, andsaccharin.

Natural sweeteners mostly come from plant sources.

Steviol glycosides, for example, come from theStevia rebaudianaspecies, a member of theSteviagenus of plants. This sugar substitute is most commonly sold under the brand name Stevia and is a popular natural option.

The stevia plant has been used for its sweet taste for centuries, but its use became commercialized in the 1970s.

Like sucralose, Stevia contains zero calories. The sweetness of Stevia is extracted from the plant’s leaves. Stevia is about 200 to 300 times sweeter than sugar.

Using any sugar substitute may cause side effects, so it’s important not to use them excessively. Talk with your healthcare provider about how to safely use alternative sweeteners.

Sucralose may not be a good fit for everyone.

You should avoid sucralose if you’re allergic to it or its components. Seek immediate medical attention if you have signs of asevere allergic reaction, including itching, hives, and shortness of breath.

Sucralose is thought to be safe to use duringpregnancyandlactation.

Interactions between sucralose and medications are not well-documented.

While anecdotal concerns exist that sucralose may negatively affect medications used to treat cancer and heart disease, there isn’t solid evidence to back up these claims. If you take these or other medications, talk with a healthcare provider about whether you should use sucralose.

It’s also worth noting that some research shows that using sucralose and other artificial sweeteners may increase food cravings.

The most important thing to remember when using sucralose is to enjoy it in moderation and avoid exceeding daily recommendations.

Summary

Sucralose is a zero-calorie sugar substitute. It is semisynthetic and is characterized as an artificial sweetener.

Sucralose has been marketed as a “better-for-you” alternative to sugar. Compared to sugar, sucralose is much lower in calories and is thought to be better for blood sugar control.

Research shows that sucralose may have some benefits over sugar, but it should still be used in moderation and may cause some adverse effects.

The FDA has classified sucralose as safe for general use. However, the FDA recommends consuming no more than 5 mg/kg (about 11 mg/pound) of sucralose per day.

Talk with a healthcare provider if you have questions about sucralose or want to know if it’s a good choice for you.

Correction - January 15, 2025: This article was updated to correct the ADI values presented in mg/pound per day.

