Table of ContentsView AllTable of ContentsWhat Is PCOS?Supplements for PCOSCurcuminVitamin DOmega-3 Fatty AcidsCinnamonInositolCoQ10BerberineFrequently Asked Questions
Table of ContentsView All
View All
Table of Contents
What Is PCOS?
Supplements for PCOS
Curcumin
Vitamin D
Omega-3 Fatty Acids
Cinnamon
Inositol
CoQ10
Berberine
Frequently Asked Questions
This article covers the research-based evidence behind some popular supplements that may improve PCOS symptoms and precautions to note if you decide to try them.
PCOS affects up to 1 in 4 females during their reproductive years.Symptomsassociated with PCOS include the following:
Lifestyle modifications like changingbody compositionandnutritioncounseling can benefit some people with PCOS.
Pharmaceutically, PCOS is typically treated withmetformin, other blood sugar medicines called thiazolidinediones, orbirth control pills.
Some supplements, including vitamins and fatty acids, may also provide a benefit.
What Supplements Are Used for PCOS?
Many vitamins and herbal supplements have been studied for their role in PCOS. Below is a brief survey of six popular ones that have evidence to back them up.
Curcumin is a compound found inturmeric, a spice used to flavor many dishes, including curries. It’s also touted as a natural medicine and has shown some benefits for PCOS.
Curcumin affects androgen receptor pathways and can decrease the expression of androgen hormones liketestosterone. It can also stimulate ovulation.
A review of five clinical trials concluded that curcumin improved blood sugar control in females with PCOS.Those who took curcumin had lower fasting blood sugar levels and responded better toinsulin treatmentthan those who took aplacebo(an inactive substance given to people in control groups in studies).
Curcumin has been studied in clinical trials for PCOS in varying doses, ranging from 80 milligrams (mg) daily to 500 mg three times a day.
Studies took place over six to 12 weeks, so not enough is known about long-term safety or effectiveness.
Some possible adverse effects of curcumin include the following:
Turmeric powder and fresh turmeric.Krisanapong Detraphiphat / Getty Images
Krisanapong Detraphiphat / Getty Images
Studies show that up to 85% of females with PCOS have low levels ofvitamin D, a hormone that helps maintain normal blood sugar levels.Vitamin D deficiency may be a risk factor for PCOS, although this conclusion is still controversial.
Vitamin D has been studied for PCOS in doses such as 200 international units (IU) daily and 50,000 IU every two weeks.
Taking high doses of vitamin D, such as 4,000 IU daily for at least 12 weeks, has improved the following levels in females with PCOS:
Like many supplements reviewed here, vitamin D has been studied for PCOS for only six months or less, meaning more research is needed.
Omega-3 fatty acidslike eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are found in fatty fish like salmon and in supplement form. These fatty acids can improve insulin sensitivity.
Small, short-term studies have shown that omega-3 fatty acids benefit PCOS, but more robust clinical trials are needed to verify these effects.Studied dosages range from 900 to 4,000 mg daily for up to 24 weeks.
The greatest evidence of benefit is for females who have PCOS plus eitherinsulin resistanceorhigh cholesterol.Omega-3 fatty acids improved these metrics but did not significantly affect testosterone levels or fasting blood sugar.
While omega-3 fatty acids aren’t routinely recommended for females with PCOS, supplementing with them may be helpful for those over 40 with heart problems or symptoms likehigh triglycerides.
Side effects to watch for mainly affect the gastrointestinal tract and include the following:
It’s essential not to use omega-3 fatty acids when takingblood thinnerslike Jantoven (warfarin) or Eliquis (apixaban).
Cinnamoncan improve the following parameters in females with PCOS, according to a review of five clinical trials:
Cinnamon is unlikely to reduce body weight orbody mass index(BMI), a flawed but widely used measure of body composition.
Clinical trials have used 1,000 mg daily for eight weeks and 1,500 mg daily for six months.Researchers note that long-term studies are needed to determine the actual effect of cinnamon on PCOS.
Adverse effects that were seen in clinical trials of cinnamon for PCOS include:
Inositolis a sugar alcohol in high amounts in the brain and muscles.While it has been referred to as “vitamin B8,” it’s not a vitamin. Inositol can help many aspects of PCOS, including regulating insulin levels and improving reproductive function.It may also help with weight loss.
