Table of ContentsView AllTable of ContentsIbuprofen vs. Naproxen: Which Is More Effective for Arthritis?Ibuprofen vs. Naproxen: Which Is Safer?Naproxen Side EffectsIbuprofen Side EffectsWhich to ChooseFrequently Asked Questions
Table of ContentsView All
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Table of Contents
Ibuprofen vs. Naproxen: Which Is More Effective for Arthritis?
Ibuprofen vs. Naproxen: Which Is Safer?
Naproxen Side Effects
Ibuprofen Side Effects
Which to Choose
Frequently Asked Questions
These two NSAIDs also have differences. For example, naproxen offers long-lasting relief and is taken twice daily. On the other hand, ibuprofen is a shorter-acting anti-inflammatory that is taken every four to six hours.
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They are both available as pills and liquid capsules, but ibuprofen is also available in liquid form. Naproxen is safe for anyone age 12 and over, whereas small doses of ibuprofen can be given to children under age 12, including infants.
The article will cover the similarities and differences between naproxen and ibuprofen, their effectiveness, safety, and side effects for people with arthritis.
Both naproxen and ibuprofen are effective at reducing pain.They are more effective than Tylenol (acetaminophen), which is not an NSAID. Naproxen and ibuprofen are given as first-line (initial) therapies for many types ofarthritis.
Naproxen and ibuprofen are classified as nonselective NSAIDs because they block bothcyclooxygenase 2(COX-2) and cyclooxygenase 1 (COX-1) enzymes. Blocking these enzymes can effectively relieve pain and bring down inflammation.
COX-2 enzymes are involved in pain signaling and inflammation, primarily at the site of inflammation.In addition to those functions, COX-1 enzymes work to protect the stomach lining from digestive juices, so blocking COX-1 can produce undesirable side effects.
Naproxen will stay active in the body for longer than ibuprofen. Its effects can last up to 12 hours, so you only need two doses to get 24-hour coverage. Naproxen is also available as a prescription-strength extended-relief tablet.
Ibuprofen is short-acting, so it needs to be taken every four to six hours.The dosing difference between naproxen and ibuprofen makes naproxen a more convenient option for arthritis pain relief.
Which Non-Steroidal Anti-Inflammatory Drug (NSAID) Is Best?
Taken occasionally and as directed, NSAIDs are generally safe. But long-term use of NSAIDs can lead to heart-related problems, kidney disease, and gastrointestinal (GI) troubles.
Heart Disease
Studies have questioned the safety of NSAIDs like naproxen and ibuprofen due to their effects on cardiovascular health.
Such findings have led the Food and Drug Administration (FDA) to require strong warnings on the drug labels of all NSAID pain relievers related to their risk forheart attackandstrokeif taken in high doses for long periods.The risk for heart attack or stroke from NSAID use is higher for people with preexisting heart disease.
What Is Heart Disease?The terms “heart disease” and “cardiovascular disease” refer to conditions that cause heart and blood vessel problems. Some heart disease conditions arecoronary artery disease,high blood pressure, heart attack, stroke, andcongestive heart failure.
What Is Heart Disease?
The terms “heart disease” and “cardiovascular disease” refer to conditions that cause heart and blood vessel problems. Some heart disease conditions arecoronary artery disease,high blood pressure, heart attack, stroke, andcongestive heart failure.
Naproxen might have a lower risk for heart problems than other NSAIDs. According to a 2017American Journal of Cardiovascular Drugsreport, over-the-counter (OTC) naproxen is believed to pose a minimal cardiovascular risk.
Kidney Problems
Overuse of all NSAIDs can also lead toacute kidney injury.That risk might be higher for some people, including:
Gastrointestinal Troubles
Ibuprofen’s risk forulcersandgastrointestinal (GI) bleeding(esophagus and stomach) is slightly lower than naproxen’s.Healthcare providers recommend taking the lowest effective NSAID dose for the shortest time possible to prevent GI problems.If you are taking NSAID pain relievers to manage arthritis pain, a healthcare provider might prescribe a combination drug of an NSAID and aproton pump inhibitor(PPI) to protect your GI tract. Alternatively, a healthcare provider might suggest adding a PPI to your treatment plan, such as Prilosec (omeprazole) or Nexium (esomeprazole).
Safer Alternatives to NSAIDs
All medications have side effects. Most of them resolve once the body gets used to the drug. Because naproxen and ibuprofen are both NSAIDs, they cause some of the same side effects.