23 SourcesVerywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read oureditorial processto learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.Tsai MJ, Li CH, Wu HT, et al.Long-term consumption of sucralose induces hepatic insulin resistance through an extracellular signal-regulated kinase 1/2-dependent pathway.Nutrients. 2023;15(12):2814. doi:10.3390/nu15122814Risdon S, Battault S, Romo-Romo A, et al.Sucralose and cardiometabolic health: current understanding from receptors to clinical investigations.Adv Nutr. 2021;12(4):1500-1513. doi:10.1093/advances/nmaa185Food and Drug Administration.Aspartame and Other Sweeteners in Food.Sharma A, Amarnath S, Thulasimani M, Ramaswamy S.Artificial sweeteners as a sugar substitute: Are they really safe?.Indian J Pharmacol. 2016;48(3):237-240. doi:10.4103/0253-7613.182888Del Pozo S, Gómez-Martínez S, Díaz LE, Nova E, Urrialde R, Marcos A.Potential effects of sucralose and saccharin on gut microbiota: a review.Nutrients. 2022;14(8):1682. doi:10.3390/nu14081682Alsunni AA.Effects of artificial sweetener consumption on glucose homeostasis and its association with type 2 diabetes and obesity.Int J Gen Med. 2020;13:775-785. doi:10.2147/IJGM.S274760Temizkan S, Deyneli O, Yasar M, et al.Sucralose enhances GLP-1 release and lowers blood glucose in the presence of carbohydrate in healthy subjects but not in patients with type 2 diabetes.Eur J Clin Nutr. 2015;69(2):162-166. doi:10.1038/ejcn.2014.208Pino-Seguel P, Moya O, Borquez JC, et al.Sucralose consumption ameliorates high-fat diet-induced glucose intolerance and liver weight gain in mice.Front Nutr. 2022;9:979624. doi:10.3389/fnut.2022.979624Ragi ME, El-Haber R, El-Masri F, Obeid OA.The effect of aspartame and sucralose intake on body weight measures and blood metabolites: role of their form (solid and/or liquid) of ingestion.Br J Nutr. 2022;128(2):352-360. doi:10.1017/S0007114521003238Pang MD, Goossens GH, Blaak EE.The impact of artificial sweeteners on body weight control and glucose homeostasis.Front Nutr. 2021;7:598340. doi:10.3389/fnut.2020.598340World Health Organization.WHO advises not to use non-sugar sweeteners for weight control in newly released guideline.Alternative sugars: Sucralose.Br Dent J224, 5 (2018). doi:10.1038/sj.bdj.2018.15Gupta P, Gupta N, Pawar AP, Birajdar SS, Natt AS, Singh HP.Role of sugar and sugar substitutes in dental caries: a review.ISRN Dent. 2013;2013:519421. doi:10.1155/2013/519421Gupta M.Sugar substitutes: mechanism, availability, current use and safety concerns-an update.Open Access Maced J Med Sci. 2018;6(10):1888-1894. doi:10.3889/oamjms.2018.336Méndez-García LA, Bueno-Hernández N, Cid-Soto MA, et al.Ten-week sucralose consumption induces gut dysbiosis and altered glucose and insulin levels in healthy young adults.Microorganisms. 2022;10(2):434. doi:10.3390/microorganisms10020434Thomson P, Santibañez R, Aguirre C, Galgani JE, Garrido D.Short-term impact of sucralose consumption on the metabolic response and gut microbiome of healthy adults.Br J Nutr. 2019;122(8):856-862. doi:10.1017/S0007114519001570Spencer M, Gupta A, Dam LV, Shannon C, Menees S, Chey WD.Artificial sweeteners: a systematic review and primer for gastroenterologists.J Neurogastroenterol Motil. 2016;22(2):168-180. doi:10.5056/jnm15206Splenda.Baking tips for Splenda original sweeteners.Eisenreich A, Gürtler R, Schäfer B.Heating of food containing sucralose might result in the generation of potentially toxic chlorinated compounds.Food Chem. 2020;321:126700. doi:10.1016/j.foodchem.2020.126700Ashwell M.Stevia, nature’s zero-calorie sustainable sweetener: a new player in the fight against obesity.Nutr Today. 2015;50(3):129-134. doi:10.1097/NT.0000000000000094Pope E, Koren G, Bozzo P.Sugar substitutes during pregnancy.Can Fam Physician. 2014;60(11):1003-1005.Drugs and Lactation Database (LactMed).Sucralose.Wilk K, Korytek W, Pelczyńska M, Moszak M, Bogdański P.The effect of artificial sweeteners use on sweet taste perception and weight loss efficacy: a review.Nutrients. 2022;14(6):1261. doi:10.3390/nu14061261

