Table of ContentsView AllTable of ContentsIs It an Opioid?UsesSide EffectsFormsLegalityAlternatives

Table of ContentsView All

View All

Table of Contents

Is It an Opioid?

Uses

Side Effects

Forms

Legality

Alternatives

Kratom is an herbal product made from the leaves of the kratom tree (Mitragyna speciosa), said to have opioid-like effects. Kratom’s reported benefits include helping people cope with withdrawal symptoms and drug-related cravings, pain, fatigue, and mental health challenges.

In the United States, the Food and Drug Administration (FDA) does not regulate supplements the way it regulates prescription drugs. That means some supplement products may not contain what the label says. Whenchoosing a supplement, look for independently tested products and consult a healthcare provider, registered dietitian nutritionist (RD or RDN), or pharmacist.

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Kratom in leaf, pill, and powder form

Is Kratom Powder an Opioid?

Kratom powder is not an opioid. Kratom powder is said to have opioid-like effects and psychostimulant effects. Kratom works on or activates opioid receptors in nerve cells. The effects are mild compared to those of opioids or heroin. This means the adverse effects of kratom or kratom side effects are also milder in comparison to those of opioids.

The naturally occurring chemical compounds in kratom also bind to receptors affecting various aspects of mental health, including serotonin receptors and dopamine receptors. These plant compounds or kratom alkaloids and receptors are linked to kratom’s stimulating or arousing effects.

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What Are Kratom’s Uses?

Researchers have reported several reasons people give for using kratom today, including:

Researchers say most people who use kratom report using it for more than one reason. The National Institute on Drug Abuse notes that though people use kratom to help cope with certain conditions including substance use disorders, kratom is not approved for safe use in helping someone cope with substance use disorders and that regulated, safe, and effective medications do exist to help people reduce the symptoms of opioid withdrawal.

Traditional Uses for KratomKratom has traditionally served as a method of increasing energy and improving work productivity as well as fighting fatigue among farming populations in Southeast Asia.

Traditional Uses for Kratom

Kratom has traditionally served as a method of increasing energy and improving work productivity as well as fighting fatigue among farming populations in Southeast Asia.

Kratom Side Effects

The FDA has issued a general warning against using kratom due to the potential for adverse effects including drug abuse and addiction.Some of this concern stems from the fact that kratom is an unregulated herbal remedy.

Kratom ContaminationContamination in herbal supplements like kratom includes excess traces of heavy metals and bacteria. The FDA has issued numerous warnings about kratom contamination, including on the risk of developing heavy metal toxicity and exposure to contamination from salmonella.

Kratom Contamination

Contamination in herbal supplements like kratom includes excess traces of heavy metals and bacteria. The FDA has issued numerous warnings about kratom contamination, including on the risk of developing heavy metal toxicity and exposure to contamination from salmonella.

General side effects of kratom include:

The U.S. Department of Justice and the U.S. Drug Enforcement Administration (DEA) say low doses of kratom have stimulating effects and higher doses of kratom have more sedating effects.

More serious side effects of kratom include:

The DEA notes several cases of psychosis or hallucinations have been reported after kratom consumption.Though possible, a research review suggests serious adverse effects from kratom are very rare.The FDA has reported few cases of kratom-related deaths.

Kratom dependence can cause someone to experiencewithdrawal symptomssuch as:

WarningThe long-term health effects of kratom use, kratom use during pregnancy, and the safety profile of kratom use while operating machinery or while consuming other substances (prescription or recreational) are not well understood.There is some evidence to suggest kratom use during pregnancy can cause withdrawal symptoms in newborns.

Warning

The long-term health effects of kratom use, kratom use during pregnancy, and the safety profile of kratom use while operating machinery or while consuming other substances (prescription or recreational) are not well understood.There is some evidence to suggest kratom use during pregnancy can cause withdrawal symptoms in newborns.

Forms of Kratom

Kratom tea and chewing the kratom tree leaves are popular in Southeast Asia. In the U.S., you may find kratom more commonly sold in powder form. People self-report using kratom powder in the following ways:

Kratom can also be found as an extract in tincture or resin form.

