Table of ContentsView AllTable of ContentsInsulin ResistanceFood and SupplementsMI and DCISide Effects

Table of ContentsView All

View All

Table of Contents

Insulin Resistance

Food and Supplements

MI and DCI

Side Effects

Treatingpolycystic ovary syndrome(PCOS) with vitamin-like substances calledinositols—a type of sugar in the body—has shown promising results.They are used to help people with PCOS control blood sugar and increase their chances of becoming pregnant.

Read on to learn more about how taking inositols can help treat PCOS.

Possible Benefits of Taking Inositol for PCOS, an illustration of a person taking a pill

Inositol Improves Insulin Resistance

Inositols are a kind of sugar the body makes. They help balance chemicals that control your blood sugar and fertility. They also affect your metabolism, which is the process of turning the food you eat into energy.

Many people with PCOS areinsulin-resistant. Their bodies make insulin but aren’t able to use it effectively.This increases the risk ofdiabetes, infertility, obesity, andhigh cholesterol.

Inositols make molecules involved in the body’s response to insulin. Researchers say inositols may be part of the body’s messaging system when the insulin signaling system fails.

Does Inositol for PCOS Make You Gain Weight?It depends on the individual. Imbalances in your levels of inositols are associated with weight changes, including weight loss and weight gain. Studies have found these weight changes are linked primarily to how myo-inositol (MI) is metabolized in the body.For many people with PCOS, inositol-based therapies may lead to weight loss.

Does Inositol for PCOS Make You Gain Weight?

It depends on the individual. Imbalances in your levels of inositols are associated with weight changes, including weight loss and weight gain. Studies have found these weight changes are linked primarily to how myo-inositol (MI) is metabolized in the body.For many people with PCOS, inositol-based therapies may lead to weight loss.

Inositols From Food and Supplements

You can also buy inositol food supplements, pills, or powders you mix with water. Inositol supplements are generally well-tolerated.

Inositols MI and DCI Benefits For PCOS

There are nine forms of inositol, but the two that have the most significant impact on PCOS are myo-inositol (MI) and D-chiro-inositol (DCI). Typically, MI is converted to DCI.

How Polycystic Ovary Syndrome (PCOS) Is Treated

MI/DCI Supplements

It is important to note that MI: DCI ratios vary in different body tissues, but in the ovary, healthy females have a ratio of approximately 100:1. PCOS patients tend to have a much higher level of DCI and very low levels of MI, leading to an abnormally low MI: DCI ratio of 0.2:1.

Combined therapy with MI and DCI is more effective than taking either inositol alone. Specifically, research shows a 40:1 MI/DCI ratio is best for restartingovulationin people with PCOS.

MI and DCI in a 40:1 ratio may be more effective than metformin. One study found people with PCOS who took the 40:1 MI/DCI supplement had significantly better ovulation and pregnancy rates (46.7% vs. 11.2%) than those who did not take the supplement.

Two grams twice a day is currently considered the optimal inositol dosage for PCOS. The best time to take inositol is just before eating.

MI to DCI and Fertility

PCOS is a common cause of infertility. Up to 80% of people with PCOS experience fertility challenges.

People with PCOS have an imbalance of MI to DCI in their ovaries. This can affect:

Inositols can help restore ovulation and improveoocyte(immature egg) quality. But researchers say taking the correct formulation is essential because high doses of DCI negatively affect oocytes and prevent the body from absorbing MI.

Should You Freeze Your Eggs If You Have PCOS?

MI Used to Treat Gestational Diabetes

People with PCOS have an increased risk ofgestational diabetes(GD), which is diabetes that develops during pregnancy. One study concluded that people with PCOS have a two-fold higher risk of developing GD than those without PCOS.

Taking MI supplements lowers blood sugar levels and GD risk in people with PCOS.Multiple studies found GD was less common in pregnant females with PCOS who took MI than those who did not take the supplement.

Side Effects and Cautions

You may feel tempted to try using inositol supplements on your own. That’s not a good idea. Taking too much DCI, for example, can lower your estrogen levels and increase male hormone levels.

Estrogen has several benefits, like protecting bones and preventing breast cancer. Increasing testosterone levels in females already at risk of infertility also isn’t wise.