23 Sources

Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read oureditorial processto learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.Tsai MJ, Li CH, Wu HT, et al.Long-term consumption of sucralose induces hepatic insulin resistance through an extracellular signal-regulated kinase 1/2-dependent pathway.Nutrients. 2023;15(12):2814. doi:10.3390/nu15122814Risdon S, Battault S, Romo-Romo A, et al.Sucralose and cardiometabolic health: current understanding from receptors to clinical investigations.Adv Nutr. 2021;12(4):1500-1513. doi:10.1093/advances/nmaa185Food and Drug Administration.Aspartame and Other Sweeteners in Food.Sharma A, Amarnath S, Thulasimani M, Ramaswamy S.Artificial sweeteners as a sugar substitute: Are they really safe?.Indian J Pharmacol. 2016;48(3):237-240. doi:10.4103/0253-7613.182888Del Pozo S, Gómez-Martínez S, Díaz LE, Nova E, Urrialde R, Marcos A.Potential effects of sucralose and saccharin on gut microbiota: a review.Nutrients. 2022;14(8):1682. doi:10.3390/nu14081682Alsunni AA.Effects of artificial sweetener consumption on glucose homeostasis and its association with type 2 diabetes and obesity.Int J Gen Med. 2020;13:775-785. doi:10.2147/IJGM.S274760Temizkan S, Deyneli O, Yasar M, et al.Sucralose enhances GLP-1 release and lowers blood glucose in the presence of carbohydrate in healthy subjects but not in patients with type 2 diabetes.Eur J Clin Nutr. 2015;69(2):162-166. doi:10.1038/ejcn.2014.208Pino-Seguel P, Moya O, Borquez JC, et al.Sucralose consumption ameliorates high-fat diet-induced glucose intolerance and liver weight gain in mice.Front Nutr. 2022;9:979624. doi:10.3389/fnut.2022.979624Ragi ME, El-Haber R, El-Masri F, Obeid OA.The effect of aspartame and sucralose intake on body weight measures and blood metabolites: role of their form (solid and/or liquid) of ingestion.Br J Nutr. 2022;128(2):352-360. doi:10.1017/S0007114521003238Pang MD, Goossens GH, Blaak EE.The impact of artificial sweeteners on body weight control and glucose homeostasis.Front Nutr. 2021;7:598340. doi:10.3389/fnut.2020.598340World Health Organization.WHO advises not to use non-sugar sweeteners for weight control in newly released guideline.Alternative sugars: Sucralose.Br Dent J224, 5 (2018). doi:10.1038/sj.bdj.2018.15Gupta P, Gupta N, Pawar AP, Birajdar SS, Natt AS, Singh HP.Role of sugar and sugar substitutes in dental caries: a review.ISRN Dent. 2013;2013:519421. doi:10.1155/2013/519421Gupta M.Sugar substitutes: mechanism, availability, current use and safety concerns-an update.Open Access Maced J Med Sci. 2018;6(10):1888-1894. doi:10.3889/oamjms.2018.336Méndez-García LA, Bueno-Hernández N, Cid-Soto MA, et al.Ten-week sucralose consumption induces gut dysbiosis and altered glucose and insulin levels in healthy young adults.Microorganisms. 2022;10(2):434. doi:10.3390/microorganisms10020434Thomson P, Santibañez R, Aguirre C, Galgani JE, Garrido D.Short-term impact of sucralose consumption on the metabolic response and gut microbiome of healthy adults.Br J Nutr. 2019;122(8):856-862. doi:10.1017/S0007114519001570Spencer M, Gupta A, Dam LV, Shannon C, Menees S, Chey WD.Artificial sweeteners: a systematic review and primer for gastroenterologists.J Neurogastroenterol Motil. 2016;22(2):168-180. doi:10.5056/jnm15206Splenda.Baking tips for Splenda original sweeteners.Eisenreich A, Gürtler R, Schäfer B.Heating of food containing sucralose might result in the generation of potentially toxic chlorinated compounds.Food Chem. 2020;321:126700. doi:10.1016/j.foodchem.2020.126700Ashwell M.Stevia, nature’s zero-calorie sustainable sweetener: a new player in the fight against obesity.Nutr Today. 2015;50(3):129-134. doi:10.1097/NT.0000000000000094Pope E, Koren G, Bozzo P.Sugar substitutes during pregnancy.Can Fam Physician. 2014;60(11):1003-1005.Drugs and Lactation Database (LactMed).Sucralose.Wilk K, Korytek W, Pelczyńska M, Moszak M, Bogdański P.The effect of artificial sweeteners use on sweet taste perception and weight loss efficacy: a review.Nutrients. 2022;14(6):1261. doi:10.3390/nu14061261

Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read oureditorial processto learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.

