Minocycline vs Doxycycline: What You Need to Know

Table of ContentsView AllTable of ContentsMinocycline vs. Doxycycline SimilaritiesWhy Take Minocycline or Doxycycline?Side Effects and SafetyHow to Choose Between Minocycline and Doxycycline

Table of ContentsView All

View All

Table of Contents

Minocycline vs. Doxycycline Similarities

Why Take Minocycline or Doxycycline?

Side Effects and Safety

How to Choose Between Minocycline and Doxycycline

Minocyclineanddoxycyclineare antibiotics commonly prescribed for various medical conditions.

Minocycline and doxycycline are effective against a variety of bacteria. Because of this, they can treat a wide range of bacterial infections, from pneumonia to sexually transmitted infections (STIs).

Milko / Getty Images

Minocycline (brand names include Dynacin, Minocin, and Solodyn) and doxycycline (brand names include Vibramycin, Oracea, and Doryx) have many shared characteristics.

They’re both in thetetracyclinefamily ofantibiotics.

Both medicines have broad-spectrum activity againstbacteria, which means that they are effective against the major types of bacteria that cause disease, including:

They are also effective against other microorganisms that cause infections, including someparasites.

Notably, many gram-positive organisms have developedresistanceto both minocycline and doxycycline.This means these bacteria have learned how to evade the antibiotics, making the medicines ineffective.

These antibiotics are taken for specific indications, includingbacterial infectionsandacne.

Both doxycycline and minocycline may be taken for conditions including but not limited to the following:

There are a few differences to keep in mind between the two antibiotics. Some scenarios dictate using one versus the other. Here are a few examples:

Your healthcare provider is the best resource to help determine which medicine will treat your infection.

Side Effects

The tetracycline class of antibiotics as a whole is associated with the following potential side effects:

Though minocycline and doxycycline can cause any of these, there are some nuances to their side effect profiles.

Minocycline Side Effects

Overall, minocycline has a higher rate of side effects than other tetracycline antibiotics.Taking an extended-release (ER) product can lower the risk of side effects.

Minocycline is the only tetracycline that’s able to cross into thebrain,so it can cause side effects in thecentral nervous system(the brain and spinal cord).

These side effects include what are known asvestibulareffects related to the inner ear. They include problems with balance, likenausea,dizziness,vertigo, or problems concentrating.It’s best to not drive or operate heavy machinery if you experience any of these side effects.These effects are usually reversible; they typically go away when you stop taking minocycline.And they’re more likely to occur if you take immediate-release (IR) products.

Other common side effects of minocycline affect up to 10% of people and include:

Serious side effects associated with minocycline are rare.They can include:

Doxycycline Side Effects

On the other hand, side effects associated with doxycycline are more common but less severe. They often affect the gastrointestinal (GI) tract and include:

Keep in mind that doxycycline products are available in multiple forms, including doxycycline hyclate and doxycycline monohydrate. Doxycycline hyclate is more likely to cause GI upset or ulcers.

Doxycycline can also cause photosensitivity, so be sure to use plenty of sunscreen if you spend time outside.

Interactions

Tetracycline antibiotics are not likely to cause significant drug interactions.That said, both minocycline and doxycycline can interact with the following medications:

There are a few differences to note:

Safe and Responsible Use of AntibioticsAntibiotics are invaluable tools for combating certain bacterial infections. But they are ineffective againstvirusesthat causecoldsandflu. And sometimes, they’re not even needed for bacterial infections: someear infectionsandsinus infectionswill clear up on their own.Using antibiotics when you don’t need them can contribute to antibiotic resistance. This means that bacteria learn to outsmart the antibiotics, so they stop working.Antibiotics should be taken at the lowest effective dose and for the shortest duration possible. To prevent resistance, it’s best to use antibiotics for less than four months at a time for most people with acne.

Safe and Responsible Use of Antibiotics

Antibiotics are invaluable tools for combating certain bacterial infections. But they are ineffective againstvirusesthat causecoldsandflu. And sometimes, they’re not even needed for bacterial infections: someear infectionsandsinus infectionswill clear up on their own.Using antibiotics when you don’t need them can contribute to antibiotic resistance. This means that bacteria learn to outsmart the antibiotics, so they stop working.Antibiotics should be taken at the lowest effective dose and for the shortest duration possible. To prevent resistance, it’s best to use antibiotics for less than four months at a time for most people with acne.

