Table of ContentsView AllTable of ContentsCaffeine and SeizuresCan It Trigger Seizures?Boosting Energy SafelyTalking to Your ProviderFrequently Asked Questions

Table of ContentsView All

View All

Table of Contents

Caffeine and Seizures

Can It Trigger Seizures?

Boosting Energy Safely

Talking to Your Provider

Frequently Asked Questions

Whilecaffeineconsumption is a daily habit for many people, it can become a little more complicated for those with a central nervous system disorder likeepilepsy.That’s because caffeine interacts with certain brain signals, andseizuresoccur when there’s an imbalance of electrical activity in the brain.

In high doses, caffeine can be a potentialepilepsy trigger—but in lower doses, research shows, it may be helpful for some people with the condition. This article provides an overview of caffeine consumption and seizure risk for people with epilepsy.

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Person drinking a cup of coffee

Caffeine acts as a stimulant forthe brain, which, along with the spinal cord, is part of thecentral nervous system. Stimulants excite or arouse these parts of the body. But researchers are still gaining an understanding of the relationship between caffeine, epilepsy, seizures, andanti-seizure medications.

Large Amounts of Caffeine and Increased Seizure Risk

Excessive caffeine intake can be risky for anyone, especially those with seizures.

Experts say that consuming more than 1,200 milligrams (mg) of caffeine—which would equal roughly 12 cups of coffee—within a short time can lead to dangerous side effects like seizures.

Specific to epilepsy, some research has suggested that more than four cups of coffee per day might trigger more seizures than usual.That equals about 400 mg of caffeine.

Within the general population, pregnant people should limit caffeine to 200 mg per day.The American Academy of Pediatrics discourages caffeine for children and adolescents.

Low-Dose Caffeine and Seizure Protection

On the flip side, animal studies have also indicated that consuming a moderate amount of caffeine regularly might protect against the risk of getting seizures.

Drug-Resistant Epilepsy

The effects of caffeine in people withdrug-resistant epilepsy(which means medications aren’t able to control their seizures very well) appear to be a little less studied.

At least one study suggests that moderate coffee consumption may be helpful for reducing seizures in people with certain types of drug-resistant epilepsy. More research is needed to confirm specifics like the exact caffeine dosage and its effects on the different types offocal epilepsy.

Can Caffeine Trigger Seizures?

Caffeine has a direct impact on the brain. While this stimulant can increase energy levels, it also comes with several negative side effects.

Caffeine Withdrawal

Stopping caffeine suddenly may be a seizure trigger in certain people who are used to consuming the stimulant regularly.

Commoncaffeine withdrawal symptomsinclude drowsiness, headaches, irritability, nausea, and vomiting.But some research done in animals suggests that abruptly stopping caffeine can increase the frequency of seizures.

If you have epilepsy, check with a healthcare provider before cutting caffeine completely out of your diet.

Dehydration

Expert opinions are mixed on whether caffeine causes dehydration.But it does have adiuretic effect(meaning it helps your body extract extra salt and water through urination).

Sleep Problems

In the short term, caffeine is known to improve alertness. But drinking too much can also lead to side effects like insomnia or other sleep issues.

Sleep deprivation is a seizure trigger for some people with epilepsy.It may be particularly important to watch your caffeine intake to ensure it’s not interfering with your sleep—and accidentally prompting seizures.

Caffeine’s Individual EffectsCaffeine impacts everyone differently. How your body responds to caffeine may depend on factors like genetic makeup, how the stimulant is metabolized (broken down) in the liver, and whether any medications or supplements you may be taking interact withcaffeine sensitivity.In addition, people consume caffeine in different ways, including coffee with creamer, a shot of espresso, or a caffeinated soft drink. Because there can be substances other than caffeine in these drinks, it’s hard for experts to pinpoint whether caffeine alone contributes to the chances of having a seizure.

Caffeine’s Individual Effects

Caffeine impacts everyone differently. How your body responds to caffeine may depend on factors like genetic makeup, how the stimulant is metabolized (broken down) in the liver, and whether any medications or supplements you may be taking interact withcaffeine sensitivity.In addition, people consume caffeine in different ways, including coffee with creamer, a shot of espresso, or a caffeinated soft drink. Because there can be substances other than caffeine in these drinks, it’s hard for experts to pinpoint whether caffeine alone contributes to the chances of having a seizure.

