Table of ContentsView AllTable of ContentsPotential BenefitsPotential DownsidesHow L-Theanine WorksDosageSimilar SupplementsFrequently Asked Questions
Table of ContentsView All
View All
Table of Contents
Potential Benefits
Potential Downsides
How L-Theanine Works
Dosage
Similar Supplements
Frequently Asked Questions
L-theanine is an amino acid found in tea leaves and theBay boletemushroom. Since the amount you might get in a cup of tea depends on variables like the type of tea plant and how long you brew the leaves, some people use L-theanine supplements to help them relax, destress, and sleep better.
In the United States, the Food and Drug Administration (FDA) does not regulate supplements the way it regulates prescription drugs. That means some supplement products may not contain what the label says. Whenchoosing a supplement, look for independently tested products and consult a healthcare provider, registered dietitian nutritionist (RD or RDN), or pharmacist.
Supplement Facts
What Are L-Theanine’s Benefits?
Researchers have studied L-theanine’s effects for several conditions.
However, it’s important to note that better-designed clinical trials are still needed.
Tea leaves.Getty Images / Dallas and John Heaton

Getty Images / Dallas and John Heaton
ADHD Symptoms
Researchers have investigated L-theanine forattention deficit hyperactivity disorder (ADHD)symptoms.
Attention issues can have the following causes and/or associations:
Addressing any underlying issues is worth considering. If you have questions about your child’s symptoms, it’s best to contact their pediatrician.
A study was conducted in male children (8 to 15 years) with ADHD. L-theanine improved total cognition compared to a placebo (an inactive substance). Both L-theanine alone and an L-theanine-caffeine combination also reduced mind wandering.
Caffeine Use in ChildrenThe American Academy of Child and Adolescent Psychiatry (AACAP) advisesagainstcaffeine for children under 12 years.
Caffeine Use in Children
The American Academy of Child and Adolescent Psychiatry (AACAP) advisesagainstcaffeine for children under 12 years.
Some children with ADHD may also have significant issues with sleep. Sleep disturbances can impact both a child’s and family’s well-being.
A clinical study suggested L-theanine helped sleep quality in male children 8 to 12 years with ADHD.
Further, higher-quality studies are needed to confirm these results.
Correct Diagnosis of ADHDCorrectly diagnosing ADHD is essential. Some gifted (highly or profoundlyintelligent) children may have behaviors that seem like ADHD due to boredom or other issues.ADHD,autism spectrum disorder(ASD), and giftedness can also share overlapping characteristics and can be correlated.A healthcare provider well-versed in both giftedness andneurodiversitycan help. Organizations like the National Association for Gifted Children have additional resources.Another study showed younger males in kindergarten were, as a group, over-diagnosed with ADHD.Developmentally normal behavior has been mistaken for a medical issue.It may be that a lower student-to-teacher ratio (smaller class size) with experienced teachers may benefit children in this case as well.Ask your child’s healthcare provider about questions or concerns. They may refer you to a healthcare provider that specializes in these areas.
Correct Diagnosis of ADHD
Correctly diagnosing ADHD is essential. Some gifted (highly or profoundlyintelligent) children may have behaviors that seem like ADHD due to boredom or other issues.ADHD,autism spectrum disorder(ASD), and giftedness can also share overlapping characteristics and can be correlated.A healthcare provider well-versed in both giftedness andneurodiversitycan help. Organizations like the National Association for Gifted Children have additional resources.Another study showed younger males in kindergarten were, as a group, over-diagnosed with ADHD.Developmentally normal behavior has been mistaken for a medical issue.It may be that a lower student-to-teacher ratio (smaller class size) with experienced teachers may benefit children in this case as well.Ask your child’s healthcare provider about questions or concerns. They may refer you to a healthcare provider that specializes in these areas.
Correctly diagnosing ADHD is essential. Some gifted (highly or profoundlyintelligent) children may have behaviors that seem like ADHD due to boredom or other issues.
ADHD,autism spectrum disorder(ASD), and giftedness can also share overlapping characteristics and can be correlated.A healthcare provider well-versed in both giftedness andneurodiversitycan help. Organizations like the National Association for Gifted Children have additional resources.
Another study showed younger males in kindergarten were, as a group, over-diagnosed with ADHD.Developmentally normal behavior has been mistaken for a medical issue.It may be that a lower student-to-teacher ratio (smaller class size) with experienced teachers may benefit children in this case as well.
Ask your child’s healthcare provider about questions or concerns. They may refer you to a healthcare provider that specializes in these areas.
Anxiety
Anxietyaffects around 12.5% of adults and 9.4% of children in the United States.Unresolved anxiety can cause further health issues.
Scientists found L-theanine hasanxiolytic(anti-anxiety) effects. A systematic review (a collection of research on a single topic) suggested L-theanine reduced anxiety in people under stress.