Inositol was shown to be as effective as the gold-standard PCOS treatment, metformin, in an extensive review of 26 clinical trials.It has a low risk of side effects, according to this review.
Clinical trials have used 4,000 mg of myo-inositol (a form of inositol) in females undergoing in vitro fertilization with PCOS.This dose helped to:
Of note, adding 50 mg of alpha-lactalbumin (α-LA) twice a day can enhance the effects of inositol supplementation and increase the likelihood of ovulation.
Coenzyme Q10 (CoQ10)is anantioxidantfound in heart, liver, and kidney cells.
Supplemental doses of 100 mg daily for 12 weeks improved blood sugar and low-density lipoprotein (LDL, or “bad”) cholesterol levels in females with PCOS.
And 200 mg a day of CoQ10 for eight weeks improvedmarkers of inflammationin a small study of 43 women with PCOS who were overweight or had obesity.Those who took CoQ10 had lowerC-reactive protein (CRP)and interleukin-6 levels, which are elevated during inflammation.
Another clinical trial showed that adding CoQ10 to the prescription medicineclomiphenemade it 6 times more likely for females with PCOS to get pregnant than if they took clomiphene alone.
Side effects of coQ10 include:
Berberine is a natural isoquinoline alkaloid (an organic compound) that comes primarily from plants likeOregon grape(Berberis aquifolium)andgoldenseal.
Clinical trials have studied berberine in people with PCOS alone or in combination with medications like metformin.In these studies, berberine decreasedinsulin resistance, lowered lipid levels, and helped improve ovulation.
The effects of berberine, when used with metformin, have been shown to be somewhat synergistic (they help increase the effects of the medication). However, researchers caution that the quality of the included studies was fairly low, and the results must be interpreted carefully.
In the United States, the Food and Drug Administration (FDA) does not regulate supplements the way it regulates prescription drugs. That means some supplement products may not contain what the label says. Whenchoosing a supplement, look for independently tested products and consult a healthcare provider, registered dietitian nutritionist (RD or RDN), or pharmacist.
Summary
PCOS is a common endocrine disorder that affects up to 25% of females. Several dietary supplements have benefitted symptoms of PCOS, like high blood sugar or menstrual cycle abnormalities. Doses studied in clinical trials vary; discuss these supplements with your healthcare provider, pharmacist, or a registered dietitian for best results and for guidance on optimizing therapy.
Also, remember that most studies reviewing supplements' effects on PCOS were small and lasted six months or less. More robust data is still needed before these supplements can be fully recommended.
Frequently Asked QuestionsVitamin D has proven benefits for PCOS. Up to 85% of females with PCOS have low levels of vitamin D, which is important in blood sugar regulation.Possibly inositol. It’s been shown to be about as effective as metformin for treating PCOS symptoms, and with less side effects.Of the supplements commonly studied, there’s evidence that curcumin,inositol,and CoQ10may restore ovulation.For best results, discuss these supplements with your obstetrician-gynecologist (ob-gyn) before self-treating.
Vitamin D has proven benefits for PCOS. Up to 85% of females with PCOS have low levels of vitamin D, which is important in blood sugar regulation.
Possibly inositol. It’s been shown to be about as effective as metformin for treating PCOS symptoms, and with less side effects.
Of the supplements commonly studied, there’s evidence that curcumin,inositol,and CoQ10may restore ovulation.For best results, discuss these supplements with your obstetrician-gynecologist (ob-gyn) before self-treating.
Of the supplements commonly studied, there’s evidence that curcumin,inositol,and CoQ10may restore ovulation.
For best results, discuss these supplements with your obstetrician-gynecologist (ob-gyn) before self-treating.
