Table of ContentsView AllTable of ContentsUsesSide EffectsPrecautionsDosageToxicityInteractionsHow to StoreSimilar SupplementsSources & What to Look For
Table of ContentsView All
View All
Table of Contents
Uses
Side Effects
Precautions
Dosage
Toxicity
Interactions
How to Store
Similar Supplements
Sources & What to Look For
Gamma-linolenic acid (GLA) is an essential polyunsaturated fat and one of the omega-6 fatty acids that support cellular health. It may fight inflammation, improve skin conditions like eczema, and treat other health conditions.
GLA supplements are made from primrose, borage, and black currant oils. Common household oils, such as sunflower, safflower, corn, and soybean oil, contain other omega-6 fatty acids that your body converts to GLA.
In the United States, the Food and Drug Administration (FDA) does not regulate supplements the way it regulates prescription drugs. That means some supplement products may not contain what the label says. Whenchoosing a supplement, look for independently tested products and consult a healthcare provider, registered dietitian nutritionist (RD or RDN), or pharmacist.
Gamma-Linolenic Acid Uses
As with many natural products, more extensive research is necessary.
People use GLA for various reasons, including to improve skin conditions and to fight inflammation.
Inflammation and Your Body
Skin Conditions
Several studies have supported GLA-enriched supplements for skin conditions such asatopic dermatitis (eczema). GLA supplements may contain borage, primrose, or black currant seed oils.
However, one review questioned the actual effectiveness of GLA-enriched supplements. While a 2014 clinical trial suggested GLA from primrose oil may benefit children and adults with atopic dermatitis.
Due to mixed research results, additional high-quality, longer-term clinical trials with larger groups of people are necessary to better assess the effects of GLA-enriched supplements.
3 Natural Remedies for Eczema
Rheumatoid Arthritis
Several studies have supported GLA-enriched supplements for rheumatoid arthritis.However, other studies suggest it’s unclear if GLA-enriched supplements are effective for RA.
One study suggested people with RA might benefit from GLA derived from primrose oil, but in this study, GLA was also combined withomega-3 fatty acids.
High-quality, longer-term clinical trials with a larger group of people are necessary to better evaluate the effects of GLA-enriched supplements on RA.
Diabetic Neuropathy
However, higher-quality, longer-term, and larger studies are necessary better to evaluate GLA’s effects and safety for diabetic neuropathy.
Supplement FactsActive ingredients (s): Gamma-linolenic acidAlternative name(s): GLA, gamolenic acid, omega-6 fatty acid, omega-6, essential fatty acidsLegal status: Legal and sold as an over-the-counter (OTC) supplement in the United StatesSuggested dose: May vary based on the specific dosage form and medical conditionSafety considerations: People normally get omega-6 fatty acids—like GLA—in 5% to 10% of total calories through their diet; high amounts or long-term use of GLA is safe, although side effects and medication interactions are still possible.
Supplement Facts
Active ingredients (s): Gamma-linolenic acidAlternative name(s): GLA, gamolenic acid, omega-6 fatty acid, omega-6, essential fatty acidsLegal status: Legal and sold as an over-the-counter (OTC) supplement in the United StatesSuggested dose: May vary based on the specific dosage form and medical conditionSafety considerations: People normally get omega-6 fatty acids—like GLA—in 5% to 10% of total calories through their diet; high amounts or long-term use of GLA is safe, although side effects and medication interactions are still possible.
Treatments for Diabetic Neuropathy
What Are the Side Effects of Gamma-Linolenic Acid?
As with many medications and natural products, side effects are possible with GLA.
Common Side Effects
Common mild side effects may include:
Severe Side Effects
One study showed no serious side effects with GLA from primrose oil.
However, a severe allergic reaction is a serious side effect possible with any medication, including supplements.
If you’re having asevere allergic reactionto GLA or any of the plants it may be derived from, you will experience symptoms such as breathing difficulties, itchiness, and rash.
Omega-6 fatty acids may reduce inflammation, but it can also promote inflammation at high doses or with long-term use. This might result in heart-related effects.
Until more high-quality and long-term clinical trials are available, consider using GLA for only a short period.
Call 911 and get medical help immediately if you have a severe allergic reaction or any of your symptoms feel life-threatening.
A healthcare provider may advise against using GLA if any of the following applies to you:
Severe allergic reaction: If you have or have had in the past a severe allergic reaction to GLA, the plants it is derived from, or any of its components (ingredients or parts), you should not take this medication.
Pregnancy and breastfeeding: Everyone—including pregnant and breastfeeding people—likely gets omega-6 fatty acids in 5% to 10% of total calories through their diet.Primrose oil, which is abundant in GLA, might be safe whilepregnantorbreastfeeding.
