Table of ContentsView AllTable of ContentsPrescription MedicationsTherapiesAlternative TreatmentsLifestyleNext in Depression GuideDifferent Types of Depression: An Overview
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Table of Contents
Prescription Medications
Therapies
Alternative Treatments
Lifestyle
Next in Depression Guide
If you’ve been diagnosed with clinicaldepression, also known as major depressive disorder (MDD), rest assured there are many treatment options available. Some people will experience only one depressive episode in their life, while others may have depression throughout their lives and require ongoing treatment.
Treatment for depression often includes a combination of prescription medication and psychotherapy. There are some lifestyle changes you can also make to manage depression symptoms. While some treatment methods help only in the short run, some can help you establish coping skills that offer lifelong benefits.
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Your healthcare provider may suggest antidepressants to help relieve symptoms and prevent their recurrence.Different types of antidepressantshave different effects on the chemicals in your brain responsible for mood management, but in general they help you feel emotionally well and restore your ability to function in everyday life. They are also used to effectively reduce anxiety, restlessness, sleep problems, and suicidal thinking.
Research has shown that over the course of several weeks, prescription medication can be effective at treating symptoms related to moderate, severe, and chronic depression, but are less likely to do so in mild cases.However, these medications come with side effects, so it’s important to discuss the pros and cons of antidepressants with your healthcare provider.
Selective Serotonin Reuptake Inhibitors (SSRIs)
SSRIs are the most commonly prescribed antidepressants. They are often used as first-line treatment for depression because they cause fewer side effects than other antidepressants. Studies have shown that SSRIs are also effective at preventing relapse of MDD.
Serotonin is associated with mood regulation, and SSRIs prevent the reabsorption of serotonin back into nerve cells, which increases the level of this neurotransmitter in the brain. A rise in serotonin levels can improve symptoms and make people more responsive to other types of treatment, such as psychotherapy.
SSRIs come with certain increased risks in those who are pregnant or breastfeeding, as well as children, adolescents, and young adults, because there’s an increased risk of serious side effects in these populations. SSRIs also need to be used with caution if a person has certain underlying health problems, such asdiabetes, epilepsy, or kidney disease.
Many people who take SSRIs experience mild side effects in the beginning of treatment that improve with time. SSRIs can interact with other medicines, including some over-the-counter painkillers and herbal remedies, such as St. John’s wort.
Serotonin-Norepinephrine Reuptake Inhibitors (SNRIs)
SNRIs that are FDA approved for treating depression include:
SSRIs and SNRIs can potentially lead to dangerously high levels of serotonin, particularly when used with other medications that impact serotonin, resulting in a condition called serotonin syndrome. People with this condition experience confusion, agitation, muscle jerks, sweating, shivering, diarrhea, and high body temperature.
Cymbalta RecallStarting in October 2024, over 200,000 bottles of duloxetine delayed-release capsules were recalled over concerns about the presence of nitrosamines, which can increase the risk of cancer.If you take duloxetine, check your medication packaging to see if it was part of the affected lots or call your pharmacist to find out. You should also contact your prescriber, as abruptly stopping a medication like duloxetinecan be dangerous.The recalled lots have expiration dates from November 2024 to December 2025. You can check the lot numbers in the FDA enforcement reports released inOctoberandDecember.
Cymbalta Recall
Starting in October 2024, over 200,000 bottles of duloxetine delayed-release capsules were recalled over concerns about the presence of nitrosamines, which can increase the risk of cancer.If you take duloxetine, check your medication packaging to see if it was part of the affected lots or call your pharmacist to find out. You should also contact your prescriber, as abruptly stopping a medication like duloxetinecan be dangerous.The recalled lots have expiration dates from November 2024 to December 2025. You can check the lot numbers in the FDA enforcement reports released inOctoberandDecember.
Starting in October 2024, over 200,000 bottles of duloxetine delayed-release capsules were recalled over concerns about the presence of nitrosamines, which can increase the risk of cancer.If you take duloxetine, check your medication packaging to see if it was part of the affected lots or call your pharmacist to find out. You should also contact your prescriber, as abruptly stopping a medication like duloxetinecan be dangerous.
