Table of ContentsView AllTable of ContentsKey DifferencesCostSide Effects and SafetyDosage and Dosage FormsIs One More Effective?Alternative Treatments
Table of ContentsView All
View All
Table of Contents
Key Differences
Cost
Side Effects and Safety
Dosage and Dosage Forms
Is One More Effective?
Alternative Treatments
Evenity is a brand of the drug romosozumab, which is known as a monoclonal antibody used for the treatment of osteoporosis in people with a high risk for fractures, including postmenopausal people (those who have gone through menopause, the period of life in which menstrual cycles have ended for 12 consecutive months).
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A Note on Gender and Sex TerminologyVerywell Health acknowledges thatsex and genderare related concepts, but they are not the same. To reflect our sources accurately, this article uses terms like “female,” “male,” “woman,” and “man” as the sources use them.
A Note on Gender and Sex Terminology
Verywell Health acknowledges thatsex and genderare related concepts, but they are not the same. To reflect our sources accurately, this article uses terms like “female,” “male,” “woman,” and “man” as the sources use them.
Key Differences Between Evenity and Prolia
Prolia is FDA-approved for the following:
Another key difference between Prolia and Evenity is their dosage and frequency of administration.
The most common side effects for Evenity are joint pain and headaches, while for Prolia, the most common side effects are back pain andmusculoskeletal pain.A serious side effect of Evenity is the increased risk of heart attack, stroke, and heart-related death.
Evenity vs. Prolia: Which Costs More?
There are nobiosimilarsof Evenity. In the spring of 2024, the FDA has approved Jubbonti (denosumab-bbdz) as an interchangeable biosimilar of Prolia.
Side Effects & Safety of Evenity and Prolia
While both Prolia and Evenity are effective medications for osteoporosis, they do not come without risks.The following are common side effects and precautions to consider before you start taking Evenity or Prolia.
Side Effects
The following are common side effects associated with Evenity:
The following are severe side effects associated with Evenity:
The following are common side effects associated with Prolia:
The following are severe side effects associated with Prolia:
While there are no studies that have directly compared the tolerability of Evenity to Prolia, both medications are well tolerated. Both also carry the serious risk of experiencing an allergic reaction and low calcium levels in the blood while taking the medications.
Evenity side effect includes an increased risk for stroke, heart attack, and heart-related death. Talk to your prescribing healthcare provider to help determine which medication is best for you.
Warnings
Evenity has the following boxed warning:
Prolia has the following boxed warning:
Who Shouldn’t Take Evenity or Prolia?
You should not take Evenity for the following reasons:
You should not take Prolia for the following reasons:
Evenity vs. Prolia: Dosage and Dosage Forms
The following table provides a comparison between the dosage and dosage forms of Prolia and Evenity:
Evenity vs. Prolia: Is One More Effective Than the Other?
While few studies have compared the effectiveness of Evenity vs. Prolia, both medications are effective at treating osteoporosis.
One study compared the active ingredient of Evenity to Prolia in postmenopausal women. It showed that the active ingredient in Evenity showed a higher potential for improving bone mineral density when compared to the active ingredient for Prolia. Since there is limited data, more studies should be conducted to determine if one is more effective than the other.
It is also important to note that everyone responds differently to medications. Consider having a conversation with your healthcare provider to help decide which is the best medication for you.
Can You Switch Between Evenity and Prolia?
Since these medications act differently from one another, it is possible and could potentially be beneficial to switch from Evenity to Prolia and vice versa. However, switching from one medication to another medication will require careful monitoring and guidance from your healthcare provider.
Since low calcium in the blood is a serious side effect that can be experienced with both Evenity and Prolia, your healthcare provider will ask you to take calcium andvitamin D supplementsdaily to minimize this risk. This means even if you stop one medication and start another, you will still be required to take calcium and vitamin D supplements.
Have a discussion with your healthcare provider to determine if it would be beneficial to stop taking one medication and begin taking the other.
Alternatives for Osteoporosis Treatment
While Evenity and Prolia are effective treatments for osteoporosis, there are other options available for osteoporosis. The following are medications that can also be used to treat osteoporosis:
If you are interested in any of these medications, you should talk to your healthcare provider to see if any of these medications may be beneficial for you.