Antibiotics are invaluable tools for combating certain bacterial infections. But they are ineffective againstvirusesthat causecoldsandflu. And sometimes, they’re not even needed for bacterial infections: someear infectionsandsinus infectionswill clear up on their own.

Using antibiotics when you don’t need them can contribute to antibiotic resistance. This means that bacteria learn to outsmart the antibiotics, so they stop working.

Antibiotics should be taken at the lowest effective dose and for the shortest duration possible. To prevent resistance, it’s best to use antibiotics for less than four months at a time for most people with acne.

Factors to consider when selecting between minocycline and doxycycline include:

Make sure you discuss treatment options with a healthcare provider to decide which medications are right for you.

Summary

Doxycycline and minocycline are broad-spectrum tetracycline antibiotics that target many of the same disease-causing bacteria.

They’re both commonly taken for acne and bacterial infections like respiratory and skin infections.

Minocycline is more likely to cause side effects than doxycycline, and these side effects can be more serious.

If you’re prescribed these or other antibiotics, follow your healthcare provider’s instructions carefully. Don’t share your medicine with others; complete the entire course, even if you start feeling better before your medicine runs out. This will help ensure the infection is fully treated. To minimize the risk of antibiotic resistance, take antibiotics for the shortest recommended time.

24 SourcesVerywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read oureditorial processto learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.LaPlante KL, Dhand A, Wright K, et al.Re-establishing the utility of tetracycline-class antibiotics for current challenges with antibiotic resistance.Ann Med. 2022;54(1):1686-1700. doi:10.1080/07853890.2022.2085881U.S. Food and Drug Administration.Doxycycline capsules prescribing information.Martins AM, Marto JM, Johnson JL, et al.A review of systemic minocycline side effects and topical minocycline as a safer alternative for treating acne and rosacea.Antibiotics (Basel). 2021;10(7):757. Published 2021 Jun 22. doi:10.3390/antibiotics10070757Carris NW, Pardo J, Montero J, et al.Minocycline as a substitute for doxycycline in targeted scenarios: a systematic review.Open Forum Infect Dis. 2015;2(4):ofv178. Published 2015 Nov 25. doi:10.1093/ofid/ofv178Bidell MR, Pai MAP, Lodise TP.Use of oral tetracyclines in the treatment of adult patients with community-acquired bacterial pneumonia: a literature review on the often-overlooked antibiotic class.Antibiotics (Basel). 2020;9(12):905. Published 2020 Dec 14. doi:10.3390/antibiotics9120905Bidell MR, Lodise TP.Use of oral tetracyclines in the treatment of adult outpatients with skin and skin structure infections: focus on doxycycline, minocycline, and omadacycline.Pharmacotherapy. 