High amounts of omega-6 fatty acids may negatively affect an unborn fetus or nursing infant.Moreover, borage seed oil is rich in GLA but may also contain certain chemicals that might be toxic to the liver and lungs. And these chemicals may also be present in breast milk. Contact a healthcare provider to discuss the benefits and risks before taking GLA.
Children: Children have participated in GLA-related studies,but many labels of GLA-containing products usually are for adults, not children.Talk with their healthcare provider if you are considering GLA for your child.
Older adults over 65 years: Older adults participated in some GLA-related clinical trials, but these studies were small.In addition, some older adults are more likely to have medication side effects. For this reason, take GLA with caution.
Heart-related conditions: High amounts or long-term use of omega-6 fatty acids might negatively affect the heart.A healthcare provider may want to closely monitor you if you already have a heart-related condition, such asheart disease.
Dosage: How Much Should I Take Gamma-Linolenic Acid?
Always speak with a healthcare provider before taking a supplement to ensure that the supplement and dosing are appropriate for your individual needs.
While there are some studies on GLA in humans, additional high-quality clinical trials are still necessary.
This is due to several reasons, including that many of the available studies are small in size, and dosages differ in each study.
For these reasons, there are no guidelines on the appropriate dosage to take GLA for any condition.
If you take GLA, follow a healthcare provider’s recommendations or label instructions.
What Happens If I Take Too Much Gamma-Linolenic Acid?
There is little information about GLA toxicity and overdoses in humans, however, high doses or long-term use of omega-6 fatty acids might negatively affect the heart.
If you suspect you’re experiencing life-threatening side effects, seek immediate medical attention.
There is limited information about possible medication interactions with omega-6 fatty acids.
However, omega-6 fatty acids found in GLA may affect inflammation pathways and substances in your body. These are the likely causes of symptoms and problems in several autoimmune diseases.
For these reasons, GLA might interact with other medications that affect inflammation or the immune system.
For example, GLA might interact withnonsteroidal anti-inflammatory drugs(NSAIDs), such as Motrin orAdvil (ibuprofen). GLA might also have additive effects (harmful increased effects of using more one drug with similar outcomes) with certain drugs, including biologics and other medications that tamp down the immune system, such asHumira (adalimumab).
With high doses or long-term use, omega-6 fatty acids may also negatively affect the heart and blood vessels.Therefore, GLA might interfere with the benefit fromheart-related medications, such as blood pressure medications—likeZestril (lisinopril)—and blood thinners—likeJantoven (warfarin).
It is essential to carefully read a supplement’s ingredients list and nutrition facts panel to learn which ingredients are present and how much of each ingredient is included. Please review this supplement label with a healthcare provider to discuss potential interactions with foods, other supplements, and medications.
How to Store Gamma-Linolenic Acid
Carefully read the directions and packaging label on the container. Keep your medications tightly closed and out of the reach and sight of children and pets, ideally locked in a cabinet or closet. Store in a cool and dry place.
Discard after one year or as indicated on the packaging.
Avoid putting unused and expired medicines down the drain or in the toilet. Visit the FDA website to learn where and how to discard of all unused and expired medicines. You may also find disposal boxes in your area.Ask a pharmacist or healthcare provider any questions you may have regarding disposing of your medications or supplements.
GLA may have potential uses for skin conditions, rheumatoid arthritis (RA), and nerve pain from high blood sugar. Other potentially similar supplements include:
Don’t combine multiple natural products until you first talk with a registered dietitian, healthcare provider, or pharmacist. Inquiring about adverse side effects can help you avoid possible interactions and side effects and ensure you’re giving these supplements a fair trial at appropriate doses.
Sources of Gamma-Linolenic Acid & What to Look For
There are several different sources of GLA.
Food Sources of Gamma-Linolenic Acid
In general, omega-6 fatty acids—like GLA—are found in various plants and seed oils, such as borage, primrose, and black currant seed oils.
Gamma-Linolenic Acid Supplements
GLA is likely available as GLA-enriched supplements, such as borage, primrose, and black currant seed oils. GLA-containing supplements might also be combined with other ingredients.
GLA-enriched supplements are generally available in several forms, including capsules and tablets.
These supplements might also be available in the following formats:
Vegetarian and vegan options might also be available.
What may work for you will depend on your preferences and what you hope to get regarding effects. Each product will work a bit differently, depending on the form.
Summary
GLA is an omega-6 fatty acid in borage, primrose, and black currant seed oils. It might have some benefit in treating atopic dermatitis (eczema), rheumatoid arthritis (RA), and diabetic neuropathy (nerve pain from high blood sugar). But, similar to many medications and natural products, side effects and medication interactions are still possible.
