EGCG: One of Green Tea's Most Prominent Antioxidants

Table of ContentsView AllTable of ContentsNutrition Sources of EGCGUsesDosageSafetyFrequently Asked Questions

Table of ContentsView All

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Table of Contents

Nutrition Sources of EGCG

Uses

Dosage

Safety

Frequently Asked Questions

Epigallocatechin gallate (EGCG) is a type of plant compound called acatechin. Catechins are part of a larger group of plant compounds (polyphenols) associated with health benefits.

EGCG has the following properties:

Due to its anti-inflammatory properties, EGCG has been studied for its potential benefits for the following:

Still, more research is needed.

This article discusses the potential benefits of EGCG. It also covers dosage and safety concerns.

EGCG Supplement Facts

Green teais the most potent source of EGCG. The EGCG content of tea varies depending on the water temperature and steeping time. Likewise, harvesting practices can affect the nutrient content of tea leaves.

Other sources of EGCG include the following:

Matcha teais a highly potent source of EGCG. Unlike green tea, matcha is not an infusion. Matcha contains a higher EGCG content than green tea due to its greater amount of compounds.

Female hand pouring tea into transparent cup.Tatiana Lavrova / Getty Images

Female hand pouring tea into transparent cup.

Tatiana Lavrova / Getty Images

Uses of EGCG

The potential health benefits of EGCG are numerous and extend to brain and heart health, cancer prevention, and multiple sclerosis. Here’s the scoop on the research.

Cognition

A systematic review suggested drinking at least 100 milliliters (mL) (about 3 ounces) of green tea daily boosted cognition and brain function and may reduce the risk of dementia. Green tea also enhanced memory and attention span.

The cognitive benefits of green tea are well established. However, it is unclear whether EGCG or other compounds found in green tea are responsible for these positive health effects.

Some studies of human brain cells (in vitro research, performed in a lab) suggested EGCG crossed theblood-brain barrier, a layer of cells that protects the brain from harmful substances. This may contribute to EGCG’s calming and stress-reducing benefits.

Mood

Regularly consuming green tea improves memory and mood and protects against depressive symptoms.

Research suggests that 300 milligrams (mg) of EGCG may increase calmness and reduce stress. However, other research notes improved overall mood only with higher dosages (800 mg) of EGCG,and achieving 300 mg EGCG through green tea alone is difficult.

One cup (8 ounces) of brewed green tea has 187 mg of EGCG.

Reaching 800 mg of EGCG would require drinking an amount of green tea that would exceed caffeine recommendations of 400 mg daily.This is not recommended.

Blood Pressure

Adding green tea to your routine may keep your blood pressure in a healthy range. Research shows that consuming any amount of green tea daily lowers blood pressure compared to not drinking green tea.

One randomized controlled trial observed a decrease in blood pressure after eight weeks with 150 mg EGCG taken twice daily.

Despite the beneficial effects of green tea on blood pressure, limited research exists on the specific influence of EGCG.

Cancer Prevention

Catechins in green tea, such as EGCG, may prevent cells from dividing and spreading.

Among randomized controlled trials, dosages of EGCG vary and are often higher than typically found in green tea. You would need to drink eight glasses of green tea to achieve the same amount of EGCG found in a supplement.

Some research suggests a link between drinking green tea and a reduced risk of cancer. However, much of the evidence is inconsistent. Again, it is unclear if EGCG supplements will yield the same benefits as green tea.

The National Cancer Institute believes insufficient evidence exists to support or reject EGCG for cancer prevention decisively.

Multiple Sclerosis

Multiple sclerosis(MS) is a chronic condition in which the body attacks thecentral nervous system, impacting communication betweenneuronsand the brain. Some people with MS may experience the following symptoms:

Animal research found aneuroprotective(brain protecting) and anti-inflammatory effect of EGCG. However, human studies have not observed similar results.

One small study of people withprogressive MSobserved no difference in the loss of brain cells (brain atrophy) between participants taking up to 1,200 mg EGCG daily and those given a placebo.

Cholesterol

Research suggests EGCG may reducelow-density lipoprotein (LDL) cholesterol.Elevated cholesterol, particularly LDL, is a significant risk factor for cardiovascular disease (CVD).

