Key TakeawaysNext-generation COVID-19 boosters are replacing the original booster formula for people ages 5 and older (Pfizer) and 6 and older (Moderna).The new shots are bivalent, meaning they protect against both the original COVID-19 and newer Omicron variants, such as BA.4 and BA.5.

Key Takeaways

Next-generation COVID-19 boosters are replacing the original booster formula for people ages 5 and older (Pfizer) and 6 and older (Moderna).The new shots are bivalent, meaning they protect against both the original COVID-19 and newer Omicron variants, such as BA.4 and BA.5.

The booster vaccines are modified to better protect vaccinated people against hospitalization and death from newer viral variants. They arebivalent, meaning they can targetthe original COVID-19 strain as well as Omicron BA.5, the dominant variant in the United States.

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Health officials emphasized the timeliness of the updated booster rollout, as people will spend more time gathered indoors in the fall and winter. Making the new booster shots available will avert thousands of deaths and hospitalizations, researcherstold a CDC advisory panellast week.

Just how effective are the new boosters and when should you get yours? Here’s what we know so far.

Who Is Eligible for the New Booster Shot?

If you’re immunocompromised, you might have received more than one booster shot already, and you can get the new booster two months after your last vaccine.

What Makes This Booster Different?

The bivalent boosters are not entirely new vaccines. Moderna and Pfizer modified their existing vaccines to target different versions of the COVID-19 virus. The new booster is designed to protect against the original strain and Omicron subvariants BA.4 and BA.5.

Both Pfizer and Moderna’s bivalent boosters are the same dose size as the previous version. Pfizer’s vaccine for ages 12 and up contains 30 micrograms of antigen, while Moderna’s contains 50 micrograms. In each vaccine, half of the dose protects against the newer Omicron variants, while the other half is the original vaccine formula.

Children will receive smaller doses: 10 micrograms from Pfizer and 25 micrograms from Moderna.

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How Well Does the New Booster Work?

Earlier this year, Moderna and Pfizer conducted clinical data on bivalent vaccines geared toward Omicron BA.1, which drove a peak in cases at the beginning of 2022. In both trials, the boosters spurredhighlevelsof protective antibodies in the study participants.

Both companies also shared data on how bivalent vaccines that target BA.4 and BA.5—the more current strains—performed in mice. The Moderna bivalent vaccine boosted neutralizing antibodies in mice more than 4-fold, while mice inoculated with the Pfizer bivalent booster saw a 2.6-fold increase in antibodies.

When Should You Get the New Booster If You Just Had COVID?

After recovering fromCOVID-19, your body has a high level of immune cells geared up to protect against reinfection. Memory B cells ensure that the body remembers how to make neutralizing antibodies for some months after.

“For persons who have had prior COVID-19, the recommendation is to generally wait at least three months before giving the dose of vaccine,”Walter Orenstein, MD, professor and associate director at the Emory Vaccine Center, said in a press call.

Regardless of the interval, it’s best to be up-to-date with your vaccinations, even if you have some extra protection due to infection. Recent data from Qatar suggests that people who have received three doses of vaccine and had a prior COVID-19 infection are best protected against being sick from COVID-19 again.

Should You Still Get a Booster Shot After a Breakthrough COVID Case?

Should You Get the Updated Booster Shot If You Recently Got One?

The CDC recommends waiting at least two months since your last dose of vaccine. If you had a recent COVID-19 infection, the agency said you could consider delaying a booster dose until three months after a positive test.

Prior to this rollout, adults were advised to wait five months between their primary mRNA series and the first booster.

While the shorter interval may be safe, a longer interval may allow your body to build a more lasting immune response. Waiting for four to six months after your last dose of vaccine may be ideal for gaining long-term protection,Andrew Pekosz, PhD,a virologist and vice chair of the department of molecular microbiology and immunology at the Johns Hopkins Bloomberg School of Public Health, said in a press call.

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Can You Mix and Match Boosters?

Moderna and Pfizer haven’t collected data on how effective it is to get a bivalent booster shot that doesn’t correspond with your primary series.

However, clinical studies on primary regimens and the initial boosters suggest that getting a mixture of the two mRNA vaccines could beeven more effectivethan getting all the shots from the same manufacturer.

Kathryn M. Edwards, MD, FIDSA, a professor of pediatrics at the Vanderbilt University School of Medicine and a fellow of the Infectious Diseases Society of America, said mixing and matching your vaccine types likely provides the broadest immunity. Ultimately, you should get whichever updated booster is available to you.

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Can You Get the Booster and the Flu Shot at the Same Time?

The CDC recommends that people get the shots in different limbs.Ashish Jha, MD, MPH,White House Coronavirus Response Coordinator, said getting both vaccines at the same time may cause similar or only slightly higher incidence of side effects, but no serious adverse outcomes.

“I really believe this is why God gave us two arms—one for the flu shot and the other one for the COVID shot,” Jha said in a press briefing.

The flu season typically starts in October or November in the U.S., though data from Australia indicates that the season may start even earlier this year.

Will the Vaccines Be Free?

In the White Housepress briefingthis week, Jha said the updated boosters “will continue to remain free.” The government has already purchased 171 million doses of bivalent vaccine for this rollout, and there should be plenty of supply.

But Congress has failed to allocate additional funds for COVID-19 prevention and response. Initiatives likefree COVID test kitshave been halted because of insufficient funding.

“It’s an important question that we need to address, either through federal funding or additional ways of funding,” Pekosz said. “We don’t want the cost of these vaccinations, testing, and treatment to limit the uptake of those, especially in the vulnerable populations.”

Will You Need Even More Boosters in the Future?

It’s probably too early to know exactly what the booster timeline will look like going forward. Scientists aren’t yet sure just how long the protection from the updated boosters will last. They also can’t predict which new variants will arise and how well they will evade existing immune defenses.