Additionally, inositol for PCOS has been linked to hair loss as well as excessive hair growth.Some people with PCOS also experience acne, which can be treated with other medications.

If your healthcare provider agrees and you decide to try inositols, you may need to be extra careful of what you eat and drink. Some artificial sugars and sugar alcohols weaken the benefits of these supplements.

Dosing Variations

Some food supplement companies continue to sell supplements with varying MI/DCI ratios. One review found that the MI to DCI ratio in PCOS products can range from as little as .04-to-1 to as high as 104-to-1.Some supplements contain only DCI,while others contain additional substances such as vitamins and artificial sugars. There’s no evidence to show these ingredients help.

Summary

Inositols are sugars the body makes that help regulate insulin and cholesterol levels. Two types of inositols, MI and DCI, help treat PCOS.

19 SourcesVerywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read oureditorial processto learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.Facchinetti F, Appetecchia M, Aragona C, et al.Experts’ opinion on inositols in treating polycystic ovary syndrome and non-insulin dependent diabetes mellitus: a further help for human reproduction and beyond.Expert Opin Drug Metab Toxicol. 2020;16(3):255-74. doi:10.1080/17425255.2020.1737675Centers for Disease Control and Prevention.PCOS (Polycystic Ovary Disease) and Diabetes.Lepore E, Lauretta R, Bianchini M, Mormando M, Di Lorenzo C, Unfer V.Inositols Depletion and Resistance: Principal Mechanisms and Therapeutic Strategies.Int J Mol Sci. 2021 Jun 24;22(13):6796. doi:10.3390/ijms22136796.Le Donne M, Metro D, Alibrandi A, Papa M, Benvenga S.Effects of three treatment modalities (diet, myoinositol or myoinositol associated with D-chiro-inositol) on clinical and body composition outcomes in women with polycystic ovary syndrome.Eur Rev Med Pharmacol Sci. 2019 Mar;23(5):2293-2301. doi:10.26355/eurrev_201903_17278.Moroni RF, Cazzaniga E, Palestini P, Sculati M.The feasibility of a diet which enhances inositol availability.Prog Nutr. 2021;23(2). doi:10.23751/pn.v23i2.10356Monastra G, Vucenik I, Harrath AH, et al.PCOS and inositols: controversial results and necessary clarifications. basic differences between d-chiro and myo-inositol.Front Endocrinol. 2021;12:269. doi:10.3389/fendo.2021.660381Kalra B, Kalra S, Sharma JB.The inositols and polycystic ovary syndrome.Indian J Endocrinol Metab. 