20 SourcesVerywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read oureditorial processto learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.Iervolino M, Lepore E, Forte G, et al.Natural molecules in the management of polycystic ovary syndrome (PCOS): An analytical review.Nutrients. 2021;13(5):1677. doi:10.3390/nu13051677Günalan E, Yaba A, Yılmaz B.The effect of nutrient supplementation in the management of polycystic ovary syndrome-associated metabolic dysfunctions: A critical review.J Turk Ger Gynecol Assoc. 2018;19(4):220-232. doi:10.4274/jtgga.2018.0077Satyaraddi A, Cherian KE, Kapoor N, et al.Body composition, metabolic characteristics, and insulin resistance in obese and nonobese women with polycystic ovary syndrome.J Hum Reprod Sci. 2019 Apr-Jun;12(2):78-84. doi: 10.4103/jhrs.JHRS_2_19Yang K, Zeng L, Bao T, et al.Effectiveness of Omega-3 fatty acid for polycystic ovary syndrome: a systematic review and meta-analysis.Reprod Biol Endocrinol. 2018;16(1):27. doi:10.1186/s12958-018-0346-xKiani AK, Donato K, Dhuli K, et al.Dietary supplements for polycystic ovary syndrome.J Prev Med Hyg. 2022;63(2 Suppl 3):E206-E213. doi:10.15167/2421-4248/jpmh2022.63.2S3.2762Abdelazeem B, Abbas KS, Shehata J, et al.The effects of curcumin as dietary supplement for patients with polycystic ovary syndrome: An updated systematic review and meta-analysis of randomized clinical trials.Phytother Res. 2022;36(1):22-32. doi:10.1002/ptr.7274Gokosmanoglu F, Onmez A, Ergenç H.The relationship between Vitamin D deficiency and polycystic ovary syndrome.Afr Health Sci. 2020;20(4):1880-1886. doi:10.4314/ahs.v20i4.45Zhang B, Yao X, Zhong X, et al.Vitamin D supplementation in the treatment of polycystic ovary syndrome: A meta-analysis of randomized controlled trials.Heliyon. 2023;9(3):e14291. doi:10.1016/j.heliyon.2023.e14291Menichini D, Facchinetti F.Effects of vitamin D supplementation in women with polycystic ovary syndrome: a review.Gynecol Endocrinol. 2020;36(1):1-5. doi:10.1080/09513590.2019.1625881Monastra G, De Grazia S, De Luca L, et al.Vitamin D: a steroid hormone with progesterone-like activity.Eur Rev Med Pharmacol Sci. 2018;22(8):2502-2512. doi:10.26355/eurrev_201804_14845Mu Y, Cheng D, Yin TL, et al.Vitamin D and polycystic ovary syndrome: a narrative review.Reprod Sci. 2021;28(8):2110-2117. doi:10.1007/s43032-020-00369-2Alesi S, Ee C, Moran LJ, et al.Nutritional supplements and complementary therapies in polycystic ovary syndrome.Adv Nutr. 2022;13(4):1243-1266. doi:10.1093/advances/nmab141Heydarpour F, Hemati N, Hadi A, et al.Effects of cinnamon on controlling metabolic parameters of polycystic ovary syndrome: A systematic review and meta-analysis.J Ethnopharmacol. 2020;254:112741. doi:10.1016/j.jep.2020.112741Greff D, Juhász AE, Váncsa S, et al.Inositol is an effective and safe treatment in polycystic ovary syndrome: a systematic review and meta-analysis of randomized controlled trials.Reprod Biol Endocrinol. 2023;21(1):10. doi:10.1186/s12958-023-01055-zPacchiarotti A, Carlomagno G, Antonini G, et al.Effect of myo-inositol and melatonin versus myo-inositol, in a randomized controlled trial, for improving in vitro fertilization of patients with polycystic ovarian syndrome.Gynecol Endocrinol. 2016;32(1):69-73. doi:10.3109/09513590.2015.1101444Montanino Oliva M, Buonomo G, Calcagno M, et al.Effects of myo-inositol plus alpha-lactalbumin in myo-inositol-resistant PCOS women.J Ovarian Res. 2018;11(1):38. Published 2018 May 10. doi:10.1186/s13048-018-0411-2Samimi M, Zarezade Mehrizi M, Foroozanfard F, et al.The effects of coenzyme Q10 supplementation on glucose metabolism and lipid profiles in women with polycystic ovary syndrome: a randomized, double-blind, placebo-controlled trial.Clin Endocrinol (Oxf). 