Consuming 2 to 8 cups ofgreen tea dailylowers LDL and total cholesterol levels.

Evidence conflicts on the benefits of EGCG supplements fortriglyceride levels. One randomized controlled trial observed a 30 milligram/deciliter (mg/dL) decrease in triglyceride levels with 300 mg EGCG daily.But other research shows increased triglyceride levels with green tea catechin or EGCG supplements.

While some research demonstrates the cholesterol-lowering ability of EGCG supplements, no conclusive evidence exists to support a specific dosage.

Energy Expenditure

EGCG may increase the amount of energy your body uses for normal functioning (energy expenditure).

One meta-analysis found that 300 mg EGCG daily could promote greaterenergy metabolism.

Another study found that consuming 100 to 460 mg of EGCG with 80 to 300 mg of caffeine daily for at least 12 weeks supported weight loss and encouraged greater changes to body composition.

However, whether the same effects can be achieved with EGCG supplementation alone is unknown.

There is no specific dose recommendation to reap the benefits of EGCG.

The FDA classifies EGCG and green tea catechins as generally recognized as safe (GRAS) but does not provide specific dosage recommendations.Moreover, dosages and supplement forms used in studies vary.

A 1-cup (8 ounces or 240 mL) serving of green tea provides roughly 187 mg of EGCG.However, this amount can vary, depending on the type of tea leaf and processing and storing methods.

Matcha tea is more concentrated than green tea. Some research indicates matcha may contain 137 times the amount of EGCG as green tea.

Concentrated capsules or tablets of green tea extract or catechins contain higher amounts of EGCG. Depending on the supplement, dosages can range from 25 to 750 mg of EGCG.Green tea extract added to drink products provides an average of 200 mg EGCG per serving.

Still, some research suggests that 1,000 to 1,600 mg daily for three months can be safe. Other recommendations include 5 mg pure EGCG per kilogram (kg) of body weight (mg/kg) daily.

Safety of EGCG

The National Center for Complementary and Integrative Health (NCCIH) at the National Institute of Health (NIH) notes that it is safe to consume up to 8 cups of green tea daily (providing nearly 1,500 mg EGCG).

It is not recommended to ingest more than 338 mg of concentrated EGCG daily in solid supplement form.However, it can be easy to exceed this amount with capsule or tablet supplements.

Side Effects

Potential side effects of green tea extract pills include the following:

Liver problems may occur with green tea extracts in pill form. People with liver disease should be more cautious, as higher doses of concentrated EGCG can contribute to liver problems.

Consult with a healthcare provider immediately if you are taking a green tea extract pill and experience these symptoms, as it may be a sign of liver trouble.

Interactions

EGCG may interact with certain medications. These medications include the following:

Consult your healthcare provider before starting a supplement, as other interactions are possible.

Precautions

The following precautions should be noted for use of EGCG and products containing green tea (and thus caffeine):

Heading

In the United States, the Food and Drug Administration (FDA) does not regulate supplements the way it regulates prescription drugs. That means some supplement products may not contain what the label says.

Summary

EGCG may improve mood, cognition, cholesterol, and blood pressure. Although the potential benefits of EGCG are plentiful, questions remain about the effectiveness of EGCG-specific supplements.

Regularly drinking green tea provides EGCG and other nutrients beneficial to health without exceeding recommended EGCG dosages. Despite the advantages of green tea, it is still important to be mindful of the caffeine content.

Frequently Asked QuestionsEGCG is a plant compound (polyphenol) found in green tea leaves. EGCG is associated with numerous health benefits.Capsule or tablet supplements of EGCG up to doses of 338 mg daily appear safe for most individuals.People with liver disease or a history of liver issues should consult their healthcare provider before taking EGCG supplements.Some EGCG supplements contain caffeine, while others do not. Read the supplement label carefully.

EGCG is a plant compound (polyphenol) found in green tea leaves. EGCG is associated with numerous health benefits.

Capsule or tablet supplements of EGCG up to doses of 338 mg daily appear safe for most individuals.People with liver disease or a history of liver issues should consult their healthcare provider before taking EGCG supplements.

Some EGCG supplements contain caffeine, while others do not. Read the supplement label carefully.