2016;20(5):720–724. doi:10.4103/2230-8210.189231Nordio M, Basciani S, Camajani E.The 40: 1 myo-inositol/D-chiro-inositol plasma ratio is able to restore ovulation in PCOS patients: comparison with other ratios.Eur Rev Med Pharmacol Sci. 2019;23(12):5512-21. doi:10.26355/eurrev_201906_18223Wojciechowska A, Osowski A, Jóźwik M, Górecki R, Rynkiewicz A, Wojtkiewicz J.Inositols' importance in the improvement of the endocrine-metabolic profile in PCOS.Int J Mol Sci. 2019;20(22):5787. doi:10.3390/ijms20225787Melo AS, Ferriani RA, Navarro PA.Treatment of infertility in women with polycystic ovary syndrome: approach to clinical practice.Clinics. 2015;70(11):765-769. doi:10.6061/clinics/2015(11)09Merviel P, James P, Bouée S, et al.Impact of myo-inositol treatment in women with polycystic ovary syndrome in assisted reproductive technologies.Reprod Health.2021;18(1):13. doi:10.1186/s12978-021-01073-3Mohammadi S, Eini F, Bazarganipour F, Taghavi SA, Kutenaee MA.The effect of myo-inositol on fertility rates in poor ovarian responder in women undergoing assisted reproductive technique: a randomized clinical trial.Reprod Biol Endocrin. 2021;19(1):61. doi:10.1186/s12958-021-00741-0Palomba S, Daolio J, La Sala GB.Oocyte competence in women with polycystic ovary syndrome.Trends Endocrinol Metab. 2017;28(3):186-98. doi:10.1016/j.tem.2016.11.008Roseff S, Montenegro M.Inositol treatment for PCOS should be science-based and not arbitrary.Int J Endocrinol.2020;6461254. doi:10.1155/2020/6461254Mills G, Badeghiesh A, Suarthana E, Baghlaf H, Dahan MH.Polycystic ovary syndrome as an independent risk factor for gestational diabetes and hypertensive disorders of pregnancy: a population-based study on 9.1 million pregnancies.Hum Reprod. 2020;35(7):1666-1674. doi:10.1093/humrep/deaa099Sobota-Grzeszyk A, Kuźmicki M, Szamatowicz J.Myoinositol in the prevention of gestational diabetes mellitus: Is it sensible?J Diabetes Res. 2019;3915253. doi:10.1155/2019/3915253Motuhifonua SK, Lin L, Alsweiler J, Crawford TJ, Crowther CA.Antenatal dietary supplementation with myo-inositol for preventing gestational diabetes.Cochrane Database of Systematic Reviews. 2023;2023(2). doi:10.1002/14651858.CD011507.pub3Troisi J, Cinque C, Giugliano L, Symes S, Richards S, Adair D,et al.Metabolomic change due to combined treatment with myo-inositol, D-chiro-inositol and glucomannan in polycystic ovarian syndrome patients: a pilot study.J Ovarian Res. 2019 Mar 23;12(1):25. doi:10.1186/s13048-019-0500-x.McCartney CR, Marshall JC.Polycystic Ovary Syndrome.N Engl J Med. 2016;375(1):54-64. doi:10.1056/NEJMcp1514916Additional ReadingUS Department of Health and Human Services.Polycystic ovary syndrome.

