Table of ContentsView AllTable of ContentsBefore the 19th Century19th Century21st Century
Table of ContentsView All
View All
Table of Contents
Before the 19th Century
19th Century
21st Century
Even so, what was learned from centuries of trial and error, research, and experimentation led to procedures that are not only commonplace today but highly effective and safe.
These advances continue asrobotic surgery,laser surgery, and microsurgery allow surgeons to treat conditions once thought untreatable. These advances have helped ensure that recovery times are shorter, hospitalization stays are fewer, outcomes are improved, and complications are minimized.
This article provides a timeline of notable surgeries and medical advances from the Stone Age through the early 2020s.
Reza Estakhrian / Getty Images

The concept of surgery was explored well before recorded history, with early surgeons grasping the basic concepts of human anatomy andorgan systems. Among some of the notable findings:
It wasn’t until the 1900s that the likelihood of surviving surgery was greater than the likelihood of dying during or as a result of surgery.
20th Century
During the 20th century, major advances in surgery not only made surgery safer and more effective but enabled the treatment of a wider range of medical conditions, including thetransplantation of organs. Among some of the key moments:
Today, surgeons have more than 2,500 different surgical techniques in their arsenal. The focus moving forward is placed more on refining those techniques to ensure better short- and long-term outcomes.
The words that arguably best describe surgery in the 21st century are “smaller” and “safer.” Every year, innovations are introduced that allow surgeries that once required lengthy hospital stays to be done on an outpatient basis. Among some of the landmarks of the 21st century thus far:
Is Head Transplantation the Next Medical Frontier?
Summary
The first surgeries were performed thousands of years ago, before anesthesia was invented and before infection prevention measures were understood. Since then, extraordinary strides have been made in how surgery is performed and what types of surgeries are now possible (such as heart transplants). Newer surgical techniques have resulted in better outcomes, faster recoveries, less pain, and longer life expectancies for patients.
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Abhyankar RS, Jessop KM.From craft to profession: the development of modern anesthesiology. Part II.Mo Med. 2022;119(1):14-20.
Maloney TR, Dilkes-Hall IE, Vlok M, et al.Surgical amputation of a limb 31,000 years ago in Borneo.Nature. 2022;609(7927):547-551. doi:10.1038/s41586-022-05160-8
Ghannaee Arani M, Fakharian E, Sarbandi F.Ancient legacy of cranial surgery.Arch Trauma Res. 2012;1(2):72-74. doi:10.5812/atr.6556
Metwaly AM, Ghoneim MM, Eissa IH, et al.Traditional ancient Egyptian medicine: A review.Saudi J Biol Sci. 2021;28(10):5823-5832. doi:10.1016/j.sjbs.2021.06.044
Singh V.Sushruta: the father of surgery.Natl J Maxillofac Surg. 2017;8(1):1-3. doi:10.4103/njms.NJMS_33_17
Markatos K, Mavrogenis A, Brilakis E, Korres D, Karamanou M, Chronopoulos E.Abulcasis (936–1013): his work and contribution to orthopaedics.Int Orthop. 2019;43(9):2199-2203. doi:10.1007/s00264-019-04371-5
Barr J, Schalick WO 3rd, Shortell CK.Surgeons in the time of plague: Guy de Chauliac in fourteenth-century France.J Vasc Surg Cases Innov Tech. 2020;6(4):657-658. doi:10.1016/j.jvscit.2020.07.006
Unsworth PA.Blood and bandages.Hektoen Int. 2020;12(2).
Laios K.Wilhelm Fabricius von Hilden (1560-1634): the pioneer of German surgery.Surg Innov. 2018;25(3):301-303. doi:10.1177/1553350618759152
Payne T, Toms JD, Zaidi A, Thrumurthy SG.The history of surgery and surgical training in the UK.Pak J Med Sci. 2021;37(5):1532-1535. doi:10.12669/pjms.37.5.4628
McNair AJ.James Blundell and the first successful hystereotomy for cancer in Great Britain.Guys Hosp Rep. 1928;8(3):254-264.
Makris EM, Makhoul KG, Lee TB Jr, Desai MS.Henry Jacob Bigelow (1818-1890): a champion for anesthesia and catalyst for the advancement of surgery.Ann Surg Open. 2022;3(1):e118. doi:10.1097/AS9.0000000000000118
National Women’s History Museum.Mary Edwards Walker (1832-1919).
Lister J.On the antiseptic principle in the practice of surgery.Br Med J. 1867;2(351):246-248. doi:10.1136/bmj.2.351.246
Columbia University Department of Surgery.Daniel Hale Williams and the first successful heart surgery.
