Table of ContentsView AllTable of ContentsSevere Drug InteractionsModerate Drug InteractionsMinor Drug InteractionsAlcohol Interaction
Table of ContentsView All
View All
Table of Contents
Severe Drug Interactions
Moderate Drug Interactions
Minor Drug Interactions
Alcohol Interaction
If you live with chronic arthritis—osteoarthritisorrheumatoid arthritis—your healthcare provider may prescribe nabumetone to relieve the pain, tenderness, swelling, and stiffness that can accompany those conditions. Some medical professionals may also prescribe nabumetone off-label to treat ankylosing spondylitis.
As with all medications, nabumetone carries the possibility of interacting with other drugs or substances, leading to adverse reactions. These reactions range from an increase in the action of either drug, a decrease in drug efficacy, a delay in drug absorption rate, or an unexpected harmful side effect.
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Once available in its brand name form, Relafen, nabumetone is now only available in its generic form.Nabumetone comes as a tablet to be taken orally in 500-milligram (mg) and 750-mg doses.
The recommended starting dose is 1,000 mg per day for people age 18 and over. However, your healthcare provider may start you on a lower dose and gradually increase it if necessary. The maximum daily dose is 2,000 mg. This drug is not indicated for people under age 18 and has not been studied in that population.
Depending on your prescribed dose, you may be instructed to take nabumetone once or twice daily with or without food. For chronic use, the lowest effective dose is recommended.Be sure to follow the instructions on your prescription label. If you have any questions, ask your healthcare provider or pharmacist.
Before beginning any new drug, it is important to let your healthcare provider or pharmacist know what medicines—prescription, supplemental, or over-the-counter—you currently take. Nabumetone has a known list of drugs it interacts with to varying degrees of severity. Mixing different drugs can cause serious side effects.
Nabumetone is known to have severe reactions with the drugs and substances listed below. However, this list is not complete.
If you take medication for any of the following conditions, check with your healthcare provider or pharmacist to ensure the drugs you take do not interact with nabumetone. Some of these drugs and their interactions include the following, but it is not an all-inclusive list:
Taking nabumetone with the following medications can cause moderate interactions. If you are being treated for other conditions, make sure to talk to your healthcare provider before starting nabumetone so that together you can make informed decisions on your care. These drugs and their interactions include:
Some drugs and substances may cause minor interactions with nabumetone. While the risks are small, it is still worth talking to your healthcare provider about any possible side effects you may experience taking these other medications and supplements with nabumetone.
Alcohol Interaction
Drinking alcohol is not recommended while on nabumetone as it can cause increased risk of stomach bleeding. Ask your healthcare provider before consuming alcohol with nabumetone.
If you experience any symptoms of stomach bleeding—black, tarry, or bloody stools, blood when coughing, or vomit that appears like coffee grounds—contact your healthcare provider immediately.
Consult a Healthcare PRovider if PregnantIf you are pregnant, do not take nabumetone unless specifically advised to do so.Taking an NSAID like nabumetone, especially during the third trimester, can lead to renal impairment in the fetus.
Consult a Healthcare PRovider if Pregnant
If you are pregnant, do not take nabumetone unless specifically advised to do so.Taking an NSAID like nabumetone, especially during the third trimester, can lead to renal impairment in the fetus.
A Word From Verywell
Many questions may arise when you start a new medication like nabumetone. When it comes to your health, staying proactive is best. Talking to your healthcare provider about your treatment plan and understanding all the possible interactions can keep you informed.
If you are being treated for other conditions outside of the one your healthcare provider has prescribed nabumetone for, make sure your practitioner knows all of the medications, substances, and supplements you take to treat these other conditions. Keep yourself informed and talk to your healthcare provider about any concerns.
Nabumetone can provide relief from some of your arthritic symptoms. Understanding the possible negative interactions can help you achieve that relief without risking negative effects.
8 SourcesVerywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read oureditorial processto learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.Prescribers Digital Reference.Nabumetone (nabumetone) dose, indications, adverse effects, interactions.Lu Y, Shen D, Pietsch M,et al.A novel algorithm for analyzing drug-drug interactions from MEDLINE literature.Sci Rep.2015;17357. doi:10.1038/srep17357MedlinePlus.Nabumetone.National Institutes of Health DailyMed.Nabumetone - nabumentone tablet.National Institutes of Health DailyMed.Nabumetone tablet, film coated.Muñoz-Cano R, Pascal M, Araujo G, et al.Mechanisms, cofactors, and augmenting factors involved in anaphylaxis.Front Immunol. 2017;8:1193. doi:10.3389/fimmu.2017.01193FDA - Package insert.Palforzia.Medline Plus Supplements.Clove.Additional ReadingLiverTox: Clinical and Research Information on Drug-Induced Liver Injury.Nabumetone.
8 Sources
Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read oureditorial processto learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.Prescribers Digital Reference.Nabumetone (nabumetone) dose, indications, adverse effects, interactions.Lu Y, Shen D, Pietsch M,et al.A novel algorithm for analyzing drug-drug interactions from MEDLINE literature.Sci Rep.2015;17357. doi:10.1038/srep17357MedlinePlus.Nabumetone.National Institutes of Health DailyMed.Nabumetone - nabumentone tablet.National Institutes of Health DailyMed.Nabumetone tablet, film coated.Muñoz-Cano R, Pascal M, Araujo G, et al.Mechanisms, cofactors, and augmenting factors involved in anaphylaxis.Front Immunol. 2017;8:1193. doi:10.3389/fimmu.2017.01193FDA - Package insert.Palforzia.Medline Plus Supplements.Clove.Additional ReadingLiverTox: Clinical and Research Information on Drug-Induced Liver Injury.Nabumetone.
Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read oureditorial processto learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.
Prescribers Digital Reference.Nabumetone (nabumetone) dose, indications, adverse effects, interactions.Lu Y, Shen D, Pietsch M,et al.A novel algorithm for analyzing drug-drug interactions from MEDLINE literature.Sci Rep.2015;17357. doi:10.1038/srep17357MedlinePlus.Nabumetone.National Institutes of Health DailyMed.Nabumetone - nabumentone tablet.National Institutes of Health DailyMed.Nabumetone tablet, film coated.Muñoz-Cano R, Pascal M, Araujo G, et al.Mechanisms, cofactors, and augmenting factors involved in anaphylaxis.Front Immunol. 2017;8:1193. doi:10.3389/fimmu.2017.01193FDA - Package insert.Palforzia.Medline Plus Supplements.Clove.
Prescribers Digital Reference.Nabumetone (nabumetone) dose, indications, adverse effects, interactions.
Lu Y, Shen D, Pietsch M,et al.A novel algorithm for analyzing drug-drug interactions from MEDLINE literature.Sci Rep.2015;17357. doi:10.1038/srep17357
MedlinePlus.Nabumetone.
National Institutes of Health DailyMed.Nabumetone - nabumentone tablet.
National Institutes of Health DailyMed.Nabumetone tablet, film coated.
Muñoz-Cano R, Pascal M, Araujo G, et al.Mechanisms, cofactors, and augmenting factors involved in anaphylaxis.Front Immunol. 2017;8:1193. doi:10.3389/fimmu.2017.01193
FDA - Package insert.Palforzia.
Medline Plus Supplements.Clove.
LiverTox: Clinical and Research Information on Drug-Induced Liver Injury.Nabumetone.
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