Tsai MJ, Li CH, Wu HT, et al.Long-term consumption of sucralose induces hepatic insulin resistance through an extracellular signal-regulated kinase 1/2-dependent pathway.Nutrients. 2023;15(12):2814. doi:10.3390/nu15122814Risdon S, Battault S, Romo-Romo A, et al.Sucralose and cardiometabolic health: current understanding from receptors to clinical investigations.Adv Nutr. 2021;12(4):1500-1513. doi:10.1093/advances/nmaa185Food and Drug Administration.Aspartame and Other Sweeteners in Food.Sharma A, Amarnath S, Thulasimani M, Ramaswamy S.Artificial sweeteners as a sugar substitute: Are they really safe?.Indian J Pharmacol. 2016;48(3):237-240. doi:10.4103/0253-7613.182888Del Pozo S, Gómez-Martínez S, Díaz LE, Nova E, Urrialde R, Marcos A.Potential effects of sucralose and saccharin on gut microbiota: a review.Nutrients. 2022;14(8):1682. doi:10.3390/nu14081682Alsunni AA.Effects of artificial sweetener consumption on glucose homeostasis and its association with type 2 diabetes and obesity.Int J Gen Med. 2020;13:775-785. doi:10.2147/IJGM.S274760Temizkan S, Deyneli O, Yasar M, et al.Sucralose enhances GLP-1 release and lowers blood glucose in the presence of carbohydrate in healthy subjects but not in patients with type 2 diabetes.Eur J Clin Nutr. 2015;69(2):162-166. doi:10.1038/ejcn.2014.208Pino-Seguel P, Moya O, Borquez JC, et al.Sucralose consumption ameliorates high-fat diet-induced glucose intolerance and liver weight gain in mice.Front Nutr. 2022;9:979624. doi:10.3389/fnut.2022.979624Ragi ME, El-Haber R, El-Masri F, Obeid OA.The effect of aspartame and sucralose intake on body weight measures and blood metabolites: role of their form (solid and/or liquid) of ingestion.Br J Nutr. 2022;128(2):352-360. doi:10.1017/S0007114521003238Pang MD, Goossens GH, Blaak EE.The impact of artificial sweeteners on body weight control and glucose homeostasis.Front Nutr. 2021;7:598340. doi:10.3389/fnut.2020.598340World Health Organization.WHO advises not to use non-sugar sweeteners for weight control in newly released guideline.Alternative sugars: Sucralose.Br Dent J224, 5 (2018). doi:10.1038/sj.bdj.2018.15Gupta P, Gupta N, Pawar AP, Birajdar SS, Natt AS, Singh HP.Role of sugar and sugar substitutes in dental caries: a review.ISRN Dent. 2013;2013:519421. doi:10.1155/2013/519421Gupta M.Sugar substitutes: mechanism, availability, current use and safety concerns-an update.Open Access Maced J Med Sci. 2018;6(10):1888-1894. doi:10.3889/oamjms.2018.336Méndez-García LA, Bueno-Hernández N, Cid-Soto MA, et al.Ten-week sucralose consumption induces gut dysbiosis and altered glucose and insulin levels in healthy young adults.Microorganisms. 2022;10(2):434. doi:10.3390/microorganisms10020434Thomson P, Santibañez R, Aguirre C, Galgani JE, Garrido D.Short-term impact of sucralose consumption on the metabolic response and gut microbiome of healthy adults.Br J Nutr. 2019;122(8):856-862. doi:10.1017/S0007114519001570Spencer M, Gupta A, Dam LV, Shannon C, Menees S, Chey WD.Artificial sweeteners: a systematic review and primer for gastroenterologists.J Neurogastroenterol Motil. 2016;22(2):168-180. doi:10.5056/jnm15206Splenda.Baking tips for Splenda original sweeteners.Eisenreich A, Gürtler R, Schäfer B.Heating of food containing sucralose might result in the generation of potentially toxic chlorinated compounds.Food Chem. 2020;321:126700. doi:10.1016/j.foodchem.2020.126700Ashwell M.Stevia, nature’s zero-calorie sustainable sweetener: a new player in the fight against obesity.Nutr Today. 2015;50(3):129-134. doi:10.1097/NT.0000000000000094Pope E, Koren G, Bozzo P.Sugar substitutes during pregnancy.Can Fam Physician. 2014;60(11):1003-1005.Drugs and Lactation Database (LactMed).Sucralose.Wilk K, Korytek W, Pelczyńska M, Moszak M, Bogdański P.The effect of artificial sweeteners use on sweet taste perception and weight loss efficacy: a review.Nutrients. 2022;14(6):1261. doi:10.3390/nu14061261

Tsai MJ, Li CH, Wu HT, et al.Long-term consumption of sucralose induces hepatic insulin resistance through an extracellular signal-regulated kinase 1/2-dependent pathway.Nutrients. 2023;15(12):2814. doi:10.3390/nu15122814

Risdon S, Battault S, Romo-Romo A, et al.Sucralose and cardiometabolic health: current understanding from receptors to clinical investigations.Adv Nutr. 2021;12(4):1500-1513. doi:10.1093/advances/nmaa185

Food and Drug Administration.Aspartame and Other Sweeteners in Food.