Caffeine impacts everyone differently. How your body responds to caffeine may depend on factors like genetic makeup, how the stimulant is metabolized (broken down) in the liver, and whether any medications or supplements you may be taking interact withcaffeine sensitivity.

In addition, people consume caffeine in different ways, including coffee with creamer, a shot of espresso, or a caffeinated soft drink. Because there can be substances other than caffeine in these drinks, it’s hard for experts to pinpoint whether caffeine alone contributes to the chances of having a seizure.

Safe Ways to Boost Your Energy With Epilepsy

Do you want to cut back on your caffeine intake but stillkeep your energy up?

Experts generally recommend the following tips as safe ways to stay alert without overdoing it on caffeine:

These lifestyle habits help promote good health and natural energy levels and can be modified to the individual’s specific situation—whether you have epilepsy or not.

Talking to Your Healthcare Provider About Epilepsy and Caffeine

Because there may be some risks that come along with caffeine consumption in people with epilepsy, it’s important to speak with a healthcare provider about your caffeine intake to determine whether it may be impacting seizure frequency.

Before having this conversation, you might consider keeping a log of your seizures and tracking your diet on those days to identify a potential pattern. Any additional or unusual symptoms you may be experiencing will also be important to note.

Summary

The relationship between caffeine and seizures is complicated. While some research indicates that consuming caffeine can be a seizure trigger, other studies suggest that regular, low doses of caffeine may protect against seizures in some people with epilepsy.

Because of this, many experts think the impact that caffeine has on seizures is likely dependent on several factors, including the caffeine dosage and frequency. Because each person’s caffeine sensitivity and how epilepsy affects them will vary, it’s best to discuss your caffeine intake with a healthcare provider who can provide a personalized recommendation.

Frequently Asked QuestionsCaffeine affects people with epilepsy differently. Studies show that consuming a low dose of caffeine on a regular basis may be OK if you have epilepsy, but it’s important to discuss this with your healthcare provider first to make sure this is safe for you.There are no official caffeine intake recommendations for people with epilepsy, and the condition affects each person differently.For reference, the Food and Drug Administration (FDA) reports that up to 400 mg of caffeine per day for most healthy adults is not associated with negative effects.But what is appropriate for you will depend on your medical history of epilepsy and any medications you may be taking. Work with your healthcare provider to determine the safest caffeine amount for you.Research has suggested that eating a ketogenic diet orgluten-free dietmay help protect against seizures.Anyone with a seizure disorder considering changing their diet for these purposes is urged to do so under the supervision of a healthcare provider.Learn MoreKetogenic Diet for Epilepsy

Caffeine affects people with epilepsy differently. Studies show that consuming a low dose of caffeine on a regular basis may be OK if you have epilepsy, but it’s important to discuss this with your healthcare provider first to make sure this is safe for you.

There are no official caffeine intake recommendations for people with epilepsy, and the condition affects each person differently.For reference, the Food and Drug Administration (FDA) reports that up to 400 mg of caffeine per day for most healthy adults is not associated with negative effects.But what is appropriate for you will depend on your medical history of epilepsy and any medications you may be taking. Work with your healthcare provider to determine the safest caffeine amount for you.

Research has suggested that eating a ketogenic diet orgluten-free dietmay help protect against seizures.Anyone with a seizure disorder considering changing their diet for these purposes is urged to do so under the supervision of a healthcare provider.Learn MoreKetogenic Diet for Epilepsy

Research has suggested that eating a ketogenic diet orgluten-free dietmay help protect against seizures.Anyone with a seizure disorder considering changing their diet for these purposes is urged to do so under the supervision of a healthcare provider.

Learn MoreKetogenic Diet for Epilepsy

27 Sources

Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read oureditorial processto learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.