The recalled lots have expiration dates from November 2024 to December 2025. You can check the lot numbers in the FDA enforcement reports released inOctoberandDecember.
Norepinephrine-Dopamine Reuptake Inhibitors (NDRIs)
The most popular NDRI used to treat depression is Wellbutrin (bupropion).It causes anxiety in some people, but is an effective treatment for anxiety for others. NDRIs are often prescribed for those who don’t respond well to SSRIs or SNRIs, or people who can’t tolerate the side effects of those medications.
Symptoms of an NDRI overdose can include seizures, hallucinations, heart problems, and loss of consciousness. If you suspect you or someone close to you has overdosed on an NDRI, go to the emergency room immediately or call 911.
Tricyclic Antidepressants (TCAs)
These medications are sometimes prescribed when other antidepressants don’t work. They are also used to treat obsessive-compulsive disorder, anxiety disorders, and chronic pain.
TCAs that are FDA-approved for treating depression include:
Monoamine Oxidase Inhibitors (MAOIs)
These medications are typically prescribed only when all other antidepressants have failed because they have a high risk of drug interactions and can interact with certain foods, including aged cheese, smoked meat, and beer. They should never be used together with SSRIs.
MAOIs commonly used for depression include:
N-Methyl-D-Aspartate (NMDA) Receptor Antagonists
Auvelity (dextromethorphan and bupropion) is the first and only oral NMDA receptor antagonist approved to treat MDD. Although the way Auvelity works in the treatment of MDD is unclear, it has two active ingredients.
Dextromethorphan blocks NMDA receptors, which increases the levels of glutamate in the brain to help regulate mood and relieve depression. Bupropion inhibits an enzyme that breaks down dextromethorphan, allowing dextromethorphan to last longer.
The Food and Drug Administration issued a warning that children, adolescents, and young adults being treated with SSRIs and other antidepressants should be monitored closely for worsening symptoms, suicidality, and unusual changes in behavior, especially during the initial few months of a course of drug therapy or at times of dosage changes.
5-HT1A Receptor Agonists
Selective serotonin 1a (5-HT1A) receptor agonists are a new class of antidepressants that selectively target serotonin 1A receptors, which are key in regulating mood and emotions.
Exxua (gepirone) is the first and only FDA-approved 5-HT1A receptor agonist to treat MDD.
Exxua is the first and only approved antidepressant that selectively targets the serotonin 1a (5-HT1a) receptor. Unlike other antidepressant medications, Exxua does not pose the risks of sexual side effects or weight gain.
Many talk therapy options are available for treating depression, but researchers have found the following provide good results for patients with depression.
Cognitive Behavioral Therapy
Exact duration depends on the severity of depression. CBT is often time limited, and may only include eight to 16 sessions in some cases.
Interpersonal Therapy
Interpersonal therapy (ITP) is based on the idea that depression is in part related to our social relationships. It focuses on providing patients with skills and strategies to make healthy changes in four areas:
Therapists teach individuals to evaluate their interactions and improve how they relate to others. For acute major depression, this form of therapy typically takes place once a week and lasts for 12 to 16 weeks.
Psychodynamic Therapy
Psychodynamic therapy focuses on how depression is related to past experiences, unresolved conflicts, and unacknowledged or repressed traumas. Therapists engaged in this type of therapy help patients recognize and understand how negative patterns of behavior and feelings are rooted in past experiences and how they can work to resolve them. Psychodynamic therapy, which can be short or long term, promotes emotional healing through self-reflection and personal growth.
People with depression can develop unhealthy coping strategies, such as isolating themselves from others and shutting down when faced with conflict. Additional forms of psychotherapy can help them learn healthier ways of communicating with others and behaving. These include supportive counseling, behavioral activation, problem-solving therapy, and family or couples therapy.
There is a wide array of alternative treatments for people seeking relief from depression, but these should never be started without consulting a healthcare provider. Some of these treatments, such as herbal remedies, can cause serious side effects and interact with antidepressants.
Although alternative treatments might be beneficial for some people, they are not a replacement for professional help, and many people with depression may need more comprehensive care.
