Table of ContentsView AllTable of ContentsProgesterone SupplementsWhat Is Progesterone?SafetyAlternativesProgesterone Replacement Therapy

Table of ContentsView All

View All

Table of Contents

Progesterone Supplements

What Is Progesterone?

Safety

Alternatives

Progesterone Replacement Therapy

If you have low progesterone levels, you may consider taking a progesterone supplement to increase them.

Progesterone, a hormone produced naturally in the body, is vital to your reproductive health and maintaining a healthy pregnancy.

It’s important to remember that your progesterone levels are also a part of your broader hormonal picture. In concert with other hormones like estrogen and androgens, progesterone helps regulate sleep, mood, bone health, cognition, mental health, cardiovascular health, and weight.

In females, progesterone helps manage symptoms of endometriosis, as well as perimenopause and menopause, such as hot flashes and mood swings. Attending to these symptoms through effective treatment is vital to improving quality of life and overall health and is critical to a healthy aging strategy.

Though progesterone supplements may support your body, they typically will not contain actual progesterone.

In the United States, the Food and Drug Administration (FDA) does not regulate supplements like prescription medications. This means some supplement products may not contain what the label says. Whenchoosing a supplement, look for independently tested products and consult a healthcare provider, registered dietitian nutritionist (RDN or RD), or pharmacist.

MTStock Studio / Getty Images

A young Asian female takes supplements while wrapped in a blanket.

People have taken progesterone supplements, either alone or in combination with other supplements or prescription medications, to try to increase theirprogesteronelevels. They typically do this because their progesterone levels are low, possibly due to specific conditions or the natural aging process.

As mentioned, though progesterone supplements may support your body’s progesterone production, they donotcontain the progesterone hormone. Supplements studied for their potential impact on the body’s production of progesterone include the following:

Progesterone is a natural hormone that plays a vital role in your reproductive system and beyond.In males, thetestesandadrenal cortex(a part of the adrenal gland) produce testosterone.In females, thecorpus luteum(a structure in theovary), the adrenal cortex, and theplacenta(in the case of pregnancy) are the primary producers of progesterone.

Progesterone is critical in regulating menstrual cycles, maintaining a healthyendometrium(uterus lining), and overall hormone balance. It is also essential for maintaining pregnancy. The root word “progesterone” itself essentially means “for pregnancy.“It’s also an essential starting material for other hormones, such asaldosterone,cortisol,estradiol, andtestosterone.

Progesterone production tends to decline with the onset ofperimenopause, and issues may occur if its levels are too low. Studies suggest that females with optimal progesterone levels may experience better sleep, emotional resilience, and more.

Healthcare providers may prescribe specific medications to increase progesterone levels for conditions that require it.

Is a Progesterone Supplement Safe for Me?

Though hormone-related supplements can offer benefits, taking them with caution is essential.

Critical precautions for specific supplements taken to increase progesterone include the following:

Interactions

Keep in mind the following interactions when considering progesterone supplements:

Dosage

The following includes dosages used in research studies and amounts needed according to dietary guidelines:

Consult your healthcare provider to avoid adverse effects or interactions before taking a progesterone supplement.

Alternative Ways to Support Your Progesterone Levels

In addition to supplements, lifestyle and therapeutic approaches may help support healthy progesterone levels.

Some of the following have better evidence to support their effectiveness than others:

Please consult your healthcare provider to determine if any of the above suits you.

The following prescription medications are taken to increase progesterone levels:

Healthcare providers typically prescribe synthetic progesterone (known as progestin) to treat or prevent the following:

Summary

Progesterone is a hormone essential for reproductive function, including the maintenance of pregnancy.

In addition to prescription progesterone medications and certain lifestyle and dietary strategies, supplements that purportedly support progesterone production include DIM, folic acid, red clover extract, zinc, and vitamin D.

It is important to consult with your healthcare provider before starting progesterone supplements because they may interact with certain prescription medications.

30 Sources

Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read oureditorial processto learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.

Bulletti C, Bulletti FM, Sciorio R, Guido M.Progesterone: the key factor of the beginning of life.Int J Mol Sci. 2022;23(22):14138. Published 2022 Nov 16. doi:10.3390/ijms232214138

Prior JC.Progesterone for the prevention and treatment of osteoporosis in women.Climacteric. 2018;21(4):366-374. doi:10.1080/13697137.2018.1467400

Süss H, Willi J, Grub J, Ehlert U.Estradiol and progesterone as resilience markers? – findings from the Swiss Perimenopause Study.Psychoneuroendocrinology. 2021;127:105177. doi:10.1016/j.psyneuen.2021.105177

Reyes-Hernández OD, Figueroa-González G, Quintas-Granados LI, et al.3,3'-Diindolylmethane and indole-3-carbinol: potential therapeutic molecules for cancer chemoprevention and treatment via regulating cellular signaling pathways.Cancer Cell Int. 2023;23(1):180. Published 2023 Aug 26. doi:10.1186/s12935-023-03031-4

Tang J, Chen LR, Chen KH.The utilization of dehydroepiandrosterone as a sexual hormone precursor in premenopausal and postmenopausal women: An overview.Pharmaceuticals (Basel). 2021;15(1):46. Published 2021 Dec 29. doi:10.3390/ph15010046