The most common side effects of naproxen are:
More severe side effects of naproxen include:
Do not take more than the recommended dosage for naproxen and ibuprofen to lessen the potential for side effects. Do not take either OTC NSAID for more than 10 days at a time without talking to a healthcare provider first.Smoking cigarettes or drinking alcohol while on NSAIDs can increase your risk for side effects.
Is It Safe to Mix Painkillers and Alcohol?
If you experience severe side effects while taking naproxen or ibuprofen, reach out to a healthcare provider. You should also reach out if you believe you may have taken too much of either drug.
Ibuprofen Dosage: A Guide on How Much to Take
Choosing the Right Medication
There is no right or wrong answer for managing your arthritis pain. You must figure out what works best for you and your overall health.
Determining the best medication for you depends on a few different factors, such as:
What works well for someone else to manage arthritis pain might not work for you. Therefore, you will need to try different pain relievers to see what helps.
Healthcare providers are a good resource for helping you manage your arthritis pain. They can assess your pain and determine whether an OTC NSAID is best or if you might need a more potent pain reliever.
DosageNaproxen comes as both an oral tablet and a liquid gel capsule. The lowest dosage of naproxen recommended for arthritis is 250 milligrams (mg), taken up to twice daily.The maximum recommended dosage for arthritis is 1,500 milligrams per day for limited periods of up to six months for everyone 12 and older.Ibuprofen comes in oral tablets, liquid gel capsules, chewable tablets, liquid drops, and a liquid suspension. It can be taken every four to six hours as needed. The recommended OTC dosages for managing arthritis pain in people ages 12 and up are 200–400 milligrams every four to six hours as needed at no more than 1,200 milligrams daily.The dosing for children 12 and under varies based on the child’s weight.
Dosage
Naproxen comes as both an oral tablet and a liquid gel capsule. The lowest dosage of naproxen recommended for arthritis is 250 milligrams (mg), taken up to twice daily.The maximum recommended dosage for arthritis is 1,500 milligrams per day for limited periods of up to six months for everyone 12 and older.Ibuprofen comes in oral tablets, liquid gel capsules, chewable tablets, liquid drops, and a liquid suspension. It can be taken every four to six hours as needed. The recommended OTC dosages for managing arthritis pain in people ages 12 and up are 200–400 milligrams every four to six hours as needed at no more than 1,200 milligrams daily.The dosing for children 12 and under varies based on the child’s weight.
Naproxen comes as both an oral tablet and a liquid gel capsule. The lowest dosage of naproxen recommended for arthritis is 250 milligrams (mg), taken up to twice daily.The maximum recommended dosage for arthritis is 1,500 milligrams per day for limited periods of up to six months for everyone 12 and older.
Ibuprofen comes in oral tablets, liquid gel capsules, chewable tablets, liquid drops, and a liquid suspension. It can be taken every four to six hours as needed. The recommended OTC dosages for managing arthritis pain in people ages 12 and up are 200–400 milligrams every four to six hours as needed at no more than 1,200 milligrams daily.The dosing for children 12 and under varies based on the child’s weight.
Summary
Both ibuprofen and naproxen are part of a class of drugs called NSAIDs. They are effective pain relievers for arthritis pain. They are fast-acting and work similarly to reduce pain and bring down inflammation.
Because they are both NSAIDs, they cause many of the same side effects. However, the risk for heart disease may be higher with ibuprofen. A healthcare provider can help you decide which NSAID is safest and more effective for managing your arthritis pain.
Frequently Asked QuestionsStudies have found that Voltaren (diclofenac) is the most effective pain reliever for arthritis.It is available as a prescription in pill form and as a topical gel, which you can buy over the counter (without a prescription).Learn MoreDiclofenac vs. IbuprofenTaking any OTC medication regularly without first talking to a healthcare provider is never a good idea. Do not take OTC pain relievers for more than 10 days. Much like prescription NSAIDs, OTC NSAIDs can cause side effects.Naproxen’s effects last longer than ibuprofen’s, but they are both strong and effective pain relievers. They also are more effective than Tylenol (acetaminophen) and are considered first-line therapies for many types of arthritis.
Studies have found that Voltaren (diclofenac) is the most effective pain reliever for arthritis.It is available as a prescription in pill form and as a topical gel, which you can buy over the counter (without a prescription).Learn MoreDiclofenac vs. Ibuprofen
Studies have found that Voltaren (diclofenac) is the most effective pain reliever for arthritis.It is available as a prescription in pill form and as a topical gel, which you can buy over the counter (without a prescription).