Researchers conducted a study in children between 4 and 17 years with Tourette’s syndrome (a nervous system condition causing sudden twitches, movements, and sounds). L-theanine with vitamin B6 reduced tics with anxiety.It’s challenging to fully understand L-theanine’s effects in this study alone as it was used in combination.
While there’s promising evidence, conflicting evidence of theanine’s effectiveness for anxiety also exists.
Speak with your healthcare provider if you’re experiencing anxiety.
Cognition
Scientists have suggested caffeine may bolster L-theanine’s impact oncognition(processing and understanding information) and working memory.
In a study of young adults, L-theanine with caffeine helped with attention.
However, in other studies of healthy adults, L-theanine alone (no caffeine added) had the following effects:
Cancer
Theanine has been investigated for its anticancer effects inin vitro(in cells in a laboratory) andin vivo(animal) studies.
However, clinical trials (research in humans) are needed before recommendations can be made.
Depression
In one study, researchers added L-theanine to current medication in people withmajor depressive disorder. The following symptoms improved:
Further, high-quality studies are needed.
Please reach out to your healthcare provider if you’re experiencing depression. Promptly diagnosing and treating this and other mental health issues is important.
Immune Effects
L-theanine impacts the immune system. In a study of professional athletes, L-theanine affected differentimmune system markers.It was associated with decreasedinterleukin-10(IL-10).
Further study is needed.
Schizophrenia
In people withschizophreniaorschizoaffective disorder, L-theanine was added toregular treatmentwith beneficial effects.
L-theanine supplementation was associated with the following improvements:
Consult with your healthcare provider before adding supplements to your medication regimen.
Sleep
Chronicsleep disorderscan seriously affect your quality of life. Sleep disorders are linked with or can worsen the following conditions:
In healthy adults, L-theanine reduced sleep latency (the time it takes to fall asleep), sleep disturbance, and the use of sleep medication.
Some children with ADHD have associated sleep problems, affecting both the child’s and family’s well-being.In a clinical study of male children 8 to 12 years with ADHD, L-theanine improved sleep.
If you or your child hassleep issues, please reach out to your healthcare provider.It’s essential to evaluate and rule out contributing issues such as:AnxietySleep apneaRestless legs syndromeInsomniaIron deficiency anemiaSleep issues can be connected with behavior and mood issues in adults and children.Your healthcare provider can help you figure out and address the root cause.
If you or your child hassleep issues, please reach out to your healthcare provider.
It’s essential to evaluate and rule out contributing issues such as:
Sleep issues can be connected with behavior and mood issues in adults and children.
Your healthcare provider can help you figure out and address the root cause.
Stress
Researchers studied theanine for itsstress-reducing effects.In young adults, L-theanine reduced stress. It also loweredblood pressurein high-stress situations.
Further study is needed to confirm these results.
What Are L-Theanine’s Downsides?
L-theanine has been mostly well-tolerated in clinical trials. However, adverse effects or interactions are still possible, including the following:
How Does L-Theanine Work?
Researchers believe L-theanine improves sleep quality viaanxiolysis(reducing anxiety), not sedation.
Scientists believe these effects may be due to theanine’s ability to benefit levels of the following:
L-theanine also impacted levels of the following when used with antipsychotic medication:
Researchers think BDNF may help the brain heal itself, which may explain some of theanine’s positive benefits.
Always speak with a healthcare provider before taking a supplement to ensure that the supplement and dosage are appropriate for your individual needs.
L-theanine is available in the following forms:
Theanine is also found intea. It’s often combined with other ingredients. Vegetarian and vegan products are available.
The following are dosages used in clinical studies. They are not meant to substitute for a consultation with your or your child’s healthcare provider:
Supplements withanxiety-loweringand/orsleep-inducingeffects include but aren’t limited to the following:
Physical activity, including but not limited toaerobic exerciseandyoga, lowers stress levels and can improve sleep.
Acupuncture has also been touted for itsanxiety-loweringandsleep-inducingeffects.
Summary
Since its discovery in the 1940s, researchers have investigated L-theanine for ADHD, anxiety, cognition, stress, and more.
While results are promising, more research is needed.
Consider avoiding L-theanine in the following situations:
And please do your best to speak with your healthcare provider, registered dietitian nutritionist (RD or RDN), and/or pharmacist about your supplements, prescriptions, and over-the-counter medication.
This way, you can collaboratively come up with a plan that optimizes safety and helps successfully meet your health goals.
Frequently Asked QuestionsL-theanine is an amino acid found in tea and some mushroom species.Clinical studies suggest L-theanine has antianxiety effects and promotes relaxation, sleep, and cognitive function.One study suggested the L-theanine content of green tea was 6.56 milligrams per gram (mg/g) of tea leaves.Conversely, white tea had 6.26 mg/g, oolong 6.09 mg/g, and black 5.13 mg/g. Anywhere from 1 to 3 g of tea have been used per cup. This means a cup of green tea may have anywhere from around 6.5 to 19.5 mg of L-theanine.
