Table of ContentsView AllTable of ContentsWhat It IsSymptomsCausesDiagnosisTreatment
Table of ContentsView All
View All
Table of Contents
What It Is
Symptoms
Causes
Diagnosis
Treatment
Coagulopathyis ableeding disorder. Many different medical conditions can cause deficits in coagulation (blood clotting), including hereditary and acquired coagulopathies. The most common symptoms are bruising and prolonged bleeding after a cut, but coagulopathies can also cause life-threatening bleeding.
Blood tests can detect the exact cause of coagulopathy. Many of these conditions can be treated with medications or procedures. This article describes the symptoms, types, causes, diagnosis, and treatments of coagulopathies.
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Coagulopathy: A Hemostasis Defect
What Is Coagulopathy?Coagulopathy includes problems with hemostasis. It can occur due to a deficiency in any of the cells, enzymes, or proteins that are involved in the steps of coagulation. Coagulopathies can be inherited, or they may be acquired due to illness, organ failure, or medication.
What Is Coagulopathy?
Coagulopathy includes problems with hemostasis. It can occur due to a deficiency in any of the cells, enzymes, or proteins that are involved in the steps of coagulation. Coagulopathies can be inherited, or they may be acquired due to illness, organ failure, or medication.
Coagulopathy Symptoms
The most noticeable symptoms of coagulopathy are bleeding and bruising. Sometimes the bleeding can lead to severe complications.
Coagulopathy can cause bleeding after injuries or sometimes without any known cause. Depending on certain factors, the bleeding problems can worsen or improve at different times. These factors may include nutrition, medications, or treatment of the underlying cause.
Signs and symptoms of coagulopathy may include:
Usually, coagulopathy does not cause other symptoms besides bleeding, but the underlying problem can cause additional associated signs and symptoms. For example, a coagulopathy that occurs due to liver disease may be associated withjaundice(yellowing of the skin and whites of the eyes).
Complications
Coagulopathies can cause severe symptoms if bleeding is rapid or causes organ damage. Extreme bleeding may also lead to blood loss or potentially cause swelling and pressure in or around vital organs.
Signs and symptoms of coagulopathy complications include:
What Causes Coagulopathy Conditions?
Hemostasis involves several steps. When the body is injured, hormones are released to signal platelets and coagulation proteins to the area of damage. This allows the blood to clot and for healing to begin.
A deficiency in platelets or proteins that are involved in the clotting cascade (the linked reactions and processes that lead to forming a clot) can cause a coagulopathy.
Conditions that cause coagulopathy include:
Hereditary coagulopathies are inherited coagulation factor deficiencies.
Associated ConditionsCoagulopathy co-occurs with or increases the risk of:Liver diseaseCancerChronic illnessSevere infectionsImmune disorders
Associated Conditions
Coagulopathy co-occurs with or increases the risk of:Liver diseaseCancerChronic illnessSevere infectionsImmune disorders
Coagulopathy co-occurs with or increases the risk of:
Testing to Diagnose Coagulopathy
Diagnostic testing for coagulopathy involves assessment of the coagulation defect, identifying the underlying cause, and diagnostic tests to assess complications.
Blood tests that are used to diagnose a coagulation defect include:
Often, when you are being treated for coagulopathy, periodic blood tests may be necessary to assess the effectiveness of your treatment.
Sometimes other testing is necessary to determine whether there is bleeding inside the body.These tests may include imaging, such as a computed tomography (CT) scan of the abdomen if there is concern about bleeding in the gastrointestinal system. In some situations, more invasive testing might be necessary, such asbronchoscopyto examine thebronchi(airways in the lungs).
Coagulopathy Treatment
Coagulopathy can often be treated with medication. Each cause of coagulopathy has its own treatment. Typically, treatment needs to be maintained for a lifetime for some types of chronic coagulopathy.
In some instances, such as when there is severe bleeding, ablood transfusionmay be necessary to replenish the blood as the body is making new blood cells to replace those that were lost.
