Allergy shots are the most common type of allergyimmunotherapy, treatments to reduce your immune system’s reaction to an allergen.They may be a promising option if you haveallergic asthmaorsymptoms like congestion and a drippy nosethat impact your quality of life.
Your healthcare provider can recommend specific allergy shots that may work for you based on testing. Read on to learn about how healthcare providers select specific allergy shots, as well as allergy shot schedules, costs, and side effects.
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Types of Allergy Shots
A healthcare provider assesses you to determine the type of allergy shot you can get. If your symptoms suggest a possible allergy, the next step istesting. Usually, this type of skin testing shows how your skin reacts to potential allergens.
Through such testing, the provider can see which substances are causing the strongest allergic reactions in your body. For example, commonly tested substances include:
Seasonal vs. Nonseasonal AllergiesSome people experience allergies seasonallyin response to substances like pollen, which are more prevalent at certain times of the year. Other people experience chronic (long-term) allergies, like those from animal dander. Allergy shots are effective in treating both seasonal and nonseasonal allergies.
Seasonal vs. Nonseasonal Allergies
Some people experience allergies seasonallyin response to substances like pollen, which are more prevalent at certain times of the year. Other people experience chronic (long-term) allergies, like those from animal dander. Allergy shots are effective in treating both seasonal and nonseasonal allergies.
What Are Allergy Shots?
Based on the findings from your allergy testing, a healthcare provider might recommend you try allergy shots. Allergy shots aren’t drugs—they are just a way to expose your immune system to an allergen over time, making you less reactive to the substance and decreasing your symptoms.
A healthcare provider will inject a small amount of the substance you react to, mixed with a delivery liquid. Gradually, they increase the concentration of the allergen over time.
Some people receive a shot for just one allergen, but others are allergic to more than one substance. For example, your testing might show that you have a mild allergy to grass pollen and a strong allergy to animal dander.
The healthcare provider can mix up an allergy shot containing both components. Depending on the combination, you may need to get more than one shot at a single visit.
So unlike medicationsfor allergies, like single-ingredient Allegra (fexofenadine), Claritin (loratadine), or Zyrtec (cetirizine), allergy shots can contain a combination of drugs tailored to your allergic response.
Where to Get Allergy ShotsYou’ll receive your allergy shots at a medical office or clinic. Usually, this happens at a healthcare provider’s office specializing in allergies (allergist), but some primary care providers also give allergy shots. You need to get your shots at a clinic so you can be monitored for potential side effects.
Where to Get Allergy Shots
You’ll receive your allergy shots at a medical office or clinic. Usually, this happens at a healthcare provider’s office specializing in allergies (allergist), but some primary care providers also give allergy shots. You need to get your shots at a clinic so you can be monitored for potential side effects.
Allergy Shot Schedule
The schedule for allergy shots varies. Traditionally, allergy shots are initially given weekly until you work up to your maintenance dose of the allergen. This usually takes around four to six months.
After that, during the maintenance phase, you receive shots every four to eight weeks for the next three to five years. The length of the maintenance phase depends on the severity of your allergies, the degree of improvement, and personal barriers to continuing to get shots.
“Rushed” Schedules
Many people believe going to the clinic to get these treatments is inconvenient, especially during the initial phase. If this is true for you, talk to your healthcare provider about “rush immunotherapy.” Using a rush schedule, you might receive your initial shots over five to seven days or even more quickly.
The advantage of a rush schedule is that you can get to the maintenance phase more quickly. You may not need as many visits, and it may be less expensive and more convenient. And you might get your symptoms relieved more quickly. However, using a rushed schedule puts you at greater risk of a serious side effect like anaphylaxis (see below).
Other schedules are somewhere between, taking somewhat less time than the traditional schedule. Most medical providers giving allergy shots have a standard protocol that they use at their clinic.
Results
Some people start to notice improvement during the initial buildup phase. However, results vary. Others don’t see significant improvement until a year of maintenance dosing.
After stopping allergy shots, some people never have a return of their allergic reactions. However, other people do have symptoms that eventually return. Having allergy shots for at least three years may increase the chance of permanent symptom relief, even years after stopping therapy.
Side Effects
Most symptoms from allergy shots show up within 30 minutes, so you are monitored in the clinic for a period after your shot. Less commonly, you might notice a later reaction appearing in the next 12 hours.
Mild swelling, itching, and redness at the injection site are common side effects of allergy shots.