Dietary Supplements
You can also ask your healthcare provider if folate supplementation may be right for you. The link between folate deficiency and depression is well documented, with studies suggesting that around a third of patients with depression may be folate deficient.Keep in mind that folate supplementation may mask vitamin B12 deficiency, so it’s a good idea to ask your healthcare provider for a blood test to check vitamin levels before starting any folate supplements.
10 Natural Remedies for Depression
Exercise
Stress and Relaxation Techniques
Stress and relaxation techniques can help a person relieve symptoms of depression. They can also help with daily functioning since they foster emotional resilience and help a person learn to self-soothe.
Popular techniques that have been shown effective include:
These techniques are most effective when combined with lifestyle modifications, including good nutritional habits, regular exercise, and a strong support system.
Bioenergetics: Mind-Body Healing Techniques
While you should never try to treat or cure a mental disorder without the help of a qualified professional, there are many ways you can support your own recovery and improve your overall well-being if you are living with depression.
Science-supported ways to improve your mood include:
If you or a loved one is struggling with depression, contact theSubstance Abuse and Mental Health Services Administration (SAMHSA) National Helplineat1-800-662-4357for information on support and treatment facilities in your area.
A Word From Verywell
Depression treatment is not one size fits all. While your social network and support system can help, you should never rely on them or strangers on the Internet for medical advice.
Talk to your healthcare provider about the best depression treatment approach for you, including the pros and cons of each option. It can take a few tries to find the right approach to depression treatment, but with support from a trained professional, you can start feeling better and minimize the effects of depression on your everyday life.
21 SourcesVerywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read oureditorial processto learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.NCBI Bookshelf.Depression: how effective are antidepressants?Clevenger SS, Malhotra D, Dang J, Vanle B, IsHak WW.The role of selective serotonin reuptake inhibitors in preventing relapse of major depressive disorder.Ther Adv Psychopharmacol. 2018 Jan;8(1):49-58. doi:10.1177/2045125317737264National Health Service.Overview - selective serotonin reuptake inhibitors (SSRIs).Food and Drug Administration.What to Know and Do About Possible Nitrosamines in Your Medication.Patel K, Allen S, Haque MN, Angelescu I, Baumeister D, Tracy DK.Bupropion: a systematic review and meta-analysis of effectiveness as an antidepressant.Therapeutic Advances in Psychopharmacology.2016 Apr;6(2):99-144. doi:10.1177/2045125316629071Qin B, Zhang Y, Zhou X, Cheng P, Liu Y, Chen J, Fu Y, Luo Q, Xie P.Selective serotonin reuptake inhibitors versus tricyclic antidepressants in young patients: a meta-analysis of efficacy and acceptability.Clin Ther. 2014 Jul 1;36(7):1087-1095.e4. doi:10.1016/j.clinthera.2014.06.001Finberg JP, Rabey JM.Inhibitors of MAO-A and MAO-B in psychiatry and neurology.Front Pharmacol. 2016 Oct 18;7:340. doi:10.3389/fphar.2016.00340Food and Drug Administration.Auvelity label.Food and Drug Administration.Revisions to product labeling.Food and Drug Administration.Exxua label.Barth J, Munder T, Gerger H, Nüesch E, Trelle S, Znoj H, Jüni P, Cuijpers P.Comparative efficacy of seven psychotherapeutic interventions for patients with depression: a network meta-analysis.PLoS Med.2013 May 28;10(5):e1001454. doi:10.1371/journal.pmed.1001454Gautam M, Tripathi A, Deshmukh D, Gaur M.Cognitive behavioral therapy for depression.Indian J Psychiatry.2020 Jan;62(Suppl 2):S223-S229. doi:10.4103/psychiatry.IndianJPsychiatry_772_19Lipsitz J, Markowitz J.Mechanisms of change in interpersonal therapy (IPT).Clin Psychol Rev.2013 Dec;33(8):1134-47. doi:10.1016/j.cpr.2013.09.002International Society of Interpersonal Psychotherapy.Overview of IPT.Driessen E, Van HL, Peen J, Don FJ, Twisk JWR, Cuijpers P, Dekker JJM.Cognitive-behavioral versus psychodynamic therapy for major depression: secondary outcomes of a randomized clinical