L-theanine is an amino acid found in tea and some mushroom species.
Clinical studies suggest L-theanine has antianxiety effects and promotes relaxation, sleep, and cognitive function.
One study suggested the L-theanine content of green tea was 6.56 milligrams per gram (mg/g) of tea leaves.Conversely, white tea had 6.26 mg/g, oolong 6.09 mg/g, and black 5.13 mg/g. Anywhere from 1 to 3 g of tea have been used per cup. This means a cup of green tea may have anywhere from around 6.5 to 19.5 mg of L-theanine.
40 Sources
Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read oureditorial processto learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.
Williams JL, Everett JM, D’Cunha NM, et al.The effects of green tea amino acid l-theanine consumption on the ability to manage stress and anxiety levels: a systematic review.Plant Foods Hum Nutr. 2020;75(1):12-23. doi:10.1007/s11130-019-00771-5
Kahathuduwa CN, Wakefield S, West BD, et al.Effects of L-theanine-caffeine combination on sustained attention and inhibitory control among children with ADHD: a proof-of-concept neuroimaging RCT.Sci Rep. 2020;10(1):13072. doi:10.1038/s41598-020-70037-7
Hidese S, Ogawa S, Ota M, et al.Effects of l-theanine administration on stress-related symptoms and cognitive functions in healthy adults: a randomized controlled trial.Nutrients. 2019;11(10):2362. doi:10.3390/nu11102362
PubChem.Theanine.
Food and Drug Administration.GRAS Notices.
Yoto A, Motoki M, Murao S, Yokogoshi H.Effects of L-theanine or caffeine intake on changes in blood pressure under physical and psychological stresses.J Physiol Anthropol. 2012;31(1):28. doi:10.1186/1880-6805-31-28
Vuong QV, Bowyer MC, Roach PD.L-theanine: properties, synthesis and isolation from tea.J Sci Food Agric. 2011;91(11):1931-1939. doi:10.1002/jsfa.4373
The American Academy of Child and Adolescent Psychiatry.Caffeine and children.
Anand S, Tong H, Besag FMC, et al.Safety, tolerability and efficacy of drugs for treating behavioural insomnia in children with attention-deficit/hyperactivity disorder: A systematic review with methodological quality assessment.Paediatr Drugs. 2017;19(3):235-250. doi:10.1007/s40272-017-0224-6
Antshel KM, Russo N.Autism spectrum disorders and ADHD: Overlapping phenomenology, diagnostic issues, and treatment considerations.Curr Psychiatry Rep. 2019;21(5):34. doi:10.1007/s11920-019-1020-5
National Association for Gifted Children.Resources.
National Association for Gifted Children.NAGC State Affiliates.
Whitely M, Raven M, Timimi S, et al.Attention deficit hyperactivity disorder late birthdate effect common in both high and low prescribing international jurisdictions: a systematic review.J Child Psychol Psychiatry. 2019;60(4):380-391. doi:10.1111/jcpp.12991
Layton TJ, Barnett ML, Hicks TR, et al.Attention deficit-hyperactivity disorder and month of school enrollment.N Engl J Med. 2018;379(22):2122-2130. doi:10.1056/NEJMoa1806828
García-Moya I, Brooks FM, Spencer NH.School-level factors associated with teacher connectedness: a multilevel analysis of the structural and relational school determinants of young people’s health.J Public Health (Oxf). 2018;40(2):366-374. doi:10.1093/pubmed/fdx089
Centers for Disease Control.Data and statistics on children’s mental health.
Centers for Disease Control.Early release of selected estimates based on data from the 2022 National Health Interview Survey.