2017;86(4):560-566. doi:10.1111/cen.13288Taghizadeh S, Izadi A, Shirazi S, et al.The effect of coenzyme Q10 supplementation on inflammatory and endothelial dysfunction markers in overweight/obese polycystic ovary syndrome patients.Gynecol Endocrinol. 2021;37(1):26-30. doi:10.1080/09513590.2020.1779689Izhar R, Husain S, Tahir MA, et al.Effect of administrating coenzyme Q10 with clomiphene citrate on ovulation induction in polycystic ovary syndrome cases with resistance to clomiphene citrate: a randomized controlled trial.J Reprod Infertil. 2022;23(3):177-183. doi:10.18502/jri.v23i3.10008Zhao H, Xing C, Zhang J, He B.Comparative efficacy of oral insulin sensitizers metformin, thiazolidinediones, inositol, and berberine in improving endocrine and metabolic profiles in women with PCOS: A network meta-analysis.Reprod Health. 2021;18(1):171. doi:10.1186/s12978-021-01207-7
20 Sources
Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read oureditorial processto learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.Iervolino M, Lepore E, Forte G, et al.Natural molecules in the management of polycystic ovary syndrome (PCOS): An analytical review.Nutrients. 2021;13(5):1677. doi:10.3390/nu13051677Günalan E, Yaba A, Yılmaz B.The effect of nutrient supplementation in the management of polycystic ovary syndrome-associated metabolic dysfunctions: A critical review.J Turk Ger Gynecol Assoc. 2018;19(4):220-232. doi:10.4274/jtgga.2018.0077Satyaraddi A, Cherian KE, Kapoor N, et al.Body composition, metabolic characteristics, and insulin resistance in obese and nonobese women with polycystic ovary syndrome.J Hum Reprod Sci. 2019 Apr-Jun;12(2):78-84. doi: 10.4103/jhrs.JHRS_2_19Yang K, Zeng L, Bao T, et al.Effectiveness of Omega-3 fatty acid for polycystic ovary syndrome: a systematic review and meta-analysis.Reprod Biol Endocrinol. 2018;16(1):27. doi:10.1186/s12958-018-0346-xKiani AK, Donato K, Dhuli K, et al.Dietary supplements for polycystic ovary syndrome.J Prev Med Hyg. 2022;63(2 Suppl 3):E206-E213. doi:10.15167/2421-4248/jpmh2022.63.2S3.2762Abdelazeem B, Abbas KS, Shehata J, et al.The effects of curcumin as dietary supplement for patients with polycystic ovary syndrome: An updated systematic review and meta-analysis of randomized clinical trials.Phytother Res. 2022;36(1):22-32. doi:10.1002/ptr.7274Gokosmanoglu F, Onmez A, Ergenç H.The relationship between Vitamin D deficiency and polycystic ovary syndrome.Afr Health Sci. 2020;20(4):1880-1886. doi:10.4314/ahs.v20i4.45Zhang B, Yao X, Zhong X, et al.Vitamin D supplementation in the treatment of polycystic ovary syndrome: A meta-analysis of randomized controlled trials.Heliyon. 2023;9(3):e14291. doi:10.1016/j.heliyon.2023.e14291Menichini D, Facchinetti F.Effects of vitamin D supplementation in women with polycystic ovary syndrome: a review.Gynecol Endocrinol. 2020;36(1):1-5. doi:10.1080/09513590.2019.1625881Monastra G, De Grazia S, De Luca L, et al.Vitamin D: a steroid hormone with progesterone-like activity.Eur Rev Med Pharmacol Sci. 2018;22(8):2502-2512. doi:10.26355/eurrev_201804_14845Mu Y, Cheng D, Yin TL, et al.Vitamin D and polycystic ovary syndrome: a narrative review.Reprod Sci. 2021;28(8):2110-2117. doi:10.1007/s43032-020-00369-2Alesi S, Ee C, Moran LJ, et al.Nutritional supplements and complementary therapies in polycystic ovary syndrome.Adv Nutr. 2022;13(4):1243-1266. doi:10.1093/advances/nmab141Heydarpour F, Hemati N, Hadi A, et al.Effects of cinnamon on controlling metabolic parameters of polycystic ovary syndrome: A systematic review and meta-analysis.J Ethnopharmacol. 