23 SourcesVerywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read oureditorial processto learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.Onakpoya I, Spencer E, Heneghan C, et al.The effect of green tea on blood pressure and lipid profile: a systematic review and meta-analysis of randomized clinical trials.Nutr Metab Cardiovasc Dis. 2014;24(8):823-836. doi:10.1016/j.numecd.2014.01.016Dietz C, Dekker M.Effect of green tea phytochemicals on mood and cognition.Current Pharmaceutical Design. 2017;23(19). doi:10.2174/1381612823666170105151800Kim HS, Quon MJ, Kim JA.New insights into the mechanisms of polyphenols beyond antioxidant properties; lessons from the green tea polyphenol, epigallocatechin 3-gallate.Redox Biol. 2014;2:187-195. doi:10.1016/j.redox.2013.12.022EFSA ANS Panel (EFSA Panel on Food Additives and Nutrient Sources added to Food.Scientific Opinion on the safety of green tea catechins.EFSA Journal2018;16(4):5239, 89 doi.org/10.2903/j.efsa.2018.5239Musial C, Kuban-Jankowska A, Gorska-Ponikowska M.Beneficial Properties of Green Tea Catechins.Int J Mol Sci. 2020;21(5):1744. doi:10.3390/ijms21051744Mancini E, Beglinger C, Drewe J, et al.Green tea effects on cognition, mood and human brain function: A systematic review.Phytomedicine. 2017;34:26-37. doi:10.1016/j.phymed.2017.07.008Hu J, Webster D, Cao J, et al.The safety of green tea and green tea extract consumption in adults - Results of a systematic review.Regul Toxicol Pharmacol. 2018;95:412-433. doi:10.1016/j.yrtph.2018.03.019Peng X, Zhou R, Wang B, et al.Effect of green tea consumption on blood pressure: a meta-analysis of 13 randomized controlled trials.Sci Rep. 2014;4:6251. doi:10.1038/srep06251Chatree S, Sitticharoon C, Maikaew P, et al.Epigallocatechin gallate decreases plasma triglyceride, blood pressure, and serum kisspeptin in obese human subjects.Exp Biol Med (Maywood). 2021;246(2):163-176. doi:10.1177/1535370220962708Filippini T, Malavolti M, Borrelli F, et al.Green tea (Camellia sinensis) for the prevention of cancer.Cochrane Database Syst Rev. 2020;3(3):CD005004. doi:10.1002/14651858.CD005004.pub3Guo Y, Zhi F, Chen P, et al.Green tea and the risk of prostate cancer: A systematic review and meta-analysis.Medicine (Baltimore). 