Learn MoreDiclofenac vs. Ibuprofen
Taking any OTC medication regularly without first talking to a healthcare provider is never a good idea. Do not take OTC pain relievers for more than 10 days. Much like prescription NSAIDs, OTC NSAIDs can cause side effects.
Naproxen’s effects last longer than ibuprofen’s, but they are both strong and effective pain relievers. They also are more effective than Tylenol (acetaminophen) and are considered first-line therapies for many types of arthritis.
13 SourcesVerywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read oureditorial processto learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.Crofford LJ.Use of NSAIDs in treating patients with arthritis.Arthritis Res Ther. 2013;15 Suppl 3(Suppl 3):S2. doi:10.1186/ar4174Hunter TS, Robison C, Gerbino PP.Emerging evidence in NSAID pharmacology: important considerations for product selection.Am J Manag Care. 2015;21:S139-S147.National Institutes of Health.NAPROXEN SODIUM tablet, film coated, extended release.MedlinePlus.Ibuprofen.Food and Drug Administration.FDA Drug Safety Communication: FDA strengthens warning that non-aspirin nonsteroidal anti-inflammatory drugs (NSAIDs) can cause heart attacks or strokes.Angiolillo DJ, Weisman SM.Clinical pharmacology and cardiovascular safety of naproxen.Am J Cardiovasc Drugs. 2017;17(2):97-107. doi:10.1007/s40256-016-0200-5Drożdżal S, Lechowicz K, Szostak B, et al.Kidney damage from nonsteroidal anti-inflammatory drugs-Myth or truth? Review of selected literature.Pharmacol Res Perspect. 2021;9(4):e00817. doi:10.1002/prp2.817Goldstein JL, Cryer B.Gastrointestinal injury associated with NSAID use: a case study and review of risk factors and preventative strategies.Drug Healthc Patient Saf. 2015;7:31-41. doi:10.2147/DHPS.S71976Davis A, Robson J.The dangers of NSAIDs: look both ways.Br J Gen Pract. 2016;66(645):172-173. doi:10.3399/bjgp16X684433Over-the-counter pain relievers. Medline Plus.National Prescribers Reference.Naproxen sodium - drug summary.Arthritis Foundation.Ibuprofen (over-the-counter).da Costa BR, Reichenbach S, Keller N, et al.Effectiveness of non-steroidal anti-inflammatory drugs for the treatment of pain in knee and hip osteoarthritis: a network meta-analysis.Lancet. 2017;390(10090):e21-e33. doi:10.1016/S0140-6736(17)31744-0
13 Sources
Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read oureditorial processto learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.Crofford LJ.Use of NSAIDs in treating patients with arthritis.Arthritis Res Ther. 2013;15 Suppl 3(Suppl 3):S2. doi:10.1186/ar4174Hunter TS, Robison C, Gerbino PP.Emerging evidence in NSAID pharmacology: important considerations for product selection.Am J Manag Care. 2015;21:S139-S147.National Institutes of Health.NAPROXEN SODIUM tablet, film coated, extended release.MedlinePlus.Ibuprofen.Food and Drug Administration.FDA Drug Safety Communication: FDA strengthens warning that non-aspirin nonsteroidal anti-inflammatory drugs (NSAIDs) can cause heart attacks or strokes.Angiolillo DJ, Weisman SM.Clinical pharmacology and cardiovascular safety of naproxen.Am J Cardiovasc Drugs. 2017;17(2):97-107. doi:10.1007/s40256-016-0200-5Drożdżal S, Lechowicz K, Szostak B, et al.Kidney damage from nonsteroidal anti-inflammatory drugs-Myth or truth? Review of selected literature.Pharmacol Res Perspect. 2021;9(4):e00817. doi:10.1002/prp2.817Goldstein JL, Cryer B.Gastrointestinal injury associated with NSAID use: a case study and review of risk factors and preventative strategies.Drug Healthc Patient Saf. 2015;7:31-41. doi:10.2147/DHPS.S71976Davis A, Robson J.The dangers of NSAIDs: look both ways.Br J Gen Pract. 2016;66(645):172-173. doi:10.3399/bjgp16X684433Over-the-counter pain relievers. Medline Plus.National Prescribers Reference.Naproxen sodium - drug summary.Arthritis Foundation.Ibuprofen (over-the-counter).da Costa BR, Reichenbach S, Keller N, et al.Effectiveness of non-steroidal anti-inflammatory drugs for the treatment of pain in knee and hip osteoarthritis: a network meta-analysis.Lancet. 2017;390(10090):e21-e33. doi:10.1016/S0140-6736(17)31744-0
Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read oureditorial processto learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.