Taraborrelli S.Physiology, production and action of progesterone.Acta Obstet Gynecol Scand. 2015;94 Suppl 161:8-16. doi:10.1111/aogs.12771

Obidiegwu JE, Lyons JB, Chilaka CA.TheDioscoreagenus (yam)—an appraisal of nutritional and therapeutic potentials.Foods. 2020;9(9):1304. Published 2020 Sep 16. doi:10.3390/foods9091304

Lee JH, Dean M, Austin JR, et al.Irilone from red clover (Trifolium pratense) potentiates progesterone signaling.J Nat Prod. 2018;81(9):1962-1967. doi:10.1021/acs.jnatprod.8b00131

Gaskins AJ, Mumford SL, Chavarro JE, et al.The impact of dietary folate intake on reproductive function in premenopausal women: a prospective cohort study.PLoS One. 2012;7(9):e46276. doi:10.1371/journal.pone.0046276

Lu X, Zhang Q, Xu L, et al.Zinc is essential for the transcription function of the PGC-1α/Nrf2 signaling pathway in human primary endometrial stromal cells.Am J Physiol Cell Physiol. 2020;318(3):C640-C648. doi:10.1152/ajpcell.00152.2019

Monastra G, De Grazia S, De Luca L, et al.Vitamin D: a steroid hormone with progesterone-like activity.Eur Rev Med Pharmacol Sci. 2018;22(8):2502-2512. doi:10.26355/eurrev_201804_14845

Donayeva A, Amanzholkyzy A, Abdelazim IA, et al.The relation between vitamin D and the adolescents' mid-luteal estradiol and progesterone.Eur Rev Med Pharmacol Sci. 2023;27(14):6792-6799. doi:10.26355/eurrev_202307_33150

Nagy B, Szekeres-Barthó J, Kovács GL, et al.Key to life: physiological role and clinical implications of progesterone.Int J Mol Sci. 2021;22(20):11039. Published 2021 Oct 13. doi:10.3390/ijms222011039

Haufe A, Baker FC, Leeners B.The role of ovarian hormones in the pathophysiology of perimenopausal sleep disturbances: a systematic review.Sleep Med Rev. 2022;66:101710. doi:10.1016/j.smrv.2022.101710

MedlinePlus.Wild yam.

National Center for Complementary and Integrative Health.Red clover.

Thomson CA, Chow HHS, Wertheim BC, et al.A randomized, placebo-controlled trial of diindolylmethane for breast cancer biomarker modulation in patients taking tamoxifen.Breast Cancer Res Treat. 2017;165(1):97-107. doi:10.1007/s10549-017-4292-7

MedlinePlus.DHEA.

Field MS, Stover PJ.Safety of folic acid.Ann N Y Acad Sci. 2018;1414(1):59-71. doi:10.1111/nyas.13499

MedlinePlus.Zinc.

Otağ A, Hazar M, Otağ İ, Beyleroğlu M.Effect of increasing maximal aerobic exercise on serum gonadal hormones and alpha-fetoprotein in the luteal phase of professional female soccer players.J Phys Ther Sci. 2016;28(3):807-810. doi:10.1589/jpts.28.807

Lee DY, Kim E, Choi MH.Technical and clinical aspects of cortisol as a biochemical marker of chronic stress.BMB Rep. 2015;48(4):209-216. doi:10.5483/bmbrep.2015.48.4.275

Pascoe MC, Thompson DR, Ski CF.Yoga, mindfulness-based stress reduction and stress-related physiological measures: a meta-analysis.Psychoneuroendocrinology. 2017;86:152-168. doi:10.1016/j.psyneuen.2017.08.008

Sundström-Poromaa I, Comasco E, Sumner R, Luders E.Progesterone – friend or foe?Front Neuroendocrinol. 2020;59:100856. doi:10.1016/j.yfrne.2020.100856

Jewson M, Purohit P, Lumsden MA.Progesterone and abnormal uterine bleeding/menstrual disorders.Best Pract Res Clin Obstet Gynaecol. 2020;69:62-73. doi:10.1016/j.bpobgyn.2020.05.004

Kalaitzopoulos DR, Samartzis N, Kolovos GN, et al.Treatment of endometriosis: a review with comparison of 8 guidelines.BMC Womens Health. 2021;21(1):397. Published 2021 Nov 29. doi:10.1186/s12905-021-01545-5

Ryu A, Kim TH.Premenstrual syndrome: a mini review.Maturitas. 2015;82(4):436-440. doi:10.1016/j.maturitas.2015.08.010

Di Renzo GC, Tosto V, Tsibizova V, Fonseca E.Prevention of preterm birth with progesterone.J Clin Med. 2021;10(19):4511. Published 2021 Sep 29. doi:10.3390/jcm10194511

Norman JE.Progesterone and preterm birth. [published correction appears in Int J Gynaecol Obstet. 2020 Dec;151(3):487. doi: 10.1002/ijgo.13390].Int J Gynaecol Obstet. 2020;150(1):24-30. doi:10.1002/ijgo.13187

Meet Our Medical Expert Board

Share Feedback

Was this page helpful?Thanks for your feedback!What is your feedback?OtherHelpfulReport an ErrorSubmit

Was this page helpful?

Thanks for your feedback!

What is your feedback?OtherHelpfulReport an ErrorSubmit

What is your feedback?