2017;96(13):e6426. doi:10.1097/MD.0000000000006426National Cancer Institute.Tea and cancer prevention.Rust R, Chien C, Scheel M, et al.Epigallocatechin Gallate in Progressive MS: A Randomized, Placebo-Controlled Trial.Neurol Neuroimmunol Neuroinflamm. 2021;8(3):e964. doi:10.1212/NXI.0000000000000964Momose Y, Maeda-Yamamoto M, Nabetani H.Systematic review of green tea epigallocatechin gallate in reducing low-density lipoprotein cholesterol levels of humans.Int J Food Sci Nutr. 2016;67(6):606-613. doi:10.1080/09637486.2016.1196655Chatree S, Sitticharoon C, Maikaew P, et al.Epigallocatechin gallate decreases plasma triglyceride, blood pressure, and serum kisspeptin in obese human subjects.Exp Biol Med (Maywood). 2021;246(2):163-176. doi:10.1177/1535370220962708Kapoor MP, Sugita M, Fukuzawa Y, Okubo T.Physiological effects of epigallocatechin-3-gallate (EGCG) on energy expenditure for prospective fat oxidation in humans: A systematic review and meta-analysis.J Nutr Biochem. 2017;43:1-10. doi:10.1016/j.jnutbio.2016.10.013Vázquez Cisneros LC, López-Uriarte P, López-Espinoza A, et al.[Effects of green tea and its epigallocatechin (EGCG) content on body weight and fat mass in humans: a systematic review].Nutr Hosp. 2017;34(3):731-737. doi:10.20960/nh.753National Institute of Health National Center for Complementary and Integrative Health.Green tea.Abdelkawy KS, Abdelaziz RM, Abdelmageed AM, et al.Effects of green tea extract on atorvastatin pharmacokinetics in healthy volunteers.Eur J Drug Metab Pharmacokinet. 2020;45(3):351-360. doi:10.1007/s13318-020-00608-6Zhang H, Su S, Yu X, et al.Dietary epigallocatechin 3-gallate supplement improves maternal and neonatal treatment outcome of gestational diabetes mellitus: a double-blind randomised controlled trial.J Hum Nutr Diet. 2017;30(6):753-758. doi:10.1111/jhn.12470Cieuta-Walti C, Cuenca-Royo A, Langohr K, et al.Safety and preliminary efficacy on cognitive performance and adaptive functionality of epigallocatechin gallate (EGCG) in children with Down syndrome. A randomized phase Ib clinical trial (PERSEUS study).Genet Med. 2022;24(10):2004-2013. doi:10.1016/j.gim.2022.06.011MedlinePlus.Caffeine.American Academy of Child and Adolescent Psychiatry.Caffeine and children.