Kratom DosingDosing for kratom can be hard to determine because dosing and effects for kratom have not been well documented. However, data from literature reviews suggest a typical dose range for consumers in the U.S. may be less than a single gram and up to 7 grams based on data from self-reporting study participants. The average dose for nearly half of the participants was reported between 1 and 3 grams per consumption or each time, with most participants reporting daily kratom use.

Kratom Dosing

Dosing for kratom can be hard to determine because dosing and effects for kratom have not been well documented. However, data from literature reviews suggest a typical dose range for consumers in the U.S. may be less than a single gram and up to 7 grams based on data from self-reporting study participants. The average dose for nearly half of the participants was reported between 1 and 3 grams per consumption or each time, with most participants reporting daily kratom use.

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Where Does the United States Stand on Kratom Legality?

Kratom is legal in the United States and is available for sale online and in some shops in some counties. Kratom is not listed under the U.S. schedule of controlled substances. However, kratom may seem to be in a legal gray area because several state regulations or prohibitions against the possession and use of kratom exist.

In some states, kratom is banned as a Schedule 1 controlled substance, while it is regulated in others. As of August 2023, it was banned or regulated in 22 states.Legislation to regulate it is being considered in others. It’s best to check with your local laws because restrictions, regulations, and bans can be updated at any time.

Many countries have banned kratom use or made kratom illegal. These include:

Alternatives to Kratom

There is an alternative to kratom called Sakae Naa. The FDA has placed an import alert on this new dietary ingredient similar to the one placed on kratom. The FDA says the import alert is due to “inadequate information to provide reasonable assurance that it does not present a significant or unreasonable risk of illness or injury.”

Is Kratom Addictive?

Summary

Kratom is a herbal substance from Southeast Asia that acts on the body in ways similar to those of opioids. Kratom is not an opioid. Kratom in smaller doses has stimulating effects and in larger doses has sedating effects. It has been traditionally used for increasing energy and worker productivity in farming communities in Southeast Asia but it is now also used in the United States for several reasons.

People report using kratom for pain relief and to help cope with depression and anxiety. Kratom has side effects including nausea and digestive upset. Very rare but serious side effects include psychosis and death. Kratom is legal in the U.S. but is not regulated and is a drug of concern due to its potential for abuse and addiction.

16 Sources

Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read oureditorial processto learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.

National Institute on Drug Abuse (NIDA).Kratom.

Váradi A, Marrone GF, Palmer TC, et al.Mitragynine/Corynantheidine pseudoindoxyls as opioid analgesics with mu agonism and Delta antagonism, which do not recruit β-arrestin-2.Journal of Medicinal Chemistry.2016;(59)18:8381-8397. doi:10.1021/acs.jmedchem.6b00748

U.S. Food and Drug Administration.Statement from FDA Commissioner Scott Gottlieb, M.D., on the agency’s scientific evidence on the presence of opioid compounds in kratom, underscoring its potential for abuse.

U.S. Food and Drug Administration.FDA In Brief: FDA releases test results identifying dangerous levels of heavy metals in certain kratom products.

Grundmann O.Patterns of Kratom use and health impact in the US—Results from an online survey.Drug Alcohol Depend. 2017;176:63-70. doi:10.1016/j.drugalcdep.2017.03.007

Garcia-Romeu A, Cox DJ, Smith KE, et al.Kratom (Mitragyna speciosa): User demographics, use patterns, and implications for the opioid epidemic.Drug Alcohol Depend. 2020;208:107849. doi:10.1016/j.drugalcdep.2020.107849

Department of Justice and Drug Enforcement Administration.Kratom.

U.S. Food and Drug Administration.Import Alert 54-15.

U.S. Food and Drug Administration.FDA announces seizure of adultered dietary supplements containing kratom.

Post, S, Spiller HA, Chounthirath T, Smith GA.Kratom exposures reported to United States poison control centers: 2011–2017.Clinical Toxicology. 2019;57(10):847-854. doi:10.1080/15563650.2019.1569236

The Recovery Village.What does kratom look like?

Legislative Analysis and Public Policy Association.Kratom: summary of state laws, August 2023.

Ocean Recovery.Kratom legality: Where kratom is legal and side effects of use.

U.S. Food and Drug Administration.Import Alert 54-18.

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