Table of ContentsView AllTable of ContentsBest Medication for Ulcerative ColitisAminosalicylates (5-ASA)CorticosteroidsImmunomodulatorsBiologicsTargeted Synthetic Small MoleculesSurgeryIntegrative ApproachesSymptomsWhen to Contact Your Healthcare Provider
Table of ContentsView All
View All
Table of Contents
Best Medication for Ulcerative Colitis
Aminosalicylates (5-ASA)
Corticosteroids
Immunomodulators
Biologics
Targeted Synthetic Small Molecules
Surgery
Integrative Approaches
Symptoms
When to Contact Your Healthcare Provider
Ulcerative colitis medications help control the symptoms of ulcerative colitis (UC) and prevent flare-ups or relapses.
UC is a chronic inflammatory bowel disease.It’s anautoimmunecondition, meaning the body’s immune system attacks healthy parts of the body.
A medication plan and lifestyle modifications tailored to you may help you minimize symptoms and prevent relapses and other complications.
Your healthcare provider will work with you to find the best medication. Regular communication with them throughout your treatment is key.
ELSA BIYICK / Contributor / Getty Images

What Is the Best Medication for Ulcerative Colitis?
The best medicine forulcerative colitisdepends on several factors, such as the severity of the disease and its location.
Moderate to severe UC means you have more than six bowel movements daily, plus rectal bleeding.Moderate to severe UC also includes signs of body-wide effects (like fever ormarkers of inflammation).
There’s no cure for UC yet, apart from surgery to remove the colon. UC may not go away with medications, but they can help manage it.
UC can also go into remission, meaning the symptoms stop for a while. However, symptoms may reappear.
The following includes medications typically used for UC.
Surgery for Ulcerative Colitis
Biologics have been a game-changer for management, but up to 15% of people with UC may still need surgery.However, some people may not be able to manage UC with medications alone.
Surgery may be needed when UC is not able to be controlled with medications and lifestyle modifications. It is also used for people who have serious complications of UC like the following:
Types of surgery for UC include the following:
Other Options for Ulcerative Colitis
Several other therapies have been studied for UC, including the following:
Sometimes, UC can affect the skin, joints, eyes, liver, or gallbladder. These are called extra-intestinal manifestations because they occur outside the gastrointestinal tract.
If it’s not controlled, UC can severely disrupt daily life. It can also cause complications such as:
If you have been diagnosed with UC, watch for flares or concerning symptoms. Contact your healthcare provider if your medications don’t seem to be working or if your symptoms worsen.
Seek emergency medical help right away if you experience any of the following:
Summary
Medications for UC are used to help control symptoms and prevent flares and complications.
Several medication options are available.
Along with medications, alternative treatments that can help manage UC include acupuncture, exercise, nutrition, dietary supplements, and mental health strategies.
If these don’t work, or you have serious complications, you may want to consider discussing surgical options with your healthcare provider.
28 Sources
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Feuerstein JD, Moss AC, Farraye FA.Ulcerative colitis.Mayo Clin Proc. 2019;94(7):1357-1373. doi:10.1016/j.mayocp.2019.01.018
Ferretti F, Cannatelli R, Monico MC, et al.An update on current pharmacotherapeutic options for the treatment of ulcerative colitis.J Clin Med. 2022;11(9):2302. doi:10.3390/jcm11092302
Segal JP, LeBlanc JF, Hart AL.Ulcerative colitis: an update.Clin Med (Lond). 2021;21(2):135-139. doi:10.7861/clinmed.2021-0080
Kayal M, Shah S.Ulcerative colitis: current and emerging treatment strategies.J Clin Med. 2019;9(1):94. doi:10.3390/jcm9010094
Aslam N, Lo SW, Sikafi R, et al.A review of the therapeutic management of ulcerative colitis.Therap Adv Gastroenterol. 2022;15:17562848221138160. doi:10.1177/17562848221138160
Guo M, Wang X.Pathological mechanism and targeted drugs of ulcerative colitis: a review.Medicine (Baltimore). 2023;102(37):e35020. doi:10.1097/MD.0000000000035020
Ooi CJ, Hilmi I, Banerjee R, et al.Best practices on immunomodulators and biologic agents for ulcerative colitis and Crohn’s disease in Asia.Intest Res. 2019;17(3):285-310. doi:10.5217/ir.2019.00026
Peyrin-Biroulet L, Sandborn WJ, Panaccione R, et al.Tumour necrosis factor inhibitors in inflammatory bowel disease: the story continues.Therap Adv Gastroenterol. 2021;14:17562848211059954. Published 2021 Dec 9. doi:10.1177/17562848211059954
Ben Ghezala I, Charkaoui M, Michiels C, et al.Small molecule drugs in inflammatory bowel diseases.Pharmaceuticals (Basel). 2021;14(7):637. doi:10.3390/ph14070637
Society of American Gastrointestinal and Endoscopic Surgeons.Colon resection surgery.