23 Sources

Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read oureditorial processto learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.Onakpoya I, Spencer E, Heneghan C, et al.The effect of green tea on blood pressure and lipid profile: a systematic review and meta-analysis of randomized clinical trials.Nutr Metab Cardiovasc Dis. 2014;24(8):823-836. doi:10.1016/j.numecd.2014.01.016Dietz C, Dekker M.Effect of green tea phytochemicals on mood and cognition.Current Pharmaceutical Design. 2017;23(19). doi:10.2174/1381612823666170105151800Kim HS, Quon MJ, Kim JA.New insights into the mechanisms of polyphenols beyond antioxidant properties; lessons from the green tea polyphenol, epigallocatechin 3-gallate.Redox Biol. 2014;2:187-195. doi:10.1016/j.redox.2013.12.022EFSA ANS Panel (EFSA Panel on Food Additives and Nutrient Sources added to Food.Scientific Opinion on the safety of green tea catechins.EFSA Journal2018;16(4):5239, 89 doi.org/10.2903/j.efsa.2018.5239Musial C, Kuban-Jankowska A, Gorska-Ponikowska M.Beneficial Properties of Green Tea Catechins.Int J Mol Sci. 2020;21(5):1744. doi:10.3390/ijms21051744Mancini E, Beglinger C, Drewe J, et al.Green tea effects on cognition, mood and human brain function: A systematic review.Phytomedicine. 2017;34:26-37. doi:10.1016/j.phymed.2017.07.008Hu J, Webster D, Cao J, et al.The safety of green tea and green tea extract consumption in adults - Results of a systematic review.Regul Toxicol Pharmacol. 2018;95:412-433. doi:10.1016/j.yrtph.2018.03.019Peng X, Zhou R, Wang B, et al.Effect of green tea consumption on blood pressure: a meta-analysis of 13 randomized controlled trials.Sci Rep. 2014;4:6251. doi:10.1038/srep06251Chatree S, Sitticharoon C, Maikaew P, et al.Epigallocatechin gallate decreases plasma triglyceride, blood pressure, and serum kisspeptin in obese human subjects.Exp Biol Med (Maywood). 2021;246(2):163-176. doi:10.1177/1535370220962708Filippini T, Malavolti M, Borrelli F, et al.Green tea (Camellia sinensis) for the prevention of cancer.Cochrane Database Syst Rev. 2020;3(3):CD005004. doi:10.1002/14651858.CD005004.pub3Guo Y, Zhi F, Chen P, et al.Green tea and the risk of prostate cancer: A systematic review and meta-analysis.Medicine (Baltimore). 2017;96(13):e6426. doi:10.1097/MD.0000000000006426National Cancer Institute.Tea and cancer prevention.Rust R, Chien C, Scheel M, et al.Epigallocatechin Gallate in Progressive MS: A Randomized, Placebo-Controlled Trial.Neurol Neuroimmunol Neuroinflamm. 2021;8(3):e964. doi:10.1212/NXI.0000000000000964Momose Y, Maeda-Yamamoto M, Nabetani H.Systematic review of green tea epigallocatechin gallate in reducing low-density lipoprotein cholesterol levels of humans.Int J Food Sci Nutr. 2016;67(6):606-613. doi:10.1080/09637486.2016.1196655Chatree S, Sitticharoon C, Maikaew P, et al.Epigallocatechin gallate decreases plasma triglyceride, blood pressure, and serum kisspeptin in obese human subjects.Exp Biol Med (Maywood). 2021;246(2):163-176. doi:10.1177/1535370220962708Kapoor MP, Sugita M, Fukuzawa Y, Okubo T.Physiological effects of epigallocatechin-3-gallate (EGCG) on energy expenditure for prospective fat oxidation in humans: A systematic review and meta-analysis.J Nutr Biochem. 2017;43:1-10. doi:10.1016/j.jnutbio.2016.10.013Vázquez Cisneros LC, López-Uriarte P, López-Espinoza A, et al.[Effects of green tea and its epigallocatechin (EGCG) content on body weight and fat mass in humans: a systematic review].Nutr Hosp. 2017;34(3):731-737. doi:10.20960/nh.753National Institute of Health National Center for Complementary and Integrative Health.Green tea.Abdelkawy KS, Abdelaziz RM, Abdelmageed AM, et al.Effects of green tea extract on atorvastatin pharmacokinetics in healthy volunteers.Eur J Drug Metab Pharmacokinet. 2020;45(3):351-360. doi:10.1007/s13318-020-00608-6Zhang H, Su S, Yu X, et al.Dietary epigallocatechin 3-gallate supplement improves maternal and neonatal treatment outcome of gestational diabetes mellitus: a double-blind randomised controlled trial.J Hum Nutr Diet. 2017;30(6):753-758. doi:10.1111/jhn.12470Cieuta-Walti C, Cuenca-Royo A, Langohr K, et al.Safety and preliminary efficacy on cognitive performance and adaptive functionality of epigallocatechin gallate (EGCG) in children with Down syndrome. A randomized phase Ib clinical trial (PERSEUS study).Genet Med. 2022;24(10):2004-2013. doi:10.1016/j.gim.2022.06.011MedlinePlus.Caffeine.American Academy of Child and Adolescent Psychiatry.Caffeine and children.