2020;254:112741. doi:10.1016/j.jep.2020.112741Greff D, Juhász AE, Váncsa S, et al.Inositol is an effective and safe treatment in polycystic ovary syndrome: a systematic review and meta-analysis of randomized controlled trials.Reprod Biol Endocrinol. 2023;21(1):10. doi:10.1186/s12958-023-01055-zPacchiarotti A, Carlomagno G, Antonini G, et al.Effect of myo-inositol and melatonin versus myo-inositol, in a randomized controlled trial, for improving in vitro fertilization of patients with polycystic ovarian syndrome.Gynecol Endocrinol. 2016;32(1):69-73. doi:10.3109/09513590.2015.1101444Montanino Oliva M, Buonomo G, Calcagno M, et al.Effects of myo-inositol plus alpha-lactalbumin in myo-inositol-resistant PCOS women.J Ovarian Res. 2018;11(1):38. Published 2018 May 10. doi:10.1186/s13048-018-0411-2Samimi M, Zarezade Mehrizi M, Foroozanfard F, et al.The effects of coenzyme Q10 supplementation on glucose metabolism and lipid profiles in women with polycystic ovary syndrome: a randomized, double-blind, placebo-controlled trial.Clin Endocrinol (Oxf). 2017;86(4):560-566. doi:10.1111/cen.13288Taghizadeh S, Izadi A, Shirazi S, et al.The effect of coenzyme Q10 supplementation on inflammatory and endothelial dysfunction markers in overweight/obese polycystic ovary syndrome patients.Gynecol Endocrinol. 2021;37(1):26-30. doi:10.1080/09513590.2020.1779689Izhar R, Husain S, Tahir MA, et al.Effect of administrating coenzyme Q10 with clomiphene citrate on ovulation induction in polycystic ovary syndrome cases with resistance to clomiphene citrate: a randomized controlled trial.J Reprod Infertil. 2022;23(3):177-183. doi:10.18502/jri.v23i3.10008Zhao H, Xing C, Zhang J, He B.Comparative efficacy of oral insulin sensitizers metformin, thiazolidinediones, inositol, and berberine in improving endocrine and metabolic profiles in women with PCOS: A network meta-analysis.Reprod Health. 2021;18(1):171. doi:10.1186/s12978-021-01207-7
Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read oureditorial processto learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.
Iervolino M, Lepore E, Forte G, et al.Natural molecules in the management of polycystic ovary syndrome (PCOS): An analytical review.Nutrients. 2021;13(5):1677. doi:10.3390/nu13051677Günalan E, Yaba A, Yılmaz B.The effect of nutrient supplementation in the management of polycystic ovary syndrome-associated metabolic dysfunctions: A critical review.J Turk Ger Gynecol Assoc. 2018;19(4):220-232. doi:10.4274/jtgga.2018.0077Satyaraddi A, Cherian KE, Kapoor N, et al.Body composition, metabolic characteristics, and insulin resistance in obese and nonobese women with polycystic ovary syndrome.J Hum Reprod Sci. 2019 Apr-Jun;12(2):78-84. doi: 10.4103/jhrs.JHRS_2_19Yang K, Zeng L, Bao T, et al.Effectiveness of Omega-3 fatty acid for polycystic ovary syndrome: a systematic review and meta-analysis.Reprod Biol Endocrinol. 2018;16(1):27. doi:10.1186/s12958-018-0346-xKiani AK, Donato K, Dhuli K, et al.Dietary supplements for polycystic ovary syndrome.J Prev Med Hyg. 2022;63(2 Suppl 3):E206-E213. doi:10.15167/2421-4248/jpmh2022.63.2S3.2762Abdelazeem B, Abbas KS, Shehata J, et al.The effects of curcumin as dietary supplement for patients with polycystic ovary syndrome: An updated systematic review and meta-analysis of randomized clinical trials.Phytother Res. 2022;36(1):22-32. doi:10.1002/ptr.7274Gokosmanoglu F, Onmez A, Ergenç H.The relationship between Vitamin D deficiency and polycystic ovary syndrome.Afr Health Sci. 2020;20(4):1880-1886. doi:10.4314/ahs.v20i4.45Zhang B, Yao X, Zhong X, et al.Vitamin D supplementation in the treatment of polycystic ovary syndrome: A meta-analysis of randomized controlled trials.Heliyon. 