Key TakeawaysLyme disease is becoming common in more parts of the U.S., but there are currently no Lyme vaccines on the market.There are multiple Lyme disease vaccines in the pipeline, including one that could be available next season.One product in development is a prophylaxis that delivers antibodies directly to the vaccinated person, rather than asking the immune system to produce antibodies, as traditional vaccines do.

Key Takeaways

Lyme disease is becoming common in more parts of the U.S., but there are currently no Lyme vaccines on the market.There are multiple Lyme disease vaccines in the pipeline, including one that could be available next season.One product in development is a prophylaxis that delivers antibodies directly to the vaccinated person, rather than asking the immune system to produce antibodies, as traditional vaccines do.

Spring is turning to summer and the ticks are ready to start biting.

As climate change shortens winters, warm-weather-loving ticks stay active for longer. Meanwhile, construction developments break up ecosystems, and the deer and mice that act as reservoirs for the Lyme-causing bacteria romp through suburbs unchecked.

Climate Change Will Aggravate the Spread of More Than 200 Infectious Diseases

The number of Lyme disease cases reported to the Centers for Disease Control and Prevention (CD) has more than doubled in the last 20 years. More than 475,000 people are diagnosed or treated for Lyme disease each year, according to CDC estimates. Once contained to small sections of the Northeast U.S. and Midwest, Lyme disease cases have skyrocketed in those regions, and tick-borne diseases are proliferating in Western states.

The rash, fever, and fatigue that typically accompany Lyme disease usually clear up after a few weeks of oral antibiotic treatment. But if left untreated for long enough, the disease can spread to the heart, joints, and nervous system, causing pain and difficulties thinking for more than six months after treatment.

But there is no pharmacological way topreventLyme disease from taking hold after a tick bite—at least not in humans. Dogs have been getting vaccinated against Lyme for more than 30 years.

Don’t Make These Common Mistakes When Checking for Ticks

A Fraught History of Lyme Vaccines

Twenty-five years ago, a vaccine called LYMErix debuted. It was shown to be 76% effective at preventing Lyme disease.

For decades, other companies kept out of the market, fearing the same outcome.

But Lyme is no longer considered a rare disease, and increasingly greater portions of the U.S. population live in areas where Lyme is endemic, saidSam Telford, MS, SD,professor of infectious diseases and global health at Tufts University, who helped run the LYMErix clinical trials.

“Mothers are fed up with checking their children for ticks every day,” Telford told Verywell. “It affects people’s quality of life. If they can’t enjoy their backyard, if they can’t go out and walk in the woods to pick blueberries, have their children play in the yard without worrying about them kicking a ball off into the edge of the yard, that diminishes from the enjoyment of their home and community.”

About 85% of Lyme cases in the U.S. occur between Memorial Day and the end of July, when young ticks the size of poppy seeds can go unnoticed.If an infected burrowing tick goes unnoticed for more than a day, its saliva can enter its host’s bloodstream, passing along Lyme-causing bacteria.

A New Type of Prevention Shot

What Purpose Do Vaccinations Serve?

A group of researchers at MassBiologics are taking a different approach—aprophylaxisshot that delivers monoclonal antibodies directly to the individual.

When a tick bites, it sucks up some of the host’s blood into its stomach. If that individual is protected with Lyme PrEP, as the product is currently called, the tick will ingest some antibodies, too. These neutralize a key protein on the outside ofBorrelia burgdorferi, the bacterium that causes most cases of Lyme disease in the U.S. This keeps the bacteria stuck in the tick’s gut and out of the host’s bloodstream.

People living in places where Lyme is endemic could get a dose that will protect them for the duration of tick season, according toMark Klempner, MD, professor of medicine and executive vice chancellor emeritus for MassBiologics of UMass Chan Medical School.

For people traveling to a high-tick area, such as those on vacation or military personnel being deployed, a one-time small-dose PrEP shot could be much more temporary, staying in their system for only a few weeks or a month.

“Depending on the dose, we think that your protection could be tailored for anywhere from a month or two months, if that’s all you wanted or needed, to up to nine months,” Klempner said. “I think most consumers today think, ‘I want to take a medicine when I need it, and then I want it to be gone.’ And that’s the kind of thing that you can do with amonoclonal antibody.”

The Lyme bacteria is a weak antigen, which makes it difficult for most people to mount an immune response. Giving the antibodies directly to the individual, rather than asking the immune system to produce them, means people receiving Lyme PrEP are likely to be protected regardless of the strength of their immune system, Klempner said.

Lyme PrEP has only been tested in a phase 1 clinical trial to date. Future trials will test the duration of protection and other key safety and efficacy measures. Klempner said his team plans to run a phase 3 clinical trial next summer and seek FDA approval in 2025.

Is Lyme Disease Curable?

A More Traditional Vaccine Could Be Available Next Summer

According to the companies,phase 2 clinical trials showedthe vaccine was safe in people as young as 5 and protective for more than six months. In February, the companiesannouncedthat the phase 3 trial is delayed as they had to discontinue half the study participants for issues unrelated to safety.

Both VLA15 and Lyme PrEP target the sameBorreliaprotein as the ill-fated LYMErix did. Will this time be different?

The answer, Telford said, is probably yes. Unlike the makers of LYMErix, Pfizer and Valneva conducted safety trials early on and included children in their studies.

In addition, general interest in protection from Lyme disease appears to be high. A 2022 study found that nearly two-thirds of survey respondents were willing to get a Lyme disease vaccine, while 7% were totally unwilling.

“It’s hard to believe anyone would argue against trying to protect children,” Telford said. “I remain optimistic on that front, but I do worry that there is going to still be some activism against the vaccine.”