19 Sources

Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read oureditorial processto learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.Facchinetti F, Appetecchia M, Aragona C, et al.Experts’ opinion on inositols in treating polycystic ovary syndrome and non-insulin dependent diabetes mellitus: a further help for human reproduction and beyond.Expert Opin Drug Metab Toxicol. 2020;16(3):255-74. doi:10.1080/17425255.2020.1737675Centers for Disease Control and Prevention.PCOS (Polycystic Ovary Disease) and Diabetes.Lepore E, Lauretta R, Bianchini M, Mormando M, Di Lorenzo C, Unfer V.Inositols Depletion and Resistance: Principal Mechanisms and Therapeutic Strategies.Int J Mol Sci. 2021 Jun 24;22(13):6796. doi:10.3390/ijms22136796.Le Donne M, Metro D, Alibrandi A, Papa M, Benvenga S.Effects of three treatment modalities (diet, myoinositol or myoinositol associated with D-chiro-inositol) on clinical and body composition outcomes in women with polycystic ovary syndrome.Eur Rev Med Pharmacol Sci. 2019 Mar;23(5):2293-2301. doi:10.26355/eurrev_201903_17278.Moroni RF, Cazzaniga E, Palestini P, Sculati M.The feasibility of a diet which enhances inositol availability.Prog Nutr. 2021;23(2). doi:10.23751/pn.v23i2.10356Monastra G, Vucenik I, Harrath AH, et al.PCOS and inositols: controversial results and necessary clarifications. basic differences between d-chiro and myo-inositol.Front Endocrinol. 2021;12:269. doi:10.3389/fendo.2021.660381Kalra B, Kalra S, Sharma JB.The inositols and polycystic ovary syndrome.Indian J Endocrinol Metab. 2016;20(5):720–724. doi:10.4103/2230-8210.189231Nordio M, Basciani S, Camajani E.The 40: 1 myo-inositol/D-chiro-inositol plasma ratio is able to restore ovulation in PCOS patients: comparison with other ratios.Eur Rev Med Pharmacol Sci. 2019;23(12):5512-21. doi:10.26355/eurrev_201906_18223Wojciechowska A, Osowski A, Jóźwik M, Górecki R, Rynkiewicz A, Wojtkiewicz J.Inositols' importance in the improvement of the endocrine-metabolic profile in PCOS.Int J Mol Sci. 2019;20(22):5787. doi:10.3390/ijms20225787Melo AS, Ferriani RA, Navarro PA.Treatment of infertility in women with polycystic ovary syndrome: approach to clinical practice.Clinics. 2015;70(11):765-769. doi:10.6061/clinics/2015(11)09Merviel P, James P, Bouée S, et al.Impact of myo-inositol treatment in women with polycystic ovary syndrome in assisted reproductive technologies.Reprod Health.2021;18(1):13. doi:10.1186/s12978-021-01073-3Mohammadi S, Eini F, Bazarganipour F, Taghavi SA, Kutenaee MA.The effect of myo-inositol on fertility rates in poor ovarian responder in women undergoing assisted reproductive technique: a randomized clinical trial.Reprod Biol Endocrin. 2021;19(1):61. doi:10.1186/s12958-021-00741-0Palomba S, Daolio J, La Sala GB.Oocyte competence in women with polycystic ovary syndrome.Trends Endocrinol Metab. 2017;28(3):186-98. doi:10.1016/j.tem.2016.11.008Roseff S, Montenegro M.Inositol treatment for PCOS should be science-based and not arbitrary.Int J Endocrinol.2020;6461254. doi:10.1155/2020/6461254Mills G, Badeghiesh A, Suarthana E, Baghlaf H, Dahan MH.Polycystic ovary syndrome as an independent risk factor for gestational diabetes and hypertensive disorders of pregnancy: a population-based study on 9.1 million pregnancies.Hum Reprod. 2020;35(7):1666-1674. doi:10.1093/humrep/deaa099Sobota-Grzeszyk A, Kuźmicki M, Szamatowicz J.Myoinositol in the prevention of gestational diabetes mellitus: Is it sensible?J Diabetes Res. 2019;3915253. doi:10.1155/2019/3915253Motuhifonua SK, Lin L, Alsweiler J, Crawford TJ, Crowther CA.Antenatal dietary supplementation with myo-inositol for preventing gestational diabetes.Cochrane Database of Systematic Reviews. 2023;2023(2). doi:10.1002/14651858.CD011507.pub3Troisi J, Cinque C, Giugliano L, Symes S, Richards S, Adair D,et al.Metabolomic change due to combined treatment with myo-inositol, D-chiro-inositol and glucomannan in polycystic ovarian syndrome patients: a pilot study.J Ovarian Res. 2019 Mar 23;12(1):25. doi:10.1186/s13048-019-0500-x.McCartney CR, Marshall JC.Polycystic Ovary Syndrome.N Engl J Med. 2016;375(1):54-64. doi:10.1056/NEJMcp1514916Additional ReadingUS Department of Health and Human Services.Polycystic ovary syndrome.

Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read oureditorial processto learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.