Babic RR, Stankovic Babic G, Babic SR, Babic NR.120 Years since the discovery of X-rays.Med Pregl. 2016;69(9-10):323-330. doi:10.2298/mpns1610323b
Werner OJ, Sohns C, Popov AF, Haskamp J, Schmitto JD.Ludwig Rehn (1849-1930): the German surgeon who performed the worldwide first successful cardiac operation.J Med Biogr. 2012;20(1):32-34. doi:10.1258/jmb.2011.011002
Brock C.Risk, responsibility and surgery in the 1890s and early 1900s.Med Hist.2013;57(3):317-37. doi:10.1017/mdh.2013.16
Crawford AZ, Patel DV, McGhee CNj.A brief history of corneal transplantation: from ancient to modern.Oman J Ophthalmol. 2013;6(Suppl 1):S12-S17. doi:10.4103/0974-620X.122289
National Army Museum (U.K.).The birth of plastic surgery.
American Chemical Society.Discovery and development of penicillin.
Science Museum (U.K.).Magnus Hirschfeld and the Institute for Sexual Science.
Van Houcke J, Khanduja V, Pattyn C, Audenaert E.The history of biomechanics in total hip arthroplasty.Indian J Orthop. 2017;51(4):359-367. doi:10.4103/ortho.IJOrtho_280_17
American Academy of Ophthalmology.Laser in situ keratomileusis (LASIK).
Nghiem DD.From the triangulation technique to the use of the donor aorta and vena cava for kidney transplantation: lessons from the past and path to the future of xenotransplantation.Uro. 2023; 3(2):151-159. doi:10.3390/uro3020016
Lewis FJ, Taufic M, Varco RL, Niazi S.The surgical anatomy of atrial septal defects: experiences with repair under direct vision.Ann Surg. 1955;142(3):401-415. doi:10.1097/00000658-195509000-00009
Kurusz M.May 6, 1953: The untold story. ASAIO J. 2012;58(1):2-5. doi:10.1097/MAT.0b013e31823ccfe7
Harvard Medicine.The fight for life: the pioneering surgeon of the world’s first successful human organ transplant reflects on the gift of life.
Casanova D; en nombre de Grupo Español de Trasplante de Páncreas.Pancreas transplantation: 50 years of experience.Cir Esp. 2017;95(5):254-260. doi:10.1016/j.ciresp.2017.02.005
Department of Veterans Affairs.First successful liver transplant.
Cooper DKC.Christiaan Barnard—the surgeon who dared: the story of the first human-to-human heart transplant. Glob Cardiol Sci Pract. 2018;2018(2):11. doi:10.21542/gcsp.2018.11
Attia M, Menhel J, Alezra D, Pffefer R, Spiegelmann R.Radiosurgery—LINAC or gamma knife: 20 years of controversy revisited.Isr Med Assoc J. 2005;7(9):583-588.
Texas Heart Institute.50th Anniversary of the world’s first total artificial heart.
Litynski GS.Kurt Semm and the fight against skepticism: endoscopic hemostasis, laparoscopic appendectomy, and Semm’s impact on the “laparoscopic revolution”.JSLS. 1998;2(3):309-313.
University of Utah Health.The first artificial heart, 30 years later.
Joyce LD, DeVries WC, Hastings WL, Olsen DB, Jarvik RK, Kolff WJ.Response of the human body to the first permanent implant of the Jarvik-7 Total Artificial Heart.Trans Am Soc Artif Intern Organs. 1983;29:81-87.
Loma Linda University Health.Infant heart transplantation.
Shao HM, Chen JY, Truong TK, Reed IS, Kwoh YS.A new CT-aided robotic stereotaxis system.Proc Annu Symp Comput Appl Med Care. 1985;668-672.
Kankariya V.The engine of innovation with a human face—Prof. Ioannis Pallikaris.Indian J Ophthalmol. 2020;68(12):2654-2655. doi:10.4103/ijo.IJO_3287_20
Gawande A.Two hundred years of surgery.N Engl J Med. 2012;366(18):1716-23. doi:10.1056/NEJMra1202392
ScienceDaily.FDA approves new robotic surgery device.
Intuitive Surgical.Safety information.
Selvaggi G, Levi DM, Kato T, et al.Expanded use of transplantation techniques: abdominal wall transplantation and intestinal autotransplantation.Transplant Proc. 2004;36(5):1561-1563. doi:10.1016/j.transproceed.2004.05.037
Rudiman R.Minimally invasive gastrointestinal surgery: from past to the future.Ann Med Surg (Lond). 2021;71:102922. doi:10.1016/j.amsu.2021.102922
Alberti FB, Hoyle V.Face transplants: an international history.J Hist Med Allied Sci. 2021;76(3):319-345. doi:10.1093/jhmas/jrab019
University of Gothenburg.Research on uterus transplant.
Washington University in St. Louis.Surgeons restore some hand function to quadriplegic patient.
University of Maryland School of Medicine.University of Maryland School of Medicine faculty scientists and clinicians perform historic first successful transplant of porcine heart into adult human with end-stage heart disease.
NYU Langone Health.NYU Langone Health performs world’s first whole-eye & partial-face transplant.
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