For people who are skeptical of a traditional vaccine, Lyme PrEP could be more appealing.

“There’s a lot of advantage to having choices,” Telford said. Everybody has their own picture of risk and their own picture of what they think they need. Having more than one option is going to be fantastic for everybody.”

Other Ways to Prevent Tick-borne Illness

While Lyme is the most common of the tick-borne diseases, it’s not the only one, saidNeeta Pardanani Connally, MSPH, PhD, professor of biology and Director of the Tickborne Disease Prevention Laboratory at Western Connecticut State University.

Ticks in the U.S. can carry pathogens that cause 16 diseases, includingPowassan virus disease,ehrlichiosis, andbabesiosis. Anti-Lyme vaccines won’t protect against these other diseases.

“People should familiarize themselves with the types of ticks that live in their region and should make sure to take preventive measures for themselves, their kids, and their pets,” Connally told Verywell in an email. “We recommend bathing after outdoor activity, performing daily tick checks, and using a tick preventive product on ticks all year long.”

Symptoms of a Tick Bite

Wearing long pants, long-sleeved shirts, and other protective clothing makes it more challenging for ticks to latch onto your skin. Wearing socks and pants treated with permethrin or otherEPA-registeredrepellents can repel ticks. Raking leaves and removing excess vegetation can make a yard less habitable for ticks.

Just as most people automatically reach for a helmet before getting on a bike, or buckle themselves into their seat, they should also reach for insect repellent to protect against tick- and other insect-borne infections, Telford said.

What This Means For YouThere is no human vaccine for Lyme disease yet, but there are steps you can take to prevent infection. If you live in a place where Lyme disease is endemic, experts recommend checking for ticks daily. Remove the tick promptly, shower afterward, and watch for signs of fever or other symptoms of Lyme disease.

What This Means For You

There is no human vaccine for Lyme disease yet, but there are steps you can take to prevent infection. If you live in a place where Lyme disease is endemic, experts recommend checking for ticks daily. Remove the tick promptly, shower afterward, and watch for signs of fever or other symptoms of Lyme disease.

5 SourcesVerywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read oureditorial processto learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.Centers for Disease Control and Prevention.Lyme disease.Steere AC, Sikand VK, Meurice F, et al.Vaccination against Lyme disease with recombinantBorrelia burgdorferiouter-surface lipoprotein A with adjuvant.N Engl J Med. 1998;339(4):209-215. doi:10.1056/NEJM199807233390401Nigrovic LE, Thompson KM.The Lyme vaccine: a cautionary tale.Epidemiol Infect. 2007;135(1):1-8. doi:10.1017/S0950268806007096Centers for Disease Control and Prevention.Lyme disease: surveillance data.Hook SA, Hansen AP, Niesobecki SA, et al.Evaluating public acceptability of a potential Lyme disease vaccine using a population-based, cross-sectional survey in high incidence areas of the United States.Vaccine.2022;40(2):298-305. doi:10.1016/j.vaccine.2021.11.065

5 Sources

Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read oureditorial processto learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.Centers for Disease Control and Prevention.Lyme disease.Steere AC, Sikand VK, Meurice F, et al.Vaccination against Lyme disease with recombinantBorrelia burgdorferiouter-surface lipoprotein A with adjuvant.N Engl J Med. 1998;339(4):209-215. doi:10.1056/NEJM199807233390401Nigrovic LE, Thompson KM.The Lyme vaccine: a cautionary tale.Epidemiol Infect. 2007;135(1):1-8. doi:10.1017/S0950268806007096Centers for Disease Control and Prevention.Lyme disease: surveillance data.Hook SA, Hansen AP, Niesobecki SA, et al.Evaluating public acceptability of a potential Lyme disease vaccine using a population-based, cross-sectional survey in high incidence areas of the United States.Vaccine.2022;40(2):298-305. doi:10.1016/j.vaccine.2021.11.065

Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read oureditorial processto learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.

Centers for Disease Control and Prevention.Lyme disease.Steere AC, Sikand VK, Meurice F, et al.Vaccination against Lyme disease with recombinantBorrelia burgdorferiouter-surface lipoprotein A with adjuvant.N Engl J Med. 1998;339(4):209-215. doi:10.1056/NEJM199807233390401Nigrovic LE, Thompson KM.The Lyme vaccine: a cautionary tale.Epidemiol Infect. 2007;135(1):1-8. doi:10.1017/S0950268806007096Centers for Disease Control and Prevention.Lyme disease: surveillance data.Hook SA, Hansen AP, Niesobecki SA, et al.Evaluating public acceptability of a potential Lyme disease vaccine using a population-based, cross-sectional survey in high incidence areas of the United States.Vaccine.2022;40(2):298-305. doi:10.1016/j.vaccine.2021.11.065

Centers for Disease Control and Prevention.Lyme disease.

Steere AC, Sikand VK, Meurice F, et al.Vaccination against Lyme disease with recombinantBorrelia burgdorferiouter-surface lipoprotein A with adjuvant.N Engl J Med. 1998;339(4):209-215. doi:10.1056/NEJM199807233390401

Nigrovic LE, Thompson KM.The Lyme vaccine: a cautionary tale.Epidemiol Infect. 2007;135(1):1-8. doi:10.1017/S0950268806007096

Centers for Disease Control and Prevention.Lyme disease: surveillance data.

Hook SA, Hansen AP, Niesobecki SA, et al.Evaluating public acceptability of a potential Lyme disease vaccine using a population-based, cross-sectional survey in high incidence areas of the United States.Vaccine.2022;40(2):298-305. doi:10.1016/j.vaccine.2021.11.065

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