2021;41(11):915-931. doi:10.1002/phar.2625Peyriere H, Makinson A, Marchandin H, et al.Doxycycline in the management of sexually transmitted infections.J Antimicrob Chemother. 2018;73(3):553-563. doi:10.1093/jac/dkx420Laux B.Treatment of acne vulgaris. A comparison of doxycycline versus minocycline.Hautarzt. 1989;40(9):577-581.Navarro-Triviño FJ, Pérez-López I, Ruiz-Villaverde R.Doxycycline, an antibiotic or an anti-inflammatory agent? The most common uses in dermatology. Doxiciclina, ¿antibiótico o antiinflamatorio? Usos más frecuentes en dermatología.Actas Dermosifiliogr (Engl Ed). 2020;111(7):561-566. doi:10.1016/j.ad.2019.12.006Armstrong AW, Hekmatjah J, Kircik LH.Oral tetracyclines and acne: a systematic review for dermatologists.J Drugs Dermatol. 2020;19(11):s6-s13.Graber EM.Treating acne with the tetracycline class of antibiotics: a review.Dermatological Reviews. doi:10.1002/der2.49Singh S, Khanna D, Kalra S.Minocycline and doxycycline: more than antibiotics.Curr Mol Pharmacol. 2021;14(6):1046-1065. doi:10.2174/1874467214666210210122628Abdi SN, Ghotaslou R, Ganbarov K, et al.Acinetobacter baumanniiefflux pumps and antibiotic resistance.Infect Drug Resist. 2020;13:423-434. Published 2020 Feb 12. doi:10.2147/IDR.S228089Cunha BA.Minocycline, often forgotten but preferred to trimethoprim-sulfamethoxazole or doxycycline for the treatment of community-acquired meticillin-resistantStaphylococcus aureusskin and soft-tissue infections.Int J Antimicrob Agents. 2013;42(6):497-499. doi:10.1016/j.ijantimicag.2013.08.006U.S. Food and Drug Administration.Minocycline hydrochloride prescribing information.Kohli M, Medland N, Fifer H, et al.BASHH updated position statement on doxycycline as prophylaxis for sexually transmitted infections.Sex Transm Infect. 2022;98(3):235-236. doi:10.1136/sextrans-2022-055425Angelette AL, Rando LL, Wadhwa RD, et al.Tetracycline-, doxycycline-, minocycline-induced pseudotumor cerebri and esophageal perforation.Adv Ther. 2023;40(4):1366-1378. doi:10.1007/s12325-023-02435-yBaldwin H.Oral antibiotic treatment options for acne vulgaris.J Clin Aesthet Dermatol. 2020;13(9):26-32.Chan PA, Le Brazidec DL, Becasen JS, et al.Safety of longer-term doxycycline use: a systematic review and meta-analysis with implications for bacterial sexually transmitted infection chemoprophylaxis.Sex Transm Dis. 2023;50(11):701-712. doi:10.1097/OLQ.0000000000001865Eljaaly K, Alghamdi H, Almehmadi H, et al.Long-term gastrointestinal adverse effects of doxycycline.J Infect Dev Ctries. 2023;17(2):281-285. Published 2023 Feb 28. doi:10.3855/jidc.16677U.S. Food and Drug Administration.DORYX® (doxycycline hyclate) Delayed-Release Tablet prescribing information.Centers for Disease Control and Prevention.Antibiotic use and antimicrobial resistance facts.Newman KQ, Castles CG.Use of doxycycline in a patient following minocycline-induced lupus.Case Rep Rheumatol. 2023;2023:7353644. Published 2023 Jul 5. doi:10.1155/2023/7353644American Society of Health-Systems Pharmacists.Comparison of doxycycline and minocycline.