It will take several months of follow-up with people who received the updated booster to know how quickly immune protection from that vaccination wanes. In the meantime, Anthony Fauci, MD, senior advisor to President Biden on coronavirus response, said at the White House press briefing that the White House was planning to give boosters once a year, as is done with flu shots. People with immunocompromised might expect to receive a booster more frequently.

“Looking forward with the COVID-19 pandemic, in the absence of a dramatically different variant, we likely are moving towards a path with a vaccination cadence similar to that of the annual influenza vaccine, with annual, updated COVID-19 shots matched to the currently circulating strains for most of the population,” Fauci said.

Scientists have also floated the idea of a universal vaccine that would protect against multiple COVID variants, including those that emerge in the future.

For now, getting the vaccines into arms and practicing masking and social distancing, are the best ways to protect people against COVID-19.

“Vaccine doses that remain in the vial are 0% effective. It’s not vaccines that save lives—it’s vaccinations that save lives,” Orenstein said.

What This Means For YouThe updated booster shots are now or will soon be available in locations where you can already be vaccinated, such as doctors’ offices, some health clinics, pharmacies, urgent care centers, and mobile COVID-19 vaccination sites. You can find vaccination sites near you atvaccines.gov.

What This Means For You

The updated booster shots are now or will soon be available in locations where you can already be vaccinated, such as doctors’ offices, some health clinics, pharmacies, urgent care centers, and mobile COVID-19 vaccination sites. You can find vaccination sites near you atvaccines.gov.

The information in this article is current as of the date listed, which means newer information may be available when you read this. For the most recent updates on COVID-19, visit ourcoronavirus news page.

6 SourcesVerywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read oureditorial processto learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.Food and Drug Administration.Coronavirus (COVID-19) update: FDA authorizes Moderna and Pfizer-BioNTech bivalent COVID-19 vaccines for use as a booster dose in younger age groups.Centers for Disease Control and Prevention.Interim clinical considerations for use of COVID-19 vaccines currently approved or authorized in the United States.Centers for Disease Control and Prevention.Interim clinical considerations for use of COVID-19 vaccines currently approved or authorized in the United States.Buckner CM, Kardava L, Merhebi OE, et al.Recent SARS-CoV-2 infection abrogates antibody and B-cell responses to booster vaccination.medRxiv. Preprint posted online August 31, 2022. doi:2022.08.30.22279344Centers for Disease Control and Prevention.Frequently asked questions about COVID-19 vaccination.Altarawneh HN, Chemaitelly H, Ayoub HH, et al.Effects of previous infection and vaccination on symptomatic Omicron infections.N Engl J Med. 2022;387(1):21-34. doi:10.1056/NEJMoa2203965

6 Sources

Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read oureditorial processto learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.Food and Drug Administration.Coronavirus (COVID-19) update: FDA authorizes Moderna and Pfizer-BioNTech bivalent COVID-19 vaccines for use as a booster dose in younger age groups.Centers for Disease Control and Prevention.Interim clinical considerations for use of COVID-19 vaccines currently approved or authorized in the United States.Centers for Disease Control and Prevention.Interim clinical considerations for use of COVID-19 vaccines currently approved or authorized in the United States.Buckner CM, Kardava L, Merhebi OE, et al.Recent SARS-CoV-2 infection abrogates antibody and B-cell responses to booster vaccination.medRxiv. Preprint posted online August 31, 2022. doi:2022.08.30.22279344Centers for Disease Control and Prevention.Frequently asked questions about COVID-19 vaccination.Altarawneh HN, Chemaitelly H, Ayoub HH, et al.Effects of previous infection and vaccination on symptomatic Omicron infections.N Engl J Med. 2022;387(1):21-34. doi:10.1056/NEJMoa2203965

Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read oureditorial processto learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.

Food and Drug Administration.Coronavirus (COVID-19) update: FDA authorizes Moderna and Pfizer-BioNTech bivalent COVID-19 vaccines for use as a booster dose in younger age groups.Centers for Disease Control and Prevention.Interim clinical considerations for use of COVID-19 vaccines currently approved or authorized in the United States.Centers for Disease Control and Prevention.Interim clinical considerations for use of COVID-19 vaccines currently approved or authorized in the United States.Buckner CM, Kardava L, Merhebi OE, et al.Recent SARS-CoV-2 infection abrogates antibody and B-cell responses to booster vaccination.medRxiv. Preprint posted online August 31, 2022. doi:2022.08.30.22279344Centers for Disease Control and Prevention.Frequently asked questions about COVID-19 vaccination.Altarawneh HN, Chemaitelly H, Ayoub HH, et al.Effects of previous infection and vaccination on symptomatic Omicron infections.N Engl J Med. 2022;387(1):21-34. doi:10.1056/NEJMoa2203965

Food and Drug Administration.Coronavirus (COVID-19) update: FDA authorizes Moderna and Pfizer-BioNTech bivalent COVID-19 vaccines for use as a booster dose in younger age groups.

Centers for Disease Control and Prevention.Interim clinical considerations for use of COVID-19 vaccines currently approved or authorized in the United States.

Buckner CM, Kardava L, Merhebi OE, et al.Recent SARS-CoV-2 infection abrogates antibody and B-cell responses to booster vaccination.medRxiv. Preprint posted online August 31, 2022. doi:2022.08.30.22279344

Centers for Disease Control and Prevention.Frequently asked questions about COVID-19 vaccination.

Altarawneh HN, Chemaitelly H, Ayoub HH, et al.Effects of previous infection and vaccination on symptomatic Omicron infections.N Engl J Med. 2022;387(1):21-34. doi:10.1056/NEJMoa2203965

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