Sharma A, Amarnath S, Thulasimani M, Ramaswamy S.Artificial sweeteners as a sugar substitute: Are they really safe?.Indian J Pharmacol. 2016;48(3):237-240. doi:10.4103/0253-7613.182888

Del Pozo S, Gómez-Martínez S, Díaz LE, Nova E, Urrialde R, Marcos A.Potential effects of sucralose and saccharin on gut microbiota: a review.Nutrients. 2022;14(8):1682. doi:10.3390/nu14081682

Alsunni AA.Effects of artificial sweetener consumption on glucose homeostasis and its association with type 2 diabetes and obesity.Int J Gen Med. 2020;13:775-785. doi:10.2147/IJGM.S274760

Temizkan S, Deyneli O, Yasar M, et al.Sucralose enhances GLP-1 release and lowers blood glucose in the presence of carbohydrate in healthy subjects but not in patients with type 2 diabetes.Eur J Clin Nutr. 2015;69(2):162-166. doi:10.1038/ejcn.2014.208

Pino-Seguel P, Moya O, Borquez JC, et al.Sucralose consumption ameliorates high-fat diet-induced glucose intolerance and liver weight gain in mice.Front Nutr. 2022;9:979624. doi:10.3389/fnut.2022.979624

Ragi ME, El-Haber R, El-Masri F, Obeid OA.The effect of aspartame and sucralose intake on body weight measures and blood metabolites: role of their form (solid and/or liquid) of ingestion.Br J Nutr. 2022;128(2):352-360. doi:10.1017/S0007114521003238

Pang MD, Goossens GH, Blaak EE.The impact of artificial sweeteners on body weight control and glucose homeostasis.Front Nutr. 2021;7:598340. doi:10.3389/fnut.2020.598340

World Health Organization.WHO advises not to use non-sugar sweeteners for weight control in newly released guideline.

Alternative sugars: Sucralose.Br Dent J224, 5 (2018). doi:10.1038/sj.bdj.2018.15

Gupta P, Gupta N, Pawar AP, Birajdar SS, Natt AS, Singh HP.Role of sugar and sugar substitutes in dental caries: a review.ISRN Dent. 2013;2013:519421. doi:10.1155/2013/519421

Gupta M.Sugar substitutes: mechanism, availability, current use and safety concerns-an update.Open Access Maced J Med Sci. 2018;6(10):1888-1894. doi:10.3889/oamjms.2018.336

Méndez-García LA, Bueno-Hernández N, Cid-Soto MA, et al.Ten-week sucralose consumption induces gut dysbiosis and altered glucose and insulin levels in healthy young adults.Microorganisms. 2022;10(2):434. doi:10.3390/microorganisms10020434

Thomson P, Santibañez R, Aguirre C, Galgani JE, Garrido D.Short-term impact of sucralose consumption on the metabolic response and gut microbiome of healthy adults.Br J Nutr. 2019;122(8):856-862. doi:10.1017/S0007114519001570

Spencer M, Gupta A, Dam LV, Shannon C, Menees S, Chey WD.Artificial sweeteners: a systematic review and primer for gastroenterologists.J Neurogastroenterol Motil. 2016;22(2):168-180. doi:10.5056/jnm15206

Splenda.Baking tips for Splenda original sweeteners.

Eisenreich A, Gürtler R, Schäfer B.Heating of food containing sucralose might result in the generation of potentially toxic chlorinated compounds.Food Chem. 2020;321:126700. doi:10.1016/j.foodchem.2020.126700

Ashwell M.Stevia, nature’s zero-calorie sustainable sweetener: a new player in the fight against obesity.Nutr Today. 2015;50(3):129-134. doi:10.1097/NT.0000000000000094

Pope E, Koren G, Bozzo P.Sugar substitutes during pregnancy.Can Fam Physician. 2014;60(11):1003-1005.

Drugs and Lactation Database (LactMed).Sucralose.

Wilk K, Korytek W, Pelczyńska M, Moszak M, Bogdański P.The effect of artificial sweeteners use on sweet taste perception and weight loss efficacy: a review.Nutrients. 2022;14(6):1261. doi:10.3390/nu14061261

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