Lifestyle Modifications
While lifestyle modification cannot cure coagulopathy, a proper diet is important for maintaining the nutrients that are necessary for the body to make platelets and proteins for hemostasis.
Nutrients that are necessary for proper blood clotting include:
People with coagulopathy have a tendency to bleed. Precautions may include:Avoiding activities with a high risk of injuries, such as contact sportsTesting before surgical proceduresClose prenatal care during pregnancyPreparation for the potential of excessive blood loss during vaginal delivery or C section
People with coagulopathy have a tendency to bleed. Precautions may include:
Medication
Medications can often cause or contribute to coagulopathy, so stopping any medications that can cause bleeding, such as nonsteroidal anti-inflammatory drugs (NSAIDs), like Advil or Motrin (ibuprofen), is often recommended.
Getting injections to replace deficient clotting factors usually is a treatment for hemophilia or Von Willebrand disease. This may be done on a scheduled basis, or it can follow blood test parameters.
Some conditions, such as severe, acute trauma, can causebothcoagulopathy andhypercoagulation(excess blood clotting).
Coagulopathy that’s associated with severe medical conditions, such as trauma or infections, is usually treated based on very close observation and blood tests. Vitamin K is sometimes given during these episodes of coagulopathy.
Procedures
You may require platelet transfusions if your platelet level is very low. These transfusions may be scheduled at regular intervals in order to prevent bleeding.
In emergency situations with severe bleeding, a blood transfusion may be necessary. Another procedure is evacuating (removing) blood from the abdomen or other areas of the body where blood can accumulate due to rapid and severe bleeding.
Summary
Coagulopathy is a bleeding disorder. It causes bleeding, which can range from minor to severe. There are numerous causes of bleeding disorders. Inherited coagulopathies are the most common types of chronic coagulopathy.
Often, testing is done before any symptoms develop for people who have a known risk of inherited coagulopathy. Blood tests can include tests of bleeding time, coagulation proteins, and genetic causes of coagulopathy.
Medical management may include medications, procedures, and lifestyle management. Chronic coagulopathies require long-term treatment to prevent serious bleeding complications.
What Is Hemophilia B?
7 SourcesVerywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read oureditorial processto learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.Mubeen S, Domingo-Fernández D, Díaz Del Ser S, et al.Exploring the complex network of heme-triggered effects on the blood coagulation system.J Clin Med.2022;11(19):5975. doi:10.3390/jcm11195975National Heart, Lung, and Blood Institute.What causes bleeding disorders?Savioli G, Ceresa IF, Caneva L, Gerosa S, Ricevuti G.Trauma-induced coagulopathy: overview of an emerging medical problem from pathophysiology to outcomes.Medicines (Basel). 2021;8(4):16. doi:10.3390/medicines8040016Nikolaidou E, Kakagia D, Kaldoudi E, Stouras J, Sovatzidis A, Tsaroucha A.Coagulation disorders and mortality In burn injury: A systematic review.Ann Burns Fire Disasters. 2022 Jun 30;35(2):103-115Kataria S, Juneja D, Singh O.Approach to thromboelastography-based transfusion in cirrhosis: an alternative perspective on coagulation disorders.World J Gastroenterol.2023;29(9):1460-1474. doi:10.3748/wjg.v29.i9.1460Hofer S, Schlimp CJ, Casu S, Grouzi E.Management of coagulopathy in bleeding patients.J Clin Med.2021;11(1):1. doi:10.3390/jcm11010001National Heart, Lung, and Blood Institute.Disseminated intravascular coagulation (DIC)
7 Sources
Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read oureditorial processto learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.Mubeen S, Domingo-Fernández D, Díaz Del Ser S, et al.Exploring the complex network of heme-triggered effects on the blood coagulation system.J Clin Med.2022;11(19):5975. doi:10.3390/jcm11195975National Heart, Lung, and Blood Institute.What causes bleeding disorders?Savioli G, Ceresa IF, Caneva L, Gerosa S, Ricevuti G.Trauma-induced coagulopathy: overview of an emerging medical problem from pathophysiology to outcomes.Medicines (Basel). 2021;8(4):16. doi:10.3390/medicines8040016Nikolaidou E, Kakagia D, Kaldoudi E, Stouras J, Sovatzidis A, Tsaroucha A.Coagulation disorders and mortality In burn injury: A systematic review.Ann Burns Fire Disasters. 2022 Jun 30;35(2):103-115Kataria S, Juneja D, Singh O.Approach to thromboelastography-based transfusion in cirrhosis: an alternative perspective on coagulation disorders.World J Gastroenterol.2023;29(9):1460-1474. doi:10.3748/wjg.v29.i9.1460Hofer S, Schlimp CJ, Casu S, Grouzi E.Management of coagulopathy in bleeding patients.J Clin Med.2021;11(1):1. doi:10.3390/jcm11010001National Heart, Lung, and Blood Institute.Disseminated intravascular coagulation (DIC)
Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read oureditorial processto learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.