24 Sources

Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read oureditorial processto learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.LaPlante KL, Dhand A, Wright K, et al.Re-establishing the utility of tetracycline-class antibiotics for current challenges with antibiotic resistance.Ann Med. 2022;54(1):1686-1700. doi:10.1080/07853890.2022.2085881U.S. Food and Drug Administration.Doxycycline capsules prescribing information.Martins AM, Marto JM, Johnson JL, et al.A review of systemic minocycline side effects and topical minocycline as a safer alternative for treating acne and rosacea.Antibiotics (Basel). 2021;10(7):757. Published 2021 Jun 22. doi:10.3390/antibiotics10070757Carris NW, Pardo J, Montero J, et al.Minocycline as a substitute for doxycycline in targeted scenarios: a systematic review.Open Forum Infect Dis. 2015;2(4):ofv178. Published 2015 Nov 25. doi:10.1093/ofid/ofv178Bidell MR, Pai MAP, Lodise TP.Use of oral tetracyclines in the treatment of adult patients with community-acquired bacterial pneumonia: a literature review on the often-overlooked antibiotic class.Antibiotics (Basel). 2020;9(12):905. Published 2020 Dec 14. doi:10.3390/antibiotics9120905Bidell MR, Lodise TP.Use of oral tetracyclines in the treatment of adult outpatients with skin and skin structure infections: focus on doxycycline, minocycline, and omadacycline.Pharmacotherapy. 2021;41(11):915-931. doi:10.1002/phar.2625Peyriere H, Makinson A, Marchandin H, et al.Doxycycline in the management of sexually transmitted infections.J Antimicrob Chemother. 2018;73(3):553-563. doi:10.1093/jac/dkx420Laux B.Treatment of acne vulgaris. A comparison of doxycycline versus minocycline.Hautarzt. 1989;40(9):577-581.Navarro-Triviño FJ, Pérez-López I, Ruiz-Villaverde R.Doxycycline, an antibiotic or an anti-inflammatory agent? The most common uses in dermatology. Doxiciclina, ¿antibiótico o antiinflamatorio? Usos más frecuentes en dermatología.Actas Dermosifiliogr (Engl Ed). 2020;111(7):561-566. doi:10.1016/j.ad.2019.12.006Armstrong AW, Hekmatjah J, Kircik LH.Oral tetracyclines and acne: a systematic review for dermatologists.J Drugs Dermatol. 2020;19(11):s6-s13.Graber EM.Treating acne with the tetracycline class of antibiotics: a review.Dermatological Reviews. doi:10.1002/der2.49Singh S, Khanna D, Kalra S.Minocycline and doxycycline: more than antibiotics.Curr Mol Pharmacol. 2021;14(6):1046-1065. doi:10.2174/1874467214666210210122628Abdi SN, Ghotaslou R, Ganbarov K, et al.Acinetobacter baumanniiefflux pumps and antibiotic resistance.Infect Drug Resist. 2020;13:423-434. Published 2020 Feb 12. doi:10.2147/IDR.S228089Cunha BA.Minocycline, often forgotten but preferred to trimethoprim-sulfamethoxazole or doxycycline for the treatment of community-acquired meticillin-resistantStaphylococcus aureusskin and soft-tissue infections.Int J Antimicrob Agents. 2013;42(6):497-499. doi:10.1016/j.ijantimicag.2013.08.006U.S. Food and Drug Administration.Minocycline hydrochloride prescribing information.Kohli M, Medland N, Fifer H, et al.BASHH updated position statement on doxycycline as prophylaxis for sexually transmitted infections.Sex Transm Infect. 2022;98(3):235-236. doi:10.1136/sextrans-2022-055425Angelette AL, Rando LL, Wadhwa RD, et al.Tetracycline-, doxycycline-, minocycline-induced pseudotumor cerebri and esophageal perforation.Adv Ther. 2023;40(4):1366-1378. doi:10.1007/s12325-023-02435-yBaldwin H.Oral antibiotic treatment options for acne vulgaris.J Clin Aesthet Dermatol. 2020;13(9):26-32.Chan PA, Le Brazidec DL, Becasen JS, et al.Safety of longer-term doxycycline use: a systematic review and meta-analysis with implications for bacterial sexually transmitted infection chemoprophylaxis.Sex Transm Dis. 2023;50(11):701-712. doi:10.1097/OLQ.0000000000001865Eljaaly K, Alghamdi H, Almehmadi H, et al.Long-term gastrointestinal adverse effects of doxycycline.J Infect Dev Ctries. 2023;17(2):281-285. Published 2023 Feb 28. doi:10.3855/jidc.16677U.S. Food and Drug Administration.DORYX® (doxycycline hyclate) Delayed-Release Tablet prescribing information.Centers for Disease Control and Prevention.Antibiotic use and antimicrobial resistance facts.Newman KQ, Castles CG.Use of doxycycline in a patient following minocycline-induced lupus.Case Rep Rheumatol. 2023;2023:7353644. Published 2023 Jul 5. doi:10.1155/2023/7353644American Society of Health-Systems Pharmacists.Comparison of doxycycline and minocycline.

Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read oureditorial processto learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.