Mithany RH, Shahid MH, Shahid R, et al.Ileostomy 101: Understanding the basics for optimal patient care.Cureus. 2023;15(10):e46822. doi:10.7759/cureus.46822
Spiers J, Smith JA, Simpson P, et al.The treatment experiences of people living with ileostomies: an interpretative phenomenological analysis.J Adv Nurs. 2016;72(11):2662-2671. doi:10.1111/jan.13018
Berghog J, Hermanson M, de la Croix H, et al.Ileo-rectal anastomosis in ulcerative colitis-Long-term outcome, failure and risk of cancer at a tertiary centre.Colorectal Dis. 2022;24(12):1535-1542. doi:10.1111/codi.16237
Wang X, Zhao NQ, Sun YX, et al.Acupuncture for ulcerative colitis: a systematic review and meta-analysis of randomized clinical trials.BMC Complement Med Ther. 2020;20(1):309. doi:10.1186/s12906-020-03101-4
Davis SP, Crane PB, Bolin LP, et al.An integrative review of physical activity in adults with inflammatory bowel disease.Intest Res. 2022;20(1):43-52. doi:10.5217/ir.2020.00049
Ordille AJ, Phadtare S.Intensity-specific considerations for exercise for patients with inflammatory bowel disease.Gastroenterol Rep (Oxf). 2023;11:goad004. doi:10.1093/gastro/goad004
Radziszewska M, Smarkusz-Zarzecka J, Ostrowska L, et al.Nutrition and supplementation in ulcerative colitis.Nutrients. 2022;14(12):2469. doi:10.3390/nu14122469
Holmes JL, Biella A, Morck T, et al.Medical foods: science, regulation, and practical aspects. summary of a workshop.Curr Dev Nutr. 2021;5(Suppl 1):nzaa172. doi:10.1093/cdn/nzaa172
Soriano RA, Ramos-Soriano AG.Clinical and pathologic remission of pediatric ulcerative colitis with serum-derived bovine immunoglobulin added to the standard treatment regimen.Case Rep Gastroenterol. 2017;11(2):335-343. doi:10.1159/000475923
Pituch-Zdanowska A, Dembiński Ł, Banaszkiewicz A.Old but fancy: curcumin in ulcerative colitis-current overview.Nutrients. 2022;14(24):5249. doi:10.3390/nu14245249
Sharma A, Sharma V.The gut-brain connection: a case report on depression in ulcerative colitis and novel treatment approach.Cureus. 2023;15(11):e48462. doi:10.7759/cureus.48462
Kaur S, D’Silva A, Shaheen AA, et al.Yoga in patients with inflammatory bowel disease: a narrative review.Crohns Colitis 360. 2022;4(2):otac014. doi:10.1093/crocol/otac014
Langhorst J, Wulfert H, Lauche R, et al.Systematic review of complementary and alternative medicine treatments in inflammatory bowel diseases.J Crohns Colitis. 2015;9(1):86-106. doi:10.1093/ecco-jcc/jju007
Fornaro R, Actis GC, Caviglia GP, et al.Inflammatory bowel disease: role of vagus nerve stimulation.J Clin Med. 2022;11(19):5690. doi:10.3390/jcm11195690
Slonovschi E, Kodela P, Okeke M, et al.Surgical treatment in ulcerative colitis, still topical: a narrative review.Cureus. 2023;15(7):e41962. doi:10.7759/cureus.41962
U.S. Centers for Disease Control.Ulcerative colitis basics.
Pouli S, Kozana A, Papakitsou I, et al.Gastrointestinal perforation: clinical and MDCT clues for identification of aetiology.Insights Imaging. 2020;11(1):31. doi:10.1186/s13244-019-0823-6
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