trial.J Consult Clin Psychol.2017 Jul;85(7):653-663. doi:10.1037/ccp0000207The Food and Drug Administration.What you need to know about dietary supplements.Ng QX, Venkatanarayanan N, Ho CY.Clinical use of Hypericum perforatum (St John’s wort) in depression: a meta-analysis.J Affect Disord.2017;210:211-221. doi:10.1016/j.jad.2016.12.048Young SN.Folate and depression—a neglected problem.J Psychiatry Neurosci.2007 Mar;32(2):80-82. PMID:17353937Zhao JL, Jiang WT, Wang X, Cai ZD, Liu ZH, Liu GR.Exercise, brain plasticity, and depression. CNS Neurosci Ther. 2020 Sept;26(9):885-895. doi:10.1111/cns.13385National Center for Complementary and Integrative Health.5 things to know about relaxation techniques for stress.Zaccaro A, Piarulli A, Laurino M, Garbella E, Menicucci D, Neri B, Gemignani A.How breath-control can change your life: a systematic review on psycho-physiological correlates of slow breathing.Front Hum Neurosci.2018 Sep 8;12:353. doi:10.3389/fnhum.2018.00353
21 Sources
Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read oureditorial processto learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.NCBI Bookshelf.Depression: how effective are antidepressants?Clevenger SS, Malhotra D, Dang J, Vanle B, IsHak WW.The role of selective serotonin reuptake inhibitors in preventing relapse of major depressive disorder.Ther Adv Psychopharmacol. 2018 Jan;8(1):49-58. doi:10.1177/2045125317737264National Health Service.Overview - selective serotonin reuptake inhibitors (SSRIs).Food and Drug Administration.What to Know and Do About Possible Nitrosamines in Your Medication.Patel K, Allen S, Haque MN, Angelescu I, Baumeister D, Tracy DK.Bupropion: a systematic review and meta-analysis of effectiveness as an antidepressant.Therapeutic Advances in Psychopharmacology.2016 Apr;6(2):99-144. doi:10.1177/2045125316629071Qin B, Zhang Y, Zhou X, Cheng P, Liu Y, Chen J, Fu Y, Luo Q, Xie P.Selective serotonin reuptake inhibitors versus tricyclic antidepressants in young patients: a meta-analysis of efficacy and acceptability.Clin Ther. 2014 Jul 1;36(7):1087-1095.e4. doi:10.1016/j.clinthera.2014.06.001Finberg JP, Rabey JM.Inhibitors of MAO-A and MAO-B in psychiatry and neurology.Front Pharmacol. 2016 Oct 18;7:340. doi:10.3389/fphar.2016.00340Food and Drug Administration.Auvelity label.Food and Drug Administration.Revisions to product labeling.Food and Drug Administration.Exxua label.Barth J, Munder T, Gerger H, Nüesch E, Trelle S, Znoj H, Jüni P, Cuijpers P.Comparative efficacy of seven psychotherapeutic interventions for patients with depression: a network meta-analysis.PLoS Med.2013 May 28;10(5):e1001454. doi:10.1371/journal.pmed.1001454Gautam M, Tripathi A, Deshmukh D, Gaur M.Cognitive behavioral therapy for depression.Indian J Psychiatry.2020 Jan;62(Suppl 2):S223-S229. doi:10.4103/psychiatry.IndianJPsychiatry_772_19Lipsitz J, Markowitz J.Mechanisms of change in interpersonal therapy (IPT).Clin Psychol Rev.2013 Dec;33(8):1134-47. doi:10.1016/j.cpr.2013.09.002International Society of Interpersonal Psychotherapy.Overview of IPT.Driessen E, Van HL, Peen J, Don FJ, Twisk JWR, Cuijpers P, Dekker JJM.Cognitive-behavioral versus psychodynamic therapy for major depression: secondary outcomes of a randomized clinical trial.J Consult Clin Psychol.2017 Jul;85(7):653-663. doi:10.1037/ccp0000207The Food and Drug Administration.What you need to know about dietary supplements.Ng QX, Venkatanarayanan N, Ho CY.Clinical use of Hypericum perforatum (St John’s wort) in depression: a meta-analysis.J Affect Disord.2017;210:211-221. doi:10.1016/j.jad.2016.12.048Young SN.Folate and depression—a neglected problem.J Psychiatry Neurosci.2007 Mar;32(2):80-82. PMID:17353937Zhao JL, Jiang WT, Wang X, Cai ZD, Liu ZH, Liu GR.Exercise, brain plasticity, and depression. CNS Neurosci Ther. 2020 Sept;26(9):885-895. doi:10.1111/cns.13385National Center for Complementary and Integrative Health.5 things to know about relaxation techniques for stress.Zaccaro A, Piarulli A, Laurino M, Garbella E, Menicucci D, Neri B, Gemignani A.How breath-control can change your life: a systematic review on psycho-physiological correlates of slow breathing.Front Hum Neurosci.2018 Sep 8;12:353. doi:10.3389/fnhum.2018.00353
Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read oureditorial processto learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.