LaPlante KL, Dhand A, Wright K, et al.Re-establishing the utility of tetracycline-class antibiotics for current challenges with antibiotic resistance.Ann Med. 2022;54(1):1686-1700. doi:10.1080/07853890.2022.2085881U.S. Food and Drug Administration.Doxycycline capsules prescribing information.Martins AM, Marto JM, Johnson JL, et al.A review of systemic minocycline side effects and topical minocycline as a safer alternative for treating acne and rosacea.Antibiotics (Basel). 2021;10(7):757. Published 2021 Jun 22. doi:10.3390/antibiotics10070757Carris NW, Pardo J, Montero J, et al.Minocycline as a substitute for doxycycline in targeted scenarios: a systematic review.Open Forum Infect Dis. 2015;2(4):ofv178. Published 2015 Nov 25. doi:10.1093/ofid/ofv178Bidell MR, Pai MAP, Lodise TP.Use of oral tetracyclines in the treatment of adult patients with community-acquired bacterial pneumonia: a literature review on the often-overlooked antibiotic class.Antibiotics (Basel). 2020;9(12):905. Published 2020 Dec 14. doi:10.3390/antibiotics9120905Bidell MR, Lodise TP.Use of oral tetracyclines in the treatment of adult outpatients with skin and skin structure infections: focus on doxycycline, minocycline, and omadacycline.Pharmacotherapy. 2021;41(11):915-931. doi:10.1002/phar.2625Peyriere H, Makinson A, Marchandin H, et al.Doxycycline in the management of sexually transmitted infections.J Antimicrob Chemother. 2018;73(3):553-563. doi:10.1093/jac/dkx420Laux B.Treatment of acne vulgaris. A comparison of doxycycline versus minocycline.Hautarzt. 1989;40(9):577-581.Navarro-Triviño FJ, Pérez-López I, Ruiz-Villaverde R.Doxycycline, an antibiotic or an anti-inflammatory agent? The most common uses in dermatology. Doxiciclina, ¿antibiótico o antiinflamatorio? Usos más frecuentes en dermatología.Actas Dermosifiliogr (Engl Ed). 2020;111(7):561-566. doi:10.1016/j.ad.2019.12.006Armstrong AW, Hekmatjah J, Kircik LH.Oral tetracyclines and acne: a systematic review for dermatologists.J Drugs Dermatol. 2020;19(11):s6-s13.Graber EM.Treating acne with the tetracycline class of antibiotics: a review.Dermatological Reviews. doi:10.1002/der2.49Singh S, Khanna D, Kalra S.Minocycline and doxycycline: more than antibiotics.Curr Mol Pharmacol. 2021;14(6):1046-1065. doi:10.2174/1874467214666210210122628Abdi SN, Ghotaslou R, Ganbarov K, et al.Acinetobacter baumanniiefflux pumps and antibiotic resistance.Infect Drug Resist. 2020;13:423-434. Published 2020 Feb 12. doi:10.2147/IDR.S228089Cunha BA.Minocycline, often forgotten but preferred to trimethoprim-sulfamethoxazole or doxycycline for the treatment of community-acquired meticillin-resistantStaphylococcus aureusskin and soft-tissue infections.Int J Antimicrob Agents. 2013;42(6):497-499. doi:10.1016/j.ijantimicag.2013.08.006U.S. Food and Drug Administration.Minocycline hydrochloride prescribing information.Kohli M, Medland N, Fifer H, et al.BASHH updated position statement on doxycycline as prophylaxis for sexually transmitted infections.Sex Transm Infect. 2022;98(3):235-236. doi:10.1136/sextrans-2022-055425Angelette AL, Rando LL, Wadhwa RD, et al.Tetracycline-, doxycycline-, minocycline-induced pseudotumor cerebri and esophageal perforation.Adv Ther. 2023;40(4):1366-1378. doi:10.1007/s12325-023-02435-yBaldwin H.Oral antibiotic treatment options for acne vulgaris.J Clin Aesthet Dermatol. 2020;13(9):26-32.Chan PA, Le Brazidec DL, Becasen JS, et al.Safety of longer-term doxycycline use: a systematic review and meta-analysis with implications for bacterial sexually transmitted infection chemoprophylaxis.Sex Transm Dis. 2023;50(11):701-712. doi:10.1097/OLQ.0000000000001865Eljaaly K, Alghamdi H, Almehmadi H, et al.Long-term gastrointestinal adverse effects of doxycycline.J Infect Dev Ctries. 2023;17(2):281-285. Published 2023 Feb 28. doi:10.3855/jidc.16677U.S. Food and Drug Administration.DORYX® (doxycycline hyclate) Delayed-Release Tablet prescribing information.Centers for Disease Control and Prevention.Antibiotic use and antimicrobial resistance facts.Newman KQ, Castles CG.Use of doxycycline in a patient following minocycline-induced lupus.Case Rep Rheumatol. 2023;2023:7353644. Published 2023 Jul 5. doi:10.1155/2023/7353644American Society of Health-Systems Pharmacists.Comparison of doxycycline and minocycline.

LaPlante KL, Dhand A, Wright K, et al.Re-establishing the utility of tetracycline-class antibiotics for current challenges with antibiotic resistance.Ann Med. 2022;54(1):1686-1700. doi:10.1080/07853890.2022.2085881

U.S. Food and Drug Administration.Doxycycline capsules prescribing information.