Additional higher-quality, longer-term, and larger clinical trials are still necessary to better evaluate the effectiveness and safety of GLA. Before taking GLA, involve a registered dietitian, pharmacist, or healthcare provider in your decision.
14 Sources
Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read oureditorial processto learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.
Mount Sinai.Gamma-linolenic acid (GLA).Sergeant S, Rahbar E, Chilton FH.Gamma-linolenic acid, dihommo-gamma linolenic, eicosanoids and inflammatory processes.European Journal of Pharmacology. 2016;15(785):77-86. doi: 10.1016%2Fj.ejphar.2016.04.020Simon D, Eng PA, Borelli S, et al.Gamma-linolenic acid levels correlate with clinical efficacy of evening primrose oil in patients with atopic dermatitis.Advances in Therapy. 2014;31(2):180-188. doi: 10.1007%2Fs12325-014-0093-0Veselinovic M, Vasiljevic D, Vucic V, et al.Clinical benefits of n-3 PUFA and ɤ-linolenic acid in patients with rheumatoid arthritis.Nutrients. 2017;9(4):325. doi: 10.3390%2Fnu9040325Won JC, Kwon HS, Moon SS, et al.γ-linolenic acid versus α-lipoic acid for treating painful diabetic neuropathy in adults: a 12-week, double-placebo, randomized, noninferiority trial.Diabetes & Metabolism Journal. 2020;44(4):542-554. doi: 10.4093%2Fdmj.2019.0099National Library of Medicine: MedlinePlus.Omega-6 fatty acids.ScienceDirect.Gamma linolenic acid.National Center for Complementary and Integrative Health.Evening primrose oil.National Institutes of Health: Office of Dietary Supplements.Dietary supplement label database.MedlinePlus.Autoimmune diseases.National Center for Complementary and Integrative Health.Skin conditions at a glance.Nationcal Center for Complementary and Integrative Health.Rheumatoid arthritis: in depth.ScienceDirect.Lipoic acid.National Center for Complementary and Integrative Health.Diabetes and dietary supplements.
Mount Sinai.Gamma-linolenic acid (GLA).
Sergeant S, Rahbar E, Chilton FH.Gamma-linolenic acid, dihommo-gamma linolenic, eicosanoids and inflammatory processes.European Journal of Pharmacology. 2016;15(785):77-86. doi: 10.1016%2Fj.ejphar.2016.04.020
Simon D, Eng PA, Borelli S, et al.Gamma-linolenic acid levels correlate with clinical efficacy of evening primrose oil in patients with atopic dermatitis.Advances in Therapy. 2014;31(2):180-188. doi: 10.1007%2Fs12325-014-0093-0
Veselinovic M, Vasiljevic D, Vucic V, et al.Clinical benefits of n-3 PUFA and ɤ-linolenic acid in patients with rheumatoid arthritis.Nutrients. 2017;9(4):325. doi: 10.3390%2Fnu9040325
Won JC, Kwon HS, Moon SS, et al.γ-linolenic acid versus α-lipoic acid for treating painful diabetic neuropathy in adults: a 12-week, double-placebo, randomized, noninferiority trial.Diabetes & Metabolism Journal. 2020;44(4):542-554. doi: 10.4093%2Fdmj.2019.0099
National Library of Medicine: MedlinePlus.Omega-6 fatty acids.
ScienceDirect.Gamma linolenic acid.
National Center for Complementary and Integrative Health.Evening primrose oil.
National Institutes of Health: Office of Dietary Supplements.Dietary supplement label database.
MedlinePlus.Autoimmune diseases.
National Center for Complementary and Integrative Health.Skin conditions at a glance.
Nationcal Center for Complementary and Integrative Health.Rheumatoid arthritis: in depth.
ScienceDirect.Lipoic acid.
National Center for Complementary and Integrative Health.Diabetes and dietary supplements.
Pitel S, Raccah D, Gerbi A, et al.At Low Doses, aγ-Linolenic Acid-Lipoic Acid Conjugate Is More Effective Than Docosahexaenoic Acid-Enriched Phospholipids in Preventing Neuropathy in Diabetic Rats.J Nutr.2007 Feb,137(2):386-72. doi:10.1093/jn/137.2.368
Reed GW, Leung K, Rossetti RG, et al.Treatment of Rheumatoid Arthritis with Marine and Botanical Oils: An 18-Month, Randomized, and Double-Blind Trial.Evid Based Complement Alternat Med. 2014;2014:857456. doi:10.1155/2014/857456
Simon D, Eng PA, Borelli S, et al.Gamma-Linolenic Acid Levels Correlate with Clinical Efficacy of Evening Primrose Oil in Patients with Atopic Dermatitis.Adv Ther. 2014;31(2):180-8. doi:10.1007/s12325-014-0093-0
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