Summary
The dose of Evenity is two prefilled syringes given subcutaneously once a month for 12 months. The dose of Prolia is one prefilled syringe given subcutaneously every six months. The most common side effects for Evenity are headaches and joint pain. The most common side effects of Prolia are back pain and musculoskeletal pain.
Both medications can cause serious side effects, like hypocalcemia and severe allergic reactions. Evenity can also increase your risk of experiencing a stroke, heart attack, and heart-related death.
6 SourcesVerywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read oureditorial processto learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.National Institutes of Health. DailyMed.Label: Evenity-romosozumab-aqqg injection, solution.Yu S, et al.Drug discovery of sclerostin inhibitors.Acta Pharm Sin B. 2022;12(5):2150-2170. doi: 10.1016/j.apsb.2022.01.012.National Institutes of Health. DailyMed.Label: Prolia-denosumab injection.Food and Drug Administration.Jubbonti label.Kobayakawa T, Miyazaki A, Saito M, et al.Denosumab versus romosozumab for postmenopausal osteoporosis treatment.Sci Rep. 2021;11(1):11801. doi: 10.1038/s41598-021-91248-6.Khosla S, Hofbauer LC.Osteoporosis treatment: recent developments and ongoing challenges. Lancet Diabetes Endocrinol. 2017;5(11):898-907. doi: 10.1016/S2213-8587(17)30188-2.
6 Sources
Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read oureditorial processto learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.National Institutes of Health. DailyMed.Label: Evenity-romosozumab-aqqg injection, solution.Yu S, et al.Drug discovery of sclerostin inhibitors.Acta Pharm Sin B. 2022;12(5):2150-2170. doi: 10.1016/j.apsb.2022.01.012.National Institutes of Health. DailyMed.Label: Prolia-denosumab injection.Food and Drug Administration.Jubbonti label.Kobayakawa T, Miyazaki A, Saito M, et al.Denosumab versus romosozumab for postmenopausal osteoporosis treatment.Sci Rep. 2021;11(1):11801. doi: 10.1038/s41598-021-91248-6.Khosla S, Hofbauer LC.Osteoporosis treatment: recent developments and ongoing challenges. Lancet Diabetes Endocrinol. 2017;5(11):898-907. doi: 10.1016/S2213-8587(17)30188-2.
Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read oureditorial processto learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.
National Institutes of Health. DailyMed.Label: Evenity-romosozumab-aqqg injection, solution.Yu S, et al.Drug discovery of sclerostin inhibitors.Acta Pharm Sin B. 2022;12(5):2150-2170. doi: 10.1016/j.apsb.2022.01.012.National Institutes of Health. DailyMed.Label: Prolia-denosumab injection.Food and Drug Administration.Jubbonti label.Kobayakawa T, Miyazaki A, Saito M, et al.Denosumab versus romosozumab for postmenopausal osteoporosis treatment.Sci Rep. 2021;11(1):11801. doi: 10.1038/s41598-021-91248-6.Khosla S, Hofbauer LC.Osteoporosis treatment: recent developments and ongoing challenges. Lancet Diabetes Endocrinol. 2017;5(11):898-907. doi: 10.1016/S2213-8587(17)30188-2.
National Institutes of Health. DailyMed.Label: Evenity-romosozumab-aqqg injection, solution.
Yu S, et al.Drug discovery of sclerostin inhibitors.Acta Pharm Sin B. 2022;12(5):2150-2170. doi: 10.1016/j.apsb.2022.01.012.
National Institutes of Health. DailyMed.Label: Prolia-denosumab injection.
Food and Drug Administration.Jubbonti label.
Kobayakawa T, Miyazaki A, Saito M, et al.Denosumab versus romosozumab for postmenopausal osteoporosis treatment.Sci Rep. 2021;11(1):11801. doi: 10.1038/s41598-021-91248-6.
Khosla S, Hofbauer LC.Osteoporosis treatment: recent developments and ongoing challenges. Lancet Diabetes Endocrinol. 2017;5(11):898-907. doi: 10.1016/S2213-8587(17)30188-2.
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