NCBI Bookshelf.Depression: how effective are antidepressants?Clevenger SS, Malhotra D, Dang J, Vanle B, IsHak WW.The role of selective serotonin reuptake inhibitors in preventing relapse of major depressive disorder.Ther Adv Psychopharmacol. 2018 Jan;8(1):49-58. doi:10.1177/2045125317737264National Health Service.Overview - selective serotonin reuptake inhibitors (SSRIs).Food and Drug Administration.What to Know and Do About Possible Nitrosamines in Your Medication.Patel K, Allen S, Haque MN, Angelescu I, Baumeister D, Tracy DK.Bupropion: a systematic review and meta-analysis of effectiveness as an antidepressant.Therapeutic Advances in Psychopharmacology.2016 Apr;6(2):99-144. doi:10.1177/2045125316629071Qin B, Zhang Y, Zhou X, Cheng P, Liu Y, Chen J, Fu Y, Luo Q, Xie P.Selective serotonin reuptake inhibitors versus tricyclic antidepressants in young patients: a meta-analysis of efficacy and acceptability.Clin Ther. 2014 Jul 1;36(7):1087-1095.e4. doi:10.1016/j.clinthera.2014.06.001Finberg JP, Rabey JM.Inhibitors of MAO-A and MAO-B in psychiatry and neurology.Front Pharmacol. 2016 Oct 18;7:340. doi:10.3389/fphar.2016.00340Food and Drug Administration.Auvelity label.Food and Drug Administration.Revisions to product labeling.Food and Drug Administration.Exxua label.Barth J, Munder T, Gerger H, Nüesch E, Trelle S, Znoj H, Jüni P, Cuijpers P.Comparative efficacy of seven psychotherapeutic interventions for patients with depression: a network meta-analysis.PLoS Med.2013 May 28;10(5):e1001454. doi:10.1371/journal.pmed.1001454Gautam M, Tripathi A, Deshmukh D, Gaur M.Cognitive behavioral therapy for depression.Indian J Psychiatry.2020 Jan;62(Suppl 2):S223-S229. doi:10.4103/psychiatry.IndianJPsychiatry_772_19Lipsitz J, Markowitz J.Mechanisms of change in interpersonal therapy (IPT).Clin Psychol Rev.2013 Dec;33(8):1134-47. doi:10.1016/j.cpr.2013.09.002International Society of Interpersonal Psychotherapy.Overview of IPT.Driessen E, Van HL, Peen J, Don FJ, Twisk JWR, Cuijpers P, Dekker JJM.Cognitive-behavioral versus psychodynamic therapy for major depression: secondary outcomes of a randomized clinical trial.J Consult Clin Psychol.2017 Jul;85(7):653-663. doi:10.1037/ccp0000207The Food and Drug Administration.What you need to know about dietary supplements.Ng QX, Venkatanarayanan N, Ho CY.Clinical use of Hypericum perforatum (St John’s wort) in depression: a meta-analysis.J Affect Disord.2017;210:211-221. doi:10.1016/j.jad.2016.12.048Young SN.Folate and depression—a neglected problem.J Psychiatry Neurosci.2007 Mar;32(2):80-82. PMID:17353937Zhao JL, Jiang WT, Wang X, Cai ZD, Liu ZH, Liu GR.Exercise, brain plasticity, and depression. CNS Neurosci Ther. 2020 Sept;26(9):885-895. doi:10.1111/cns.13385National Center for Complementary and Integrative Health.5 things to know about relaxation techniques for stress.Zaccaro A, Piarulli A, Laurino M, Garbella E, Menicucci D, Neri B, Gemignani A.How breath-control can change your life: a systematic review on psycho-physiological correlates of slow breathing.Front Hum Neurosci.2018 Sep 8;12:353. doi:10.3389/fnhum.2018.00353
NCBI Bookshelf.Depression: how effective are antidepressants?