2023;9(3):e14291. doi:10.1016/j.heliyon.2023.e14291Menichini D, Facchinetti F.Effects of vitamin D supplementation in women with polycystic ovary syndrome: a review.Gynecol Endocrinol. 2020;36(1):1-5. doi:10.1080/09513590.2019.1625881Monastra G, De Grazia S, De Luca L, et al.Vitamin D: a steroid hormone with progesterone-like activity.Eur Rev Med Pharmacol Sci. 2018;22(8):2502-2512. doi:10.26355/eurrev_201804_14845Mu Y, Cheng D, Yin TL, et al.Vitamin D and polycystic ovary syndrome: a narrative review.Reprod Sci. 2021;28(8):2110-2117. doi:10.1007/s43032-020-00369-2Alesi S, Ee C, Moran LJ, et al.Nutritional supplements and complementary therapies in polycystic ovary syndrome.Adv Nutr. 2022;13(4):1243-1266. doi:10.1093/advances/nmab141Heydarpour F, Hemati N, Hadi A, et al.Effects of cinnamon on controlling metabolic parameters of polycystic ovary syndrome: A systematic review and meta-analysis.J Ethnopharmacol. 2020;254:112741. doi:10.1016/j.jep.2020.112741Greff D, Juhász AE, Váncsa S, et al.Inositol is an effective and safe treatment in polycystic ovary syndrome: a systematic review and meta-analysis of randomized controlled trials.Reprod Biol Endocrinol. 2023;21(1):10. doi:10.1186/s12958-023-01055-zPacchiarotti A, Carlomagno G, Antonini G, et al.Effect of myo-inositol and melatonin versus myo-inositol, in a randomized controlled trial, for improving in vitro fertilization of patients with polycystic ovarian syndrome.Gynecol Endocrinol. 2016;32(1):69-73. doi:10.3109/09513590.2015.1101444Montanino Oliva M, Buonomo G, Calcagno M, et al.Effects of myo-inositol plus alpha-lactalbumin in myo-inositol-resistant PCOS women.J Ovarian Res. 2018;11(1):38. Published 2018 May 10. doi:10.1186/s13048-018-0411-2Samimi M, Zarezade Mehrizi M, Foroozanfard F, et al.The effects of coenzyme Q10 supplementation on glucose metabolism and lipid profiles in women with polycystic ovary syndrome: a randomized, double-blind, placebo-controlled trial.Clin Endocrinol (Oxf). 2017;86(4):560-566. doi:10.1111/cen.13288Taghizadeh S, Izadi A, Shirazi S, et al.The effect of coenzyme Q10 supplementation on inflammatory and endothelial dysfunction markers in overweight/obese polycystic ovary syndrome patients.Gynecol Endocrinol. 2021;37(1):26-30. doi:10.1080/09513590.2020.1779689Izhar R, Husain S, Tahir MA, et al.Effect of administrating coenzyme Q10 with clomiphene citrate on ovulation induction in polycystic ovary syndrome cases with resistance to clomiphene citrate: a randomized controlled trial.J Reprod Infertil. 2022;23(3):177-183. doi:10.18502/jri.v23i3.10008Zhao H, Xing C, Zhang J, He B.Comparative efficacy of oral insulin sensitizers metformin, thiazolidinediones, inositol, and berberine in improving endocrine and metabolic profiles in women with PCOS: A network meta-analysis.Reprod Health. 2021;18(1):171. doi:10.1186/s12978-021-01207-7
Iervolino M, Lepore E, Forte G, et al.Natural molecules in the management of polycystic ovary syndrome (PCOS): An analytical review.Nutrients. 2021;13(5):1677. doi:10.3390/nu13051677
Günalan E, Yaba A, Yılmaz B.The effect of nutrient supplementation in the management of polycystic ovary syndrome-associated metabolic dysfunctions: A critical review.J Turk Ger Gynecol Assoc. 2018;19(4):220-232. doi:10.4274/jtgga.2018.0077
Satyaraddi A, Cherian KE, Kapoor N, et al.Body composition, metabolic characteristics, and insulin resistance in obese and nonobese women with polycystic ovary syndrome.J Hum Reprod Sci. 2019 Apr-Jun;12(2):78-84. doi: 10.4103/jhrs.JHRS_2_19
Yang K, Zeng L, Bao T, et al.Effectiveness of Omega-3 fatty acid for polycystic ovary syndrome: a systematic review and meta-analysis.Reprod Biol Endocrinol. 2018;16(1):27. doi:10.1186/s12958-018-0346-x