Rizzo R, Prato A, Scerbo M, et al.Use of nutritional supplements based on l-theanine and vitamin B6 in children with Tourette syndrome, with anxiety disorders: A pilot study.Nutrients. 2022;14(4):852. doi:10.3390/nu14040852
Sarris J, Byrne GJ, Cribb L, et al.L-theanine in the adjunctive treatment of generalized anxiety disorder: A double-blind, randomised, placebo-controlled trial.J Psychiatr Res. 2019;110:31-37. doi:10.1016/j.jpsychires.2018.12.014
Zhang W, Yan Y, Wu Y, et al.Medicinal herbs for the treatment of anxiety: A systematic review and network meta-analysis.Pharmacol Res. 2022;179:106204. doi:10.1016/j.phrs.2022.106204
Mancini E, Beglinger C, Drewe J, Zanchi D, Lang UE, Borgwardt S.Green tea effects on cognition, mood and human brain function: A systematic review.Phytomedicine. 2017;34:26-37. doi:10.1016/j.phymed.2017.07.008
Giesbrecht T, Rycroft JA, Rowson MJ, De Bruin EA.The combination of L-theanine and caffeine improves cognitive performance and increases subjective alertness.Nutr Neurosci. 2010;13(6):283-290. doi:10.1179/147683010X12611460764840
Foxe JJ, Morie KP, Laud PJ, et al.Assessing the effects of caffeine and theanine on the maintenance of vigilance during a sustained attention task.Neuropharmacology. 2012;62(7):2320-2327. doi:10.1016/j.neuropharm.2012.01.020
Baba Y, Inagaki S, Nakagawa S, et al.Effects of l-theanine on cognitive function in middle-aged and older subjects: a randomized placebo-controlled Study.J Med Food. 2021;24(4):333-341. doi:10.1089/jmf.2020.4803
Dassanayake TL, Kahathuduwa CN, Weerasinghe VS.L-theanine improves neurophysiological measures of attention in a dose-dependent manner: a double-blind, placebo-controlled, crossover study.Nutr Neurosci. 2022;25(4):698-708. doi:10.1080/1028415X.2020.1804098
Shojaei-Zarghani S, Rafraf M, Yari-Khosroushahi A.Theanine and cancer: a systematic review of the literature.Phytother Res. 2021;35(9):4782-4794. doi:10.1002/ptr.7110
Hidese S, Ota M, Wakabayashi C, et al.Effects of chronic l-theanine administration in patients with major depressive disorder: an open-label study.Acta Neuropsychiatr. 2017;29(2):72-79. doi:10.1017/neu.2016.33
Juszkiewicz A, Glapa A, Basta P, et al.The effect of L-theanine supplementation on the immune system of athletes exposed to strenuous physical exercise.J Int Soc Sports Nutr. 2019;16(1):7. doi:10.1186/s12970-019-0274-y
Ota M, Wakabayashi C, Sato N, et al.Effect of L-theanine on glutamatergic function in patients with schizophrenia.Acta Neuropsychiatr. 2015;27(5):291-296. doi:10.1017/neu.2015.22
Ritsner MS, Miodownik C, Ratner Y, et al.L-theanine relieves positive, activation, and anxiety symptoms in patients with schizophrenia and schizoaffective disorder: an 8-week, randomized, double-blind, placebo-controlled, 2-center study.J Clin Psychiatry. 2011;72(1):34-42. doi:10.4088/JCP.09m05324gre
Rao TP, Ozeki M, Juneja LR.In search of a safe natural sleep aid.J Am Coll Nutr. 2015;34(5):436-447. doi:10.1080/07315724.2014.926153
Lyon MR, Kapoor MP, Juneja LR.The effects of L-theanine (Suntheanine®) on objective sleep quality in boys with attention deficit hyperactivity disorder (ADHD): a randomized, double-blind, placebo-controlled clinical trial.Altern Med Rev. 2011;16(4):348-354.
White DJ, De Klerk S, Woods W, et al.Anti-stress, behavioural and magnetoencephalography effects of an l-theanine-based nutrient drink: a randomised, double-blind, placebo-controlled, crossover trial.Nutrients. 2016; 8(1):53. doi: 10.3390/nu8010053.
Nobre AC, Rao A, Owen GN.L-theanine, a natural constituent in tea, and its effect on mental state.Asia Pac J Clin Nutr. 2008;17 Suppl 1:167-168.
Anas Sohail A, Ortiz F, Varghese T, et al.The cognitive-enhancing outcomes of caffeine and l-theanine: a systematic review.Cureus. 2021;13(12):e20828. doi:10.7759/cureus.20828
Miodownik C, Maayan R, Ratner Y, et al.Serum levels of brain-derived neurotrophic factor and cortisol to sulfate of dehydroepiandrosterone molar ratio associated with clinical response to L-theanine as augmentation of antipsychotic therapy in schizophrenia and schizoaffective disorder patients.Clin Neuropharmacol. 2011;34(4):155-160. doi:10.1097/WNF.0b013e318220d8c6
National Institutes of Health.Dietary supplement label database.
Chen Z, Wang Z, Yuan H, He N.From tea leaves to factories: a review of research progress in l-theanine biosynthesis and production. JAgric Food Chem. 2021;69(4):1187-1196. doi:10.1021/acs.jafc.0c06694
Boros K, Jedlinszki N, Csupor D.Theanine and caffeine content of infusions prepared from commercial tea samples.Pharmacogn Mag. 2016;12(45):75-79. doi:10.4103/0973-1296.176061
Meet Our Medical Expert Board
Share Feedback
Was this page helpful?Thanks for your feedback!What is your feedback?OtherHelpfulReport an ErrorSubmit
Was this page helpful?
Thanks for your feedback!
What is your feedback?OtherHelpfulReport an ErrorSubmit
What is your feedback?