Clevenger SS, Malhotra D, Dang J, Vanle B, IsHak WW.The role of selective serotonin reuptake inhibitors in preventing relapse of major depressive disorder.Ther Adv Psychopharmacol. 2018 Jan;8(1):49-58. doi:10.1177/2045125317737264
National Health Service.Overview - selective serotonin reuptake inhibitors (SSRIs).
Food and Drug Administration.What to Know and Do About Possible Nitrosamines in Your Medication.
Patel K, Allen S, Haque MN, Angelescu I, Baumeister D, Tracy DK.Bupropion: a systematic review and meta-analysis of effectiveness as an antidepressant.Therapeutic Advances in Psychopharmacology.2016 Apr;6(2):99-144. doi:10.1177/2045125316629071
Qin B, Zhang Y, Zhou X, Cheng P, Liu Y, Chen J, Fu Y, Luo Q, Xie P.Selective serotonin reuptake inhibitors versus tricyclic antidepressants in young patients: a meta-analysis of efficacy and acceptability.Clin Ther. 2014 Jul 1;36(7):1087-1095.e4. doi:10.1016/j.clinthera.2014.06.001
Finberg JP, Rabey JM.Inhibitors of MAO-A and MAO-B in psychiatry and neurology.Front Pharmacol. 2016 Oct 18;7:340. doi:10.3389/fphar.2016.00340
Food and Drug Administration.Auvelity label.
Food and Drug Administration.Revisions to product labeling.
Food and Drug Administration.Exxua label.
Barth J, Munder T, Gerger H, Nüesch E, Trelle S, Znoj H, Jüni P, Cuijpers P.Comparative efficacy of seven psychotherapeutic interventions for patients with depression: a network meta-analysis.PLoS Med.2013 May 28;10(5):e1001454. doi:10.1371/journal.pmed.1001454
Gautam M, Tripathi A, Deshmukh D, Gaur M.Cognitive behavioral therapy for depression.Indian J Psychiatry.2020 Jan;62(Suppl 2):S223-S229. doi:10.4103/psychiatry.IndianJPsychiatry_772_19
Lipsitz J, Markowitz J.Mechanisms of change in interpersonal therapy (IPT).Clin Psychol Rev.2013 Dec;33(8):1134-47. doi:10.1016/j.cpr.2013.09.002
International Society of Interpersonal Psychotherapy.Overview of IPT.
Driessen E, Van HL, Peen J, Don FJ, Twisk JWR, Cuijpers P, Dekker JJM.Cognitive-behavioral versus psychodynamic therapy for major depression: secondary outcomes of a randomized clinical trial.J Consult Clin Psychol.2017 Jul;85(7):653-663. doi:10.1037/ccp0000207
The Food and Drug Administration.What you need to know about dietary supplements.
Ng QX, Venkatanarayanan N, Ho CY.Clinical use of Hypericum perforatum (St John’s wort) in depression: a meta-analysis.J Affect Disord.2017;210:211-221. doi:10.1016/j.jad.2016.12.048
Young SN.Folate and depression—a neglected problem.J Psychiatry Neurosci.2007 Mar;32(2):80-82. PMID:17353937
Zhao JL, Jiang WT, Wang X, Cai ZD, Liu ZH, Liu GR.Exercise, brain plasticity, and depression. CNS Neurosci Ther. 2020 Sept;26(9):885-895. doi:10.1111/cns.13385
National Center for Complementary and Integrative Health.5 things to know about relaxation techniques for stress.
Zaccaro A, Piarulli A, Laurino M, Garbella E, Menicucci D, Neri B, Gemignani A.How breath-control can change your life: a systematic review on psycho-physiological correlates of slow breathing.Front Hum Neurosci.2018 Sep 8;12:353. doi:10.3389/fnhum.2018.00353
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