Kiani AK, Donato K, Dhuli K, et al.Dietary supplements for polycystic ovary syndrome.J Prev Med Hyg. 2022;63(2 Suppl 3):E206-E213. doi:10.15167/2421-4248/jpmh2022.63.2S3.2762
Abdelazeem B, Abbas KS, Shehata J, et al.The effects of curcumin as dietary supplement for patients with polycystic ovary syndrome: An updated systematic review and meta-analysis of randomized clinical trials.Phytother Res. 2022;36(1):22-32. doi:10.1002/ptr.7274
Gokosmanoglu F, Onmez A, Ergenç H.The relationship between Vitamin D deficiency and polycystic ovary syndrome.Afr Health Sci. 2020;20(4):1880-1886. doi:10.4314/ahs.v20i4.45
Zhang B, Yao X, Zhong X, et al.Vitamin D supplementation in the treatment of polycystic ovary syndrome: A meta-analysis of randomized controlled trials.Heliyon. 2023;9(3):e14291. doi:10.1016/j.heliyon.2023.e14291
Menichini D, Facchinetti F.Effects of vitamin D supplementation in women with polycystic ovary syndrome: a review.Gynecol Endocrinol. 2020;36(1):1-5. doi:10.1080/09513590.2019.1625881
Monastra G, De Grazia S, De Luca L, et al.Vitamin D: a steroid hormone with progesterone-like activity.Eur Rev Med Pharmacol Sci. 2018;22(8):2502-2512. doi:10.26355/eurrev_201804_14845
Mu Y, Cheng D, Yin TL, et al.Vitamin D and polycystic ovary syndrome: a narrative review.Reprod Sci. 2021;28(8):2110-2117. doi:10.1007/s43032-020-00369-2
Alesi S, Ee C, Moran LJ, et al.Nutritional supplements and complementary therapies in polycystic ovary syndrome.Adv Nutr. 2022;13(4):1243-1266. doi:10.1093/advances/nmab141
Heydarpour F, Hemati N, Hadi A, et al.Effects of cinnamon on controlling metabolic parameters of polycystic ovary syndrome: A systematic review and meta-analysis.J Ethnopharmacol. 2020;254:112741. doi:10.1016/j.jep.2020.112741
Greff D, Juhász AE, Váncsa S, et al.Inositol is an effective and safe treatment in polycystic ovary syndrome: a systematic review and meta-analysis of randomized controlled trials.Reprod Biol Endocrinol. 2023;21(1):10. doi:10.1186/s12958-023-01055-z
Pacchiarotti A, Carlomagno G, Antonini G, et al.Effect of myo-inositol and melatonin versus myo-inositol, in a randomized controlled trial, for improving in vitro fertilization of patients with polycystic ovarian syndrome.Gynecol Endocrinol. 2016;32(1):69-73. doi:10.3109/09513590.2015.1101444
Montanino Oliva M, Buonomo G, Calcagno M, et al.Effects of myo-inositol plus alpha-lactalbumin in myo-inositol-resistant PCOS women.J Ovarian Res. 2018;11(1):38. Published 2018 May 10. doi:10.1186/s13048-018-0411-2
Samimi M, Zarezade Mehrizi M, Foroozanfard F, et al.The effects of coenzyme Q10 supplementation on glucose metabolism and lipid profiles in women with polycystic ovary syndrome: a randomized, double-blind, placebo-controlled trial.Clin Endocrinol (Oxf). 2017;86(4):560-566. doi:10.1111/cen.13288
Taghizadeh S, Izadi A, Shirazi S, et al.The effect of coenzyme Q10 supplementation on inflammatory and endothelial dysfunction markers in overweight/obese polycystic ovary syndrome patients.Gynecol Endocrinol. 2021;37(1):26-30. doi:10.1080/09513590.2020.1779689
Izhar R, Husain S, Tahir MA, et al.Effect of administrating coenzyme Q10 with clomiphene citrate on ovulation induction in polycystic ovary syndrome cases with resistance to clomiphene citrate: a randomized controlled trial.J Reprod Infertil. 2022;23(3):177-183. doi:10.18502/jri.v23i3.10008
Zhao H, Xing C, Zhang J, He B.Comparative efficacy of oral insulin sensitizers metformin, thiazolidinediones, inositol, and berberine in improving endocrine and metabolic profiles in women with PCOS: A network meta-analysis.Reprod Health. 2021;18(1):171. doi:10.1186/s12978-021-01207-7
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