Facchinetti F, Appetecchia M, Aragona C, et al.Experts’ opinion on inositols in treating polycystic ovary syndrome and non-insulin dependent diabetes mellitus: a further help for human reproduction and beyond.Expert Opin Drug Metab Toxicol. 2020;16(3):255-74. doi:10.1080/17425255.2020.1737675Centers for Disease Control and Prevention.PCOS (Polycystic Ovary Disease) and Diabetes.Lepore E, Lauretta R, Bianchini M, Mormando M, Di Lorenzo C, Unfer V.Inositols Depletion and Resistance: Principal Mechanisms and Therapeutic Strategies.Int J Mol Sci. 2021 Jun 24;22(13):6796. doi:10.3390/ijms22136796.Le Donne M, Metro D, Alibrandi A, Papa M, Benvenga S.Effects of three treatment modalities (diet, myoinositol or myoinositol associated with D-chiro-inositol) on clinical and body composition outcomes in women with polycystic ovary syndrome.Eur Rev Med Pharmacol Sci. 2019 Mar;23(5):2293-2301. doi:10.26355/eurrev_201903_17278.Moroni RF, Cazzaniga E, Palestini P, Sculati M.The feasibility of a diet which enhances inositol availability.Prog Nutr. 2021;23(2). doi:10.23751/pn.v23i2.10356Monastra G, Vucenik I, Harrath AH, et al.PCOS and inositols: controversial results and necessary clarifications. basic differences between d-chiro and myo-inositol.Front Endocrinol. 2021;12:269. doi:10.3389/fendo.2021.660381Kalra B, Kalra S, Sharma JB.The inositols and polycystic ovary syndrome.Indian J Endocrinol Metab. 2016;20(5):720–724. doi:10.4103/2230-8210.189231Nordio M, Basciani S, Camajani E.The 40: 1 myo-inositol/D-chiro-inositol plasma ratio is able to restore ovulation in PCOS patients: comparison with other ratios.Eur Rev Med Pharmacol Sci. 2019;23(12):5512-21. doi:10.26355/eurrev_201906_18223Wojciechowska A, Osowski A, Jóźwik M, Górecki R, Rynkiewicz A, Wojtkiewicz J.Inositols' importance in the improvement of the endocrine-metabolic profile in PCOS.Int J Mol Sci. 2019;20(22):5787. doi:10.3390/ijms20225787Melo AS, Ferriani RA, Navarro PA.Treatment of infertility in women with polycystic ovary syndrome: approach to clinical practice.Clinics. 2015;70(11):765-769. doi:10.6061/clinics/2015(11)09Merviel P, James P, Bouée S, et al.Impact of myo-inositol treatment in women with polycystic ovary syndrome in assisted reproductive technologies.Reprod Health.2021;18(1):13. doi:10.1186/s12978-021-01073-3Mohammadi S, Eini F, Bazarganipour F, Taghavi SA, Kutenaee MA.The effect of myo-inositol on fertility rates in poor ovarian responder in women undergoing assisted reproductive technique: a randomized clinical trial.Reprod Biol Endocrin. 2021;19(1):61. doi:10.1186/s12958-021-00741-0Palomba S, Daolio J, La Sala GB.Oocyte competence in women with polycystic ovary syndrome.Trends Endocrinol Metab. 2017;28(3):186-98. doi:10.1016/j.tem.2016.11.008Roseff S, Montenegro M.Inositol treatment for PCOS should be science-based and not arbitrary.Int J Endocrinol.2020;6461254. doi:10.1155/2020/6461254Mills G, Badeghiesh A, Suarthana E, Baghlaf H, Dahan MH.Polycystic ovary syndrome as an independent risk factor for gestational diabetes and hypertensive disorders of pregnancy: a population-based study on 9.1 million pregnancies.Hum Reprod. 2020;35(7):1666-1674. doi:10.1093/humrep/deaa099Sobota-Grzeszyk A, Kuźmicki M, Szamatowicz J.Myoinositol in the prevention of gestational diabetes mellitus: Is it sensible?J Diabetes Res. 2019;3915253. doi:10.1155/2019/3915253Motuhifonua SK, Lin L, Alsweiler J, Crawford TJ, Crowther CA.Antenatal dietary supplementation with myo-inositol for preventing gestational diabetes.Cochrane Database of Systematic Reviews. 2023;2023(2). doi:10.1002/14651858.CD011507.pub3Troisi J, Cinque C, Giugliano L, Symes S, Richards S, Adair D,et al.Metabolomic change due to combined treatment with myo-inositol, D-chiro-inositol and glucomannan in polycystic ovarian syndrome patients: a pilot study.J Ovarian Res. 2019 Mar 23;12(1):25. doi:10.1186/s13048-019-0500-x.McCartney CR, Marshall JC.Polycystic Ovary Syndrome.N Engl J Med. 2016;375(1):54-64. doi:10.1056/NEJMcp1514916

Facchinetti F, Appetecchia M, Aragona C, et al.Experts’ opinion on inositols in treating polycystic ovary syndrome and non-insulin dependent diabetes mellitus: a further help for human reproduction and beyond.Expert Opin Drug Metab Toxicol. 2020;16(3):255-74. doi:10.1080/17425255.2020.1737675

Centers for Disease Control and Prevention.PCOS (Polycystic Ovary Disease) and Diabetes.

Lepore E, Lauretta R, Bianchini M, Mormando M, Di Lorenzo C, Unfer V.Inositols Depletion and Resistance: Principal Mechanisms and Therapeutic Strategies.Int J Mol Sci. 2021 Jun 24;22(13):6796. doi:10.3390/ijms22136796.