Onakpoya I, Spencer E, Heneghan C, et al.The effect of green tea on blood pressure and lipid profile: a systematic review and meta-analysis of randomized clinical trials.Nutr Metab Cardiovasc Dis. 2014;24(8):823-836. doi:10.1016/j.numecd.2014.01.016Dietz C, Dekker M.Effect of green tea phytochemicals on mood and cognition.Current Pharmaceutical Design. 2017;23(19). doi:10.2174/1381612823666170105151800Kim HS, Quon MJ, Kim JA.New insights into the mechanisms of polyphenols beyond antioxidant properties; lessons from the green tea polyphenol, epigallocatechin 3-gallate.Redox Biol. 2014;2:187-195. doi:10.1016/j.redox.2013.12.022EFSA ANS Panel (EFSA Panel on Food Additives and Nutrient Sources added to Food.Scientific Opinion on the safety of green tea catechins.EFSA Journal2018;16(4):5239, 89 doi.org/10.2903/j.efsa.2018.5239Musial C, Kuban-Jankowska A, Gorska-Ponikowska M.Beneficial Properties of Green Tea Catechins.Int J Mol Sci. 2020;21(5):1744. doi:10.3390/ijms21051744Mancini E, Beglinger C, Drewe J, et al.Green tea effects on cognition, mood and human brain function: A systematic review.Phytomedicine. 2017;34:26-37. doi:10.1016/j.phymed.2017.07.008Hu J, Webster D, Cao J, et al.The safety of green tea and green tea extract consumption in adults - Results of a systematic review.Regul Toxicol Pharmacol. 2018;95:412-433. doi:10.1016/j.yrtph.2018.03.019Peng X, Zhou R, Wang B, et al.Effect of green tea consumption on blood pressure: a meta-analysis of 13 randomized controlled trials.Sci Rep. 2014;4:6251. doi:10.1038/srep06251Chatree S, Sitticharoon C, Maikaew P, et al.Epigallocatechin gallate decreases plasma triglyceride, blood pressure, and serum kisspeptin in obese human subjects.Exp Biol Med (Maywood). 2021;246(2):163-176. doi:10.1177/1535370220962708Filippini T, Malavolti M, Borrelli F, et al.Green tea (Camellia sinensis) for the prevention of cancer.Cochrane Database Syst Rev. 2020;3(3):CD005004. doi:10.1002/14651858.CD005004.pub3Guo Y, Zhi F, Chen P, et al.Green tea and the risk of prostate cancer: A systematic review and meta-analysis.Medicine (Baltimore). 2017;96(13):e6426. doi:10.1097/MD.0000000000006426National Cancer Institute.Tea and cancer prevention.Rust R, Chien C, Scheel M, et al.Epigallocatechin Gallate in Progressive MS: A Randomized, Placebo-Controlled Trial.Neurol Neuroimmunol Neuroinflamm. 2021;8(3):e964. doi:10.1212/NXI.0000000000000964Momose Y, Maeda-Yamamoto M, Nabetani H.Systematic review of green tea epigallocatechin gallate in reducing low-density lipoprotein cholesterol levels of humans.Int J Food Sci Nutr. 2016;67(6):606-613. doi:10.1080/09637486.2016.1196655Chatree S, Sitticharoon C, Maikaew P, et al.Epigallocatechin gallate decreases plasma triglyceride, blood pressure, and serum kisspeptin in obese human subjects.Exp Biol Med (Maywood). 2021;246(2):163-176. doi:10.1177/1535370220962708Kapoor MP, Sugita M, Fukuzawa Y, Okubo T.Physiological effects of epigallocatechin-3-gallate (EGCG) on energy expenditure for prospective fat oxidation in humans: A systematic review and meta-analysis.J Nutr Biochem. 2017;43:1-10. doi:10.1016/j.jnutbio.2016.10.013Vázquez Cisneros LC, López-Uriarte P, López-Espinoza A, et al.[Effects of green tea and its epigallocatechin (EGCG) content on body weight and fat mass in humans: a systematic review].Nutr Hosp. 2017;34(3):731-737. doi:10.20960/nh.753National Institute of Health National Center for Complementary and Integrative Health.Green tea.Abdelkawy KS, Abdelaziz RM, Abdelmageed AM, et al.Effects of green tea extract on atorvastatin pharmacokinetics in healthy volunteers.Eur J Drug Metab Pharmacokinet. 2020;45(3):351-360. doi:10.1007/s13318-020-00608-6Zhang H, Su S, Yu X, et al.Dietary epigallocatechin 3-gallate supplement improves maternal and neonatal treatment outcome of gestational diabetes mellitus: a double-blind randomised controlled trial.J Hum Nutr Diet. 2017;30(6):753-758. doi:10.1111/jhn.12470Cieuta-Walti C, Cuenca-Royo A, Langohr K, et al.Safety and preliminary efficacy on cognitive performance and adaptive functionality of epigallocatechin gallate (EGCG) in children with Down syndrome. A randomized phase Ib clinical trial (PERSEUS study).Genet Med. 2022;24(10):2004-2013. doi:10.1016/j.gim.2022.06.011MedlinePlus.Caffeine.American Academy of Child and Adolescent Psychiatry.Caffeine and children.