Martins AM, Marto JM, Johnson JL, et al.A review of systemic minocycline side effects and topical minocycline as a safer alternative for treating acne and rosacea.Antibiotics (Basel). 2021;10(7):757. Published 2021 Jun 22. doi:10.3390/antibiotics10070757

Carris NW, Pardo J, Montero J, et al.Minocycline as a substitute for doxycycline in targeted scenarios: a systematic review.Open Forum Infect Dis. 2015;2(4):ofv178. Published 2015 Nov 25. doi:10.1093/ofid/ofv178

Bidell MR, Pai MAP, Lodise TP.Use of oral tetracyclines in the treatment of adult patients with community-acquired bacterial pneumonia: a literature review on the often-overlooked antibiotic class.Antibiotics (Basel). 2020;9(12):905. Published 2020 Dec 14. doi:10.3390/antibiotics9120905

Bidell MR, Lodise TP.Use of oral tetracyclines in the treatment of adult outpatients with skin and skin structure infections: focus on doxycycline, minocycline, and omadacycline.Pharmacotherapy. 2021;41(11):915-931. doi:10.1002/phar.2625

Peyriere H, Makinson A, Marchandin H, et al.Doxycycline in the management of sexually transmitted infections.J Antimicrob Chemother. 2018;73(3):553-563. doi:10.1093/jac/dkx420

Laux B.Treatment of acne vulgaris. A comparison of doxycycline versus minocycline.Hautarzt. 1989;40(9):577-581.

Navarro-Triviño FJ, Pérez-López I, Ruiz-Villaverde R.Doxycycline, an antibiotic or an anti-inflammatory agent? The most common uses in dermatology. Doxiciclina, ¿antibiótico o antiinflamatorio? Usos más frecuentes en dermatología.Actas Dermosifiliogr (Engl Ed). 2020;111(7):561-566. doi:10.1016/j.ad.2019.12.006

Armstrong AW, Hekmatjah J, Kircik LH.Oral tetracyclines and acne: a systematic review for dermatologists.J Drugs Dermatol. 2020;19(11):s6-s13.

Graber EM.Treating acne with the tetracycline class of antibiotics: a review.Dermatological Reviews. doi:10.1002/der2.49

Singh S, Khanna D, Kalra S.Minocycline and doxycycline: more than antibiotics.Curr Mol Pharmacol. 2021;14(6):1046-1065. doi:10.2174/1874467214666210210122628

Abdi SN, Ghotaslou R, Ganbarov K, et al.Acinetobacter baumanniiefflux pumps and antibiotic resistance.Infect Drug Resist. 2020;13:423-434. Published 2020 Feb 12. doi:10.2147/IDR.S228089

Cunha BA.Minocycline, often forgotten but preferred to trimethoprim-sulfamethoxazole or doxycycline for the treatment of community-acquired meticillin-resistantStaphylococcus aureusskin and soft-tissue infections.Int J Antimicrob Agents. 2013;42(6):497-499. doi:10.1016/j.ijantimicag.2013.08.006

U.S. Food and Drug Administration.Minocycline hydrochloride prescribing information.

Kohli M, Medland N, Fifer H, et al.BASHH updated position statement on doxycycline as prophylaxis for sexually transmitted infections.Sex Transm Infect. 2022;98(3):235-236. doi:10.1136/sextrans-2022-055425

Angelette AL, Rando LL, Wadhwa RD, et al.Tetracycline-, doxycycline-, minocycline-induced pseudotumor cerebri and esophageal perforation.Adv Ther. 2023;40(4):1366-1378. doi:10.1007/s12325-023-02435-y

Baldwin H.Oral antibiotic treatment options for acne vulgaris.J Clin Aesthet Dermatol. 2020;13(9):26-32.

Chan PA, Le Brazidec DL, Becasen JS, et al.Safety of longer-term doxycycline use: a systematic review and meta-analysis with implications for bacterial sexually transmitted infection chemoprophylaxis.Sex Transm Dis. 2023;50(11):701-712. doi:10.1097/OLQ.0000000000001865

Eljaaly K, Alghamdi H, Almehmadi H, et al.Long-term gastrointestinal adverse effects of doxycycline.J Infect Dev Ctries. 2023;17(2):281-285. Published 2023 Feb 28. doi:10.3855/jidc.16677

U.S. Food and Drug Administration.DORYX® (doxycycline hyclate) Delayed-Release Tablet prescribing information.

Centers for Disease Control and Prevention.Antibiotic use and antimicrobial resistance facts.

Newman KQ, Castles CG.Use of doxycycline in a patient following minocycline-induced lupus.Case Rep Rheumatol. 2023;2023:7353644. Published 2023 Jul 5. doi:10.1155/2023/7353644

American Society of Health-Systems Pharmacists.Comparison of doxycycline and minocycline.

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