Severe reactions affecting your whole body are more concerning and can indicate a potentially life-threatening reaction calledanaphylaxis.Symptoms of anaphylaxis include:
Such reactions occur in approximately 1 in 1,000 people treated with allergy shots.Fortunately, a healthcare provider can quickly and effectively treat such reactions withepinephrine.
Cost
Allergy shots can become costly, even with health insurance. If you have insurance, talk to your insurance company for exact coverage details before arranging for allergy shots. You might have a co-pay of $20 to $40 for each visit.
If you don’t have health insurance, the out-of-pocket cost of allergy shots could be between $120 and $200 per visit.The total treatment can cost thousands of dollars, even for people with insurance.
It’s important to consider more than allergy shot treatment when considering costs. Compare the price of allergy shots to the costs of your current therapy, like symptoms for allergic asthma. It would be best to consider how your symptoms impact your ability to work.
Several studies indicate that although they involve more initial expense, getting allergy shots often saves people money over the long term.However, you’ll also have toweigh different factorswhen considering whether allergy shots are worth it, like the severity of your current symptoms and flexibility in attending the clinic.
Considering Other Immunotherapy Treatment
For many years, allergy shots were the only type of immunotherapy available to treat allergies. However, newer therapies can be given underneath the tongue and swallowed after they dissolve, called sublingual therapies.
These are other options to think about when weighing cost. Their upfront costs may be higher, but you may be able to take them at home, which can reduce the overall expenses.Sublingual therapies are only available for certain allergens such as ragweed, grass, and dust mites.
Summary
Allergy shots are the most common form of immunotherapy and can deliver long-term relief of allergy symptoms. These shots contain small amounts of a substance you are allergic to, increasing the concentration of the allergen over time. The initial phase of therapy typically requires a weekly shot for four to six months. After that, you continue to receive less frequent shots for three years or more.
Most side effects from allergy shots are mild, but treatable life-threatening reactions are possible. Such shots are always given in a clinic. Costs of allergy shots will vary based on your insurance plan. However, even with a relatively small co-pay, costs can add up. You might want to discuss rush immunotherapy with your healthcare provider to save money.
12 SourcesVerywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read oureditorial processto learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.Durham SR, Shamji MH.Allergen immunotherapy: past, present and future.Nat Rev Immunol. 2022;1-12. doi:10.1038/s41577-022-00786-1American Academy of Allergy, Asthma, and Immunology.Allergy shots.Bright D, Pollart SM, Franko J.Allergy immunotherapy: Who, what, when…and how safe?.J Fam Pract. 2019;68(5):270-276.Arshad SH.An update on allergen immunotherapy.Clin Med (Lond). 2016 Dec;16(6):584-587. doi:10.7861/clinmedicine.16-6-584Uchida T, Nakagome K, Iemura H, et al.Clinical evaluation of rush immunotherapy using house dust mite allergen in Japanese asthmatics.Asia Pac Allergy. 2021 Jul 19;11(3):e32. doi:10.5415/apallergy.2021.11.e32American Academy of Allergy, Asthma, and Immunology.Allergy shots (immunotherapy).Penagos M, Eifan AO, Durham SR, Scadding GW.Duration of allergen immunotherapy for long-term efficacy in allergic rhinoconjunctivitis.Curr Treat Options Allergy. 2018;5(3):275-290. doi:10.1007/s40521-018-0176-2American College of Allergy, Asthma, and Immunology.Anaphylaxis.Stachler R. American Academy of Otolaryngic Allergy.Hidden costs of allergy shots.Mira.How much do allergy shots cost without insurance in 2023?Asaria M, Dhami S, van Ree R, et al.Health economic analysis of allergen immunotherapy for the management of allergic rhinitis, asthma, food allergy and venom allergy: A systematic overview.Allergy. 2018;73(2):269-283. doi:10.1111/all.13254American College of Allergy, Asthma, and Immunology.SLIT.