Mubeen S, Domingo-Fernández D, Díaz Del Ser S, et al.Exploring the complex network of heme-triggered effects on the blood coagulation system.J Clin Med.2022;11(19):5975. doi:10.3390/jcm11195975National Heart, Lung, and Blood Institute.What causes bleeding disorders?Savioli G, Ceresa IF, Caneva L, Gerosa S, Ricevuti G.Trauma-induced coagulopathy: overview of an emerging medical problem from pathophysiology to outcomes.Medicines (Basel). 2021;8(4):16. doi:10.3390/medicines8040016Nikolaidou E, Kakagia D, Kaldoudi E, Stouras J, Sovatzidis A, Tsaroucha A.Coagulation disorders and mortality In burn injury: A systematic review.Ann Burns Fire Disasters. 2022 Jun 30;35(2):103-115Kataria S, Juneja D, Singh O.Approach to thromboelastography-based transfusion in cirrhosis: an alternative perspective on coagulation disorders.World J Gastroenterol.2023;29(9):1460-1474. doi:10.3748/wjg.v29.i9.1460Hofer S, Schlimp CJ, Casu S, Grouzi E.Management of coagulopathy in bleeding patients.J Clin Med.2021;11(1):1. doi:10.3390/jcm11010001National Heart, Lung, and Blood Institute.Disseminated intravascular coagulation (DIC)
Mubeen S, Domingo-Fernández D, Díaz Del Ser S, et al.Exploring the complex network of heme-triggered effects on the blood coagulation system.J Clin Med.2022;11(19):5975. doi:10.3390/jcm11195975
National Heart, Lung, and Blood Institute.What causes bleeding disorders?
Savioli G, Ceresa IF, Caneva L, Gerosa S, Ricevuti G.Trauma-induced coagulopathy: overview of an emerging medical problem from pathophysiology to outcomes.Medicines (Basel). 2021;8(4):16. doi:10.3390/medicines8040016
Nikolaidou E, Kakagia D, Kaldoudi E, Stouras J, Sovatzidis A, Tsaroucha A.Coagulation disorders and mortality In burn injury: A systematic review.Ann Burns Fire Disasters. 2022 Jun 30;35(2):103-115
Kataria S, Juneja D, Singh O.Approach to thromboelastography-based transfusion in cirrhosis: an alternative perspective on coagulation disorders.World J Gastroenterol.2023;29(9):1460-1474. doi:10.3748/wjg.v29.i9.1460
Hofer S, Schlimp CJ, Casu S, Grouzi E.Management of coagulopathy in bleeding patients.J Clin Med.2021;11(1):1. doi:10.3390/jcm11010001
National Heart, Lung, and Blood Institute.Disseminated intravascular coagulation (DIC)
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