Crofford LJ.Use of NSAIDs in treating patients with arthritis.Arthritis Res Ther. 2013;15 Suppl 3(Suppl 3):S2. doi:10.1186/ar4174Hunter TS, Robison C, Gerbino PP.Emerging evidence in NSAID pharmacology: important considerations for product selection.Am J Manag Care. 2015;21:S139-S147.National Institutes of Health.NAPROXEN SODIUM tablet, film coated, extended release.MedlinePlus.Ibuprofen.Food and Drug Administration.FDA Drug Safety Communication: FDA strengthens warning that non-aspirin nonsteroidal anti-inflammatory drugs (NSAIDs) can cause heart attacks or strokes.Angiolillo DJ, Weisman SM.Clinical pharmacology and cardiovascular safety of naproxen.Am J Cardiovasc Drugs. 2017;17(2):97-107. doi:10.1007/s40256-016-0200-5Drożdżal S, Lechowicz K, Szostak B, et al.Kidney damage from nonsteroidal anti-inflammatory drugs-Myth or truth? Review of selected literature.Pharmacol Res Perspect. 2021;9(4):e00817. doi:10.1002/prp2.817Goldstein JL, Cryer B.Gastrointestinal injury associated with NSAID use: a case study and review of risk factors and preventative strategies.Drug Healthc Patient Saf. 2015;7:31-41. doi:10.2147/DHPS.S71976Davis A, Robson J.The dangers of NSAIDs: look both ways.Br J Gen Pract. 2016;66(645):172-173. doi:10.3399/bjgp16X684433Over-the-counter pain relievers. Medline Plus.National Prescribers Reference.Naproxen sodium - drug summary.Arthritis Foundation.Ibuprofen (over-the-counter).da Costa BR, Reichenbach S, Keller N, et al.Effectiveness of non-steroidal anti-inflammatory drugs for the treatment of pain in knee and hip osteoarthritis: a network meta-analysis.Lancet. 2017;390(10090):e21-e33. doi:10.1016/S0140-6736(17)31744-0
Crofford LJ.Use of NSAIDs in treating patients with arthritis.Arthritis Res Ther. 2013;15 Suppl 3(Suppl 3):S2. doi:10.1186/ar4174
Hunter TS, Robison C, Gerbino PP.Emerging evidence in NSAID pharmacology: important considerations for product selection.Am J Manag Care. 2015;21:S139-S147.
National Institutes of Health.NAPROXEN SODIUM tablet, film coated, extended release.
MedlinePlus.Ibuprofen.
Food and Drug Administration.FDA Drug Safety Communication: FDA strengthens warning that non-aspirin nonsteroidal anti-inflammatory drugs (NSAIDs) can cause heart attacks or strokes.
Angiolillo DJ, Weisman SM.Clinical pharmacology and cardiovascular safety of naproxen.Am J Cardiovasc Drugs. 2017;17(2):97-107. doi:10.1007/s40256-016-0200-5
Drożdżal S, Lechowicz K, Szostak B, et al.Kidney damage from nonsteroidal anti-inflammatory drugs-Myth or truth? Review of selected literature.Pharmacol Res Perspect. 2021;9(4):e00817. doi:10.1002/prp2.817
Goldstein JL, Cryer B.Gastrointestinal injury associated with NSAID use: a case study and review of risk factors and preventative strategies.Drug Healthc Patient Saf. 2015;7:31-41. doi:10.2147/DHPS.S71976
Davis A, Robson J.The dangers of NSAIDs: look both ways.Br J Gen Pract. 2016;66(645):172-173. doi:10.3399/bjgp16X684433
Over-the-counter pain relievers. Medline Plus.
National Prescribers Reference.Naproxen sodium - drug summary.
Arthritis Foundation.Ibuprofen (over-the-counter).
da Costa BR, Reichenbach S, Keller N, et al.Effectiveness of non-steroidal anti-inflammatory drugs for the treatment of pain in knee and hip osteoarthritis: a network meta-analysis.Lancet. 2017;390(10090):e21-e33. doi:10.1016/S0140-6736(17)31744-0
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