Dietz C, Dekker M.Effect of green tea phytochemicals on mood and cognition.Current Pharmaceutical Design. 2017;23(19). doi:10.2174/1381612823666170105151800

Kim HS, Quon MJ, Kim JA.New insights into the mechanisms of polyphenols beyond antioxidant properties; lessons from the green tea polyphenol, epigallocatechin 3-gallate.Redox Biol. 2014;2:187-195. doi:10.1016/j.redox.2013.12.022

EFSA ANS Panel (EFSA Panel on Food Additives and Nutrient Sources added to Food.Scientific Opinion on the safety of green tea catechins.EFSA Journal2018;16(4):5239, 89 doi.org/10.2903/j.efsa.2018.5239

Musial C, Kuban-Jankowska A, Gorska-Ponikowska M.Beneficial Properties of Green Tea Catechins.Int J Mol Sci. 2020;21(5):1744. doi:10.3390/ijms21051744

Mancini E, Beglinger C, Drewe J, et al.Green tea effects on cognition, mood and human brain function: A systematic review.Phytomedicine. 2017;34:26-37. doi:10.1016/j.phymed.2017.07.008

Hu J, Webster D, Cao J, et al.The safety of green tea and green tea extract consumption in adults - Results of a systematic review.Regul Toxicol Pharmacol. 2018;95:412-433. doi:10.1016/j.yrtph.2018.03.019

Peng X, Zhou R, Wang B, et al.Effect of green tea consumption on blood pressure: a meta-analysis of 13 randomized controlled trials.Sci Rep. 2014;4:6251. doi:10.1038/srep06251

Chatree S, Sitticharoon C, Maikaew P, et al.Epigallocatechin gallate decreases plasma triglyceride, blood pressure, and serum kisspeptin in obese human subjects.Exp Biol Med (Maywood). 2021;246(2):163-176. doi:10.1177/1535370220962708

Filippini T, Malavolti M, Borrelli F, et al.Green tea (Camellia sinensis) for the prevention of cancer.Cochrane Database Syst Rev. 2020;3(3):CD005004. doi:10.1002/14651858.CD005004.pub3

Guo Y, Zhi F, Chen P, et al.Green tea and the risk of prostate cancer: A systematic review and meta-analysis.Medicine (Baltimore). 2017;96(13):e6426. doi:10.1097/MD.0000000000006426

National Cancer Institute.Tea and cancer prevention.

Rust R, Chien C, Scheel M, et al.Epigallocatechin Gallate in Progressive MS: A Randomized, Placebo-Controlled Trial.Neurol Neuroimmunol Neuroinflamm. 2021;8(3):e964. doi:10.1212/NXI.0000000000000964

Momose Y, Maeda-Yamamoto M, Nabetani H.Systematic review of green tea epigallocatechin gallate in reducing low-density lipoprotein cholesterol levels of humans.Int J Food Sci Nutr. 2016;67(6):606-613. doi:10.1080/09637486.2016.1196655

Kapoor MP, Sugita M, Fukuzawa Y, Okubo T.Physiological effects of epigallocatechin-3-gallate (EGCG) on energy expenditure for prospective fat oxidation in humans: A systematic review and meta-analysis.J Nutr Biochem. 2017;43:1-10. doi:10.1016/j.jnutbio.2016.10.013

Vázquez Cisneros LC, López-Uriarte P, López-Espinoza A, et al.[Effects of green tea and its epigallocatechin (EGCG) content on body weight and fat mass in humans: a systematic review].Nutr Hosp. 2017;34(3):731-737. doi:10.20960/nh.753

National Institute of Health National Center for Complementary and Integrative Health.Green tea.

Abdelkawy KS, Abdelaziz RM, Abdelmageed AM, et al.Effects of green tea extract on atorvastatin pharmacokinetics in healthy volunteers.Eur J Drug Metab Pharmacokinet. 2020;45(3):351-360. doi:10.1007/s13318-020-00608-6

Zhang H, Su S, Yu X, et al.Dietary epigallocatechin 3-gallate supplement improves maternal and neonatal treatment outcome of gestational diabetes mellitus: a double-blind randomised controlled trial.J Hum Nutr Diet. 2017;30(6):753-758. doi:10.1111/jhn.12470

Cieuta-Walti C, Cuenca-Royo A, Langohr K, et al.Safety and preliminary efficacy on cognitive performance and adaptive functionality of epigallocatechin gallate (EGCG) in children with Down syndrome. A randomized phase Ib clinical trial (PERSEUS study).Genet Med. 2022;24(10):2004-2013. doi:10.1016/j.gim.2022.06.011

MedlinePlus.Caffeine.

American Academy of Child and Adolescent Psychiatry.Caffeine and children.

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EGCG Supplement Facts#

Uses of EGCG#

Cognition#

Mood#

Blood Pressure#

Cancer Prevention#

Multiple Sclerosis#

Cholesterol#

Energy Expenditure#

Safety of EGCG#

Side Effects#

Interactions#

Precautions#

Heading#

Summary#