Le Donne M, Metro D, Alibrandi A, Papa M, Benvenga S.Effects of three treatment modalities (diet, myoinositol or myoinositol associated with D-chiro-inositol) on clinical and body composition outcomes in women with polycystic ovary syndrome.Eur Rev Med Pharmacol Sci. 2019 Mar;23(5):2293-2301. doi:10.26355/eurrev_201903_17278.

Moroni RF, Cazzaniga E, Palestini P, Sculati M.The feasibility of a diet which enhances inositol availability.Prog Nutr. 2021;23(2). doi:10.23751/pn.v23i2.10356

Monastra G, Vucenik I, Harrath AH, et al.PCOS and inositols: controversial results and necessary clarifications. basic differences between d-chiro and myo-inositol.Front Endocrinol. 2021;12:269. doi:10.3389/fendo.2021.660381

Kalra B, Kalra S, Sharma JB.The inositols and polycystic ovary syndrome.Indian J Endocrinol Metab. 2016;20(5):720–724. doi:10.4103/2230-8210.189231

Nordio M, Basciani S, Camajani E.The 40: 1 myo-inositol/D-chiro-inositol plasma ratio is able to restore ovulation in PCOS patients: comparison with other ratios.Eur Rev Med Pharmacol Sci. 2019;23(12):5512-21. doi:10.26355/eurrev_201906_18223

Wojciechowska A, Osowski A, Jóźwik M, Górecki R, Rynkiewicz A, Wojtkiewicz J.Inositols' importance in the improvement of the endocrine-metabolic profile in PCOS.Int J Mol Sci. 2019;20(22):5787. doi:10.3390/ijms20225787

Melo AS, Ferriani RA, Navarro PA.Treatment of infertility in women with polycystic ovary syndrome: approach to clinical practice.Clinics. 2015;70(11):765-769. doi:10.6061/clinics/2015(11)09

Merviel P, James P, Bouée S, et al.Impact of myo-inositol treatment in women with polycystic ovary syndrome in assisted reproductive technologies.Reprod Health.2021;18(1):13. doi:10.1186/s12978-021-01073-3

Mohammadi S, Eini F, Bazarganipour F, Taghavi SA, Kutenaee MA.The effect of myo-inositol on fertility rates in poor ovarian responder in women undergoing assisted reproductive technique: a randomized clinical trial.Reprod Biol Endocrin. 2021;19(1):61. doi:10.1186/s12958-021-00741-0

Palomba S, Daolio J, La Sala GB.Oocyte competence in women with polycystic ovary syndrome.Trends Endocrinol Metab. 2017;28(3):186-98. doi:10.1016/j.tem.2016.11.008

Roseff S, Montenegro M.Inositol treatment for PCOS should be science-based and not arbitrary.Int J Endocrinol.2020;6461254. doi:10.1155/2020/6461254

Mills G, Badeghiesh A, Suarthana E, Baghlaf H, Dahan MH.Polycystic ovary syndrome as an independent risk factor for gestational diabetes and hypertensive disorders of pregnancy: a population-based study on 9.1 million pregnancies.Hum Reprod. 2020;35(7):1666-1674. doi:10.1093/humrep/deaa099

Sobota-Grzeszyk A, Kuźmicki M, Szamatowicz J.Myoinositol in the prevention of gestational diabetes mellitus: Is it sensible?J Diabetes Res. 2019;3915253. doi:10.1155/2019/3915253

Motuhifonua SK, Lin L, Alsweiler J, Crawford TJ, Crowther CA.Antenatal dietary supplementation with myo-inositol for preventing gestational diabetes.Cochrane Database of Systematic Reviews. 2023;2023(2). doi:10.1002/14651858.CD011507.pub3

Troisi J, Cinque C, Giugliano L, Symes S, Richards S, Adair D,et al.Metabolomic change due to combined treatment with myo-inositol, D-chiro-inositol and glucomannan in polycystic ovarian syndrome patients: a pilot study.J Ovarian Res. 2019 Mar 23;12(1):25. doi:10.1186/s13048-019-0500-x.

McCartney CR, Marshall JC.Polycystic Ovary Syndrome.N Engl J Med. 2016;375(1):54-64. doi:10.1056/NEJMcp1514916

US Department of Health and Human Services.Polycystic ovary syndrome.

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