Nehlig A.Effects of coffee/caffeine on brain health and disease: What should I tell my patients?Pract Neurol. 2016;16(2):89-95. doi:10.1136/practneurol-2015-001162

Akyuz E, Polat AK, Eroglu E, Kullu I, Angelopoulou E, Paudel YN.Revisiting the role of neurotransmitters in epilepsy: an updated review.Life Sci. 2021;265:118826. doi:10.1016/j.lfs.2020.118826

Fiani B, Zhu L, Musch B L, et al.The neurophysiology of caffeine as a central nervous system stimulant and the resultant effects on cognitive function.Cureus.2021;13(5):e15032. doi:10.7759/cureus.15032

MedlinePlus.Seizures.

van Koert RR, Bauer PR, Schuitema I, Sander JW, Visser GH.Caffeine and seizures: a systematic review and quantitative analysis.Epilepsy Behav. 2018;80:37-47. doi:10.1016/j.yebeh.2017.11.003

Pham K, Mulugeta A, Zhou A, O’Brien JT, Llewellyn DJ, Hyppönen E.High coffee consumption, brain volume and risk of dementia and stroke.Nutr Neurosci. 2022;25(10):2111-211. doi:10.1080/1028415x.2021.1945858

MedlinePlus.Caffeine in the diet.

Jailani M, Mubarak M, Sarkhouh M, et al.The effect of low-doses of caffeine and taurine on convulsive seizure parameters in rats.Behav Sci (Basel). 2020;10(2):43. doi:10.3390/bs10020043

Samsonsen C, Bråthen G, Reimers A, Helde G, Brodtkorb E.Is dietary caffeine involved in seizure precipitation?Epilepsy Behav. 2013;28(2):147-50. doi:10.1016/j.yebeh.2013.05.003.

Bourgeois-Vionnet J, Jung J, Bouet R, Leclercq M.Relation between coffee consumption and risk of seizure-related respiratory dysfunction in patients with drug-resistant focal epilepsy.Epilepsy.Feb 2021;62(3):765-777. doi:10.1111/epi.16837

Bourgeois-Vionnet J, Ryvlin P, Elsensohn MH, et al.Coffee consumption and seizure frequency in patients with drug-resistant focal epilepsy.Epilepsy Behav. 2022;126:108486. doi:10.1016/j.yebeh.2021.108486

Richards G, Smith AP.A review of energy drinks and mental health, with a focus on stress, anxiety, and depression.J Caffeine Res. 2016;6(2):49-63. doi:10.1089/jcr.2015.0033

Matouv D, Alele PE.Seizure vulnerability and anxiety responses following chronic co-administration and acute withdrawal of caffeine and ethanol in a rat model.J Basic Clin Physiol Pharmacol.2018;29(1):1-10. doi:10.1515/jbcpp-2017-0018

Killer SC, Blannin AK, Jeukendrup AE.No evidence of dehydration with moderate daily coffee intake: a counterbalanced cross-over study in a free-living population.PLoS One. 2014;9(1):e84154. doi:10.1371/journal.pone.0084154

MedlinePlus.Caffeine.

American Psychiatric Association.Diagnostic and Statistical Manual of Mental Disorders.5th edition. Washington DC; 2013.

Dell’Aquila JT, Soti V.Sleep deprivation: a risk for epileptic seizures.Sleep Sci. 2022;15(2):245-249. doi:10.5935/1984-0063.20220046

Erblang M, Drogou C, Gomez-Merino D, et al.The impact of genetic variations in ADORA2A in the association between caffeine consumption and sleep.Genes.2019;10(12):1021. doi:10.3390/genes10121021

Belayneh A, Molla F.The effect of coffee on pharmacokinetic properties of drugs: a review.Biomed Res Int. 2020;2020:1-11. doi:10.1155/2020/7909703

Tian DD, Natesan S, White JR, Paine MF.Effects of common CYP1A2 genotypes and other key factors on intraindividual variation in the caffeine metabolic ratio: an exploratory analysis.Clin Transl Sci. 2019;12(1):39-46. doi:10.1111/cts.12598

MedlinePlus.Fatigue.

MedlinePlus.Can you boost your metabolism?.

Food and Drug Administration.Spilling the beans: how much caffeine is too much?.

D’Andrea Meira I, Romão TT, Pires do Prado HJ, Krüger LT, Pires MEP, da Conceição PO.Ketogenic diet and epilepsy: what we know so far.Front Neurosci. 2019;13:5. doi:10.3389/fnins.2019.00005

NYU Langone Health.Dietary therapies for epilepsy and seizure disorders.

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