12 Sources
Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read oureditorial processto learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.Durham SR, Shamji MH.Allergen immunotherapy: past, present and future.Nat Rev Immunol. 2022;1-12. doi:10.1038/s41577-022-00786-1American Academy of Allergy, Asthma, and Immunology.Allergy shots.Bright D, Pollart SM, Franko J.Allergy immunotherapy: Who, what, when…and how safe?.J Fam Pract. 2019;68(5):270-276.Arshad SH.An update on allergen immunotherapy.Clin Med (Lond). 2016 Dec;16(6):584-587. doi:10.7861/clinmedicine.16-6-584Uchida T, Nakagome K, Iemura H, et al.Clinical evaluation of rush immunotherapy using house dust mite allergen in Japanese asthmatics.Asia Pac Allergy. 2021 Jul 19;11(3):e32. doi:10.5415/apallergy.2021.11.e32American Academy of Allergy, Asthma, and Immunology.Allergy shots (immunotherapy).Penagos M, Eifan AO, Durham SR, Scadding GW.Duration of allergen immunotherapy for long-term efficacy in allergic rhinoconjunctivitis.Curr Treat Options Allergy. 2018;5(3):275-290. doi:10.1007/s40521-018-0176-2American College of Allergy, Asthma, and Immunology.Anaphylaxis.Stachler R. American Academy of Otolaryngic Allergy.Hidden costs of allergy shots.Mira.How much do allergy shots cost without insurance in 2023?Asaria M, Dhami S, van Ree R, et al.Health economic analysis of allergen immunotherapy for the management of allergic rhinitis, asthma, food allergy and venom allergy: A systematic overview.Allergy. 2018;73(2):269-283. doi:10.1111/all.13254American College of Allergy, Asthma, and Immunology.SLIT.
Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read oureditorial processto learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.
Durham SR, Shamji MH.Allergen immunotherapy: past, present and future.Nat Rev Immunol. 2022;1-12. doi:10.1038/s41577-022-00786-1American Academy of Allergy, Asthma, and Immunology.Allergy shots.Bright D, Pollart SM, Franko J.Allergy immunotherapy: Who, what, when…and how safe?.J Fam Pract. 2019;68(5):270-276.Arshad SH.An update on allergen immunotherapy.Clin Med (Lond). 2016 Dec;16(6):584-587. doi:10.7861/clinmedicine.16-6-584Uchida T, Nakagome K, Iemura H, et al.Clinical evaluation of rush immunotherapy using house dust mite allergen in Japanese asthmatics.Asia Pac Allergy. 2021 Jul 19;11(3):e32. doi:10.5415/apallergy.2021.11.e32American Academy of Allergy, Asthma, and Immunology.Allergy shots (immunotherapy).Penagos M, Eifan AO, Durham SR, Scadding GW.Duration of allergen immunotherapy for long-term efficacy in allergic rhinoconjunctivitis.Curr Treat Options Allergy. 2018;5(3):275-290. doi:10.1007/s40521-018-0176-2American College of Allergy, Asthma, and Immunology.Anaphylaxis.Stachler R. American Academy of Otolaryngic Allergy.Hidden costs of allergy shots.Mira.How much do allergy shots cost without insurance in 2023?Asaria M, Dhami S, van Ree R, et al.Health economic analysis of allergen immunotherapy for the management of allergic rhinitis, asthma, food allergy and venom allergy: A systematic overview.Allergy. 2018;73(2):269-283. doi:10.1111/all.13254American College of Allergy, Asthma, and Immunology.SLIT.
Durham SR, Shamji MH.Allergen immunotherapy: past, present and future.Nat Rev Immunol. 2022;1-12. doi:10.1038/s41577-022-00786-1
American Academy of Allergy, Asthma, and Immunology.Allergy shots.
Bright D, Pollart SM, Franko J.Allergy immunotherapy: Who, what, when…and how safe?.J Fam Pract. 2019;68(5):270-276.
Arshad SH.An update on allergen immunotherapy.Clin Med (Lond). 2016 Dec;16(6):584-587. doi:10.7861/clinmedicine.16-6-584
Uchida T, Nakagome K, Iemura H, et al.Clinical evaluation of rush immunotherapy using house dust mite allergen in Japanese asthmatics.Asia Pac Allergy. 2021 Jul 19;11(3):e32. doi:10.5415/apallergy.2021.11.e32
American Academy of Allergy, Asthma, and Immunology.Allergy shots (immunotherapy).
Penagos M, Eifan AO, Durham SR, Scadding GW.Duration of allergen immunotherapy for long-term efficacy in allergic rhinoconjunctivitis.Curr Treat Options Allergy. 2018;5(3):275-290. doi:10.1007/s40521-018-0176-2
American College of Allergy, Asthma, and Immunology.Anaphylaxis.
Stachler R. American Academy of Otolaryngic Allergy.Hidden costs of allergy shots.
Mira.How much do allergy shots cost without insurance in 2023?
Asaria M, Dhami S, van Ree R, et al.Health economic analysis of allergen immunotherapy for the management of allergic rhinitis, asthma, food allergy and venom allergy: A systematic overview.Allergy. 2018;73(2):269-283. doi:10.1111/all.13254
American College of Allergy, Asthma, and Immunology.SLIT.
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