Key TakeawaysA preliminary study found that a urine-based antibody test might be as effective at detecting antibodies against COVID-19 as blood tests.For many patients, urine tests would be easier, less invasive, and more convenient than giving a blood sample.While it’s promising, more research is needed on urine-based COVID antibody testing, and the test would need FDA authorization before it could be made available to patients.

Key Takeaways

A preliminary study found that a urine-based antibody test might be as effective at detecting antibodies against COVID-19 as blood tests.For many patients, urine tests would be easier, less invasive, and more convenient than giving a blood sample.While it’s promising, more research is needed on urine-based COVID antibody testing, and the test would need FDA authorization before it could be made available to patients.

If you’ve had COVID-19, you likely haveantibodies to the SARS-CoV-2 virusin your blood. To know for sure, you would need to have a blood test to check for those antibodies.

However, that might not be your only option in the future. A new study published inScience Advancesfound thatusing urine as a sample instead of a blood sample can be as effective at detecting anti–SARS-CoV-2 antibodies.

When Should You Get a COVID-19 Antibody Test?

Urine vs. Blood COVID Antibody Tests

An important performance metric of an antibody test is how well it correctly finds antibodies when they are truly present (sensitivity) and how well it correctly identifies when antibodies are trulynotpresent (specificity).

When the tests are accurate, it helps make sure that someone who really has COVIDgets a positive testand someone who doesnothave COVIDgets a negative test.

In the new study, the researchers developed a urine-based antibody test that had higher sensitivity (94%) than serum-based (blood) COVID antibody tests (88%). Both tests had 100% specificity.

Marc Sala, MD, a pulmonary and critical care specialist withNorthwestern Medicine Comprehensive COVID-19 Center, said that the two kinds of antibody tests were found to be equally accurate in the study, which used urine and blood samples collected at the same time from hospitalized and non-hospitalized patients.

What About Other Coronaviruses?

The urine test has some limitations right now because SARS-CoV-2 is not the only coronavirus that infects humans.

A New COVID-19 Antibody Test ‘Glows’ Like Fireflies

Potential Benefits of Urine-Based Antibody Tests

Serum-based (blood) antibody tests are accurate and have a low rate of complications, but a urine-based test would still be useful for providers and patients.

Urine samples are also convenient for clinical practice because they’re easier to handle and store than blood samples. Self-collection of a sample would also make a urine-based test much cheaper than a blood test.

Beth Oller, MDOverall, this is very exciting because it could very well mean that there could be ways to test for antibodies for other viruses and infections the same way.

Beth Oller, MD

Overall, this is very exciting because it could very well mean that there could be ways to test for antibodies for other viruses and infections the same way.

However, Oller said that the main benefit of urine-based COVID antibody testing is that people will probably be more comfortable giving a urine sample than having their blood drawn since it’s less invasive.

Sala added that a non-invasive test urine test would be helpful for children since it can be hard to get a blood sample from kids.

FDA: Don’t Use Antibody Tests to Check if Your COVID Vaccine Worked

You Can’t Get a Urine COVID Antibody Test—Yet

Although the study showed promising results, urine-based COVID antibody tests are not market-ready just yet.

According to Sala, the study’s findings (which came from a small sample) would need to be validated in a larger group first because there are some aspects that still aren’t clear to researchers.

For example, Sala said that providers would need to know if the antibodies in a patient’s urine rise and fall over time with the same pattern (as the antibodies found in the blood do) or if a person’s kidney function could affect the results of the test.

Oller added that if the goal is to make the test commercially available for at-home use, it would need to get authorization from the Food and Drug Administration (FDA). Anemergency use authorization (EUA)would likely be issued first.

A urine test could also be made available for point-of-care testing at a laboratory, walk-in clinic, or a provider’s office.

What This Means For YouA urine-based COVID antibody test could be on the horizon. Research has shown that using a urine sample is just as good at detecting SARS-CoV-2 antibodies as a blood test. However, more research needs to be done before the urine-based COVID antibody test could be made available to patients.

What This Means For You

A urine-based COVID antibody test could be on the horizon. Research has shown that using a urine sample is just as good at detecting SARS-CoV-2 antibodies as a blood test. However, more research needs to be done before the urine-based COVID antibody test could be made available to patients.

The information in this article is current as of the date listed, which means newer information may be available when you read this. For the most recent updates on COVID-19, visit ourcoronavirus news page.

2 SourcesVerywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read oureditorial processto learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.Ludolf F, Ramos FF, Bagno FF, et al.Detecting anti–SARS-CoV-2 antibodies in urine samples: a noninvasive and sensitive way to assay COVID-19 immune conversion.Sci Adv. 2022;8(19). doi:10.1126/sciadv.abn7424Food and Drug Administration.EUA authorized serology test performance.

2 Sources

Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read oureditorial processto learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.Ludolf F, Ramos FF, Bagno FF, et al.Detecting anti–SARS-CoV-2 antibodies in urine samples: a noninvasive and sensitive way to assay COVID-19 immune conversion.Sci Adv. 2022;8(19). doi:10.1126/sciadv.abn7424Food and Drug Administration.EUA authorized serology test performance.

Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read oureditorial processto learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.

Ludolf F, Ramos FF, Bagno FF, et al.Detecting anti–SARS-CoV-2 antibodies in urine samples: a noninvasive and sensitive way to assay COVID-19 immune conversion.Sci Adv. 2022;8(19). doi:10.1126/sciadv.abn7424Food and Drug Administration.EUA authorized serology test performance.

Ludolf F, Ramos FF, Bagno FF, et al.Detecting anti–SARS-CoV-2 antibodies in urine samples: a noninvasive and sensitive way to assay COVID-19 immune conversion.Sci Adv. 2022;8(19). doi:10.1126/sciadv.abn7424

Food and Drug Administration.EUA authorized serology test performance.

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